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All Journal MANAJEMEN HUTAN TROPIKA Journal of Tropical Forest Management Jurnal Ilmu Dasar Indonesian Journal of Cancer Chemoprevention AGRIVITA, Journal of Agricultural Science Indonesian Journal of Biotechnology Bioeksperimen: Jurnal Penelitian Biologi Pharmacon Majalah Obat Tradisional Journal of Tropical Biodiversity and Biotechnology The Indonesian Biomedical Journal Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Jurnal Biologi Tropis JSFK (Jurnal Sains Farmasi & Klinis) Menara Perkebunan Advances in Tropical Biodiversity and Environmental Sciences Proceeding Biology Education Conference Berkala Ilmiah Biologi
Tri Rini Nuringtyas
Department Of Biology, Faculty Of Biology, Universitas Gadjah Mada, Jl. Bulaksumur, Sleman, DI Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Veterinary

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Journal : JSFK (Jurnal Sains Farmasi

 1 
Formulation and Characterization Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) Chloroform Extract of Gaharu Leaves (Gyrinops verstegii (Gilg.) Domke Dewi, Siska Noviana; Martien, Ronny; Novitasari, Laras; Nuringtyas, Tri Rini
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.179-188.2024

Abstract

Gaharu (Gyrinops versteegii (Gilg.) Domke) is a native Indonesian plant with many potential medicinal compounds. The compounds contained in the chloroform extract of gaharu leaves are mostly nonpolar terpenoids and fatty acids, so their solubility in water is low. Self-nanoemulsifying drugs delivery system (SNEDDS) technology can increase the solubility and bioavailability of drugs or active compounds in cells. This study aims to formulate and characterize SNEDDS from chloroform extract of gaharu leaves. The research began with the extraction of gaharu leaves by soxhletation. Formula optimization was carried out with various oils, surfactants, and cosurfactants. SNEDDS preparations were then characterized by testing particle size, polydispersity index, percent transmittance, and determining globule morphology. The optimal SNEDDS formula contained miglyol® 812N oil and Tween 80 (32%:68%) with particle size 63.25 ± 5.93 nm, polydispersity index 0.272 ± 0.016, and percent transmittance 98.33 ± 0.23%, spherical globule morphology. This study concluded that the optimal formula for SNEDDS chloroform extract of gaharu leaves (Gyrinops versteegii (Gilg.) Domke) had good physical characteristics. Keywords: Gyrinops verstegii (Gilg.) Domke; gaharu; SNEDDS gaharu; miglyol
Co-Authors Adita Yuniati Puspitasari Afifah, Laelatul ALIM ISNANSETYO Amalia, Alifa Andi Nur Cahyo Andyra, Vania Uly Aries Bagus Sasongko Caroline Dwiseptianti Chandra, Klara Kharisma Bunga Charlie Ester de Fretes Damayanti, Frisca Dedi Setiadi Denis FABRE Dewi, Siska Noviana Diani Mentari Dio N. Wijaya Donny Widianto Dwi Indriani Manurung Dwiseptianti, Caroline Dyah Ismoyowati, Dyah Eka Tarwaca Susila Putra Eko Pujiono Endar Marraskuranto Enik Nurlaili Afifah Erwin Nur Indiarto Fajri Marisa Febri Adi Susanto Febri Adi Susanto Harno Dwi Pranowo Hiqmah Yusi Yana ILG Nurtjahjaningsih, ILG JAKA WIDADA Krisnanda Surya Dharma Krisnanda Surya Dharma L. Hartanto Nugroho Lailaty, Intani Quarta Liliana Baskorowati Lindia Anggraini Lindia Anggraini Lisna Hidayati Marlyn Dian Laksitorini, Marlyn Dian Mashudi Mashudi Megayani Sri Rahayu Mirtani Naima Muhammad Imam Surya Muhammad Nursid Mustafid Rasyiid Naima, Mirtani Nastiti Wijayanti Nastiti Wijayanti Nastiti Wijayanti Nastiti Wijayanti Nastiti, Anisa Diana Novitasari, Laras Nugroho, Hartanto Nurrahmi Dewi Fajarningsih, Nurrahmi Dewi Pascal MONTORO Rahma Nurdiyanti Rahma Nurdiyanti Rahmawati, Rahmawati Rendi Mahadi Rendi Mahadi Respati Tri Swasono Rina Laksmi Hendrati Rina Sri Kasiamdari Riris Istighfari Jenie Riska Wulansari Ronny Martien Rudi Hari Murti Rudi Hari Murti Sebastian, Alfino Setiowati, Retno Diah Sri Wening Sudarsono Sugeng Pudjiono, Sugeng Sumardi . Surta, Muhammad Imam Susanto, Febri Adi Tri Joko Raharjo Tri Joko Raharjo Tri Wibawa Triyaningsih Triyaningsih, Triyaningsih Wibisono, Mochamat Gunawan Wulansari, Riska Yekti Asih Purwestri Yosi Bayu Murti Zulkifli Zulkifli