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All Journal Indonesian Journal of Cancer Chemoprevention PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Kreativitas PKM Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Buana Farma Mejuajua Indonesian Community Journal Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Helium: Journal of Science and Applied Chemistry Jurnal Pengabdian Masyarakat Medika Jurnal Pengabdian Masyarakat Bangsa TeknoKreatif: Jurnal Pengabdian kepada Masyarakat Helium: Journal of Science and Applied Chemistry
Refsya Azanti Putri
Institut Teknologi Sumatera, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Penyuluhan Pemanfaatan Kacang Hijau dan Daun Bayam Sebagai Produk Minuman Serbuk Herbal “BHESTI” dalam Upaya Pencegahan Stunting di Desa Way Galih, Lampung Selatan Intan kusuma wardani; Putri, Refsya Azanti; Andrea, Nabila; Putri, Suci Ananda; Ramdhani, Adean Naufal; Tsamarah, Dinda Taqiyyah; Adyani, Made Ninta; Khasanah, Zahrotun; Dzafitri, Rizka; Hindyana, Daffa Aqilla; Rahmawati, Winda; Safitri , Regif Desty; Sifana, Afiqa Najla; Faridah, Adinda Fitri Nur
Jurnal Dimas Vol 6 No 1 (2024): Jurnal Pengabdian Kepada Masyarakat
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/dimas.v6i1.79

Abstract

Stunting is a condition where toddlers fail to thrive due to prolonged chronic malnutrition and repeated exposure to infections, especially in the first 1000 days of life (HPK), resulting in short growth in children who do not meet standards. Based on Riskesdas data, the stunting rate in 2023 will reach 21.6% and every year the stunting rate in Indonesia continues to decline. One of the vegetable or legume commodities that is useful in fulfilling nutrition during the growing period is spinach leaves and soybeans. This is because green beans contain complete protein, namely calcium, potassium, phosphorus, iron, vitamins A, B, C. , E, and K. Apart from that, the nutritional content of spinach includes vitamins and minerals, including vitamins A, B, C, protein, fat, carbohydrates, potassium, calcium, phosphorus and iron. One local food product that is well received by the public is a drink in the form of herbal powder with the main ingredients being green beans and spinach leaves. This community service (PkM) activity was carried out to introduce the results of innovations in making products that can be produced independently by the people of Way Galih Village, Tanjung Bintang District, South Lampung Regency. This activity consists of three stages including preparation, implementation and evaluation stages. The results of this activity are an increase in the understanding of the Way Galih Village community regarding education about stunting as well as nutritional information needed by children during the growth period which can be obtained through foods that are easy to find in everyday life such as green beans and spinach.
Pelatihan Pengolahan Limbah Produksi Tahu menjadi Produk Bernilai Guna pada Kelompok PKK Desa Padang Rejo Kecamatan Pagelaran Kabupaten Pringsewu Ayuwulanda, Aditya; Kurniawan, Rahmat; Putri, Refsya Azanti; Ashari, Arif; Pratama, Yoga Anjas; Aurell S, Nasheka Rajwaa; Azzahra, Raihana; Simamora, Benget Backtiar; Fitriya, Marsela Nur; Apriliani, Ester; Sihombing, Zoel Fresly; Sinaga, Hanzel Nomensen
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 9 (2025): November
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i9.3371

Abstract

Kegiatan Pengabdian kepada Masyarakat (PkM) ini bertujuan meningkatkan pengetahuan dan keterampilan masyarakat dalam mengolah limbah tahu menjadi produk bernilai tambah, yaitu pupuk organik cair (POC) dari whey tahu dan abon ayam dari ampas tahu. Kegiatan dilaksanakan di Desa Padang Rejo dengan melibatkan kelompok PKK dan kelompok tani sebagai peserta. Metode pelaksanaan mencakup sosialisasi, demonstrasi pembuatan produk, serta diskusi interaktif mengenai manfaat dan potensi ekonomi dari pengelolaan limbah tahu. Hasil kuesioner menunjukkan sebagian besar peserta menilai materi mudah dipahami, proses pembuatan jelas, dan produk bermanfaat. Pada kegiatan POC, 100% peserta berminat mencoba pembuatan mandiri, sementara pada kegiatan abon, 80% peserta tertarik mengembangkan produk pangan berbasis limbah tahu. Temuan ini menegaskan keberhasilan PkM dalam meningkatkan kesadaran, motivasi, dan keterampilan masyarakat terkait pengelolaan limbah tahu secara produktif. Program ini juga memberikan dampak positif terhadap penerapan ekonomi sirkular, pengurangan limbah, serta pemberdayaan masyarakat, mendukung kemandirian ekonomi dan pertanian berkelanjutan di tingkat lokal.
The Potential of Isoniazid Derivatives as Anti-Tuberculosis Drugs targeting 6MA8: In Silico Study Saputra, Muhammad Yogi; Ivansyah, Atthar Luqman; Maharani, Nabila Aprilia; Kurniawan, Rahmat; Putri, Refsya Azanti; Abshar, Irham Fauzi
Helium: Journal of Science and Applied Chemistry Vol. 5 No. 1 (2025): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v5i1.13

Abstract

Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis. Isoniazid, a synthetic antimicrobial agent, remains one of the most crucial first-line medications in TB therapy. Enhancing TB treatment strategies can be achieved through structural modifications of existing drugs. This study investigates the potential of isoniazid derivatives as anti-tuberculosis agents targeting the CYP3A4 protein complexed with a small-molecule inhibitor (PDB ID: 6MA8) and evaluates their toxicity profiles using in silico methods. The ligands analyzed include isoniazid derivatives 1–5, with isoniazid as a reference compound and protoporphyrin as the native ligand. The structure of ligands was prepared using Avogadro software and optimized with ORCA software. The crystal structures of 6MA8 were retrieved from the PDB database and further validated using YASARA. In silico methods such as molecular docking and ProTox prediction were employed to evaluate the potential of these isoniazid derivatives as anti-TB drugs. The interactions were visualized using Biovia Discovery to assess the interaction between the isoniazid derivatives and the receptor. The results showed derivative 4 exhibited the lowest binding affinity (-71.56 kcal/mol) compared to isoniazid (-65.90 kcal/mol), derivative 1 (-63.65 kcal/mol), derivative 2 (-67.01 kcal/mol), derivative 3 (-67.37 kcal/mol), derivative 5 (-69.02 kcal/mol), and native ligand (-182.68 kcal/mol). Biovia Discovery Studio simulations indicated that the isoniazid derivatives interacted with 6MA8 via conventional hydrogen bonds, carbon-hydrogen bonds, and other interactions. The toxicity analysis showed that the derivatives had safe LD50 values, supporting their safety profiles. These results suggest that isoniazid derivatives have promising potential as anti-tuberculosis agents targeting 6MA8.
Formulasi Hand Soap dari Kombucha Bonggol Nanas (Ananas comosus (L.) Merr.) dan Uji Aktivitasnya terhadap Bakteri Staphylococcus aureus Ramadhani, Untia Kartika Sari; Aulia, Nanda; Putri, Refsya Azanti; Yunira, Eka Nur’azmi; Amelia, Okta
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 22 No. 02 Desember 2025
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Bonggol nanas (Ananas comosus (L.) Merr.) merupakan limbah dari buah nanas yang berperan sebagai antibakteri karena memiliki kandungan senyawa flavonoid, saponin, enzim bromelin, dan tanin. Bonggol nanas dibuat dalam bentuk fermentasi kombucha menghasilkan asam organik yang dapat meningkatkan potensi antibakteri bonggol nanas, kemudian diformulasikan sebagai hand soap untuk mengurangi diare. Penelitian ini bertujuan untuk melihat pengaruh variasi konsentrasi kombucha bonggol nanas terhadap sifat dan stabilitas fisik sediaan hand soap, serta pengaruhnya terhadap aktivitas antibakteri terhadap bakteri S.aureus. Formula sediaan hand soap terdapat empat formula yang memiliki perbedaan variasi konsentrasi kombucha yaitu 0% (F0), 15% (F1), 25% (F2), dan 35% F3. Hasil uji sifat fisik pada F0 berwarna kuning, F1 berwarna orange, F2 berwarna orange tua, F3 berwarna orange kecoklatan, berbau nanas, dan tekstur kental, memiliki pH 7,68 - 7,19, tinggi busa 81-110 mm, viskositas 860,00-1396,33 cPs, bobot jenis 1,04-1,09 g/mL, serta kadar air 37,79%-26,55%. Setelah dilakukan stabilitas fisik terjadi penurunan pH, viskositas, bobot jenis dan peningkatan kadar air, namun busa tetap stabil. Aktivitas antibakteri sangat kuat terdapat pada F3 dengan daya hambat 22,16 ± 2,24 mm. Berdasarkan hasil uji tersebut dapat disimpulkan bahwa sediaan hand soap yang diformulasikan berkhasiat sebagai antibakteri dan dapat dimanfaatkan untuk mengurangi terjadinya diare.
Co-Authors A.L, Ihza Adzkiya Mubarak Abshar, Irham Fauzi Adyani, Made Ninta Amanda Wahyu Kurniawan Ambar Yunita Ambar Yunita Nugraheni Amelia, Okta Andrea, Nabila Apriliani, Ester Arif Ashari Arrafi, Muhammad Zhafran Atthar Luqman Ivansyah Audi Tahta Aurellia Aulia, Nanda Aurell S, Nasheka Rajwaa Ayu, Rakyan Wening Puspa Ayuwulanda, Aditya Azzahra, Raihana A’dilah, Anis Afkar Brainandiva Ade Fitria Cahya Rahma Utami Cahyadi, Dzaky Raihan Cholisoh, Zakky Dedi Hanwar Dewi, Sri Kumala Dina Putri Agustina Dzafitri, Rizka Dzaki Arrafif Endang Setyaningsih Enggelina, Nia Natalia Erindyah Retno Wikantyasning Fadhilla, Hana Fajar Fauzi, Muh Faj’riati, Nur Alfi Khoirul Faridah, Adinda Fitri Nur Fauziyya, Riri Findawan, Geofany Hargi Fitriya, Marsela Nur Hakim, Ahmad Zammi Autadan Hanifa, Milla hanifah, zulfa nur Hart, A’Ang Yuanita Hasna, Naurah Rosyidah Hindyana, Daffa Aqilla Ika Trisharyanti Dian Kusumowati intan kusuma wardani Irawan, Siti Azara Nayla Isna Mulyani Kartika Sari Ramadhani, Untia Keisya Aurora Natasha Chairunisa Khasanah, Zahrotun Khoirunnisa Khoirunnisa Kiki Yuli Handayani Lulu Zaqia Luluk Ria Rakhma Maharani, Maisa Maharani, Nabila Aprilia Mariska, Soraya Maulidia Rahayyu, Annisa Meiliana, Sherin Isna Muhammad Ikhsan Al Af Ghani Muhammad Yogi Saputra N.S, Yonatan Adi Nabila Ahlika Ulya Nadia Nur Syakilla Natasya Armelia Putri Ningtiyas, Amelia Rizki Nisa Yulianti Suprahman Nur Mahmudah Nur ‘Azah Nurnahari, Naura Putri, Erika Arista Putri, Suci Ananda Rahmadi, Muhammad Zaki Ammar Rahmat Kurniawan Ramadhani, Salsabila Putri Ramadhani, Untia Kartika Sari Ramdhani, Adean Naufal Retinovaliani, Aviolena Rima Munawaroh Riyadi, Eka Putri Widya Arsia Saeli, Pinka Mustika Safitri , Regif Desty Salsabila Fauziah Sania Nayasari Khoirunnisa Sarmoko Sarmoko Sayekti, Nurul Cahyaning Nardi Sekarsari Yusuf, Mubarika Setyo Nurwaini Sifana, Afiqa Najla Sihombing, Zoel Fresly Simamora, Benget Backtiar Sinaga, Hanzel Nomensen Syahdiba, Natasya Maula Syaikhul Aziz Tantri Liris Nareswari Tsamarah, Dinda Taqiyyah Winda Rahmawati Windari, Nurul Irna Windasari, Liska Winni Nur Auli Yoga Anjas Pratama Yuka Aulia Rahma Yunira, Eka Nur’azmi Zada Agna Talitha