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All Journal MANAJEMEN HUTAN TROPIKA Journal of Tropical Forest Management Jurnal Ilmu Dasar Indonesian Journal of Cancer Chemoprevention AGRIVITA, Journal of Agricultural Science Indonesian Journal of Biotechnology Bioeksperimen: Jurnal Penelitian Biologi Pharmacon Majalah Obat Tradisional Journal of Tropical Biodiversity and Biotechnology The Indonesian Biomedical Journal Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Jurnal Biologi Tropis JSFK (Jurnal Sains Farmasi & Klinis) Menara Perkebunan Advances in Tropical Biodiversity and Environmental Sciences Proceeding Biology Education Conference Berkala Ilmiah Biologi
Tri Rini Nuringtyas
Department Of Biology, Faculty Of Biology, Universitas Gadjah Mada, Jl. Bulaksumur, Sleman, DI Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Public Health Veterinary

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Journal : Indonesian Journal of Cancer Chemoprevention

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Antioxidant and Anticancer Activity of Dillenia serrata Thunb Ethanol Extract Against MCF-7 Breast Cancer Cell Line Rahmawati, Rahmawati; Zulkifli, Zulkifli; Nuringtyas, Tri Rini; Jenie, Riris Istighfari; Nugroho, Laurentius Hartanto
Indonesian Journal of Cancer Chemoprevention Vol 13, No 3 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss3pp175-183

Abstract

Women’s breast cancer incidence rate in Indonesia ranks number one with 12 per 100,000 cases, with luminal A as the dominant subtype. Currently, chemotherapeutic agents have limitations that lead to inefficiencies in therapy, therefore it is necessary to develop more effective and efficient chemopreventive agents. Plant secondary metabolites can provide pharmacological effects that can be used as chemoprevention agents. Secondary metabolites of D. serrata may have pharmacological effects as antioxidants and cytotoxic. This study aims to determine the antioxidant properties and cytotoxic activity of D. serrata ethanolic extract on the MCF-7 breast cancer cell line. The leaves of D. serrata were macerated, while the bark and root samples were refluxed with 96% ethanol as solvent. All extracts were evaporated with a rotary evaporator. Qualitative evaluation of the phytochemical content of leaf ethanolic extract, bark ethanolic extract, and root ethanolic extract was done using the standard tube test method. The antioxidant assay was carried out using the DPPH. The cytotoxic activity was determined in vitro using an MTT assay against the MCF-7 cell line with a series of concentrations from 12.5–400 μg/mL. Doxorubicin was the positive control treated at a 3.125–100 μg/mL concentration. The antioxidant activity showed that leaf extract had the highest antioxidant activity, followed by root and bark extract, with IC50 values of 95.66, 270.5, and 335.96 ppm, respectively. Leaf ethanolic extract and root ethanolic extract’s cytotoxic ability is considered moderate cytotoxic with IC50 values of 493.17 and 229.82 μg/mL, respectively. Amongst the ethanolic extract from the leaf, bark, and root of D. serrata, the leaf ethanolic extract has the best anti-oxidant activity and the bark ethanolic extract was the most cytotoxic one against MCF-7 cells.Keywords: Antioxidant, Cytotoxic, Dillenia serrata, MCF-7.
Co-Authors Adita Yuniati Puspitasari Afifah, Laelatul ALIM ISNANSETYO Amalia, Alifa Andi Nur Cahyo Andyra, Vania Uly Aries Bagus Sasongko Caroline Dwiseptianti Chandra, Klara Kharisma Bunga Charlie Ester de Fretes Damayanti, Frisca Dedi Setiadi Denis FABRE Dewi, Siska Noviana Diani Mentari Dio N. Wijaya Donny Widianto Dwi Indriani Manurung Dwiseptianti, Caroline Dyah Ismoyowati, Dyah Eka Tarwaca Susila Putra Eko Pujiono Endar Marraskuranto Enik Nurlaili Afifah Erwin Nur Indiarto Fajri Marisa Febri Adi Susanto Febri Adi Susanto Harno Dwi Pranowo Hiqmah Yusi Yana ILG Nurtjahjaningsih, ILG JAKA WIDADA Krisnanda Surya Dharma Krisnanda Surya Dharma L. Hartanto Nugroho Lailaty, Intani Quarta Liliana Baskorowati Lindia Anggraini Lindia Anggraini Lisna Hidayati Marlyn Dian Laksitorini, Marlyn Dian Mashudi Mashudi Megayani Sri Rahayu Mirtani Naima Muhammad Imam Surya Muhammad Nursid Mustafid Rasyiid Naima, Mirtani Nastiti Wijayanti Nastiti Wijayanti Nastiti Wijayanti Nastiti Wijayanti Nastiti, Anisa Diana Novitasari, Laras Nugroho, Hartanto Nurrahmi Dewi Fajarningsih, Nurrahmi Dewi Pascal MONTORO Rahma Nurdiyanti Rahma Nurdiyanti Rahmawati, Rahmawati Rendi Mahadi Rendi Mahadi Respati Tri Swasono Rina Laksmi Hendrati Rina Sri Kasiamdari Riris Istighfari Jenie Riska Wulansari Ronny Martien Rudi Hari Murti Rudi Hari Murti Sebastian, Alfino Setiowati, Retno Diah Sri Wening Sudarsono Sugeng Pudjiono, Sugeng Sumardi . Surta, Muhammad Imam Susanto, Febri Adi Tri Joko Raharjo Tri Joko Raharjo Tri Wibawa Triyaningsih Triyaningsih, Triyaningsih Wibisono, Mochamat Gunawan Wulansari, Riska Yekti Asih Purwestri Yosi Bayu Murti Zulkifli Zulkifli