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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Molecular and Cellular Biomedical Sciences (MCBS) IRJE (Indonesian Research Journal in Education) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Daur Lingkungan MEDIC MEdical Dedication Journal of Medical Studies Neurona
Nyimas Natasha Ayu Shafira
Universitas Jambi, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Molecular and Cellular Biomedical Sciences (MCBS)

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Angiotensin-Converting Enzyme Genetic Polymorphism rs4343 as Risk of Diabetic Nephropathy in Jambi-Malay Population Elfiani, Elfiani; Puspasari, Anggelia; Arif, Cut Wulan; Maharani, Citra; Ali, Zulkhair; Suhaimi, Novadian; Effendi, Ian; Suprapti, Suprapti; Shafira, Nyimas Natasha Ayu
Molecular and Cellular Biomedical Sciences Vol 8, No 1 (2024)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v8i1.410

Abstract

Background: Diabetic nephropathy (DN) is one of the frequent complications of type II diabetes mellitus (T2DM) in Jambi province. Controlling blood glucose and blood pressure does not guarantee DN prevention, since genetic factors may also contribute to this disease. Multi-ethnic studies showed that one of the strongest genetic factors associated with DN was single nucleotide polymorphism rs4343 of angiotensin-converting enzyme (ACE) gene. Study regarding phenotype-genotype association of ACE rs4343 and DN has not yet been performed in Jambi Province, which is dominated by Malay ethnicity. This study was conducted to reveal the association between ACE rs4343 and the risk of DN in the Jambi-Malay population.Materials and methods: This was a cross-sectional study involving 75 subjects (44 with DN and 31 without DN) who suffered from T2DM and hypertension. DN was defined as albumin to creatinine ratio (ACR) ≥30 mg/g. Genotyping was performed with one-step tetra amplification refractory mutation system-polymerase chain reaction (PCR) using specific primer for ACE rs4343. Bivariate and multivariate analyses were performed to analyze the genetic risk for DN.Results: The bivariate analysis showed the proportion of DN subjects was higher than non-DN within the AG genotype (11:1) than within the AA (33:30) genotype. This difference was statistically significant (p=0.012; OR (95% CI): 10.00 (1.22-82.15)). Multivariate analysis showed that AG genotype (p=0.047; OR (95% CI): 10.04 (1.03-97.31)) and uncontrolled blood pressure (p=0.001; OR (95% CI): 6.72 (2.08-21.71)) were the risk factors of DN in the Jambi-Malay population.Conclusion: Polymorphism of ACE rs4343 is a risk factor of DN in the Jambi-Malay Population.Keywords: rs4343, angiotensin-converting enzyme gene, diabetic nephropathy, Malay, Jambi
Co-Authors Abdul Haris Agnesia Feronika Panggabean Ahmad Syauqy Albashir Feriohadi Amalya Salsabila Amelda Mutia Sabrini Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri, Amelia Dwi Anati Purwakanthi Anati Purwakanthi, Anati Anggelia Puspasari Anggelia Puspasari Anwar Jusuf Arif, Cut Wulan Armaidi Darmawan ATTIYA ISTARINI Ave Olivia Rahman Citra Maharani Citra Maharani De Jonge, Laury P.J.W.M. Dhea Assyifa Effendi, Ian Ekaputri, Tia Wida Elfiani Erny Kusdiyah Esa Indah Ayu, Esa Indah Faila Sufa Fairuz Quzwain Fenny Febrianty Gading, Patrick William Haifa Nida Firdausa Hanina Harahap, Asro Hayani Hasna Dewi Hendra Herman Herlambang Herlambang Herlambang Herlambang HERLAMBANG HERLAMBANG Herlambang Herlambang, Herlambang Huntari Harahap Iskandar, Mirna Marhami JMJ, Jurnal Lipinwati ., Lipinwati Lisa, Mei Nindya Aryanty Nofrans Eka Saputra, Nofrans Eka Nur Id'ys Oktari, Intan Patrick William Gading Putri Sari Wulandari Putri, Loli Melatina Putri, Nadhilah Aulia Randy Fauzan Ratu Bulqis Raudhoh, Siti Rina Nofri Enis Rina Nofrienis Risa Nabila Rita Halim Rita Halim Sabar Hutabarat Sari, Anggia Rohdila Setyawati Budiningsih Shabrina Nadilah Zahra Sholahuddin Tumanggor Siti Hediaty Sri Mulyani Suhaimi, Novadian Suprapti Suprapti Suryati Suryati Susan Tarawifa Susan Tarawifa Syatria Esa Putra Tarawifa, Susan Tia Wida Ekaputri Virginsia, Sonya Vivekanantharasa, Raveenthiran Wahyu Indah Dewi Aurora Zulkhair Ali