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All Journal Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Interdisciplinary Social Studies Jurnal Abdimas Kartika Wijayakusuma Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat Jurnal Janata Sciences of Phytochemistry Journal of Natural Product for Degenerative Diseases Journal of Health Sciences, Medicine, Biotechnology, and Pharmaceutical Research
Gumilar Adhi Nugroho
Faculty Of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Transportation Other

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The nanoparticle formula optimization from Temulawak extract (Curcuma xanthorrhiza) as adjuvant therapy Swandiny, Greesty Finotory; Nafisa, Safira; Qodriah, Rahmatul; Nugroho, Gumilar Adhi; Bakhtiar, Muhammad Taher
Interdisciplinary Social Studies Vol. 3 No. 2 (2024): January-March 2024 (Regular Issue)
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/iss.v3i2.629

Abstract

Temulawak extract was synthesized using temulawak sodium alginate. The nanoparticle formula was obtained by combining the characteristics of temuwak extract and temusawak. The microbeads were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The size of Alg-Curcuma was measured at SEM. The particle size distribution of the sample was analyzed using FTIR spectra. The results showed that the size of the resulting beads is microparticle in size. It was found that the temurawak extract is a good candidate as an anticancer agent. Therefore, there are several recommendations that can be done to optimize the synthesis of the material. The study reported that the recommended parameter is 12.5 kV with a flow rate of 0.1 mL/h (first batch synthesis).
Diversifikasi Umbi Porang Menjadi Pangan Olahan Yang Sehat dan Memiliki Nilai Gizi Melalui Pendekatan P5 dalam Kurikulum Merdeka Belajar Qodriah, Rahmatul; Nafisa, Safira; Nugroho, Gumilar Adhi; Aziz, Zuhelmi; Rahmandani, Arif
Jurnal Abdimas Kartika Wijayakusuma Vol 7 No 1 (2026): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v7i1.1223

Abstract

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pemahaman dan keterampilan peserta dalam mengolah umbi porang menjadi berbagai produk pangan sehat dan bernilai gizi tinggi melalui pendekatan Proyek Penguatan Profil Pelajar Pancasila (P5) dalam Kurikulum Merdeka Belajar. Umbi porang merupakan komoditas lokal yang memiliki potensi ekonomi serta kandungan glukomanan yang bermanfaat bagi kesehatan, namun pemanfaatannya sebagai pangan olahan masih terbatas di masyarakat. Melalui pendekatan P5, kegiatan ini dirancang untuk menumbuhkan kreativitas, gotong royong, kemandirian, dan kemampuan berpikir kritis siswa SDIT Lentera Insan Depok. Metode pelaksanaan meliputi penyuluhan gizi, pelatihan teknik pengolahan porang menjadi produk beras analog porang, serta praktik langsung dalam kelompok kecil. Hasil kegiatan menunjukkan peningkatan pengetahuan peserta mengenai nilai gizi porang dan teknik pengolahannya, serta tumbuhnya keterampilan dalam menghasilkan produk pangan yang inovatif dan layak konsumsi. Kegiatan ini diharapkan dapat mendorong diversifikasi pangan lokal serta membuka peluang ekonomi kreatif berbasis potensi daerah.
Herb–Drug Interactions Between Common Indonesian Medicinal Plants and Cardiovascular Medications: A Narrative Review Aditya Sindu Sakti; Gumilar Adhi Nugroho; Febrika Wediasari; Muhammad Adil Khan; Muhammad Subhan A. Sibadu
Journal of Health Sciences, Medicine, Biotechnology, and Pharmaceutical Research Vol. 1 No. 2 (2025): Journal of Health Sciences, Medicine, Biotechnology, and Pharmaceutical Researc
Publisher : Yayasan Cendekia Gagayunan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63142/jhsmbp.v1i2.263

Abstract

The simultaneous use of herbal medicines and cardiovascular drugs is prevalent in Indonesia, a country rich in ethnomedicinal diversity. However, such combinations may lead to clinically significant herb–drug interactions, potentially compromising therapeutic efficacy and safety. This narrative review aims to summarize and evaluate the pharmacokinetic and pharmacodynamic interactions between commonly used Indonesian medicinal herbs and cardiovascular agents. A comprehensive literature search was conducted using PubMed, Scopus, ScienceDirect, and Google Scholar. The included studies reported interactions involving cytochrome P450 modulation, P-glycoprotein activity, and receptor-level mechanisms. Medicinal plants such as Panax ginseng, Allium sativum, Ginkgo biloba, Glycyrrhiza glabra, Zingiber officinale, and Cassia species were found to affect drug absorption, metabolism, and bioavailability. These interactions, primarily through CYP3A4 and P-gp modulation, altered the pharmacokinetic profiles of drugs such as warfarin, digoxin, verapamil, and simvastatin. Some herbs also exert synergistic or antagonistic pharmacodynamic effects, particularly against anticoagulants and antihypertensives. Given the chronic nature of cardiovascular therapy, herb–drug interactions pose serious clinical concerns. Enhanced awareness and monitoring are essential to prevent adverse events and therapeutic failure. Further research is needed to establish safe and evidence-based integration of herbal medicines into cardiovascular care.
Co-Authors Aditya Sindu Sakti Andam Dewi, Mira Anggiyasari Anggiyasari Arfin Ahsanul Ihsan Arif Tatak Bakhtiar, Muhammad Taher Camalia Hartantrie, Rovida Deni Rahmat Fahleni Fahleni Faizatun FAIZATUN, FAIZATUN Faridah Faridah Faridah Faridah Fauzia Noprima Okta Fauzia Noprima Okta Febrika Wediasari Hakim, Zainur Rahman Jasmadeti, Jasmadeti Kurniawan, Fajar Ary Larasinta, Nadia Lhu Muslimah, Lhu Lim, Helsa Mantika Atiqah Baihaty Marwati, Umi Muhammad Adil Khan Muhammad Subhan A Sibadu Mulatsari, Esti Nathalia Perdhani Soemantri Ni Made Dwi Sandhiutami Noviyantih, Noviyantih Okta, Fauzia Noprima Partomuan Simanjuntak Pratita, Rasta Naya Priyanti, Ike Ari Qodriah, Rahmatul Rahmandani, Arif Safira Nafisa Sari, Intan Pertama Shirly Kumala Suherman, Sandra Loretta Swandiny, Greesty Finotory Trisna Permadi YATI SUMIYATI Yati Sumiyati, Yati Yesi Desmiaty, Yesi Zahra Afifah Zuhelmi Aziz