Article Per Year (5 Year)
p-Index From 2020 - 2025
1.881
P-Index
This Author published in this journals
All Journal Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Interdisciplinary Social Studies Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat Jurnal Janata Sciences of Phytochemistry Journal of Natural Product for Degenerative Diseases
Gumilar Adhi Nugroho
Faculty Of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Transportation

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Study of Potential Antiobesity Compounds from Amylchlorogenate Derivates on Leptin Hormone and their Toxicity using Molecular Docking Approach Faridah; Shirly Kumala; Gumilar Adhi Nugroho; Partomuan Simanjuntak
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 2 (2024): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i2.6070

Abstract

Chlorogenic acid, a type of phenolic acid, is a polar compound that has anti-obesity effects with unclear mechanisms. This study aims to obtain compounds that are active as antiobesity, their interaction with receptors and its toxicity. This research was carried out in several steps, internal validation of targets and methods using Yasara, docking of test compounds and positive control using PLANTs, interaction visualization using Pymol and toxicity testing using Protox-II. Validation results show four receptors and test method meet the requirements. Docking results of setmelanotide on receptor code 1PXH -113.81; 2QBP -109.163; 2QBR -110.113, 2; QBS -110.817 kcal/mol respectively. The docking results of the test compounds in 1PXH namely 7,4,5-Triamylchlorogenate (compound a) -114,333 kcal/mol. In 2QBP namely 7,3'-Diamylchlorogenate (110,152) (compound b), (compound a) (-109,818), 7,4,3',4'-Tetraamylchlorogenate (compound c) (-115,309), 7,5,3',4'-Tetraamylchlorogenate (compound d) (-112,85), 7,4,5,3',4'-Pentaamylchlorogenate (compound e) (-110,414) and 2',5'-Diamylchlorogenic acid (compound f) (-113, 565) kcal/mol. In 2QBR namely, (compound a) (-114,276), (compound e) (-111,059), and (compound f) (-110,398) kcal/mol. In 2QBS namely, (compound a) (-113.53), and (compound d) (-111,676) kcal / mol. The active site of amino acids that have affinity are, ARG45 and LYS120 in 1PXH; ASP48, SER118 and ARG47 in 2QBP; ASP48 and ARG24 in 2QBR; ASP48 and GLN262 in 2QBS code. Toxicity tests obtained oral LD50 of 5000 mg/kg BW (compounds a and f); 3800 mg/kg BW (compounds b, c, d and e). The potential compound that was active in all the test receptor codes was 7,4,5-Tripentylchlorogenate (compound a). All active test compounds were relatively safe.
Co-Authors Andam Dewi, Mira Anggiyasari Anggiyasari Arfin Ahsanul Ihsan Arif Tatak Camalia Hartantrie, Rovida Deni Rahmat Fahleni Fahleni Faizatun FAIZATUN, FAIZATUN FARIDAH Fauzia Noprima Okta Fauzia Noprima Okta Greesty Finotory Swandiny Hakim, Zainur Rahman Jasmadeti, Jasmadeti Kurniawan, Fajar Ary Larasinta, Nadia Lhu Muslimah, Lhu Lim, Helsa Mantika Atiqah Baihaty Marwati, Umi Muhammad Taher Bakhtiar Mulatsari, Esti Nathalia Perdhani Soemantri Ni Made Dwi Sandhiutami Noviyantih, Noviyantih Okta, Fauzia Noprima Partomuan Simanjuntak Pratita, Rasta Naya Priyanti, Ike Ari Qodriah, Rahmatul Safira Nafisa Sari, Intan Pertama Shirly Kumala Suherman, Sandra Loretta Trisna Permadi YATI SUMIYATI Yati Sumiyati, Yati Yesi Desmiaty, Yesi Zahra Afifah