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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention MPI (Media Pharmaceutica Indonesiana) Jurnal Kedokteran Gigi Universitas Padjadjaran Acta Pharmaciae Indonesia : Acta Pharm Indo ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Jurnal Kartika Kimia Pharmacy Reports Kolaborasi Jurnal Pengabdian Masyarakat Jurnal Ilmiah Berkala Sains dan Terapan Kimia Mandala of Health : A Scientific Journal Molekul: Jurnal Ilmiah Kimia Journal of Applied Science for Pharmaceuticals and Health

Fareza, Muhamad Salman

Unknown Affiliation

Author-ID : 776584

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Phytochemical Screening and Antibacterial Activity of Ethanolic Extract of Syzygium samarangense Leaves Nur Amalia Choironi; Muhamad Salman Fareza
Jurnal Kartika Kimia Vol 1 No 1 (2018): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

The ethanolic extracts of S. samarangense leaves were examined for antibacterial activity in vitro using broth microdillution method. The extracts showed effective against Bacillus cereus, Salmonella enterica with MIC (minimum inhibition concentration) value 78 µg/ml and against multi strains of Escherichia coli, Enterobacter aerogenes, Kocuria rhizophila with MIC value 2500 µg/mL, 2500 µg/mL and 156 µg/mL. Phytochemical screening of S. samarangense was observed for the presence of tannins, alkaloids, flavonoids, and terpenoids.

ISOLASI DAN IDENTIFIKASI SENYAWA AKTIF DARI DAUN JAMBU MAWAR (SYZYGIUM JAMBOS (L.) Alston) Soenarto Soetomo; Eviyana Eviyana; Nur Amalia Choironi; Nilta Dizzania; Muhamad Salman Fareza; Ade Martinus
Jurnal Sains dan Terapan Kimia Vol 13, No 2 (2019)
Publisher : Program Studi Kimia, Universitas Lambung Mangkurat

Syzygium jambos (jambu mawar) merupakan salah satu tumbuhan tropis khas Indonesia. Tumbuhan ini secara empiris telah digunakan sebagai tumbuhan obat tradisional. Kajian fitokimia tumbuhan ini yang berasal dari Indonesia masih terbatas.Tujuan penelitian ini adalah mengisolasi dan mengidentifikasi senyawa fenolik dari bagian daun S. jambos asal Purwokerto. Proses ektraksi daun S. jambos dilakukan dengan menggunakan metode maserasi. Fraksinasi dan pemurnian ektrak menggunakan metode kromatografi vakum cair dan kromatografi gravitasi. Identifikasi isolat dilakukan menggunakan metode spektroskopi 1H-NMR dan 13C-NMR. Berdasarkan hasil isolasi yang dilakukan telah diperoleh satu senyawa fenolik yaitu asam anakardat dengan rantai samping alkil diena.

Phytochemical screening and purification of n-hexane fraction of Calophyllum soulattri leaves Sunarto Sunarto; Agnes Yuliasari; Sri Sutji Susilowati; Hendri Wasito; Triyadi Hendra Wijaya; Muhamad Salman Fareza
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo (in progress)
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5858

Background: Calophyllum soulattri Burm F. is widely utilized in traditional medicine. It is necessary to identify secondary metabolites from C. soulattri leaves to determine the pharmacologically active chemicals. Objective: This study aimed to screen the phytochemical content and purify the n-hexane fraction of C. soulattri leaves from Banyumas, Indonesia. Methods: The n-hexane fraction was macerated with methanol, followed by liquid-liquid fractionation with n-hexane. The n-hexane fraction was tested for flavonoids, triterpenoids/steroids, saponins, and phenols using the test tube method. In addition, the compounds were purified using column chromatography. The purified compound was identified by the Liebermann-Burchard reagent, which was compared with commercially available steroid drugs as reference. Results: Phytochemical analysis revealed that the n-hexane fraction of C. soulattri leaves contained secondary metabolites such as flavonoid, steroid, and phenol compounds. Analyses with the Liebermann-Burchard reagent indicated that the purified compound was potentially a steroid. Conclusion: The compound extracted from the n-hexane fraction of C. soulattri leaves was expected as a steroid.

Peningkatan Pengetahuan dan Sikap Masyarakat terhadap Upaya Pencegahan dan Pengendalian Covid-19 di Desa Kejawar Banyumas Hening Pratiwi; Beti Pudyastuti; Warsinah; Nia Kurnia Sholihat; Triyadi Hendra; Nur Amalia Choironi; M. Salman Fareza
KOLABORASI JURNAL PENGABDIAN MASYARAKAT Vol 2 No 5 (2022): Kolaborasi: Jurnal Pengabdian Masyarakat
Publisher : Yayasan Inspirasi El Burhani

Introduction: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) better known as Covid-19 is a new type of coronavirus that transmitted to humans. This virus is contagious quickly and has spread to almost all countries, including Indonesia, in just a few months. Public awareness and behavior are needed to prevent and control COVID-19. Objective: This activity aimed to increase public knowledge and attitudes to actively participate in preventing and controlling the transmission of Covid 19. Method: The implementation of this activity begins with the process of evaluating the level of knowledge and attitudes of PKK cadres regarding the prevention and control of Covid-19 by conducting a pre-test using a questionnaire. Then, the team provided education about the prevention and control of Covid-19 by using appropriate media. This activity was carried out using the transfer & sharing method of knowledge by using aids of audiovisual media and leaflets. Besides being open for discussion sessions, questions, and answers related to Covid-19. Result: The results showed an increase in respondents' knowledge before and after education by as much as 47%, while the attitudes of respondents showed an increase before and after education by as much as 47%. Conclusion: We concluded that providing education related to Covid 19 could increase people's knowledge and attitudes.

THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) TO THE NUMBER OF FIBROBLASTS IN IMIQUIMOD INDUCES PSORIASIS MICE MODEL Irse Priyaganda Bani Musa; Thianti Sylviningrum; Dody Novrial; Muhamad Salman Fareza
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Imiquimod induces activation of Th17 cells and dendritic cells that play a role in psoriasis. Ciplukan extract ( Physalis angulata L.) contains steroid compounds, flavonoids, alkaloids, and saponins such as Physalin B, Physalin F, Physalin G which have anti-inflammatory activity in psoriasis pathophysiology. This research is an experimental research with post test only with control group design. Thirty five female mice were divided into 7 groups. Group A: negative control, group B: positive control, group C induced by imiquimod and given with ciplukan extract 400 mg/kg BW for 7 days, group D induced by imiquimod and given with ciplukan extract 800 mg/kg BW for 7 days, group E induced imiquimod and given with ciplukan extract 1,200 mg/kg BW for 7 days, group F induced by imiquimod and given with methotrexate 1 mg/kg BW for 7 days, and group G induced by imiquimod and given with a combination of ciplukan extract 1,200 mg/kgBW and methotrexate 1mg/kgBW for 7 days. 7 days. The number of fibroblast cells was counted on the fifteenth day by taken a sample of mouse skin and made histological preparations and then counted manually used a microscope. The mean number of fibroblast cells in groups A, B, C, D, E, F, and G were 21.6±2.3, respectively; 39.2±5.5; 30.6±1.3; 24.0±2.8; 24.8±2.9; 28,4±3,0;28,2±3,2 . The results of the test One Way ANOVA showed a value of p = 0.000 (p < 0.05), so that the results are significant. Keywords: ciplukan extract, fibroblast, methotrexate , Physalis angulata

THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) AS ANTIPSORIATIC AND TO LYMPHOCYTES COUNT OF SKIN TISSUE IN PSORIASIS MICE MODEL Putri Nur'afni Sa'adah; Thianti Sylviningrum; Dody Novrial; Fajar Wahyu Pribadi; Wahyu Dwi Kusdaryanto; Muhamad Salman Fareza
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

ABSTRACT Psoriasis is a chronic skin disease in form of papule-shaped lesion and erythematous plaques with thick white scales. The pathogenesis of psoriasis involves IL-23/Th-17 cytokine pathway that contributes the activation of T-lymphocytes and proinflammatory cytokines. Treatment of psoriasis using methotrexate has inhibitory effect of the synthesis of nucleic acid towards T-lymphocytes and keratinocytes. Ciplukan (Physalis angulata L.) has anti-inflammatory potential effect which contains steroid, flavonoid, alkaloid, and physalin that may inhibit lymphocyte activation and proinflammatory cytokine production. The study is used the method of experimental study with post test only with control group design. Thirty five female mices were divided into 7 groups. The parameters of this study is anti-psoriatic (PASI and Baker’s score) and lymphocytes count in psoriasis mice model. The results of Kruskal-Wallis, PASI and Baker’s score showed that p=0,001 (p<0,05) and the result of lymphocytes count using One Way ANOVA showed that p=0,001 (p<0,05). The 800 mg/kgBW dose of ciplukan extract showed the largest decrease on PASI score and lymphocytes count, and the 1200 mg/kgBW dose one showed the largest decrease on the Baker’s score. The present of the 800 mg/kgBW dose of ciplukan extract gives the most optimal effect in reducing PASI score and skin tissue lymphocytes count in psoriasis mice model that were not significantly different with the treatment control group, while 1200 mg/kgBW dose one gives the most optimal effect in reducing Baker’s score that were significantly different with the treatment control group. Keywords: Ciplukan extract, lymphocytes, methotrexate, Physalis angulata L

Bioinformatic Study of the Active Compound of Morusin in Mulberry (Morus alba) against Breast Cancer Sarmoko Sarmoko; Afif Hariawan Pratama; Nur Amalia Choironi; Muhammad Salman Fareza
Indonesian Journal of Cancer Chemoprevention Vol 14, No 1 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss1pp60-71

Morusin, an active constituent of the mulberry plant (Morus alba), exhibits inhibitory effects on several types of cancer cells in vitro, including breast cancer. This study aimed to identify potential target proteins of morusin, investigate the binding energy, and explore type of interactions between morusin and the target protein. Morusin target was searched using the PubMed, STITCH, STRING, and Cytoscape databases. Subsequently, the obtained morusin target protein data underwent processing using Autodock Tools and DS BIOVIA to facilate the simulation of molecular docking between morusin and the target protein. The study identified EGFR, SRC, and MAPK1 as potential targets for morusin. Docking simulations revealed that both EGFR and SRC represent viable targets for morusin, as their binding energies were lower than those of the native ligand and lapatinib. Specifically, the bond energies at EGFR were -9.6, -7.5, and -9.2 kcal/mol for morusin, the native ligand, and lapatinib, respectively. Similarly, at SRC, the corresponding bond energies were -8.2, -6.4, and -5.3 kcal/mol. Morusin demonstrated binding interactions with Leu694, Val702, Leu820, Ala719, Leu768, and Lys721 at the active site of EGFR, and with Lys295 and Gly344 at the binding active sites of SRC. Consequently, morusin has the potential to suppress cancer cell growth by targeting EGFR and SRC.Keywords: cancer cells, EGFR and SRC as targets, molecular docking, morusin, mulberry plant.

Free Chlorine Determination in Disinfectant Product using Visible Spectrophotometry based on Prussian Blue Degradation Wasito, Hendri; Siagian, Defi Srium; Fareza, Muhamad Salman
Acta Pharmaciae Indonesia Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.5371

Disinfectant products with excessive chlorine could be dangerous for health and need quality control. It is important to develop an analytical method for monitoring product quality. The main objective of this work is to develop an alternative method and evaluate the analytical performance of visible spectrophotometry for determining free chlorine in disinfectant products based on the Prussian blue decomposition process. The capability of chlorine to oxidize ferrous to ferric ions makes the Prussian blue generated by ferrosulfate and potassium ferricyanide is decomposed and measured by spectrophotometer. The formation of Prussian blue was improved by optimizing some reaction conditions and assessing incubation time. Linearity, analytical concentration range, precision, accuracy, detection limit, and quantitation limit parameters were among the examined analytical parameters. The results showed that the optimum concentration of ferrosulfate, potassium ferysianide, and hydrochloric acid for Prussian blue formation was 2.0 mmol L-1, 3.0 mmol L-1, and 0.5 mol L-1, respectively, with 15 minutes incubation time after chlorine addition. Analytical performance parameters seemed appropriate for routine analysis purposes. The developed method can also be applied as an alternative analytical method to determine the free chlorine concentration of disinfection products in the market.

Phytochemical screening and purification of n-hexane fraction of Calophyllum soulattri leaves Sunarto, Sunarto; Yuliasari, Agnes; Susilowati, Sri Sutji; Wasito, Hendri; Wijaya, Triyadi Hendra; Fareza, Muhamad Salman
Acta Pharmaciae Indonesia Vol 10 No 2 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.2.5858

Evaluation of natural compounds as VEGFR-2 inhibitors for breast cancer therapy: insights from molecular docking and drug-likeness analysis Aprilia, Vika; Sarmoko; Fareza, Muhamad Salman; Baroroh, Hanif Nasiatul; Choironi, Nur Amalia
Pharmacy Reports Vol. 4 No. 2 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.82

Breast cancer remains one of the most common cancers worldwide, with VEGFR-2 (KDR) playing a key role in tumor angiogenesis. Inhibiting VEGFR-2 is a promising therapeutic strategy. Natural compounds are increasingly studied for their potential to inhibit VEGFR-2. This study aims to assess the binding affinity of 11 natural compounds (andrographolide, alpha-mangostin, pinostrobin, pinocembrin, ethyl-p-methoxycinnamate (EPMS), xanthorrhizol, galangin, gamma-mangostin, curcumin, cinnamaldehyde, and alashanoid B) to the VEGFR-2 protein through molecular docking and Lipinski's rule analysis, identifying promising candidates for breast cancer treatment. Molecular docking simulations were performed for 11 compounds and sunitinib as a control, with binding energies and interactions analyzed. The compounds were also evaluated for drug-likeness using Lipinski’s rule of five. Curcumin showed the highest binding affinity to VEGFR-2 with a binding energy of -9.9 kcal/mol, surpassing sunitinib (-9.4 kcal/mol). Key interactions were observed with active site residues Cys919 and Asp1046. All tested compounds met the criteria for oral bioavailability per Lipinski’s rules. Curcumin demonstrates potential as a VEGFR-2 inhibitor due to its favorable binding affinity and drug-like properties. Enhancing curcumin’s bioavailability is recommended for effective therapeutic application.

Co-Authors . Harwoko Ade Martinus Ade Martinus Afif Hariawan Pratama Agnes Yuliasari Anggraeni, Vina Juliana Aprilia, Vika Ari Asnani Ari Wahyudi Asrada, Syahdan Ayunda Tasya Hapsari Beti Pudyastuti Beti Pudyastuti Choironi, Nur Amalia Defi Srium Siagian Didin Mujahidin Dina Parika Dody Novrial Dody Novrial, Dody Dwi Utami Anjarwati Elesenda May GIta Esti Dyah Utami Eviyana Eviyana Fadlan, Arif Fadlan, Arif Fajar Wahyu Pribadi Febrian, Dicky Rizky Fischellya, Dafi Giri Gumelar Hanif Nasiatul Baroroh Harwoko Harwoko Hasan, Nahrul Hendri Wasito HENDRI WASITO Hening Pratiwi Irse Priyaganda Bani Musa Joko Setyono Joko Setyono Joko Setyono Kaefiyah Nurul Insani Lela Lailatul Khumaisah Mustikaningtyas, Ika Nadia Sayyidadah Aulia Nia Kurnia Sholihat Nilta Dizzania Nur Amalia Choironi Nur Amalia Choironi Nur Amalia Choironi Nur Amalia Choironi Nuryanti Nuryanti Ponco Iswanto Putri Khaerani Cahyaningrum Putri Nur'afni Sa'adah Rehana Rehana Rehana Rehana Rehana, Rehana Rifki Febriansah Rizka Hidayati Rizki Akbar Ramadhan Samudra, Genta Hafied Naga Sarmoko Sarmoko Sekar Cahyo Nurani Setiyabudi, Lulu Siagian, Defi Srium Siska Febdian Nitami Soenarto Soetomo Sri Sutji Susilowati Sri Sutji Susilowati Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto Sunarto, Sunarto Thianti Sylviningrum Triyadi Hendra Triyadi Hendra Wijaya Triyadi Hendra Wijaya Tryandika Telaumbanua Tuti Sri Suhesti Vintya Roosalinda Permatasari Wahyu Dwi Kusdaryanto Warsinah Yuliasari, Agnes

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