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A retrospective descriptive cross-sectional study of Oral Dosage Form Administered in The Form of Suspension to ICU Patients at Hospital X Suryani, Nelly; Anwar, Vidia Arliani; Saibi, Yardi; Dhilasari, Estu Mahanani; Dahlizar, Sabrina; Betha, Ofa Suzanti; Komala, Ismiarni; Azzahra, Afifah Nurnishrina
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 6, No 2 (2024)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.41341

Patients in the intensive care unit were often very sick and had lost consciousness. Because they had trouble swallowing, individuals with reduced awareness frequently depended on enteral tubes (NGT) for their daily medical and nutritional requirements. Since not all medications were accessible in parenteral forms, patients who relied on enteral tubes often had issues, including drug stability. Many problems arose in clinical usage when the medication was crushed or suspended and put into the NGT, including drug obstruction in the enteral tube and a reduction in drug stability as a result of the dose form being altered, making the drug unstable. Thus, this study aimed to ascertain the stability of oral suspension medications given to intensive care unit patients. The medical records of intensive care unit patients who had received oral medication therapy at X Hospital in Jakarta were examined retrospectively using a cross-sectional, descriptive approach. According to the statistics, coated tablets accounted for 68% of the most frequently used oral medication preparations. It was highly likely that crushing the coated tablets and administering them via NGT had resulted in tube obstruction. Additionally, 59.26% of the medications used had exhibited hygroscopic qualities, and several had been readily hydrolyzed. Based on these findings, it was concluded that oral medications, particularly crushed-coated tablets, could negatively affect drug stability. Active substances with hygroscopic properties and those prone to hydrolysis were also identified as potential contributors to instability.

Physical-chemical stability test on spray gel with active compound ethyl p-methoxycinnamate (Kaempferia galanga Linn.) and menthol, using combination gelling agent na cmc and copovidone Suryani, Nelly; Komala, Ismiarni; Akhsani, Luthfia Wikhdatul; Dahlizar, Sabrina; Betha, Ofa Suzanti; Rahmat, Deni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1626

The major component of galangal rhizome (Kaempferia galanga Linn) is ethyl p-methoxycinnamate (EPMS), which amounts to 80.05%. Significant anti-inflammatory activity is exhibited by EPMS from galangal rhizome through the inhibition of carrageenan-induced mouse edema and the inhibition of IL-6 production. EPMC is recognized for various pharmacological effects, particularly its potential as a wound healing agent due to its anti-inflammatory properties. The choice of spray was made because it meets the characteristics of anti-inflammatory preparations in the wound healing process. The preparation must be moist, easily adjusted to the shape of the wound (flexible), sterile, and evenly distributed, covering the tissue, and can be easily removed from the tissue, including the wound. A spray gel dosage form was formulated with varying concentrations of the gelling agent Na CMC, F1 (0.5%), F2 (1.0%), and F3 (1.5%). Physical stability was evaluated at room temperature storage on days 0, 7, 14, and 21. Organoleptics, homogeneity, viscosity, pH, spray pattern, adhesive spread ability, centrifugation test, and cycling test were evaluated. Chemical stability evaluation was carried out using UV-Vis spectrophotometry to assess the EPMS levels in the preparation. The results of the physical evaluation showed that all formulas were stable in terms of organoleptics, homogeneity, and pH, which was in the range of 6.6–7.1; the weight per spray was uniform and relatively stable in centrifugation and cycling tests. The use of a combination of sodium carboxymethylcellulose and copovidone can produce a spray gel preparation of a good aromatic ginger (Kaempferia galanga Linn) crystal with a 1%.

The Effect of Green Accounting, Digital Financial Literacy, and Carbon Emission Disclosure on Sustainable Financial Performance Yanto, Supri; Sari, Putri Irmala; Suryani, Nelly
Applied Business and Administration Journal Vol. 4 No. 2 (2025): Financial Accountability, Technological Innovation, and Sustainable Development
Publisher : Ebiz Prima Nusa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62201/abaj.v4i02.215

This study examines the effect of green accounting (GA), digital financial literacy (DFL), and carbon emission disclosure (CED) on sustainable financial performance (SFP) in ISSI-listed companies adopting ESG practices (2019–2023). Using a quantitative approach, panel data from annual reports, sustainability reports, and ESG databases were analyzed via EViews 12, employing moderated regression analysis (MRA) to test interactions. Findings reveal that GA and DFL significantly enhance SFP (β = +, p < 0.05), with CED and firm size acting as positive moderators. The study highlights DFL as a novel driver of SFP in emerging markets, while emphasizing the regulatory role of CED in Indonesia. Limitations include a focus on Sharia-compliant firms, suggesting future research should expand to non-Sharia companies and longitudinal post-2023 data. Practical implications urge policymakers to mandate CED and firms to invest in DFL training. The research contributes originality by integrating GA, DFL, and CED previously unexplored in combination within an ESG framework, offering empirical insights for sustainable finance strategies.

The Effect of Gelatin and Propylene Glycol on the Penetration Rate of Asiaticoside from Centella asiatica (L.) Urb Leaf Extract Gel Dahlizar, Sabrina; Anggraeni, Yuni; Munfarikhatin, Atina; Suryani, Nelly; Betha, Ofa Suzanti; Zilhadia, Zilhadia; Fajriah, Sofa; Septama, Abdi Wira; Handayani, Maulina; Herdini, Herdini
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.43891

Centella asiatica (L.) Urb. is a plant known for its potential in scar treatment due to the presence of asiaticoside, a compound capable of promoting skin cell tissue repair. However, the large molecular size of asiaticoside hinders its penetration through the skin. This study aims to evaluate the effect of gelatin and propylene glycol on the transdermal penetration of asiaticoside from a gel formulation containing Centella asiatica leaf extract. Four different formulations were tested: a control (F1, without gelatin or propylene glycol); one with 15% propylene glycol (F2); one with 4% gelatin (F3); and one with 4% gelatin and 15% propylene glycol (F4). The physical characteristics of the formulations were assessed using several parameters: organoleptic properties, pH, homogeneity, centrifugation, spreadability, viscosity, and rheological behaviour. Penetration studies were performed using a Franz Diffusion Cell with a Whatman No. 1 membrane (pre-coated with Spangler solution) for 360 minutes. The penetration data were analyzed using Liquid Chromatography–Tandem Mass Spectrometry (LC–MS/MS) with a C18 BEH column (2.1 × 50 mm; 1.8 μm particle size). The results showed that each formulation exhibited distinct characteristics. The study findings indicated that both gelatin and propylene glycol, as well as their combination, significantly influenced the penetration of asiaticoside in the gel formulation. Propylene glycol, functioning as a penetration enhancer, was found to increase the penetration of asiaticoside in both gelatin-based and liquid formulations.

Pemberian Informasi Obat Pasien Dengan Resep Antibiotik dan Penyediaan Antibiotik Tanpa Resep di Tangerang Selatan: Providing Drug Information to Patients with Prescribing Antibiotics and Provision of Antibiotics without Prescription in South Tangerang Saibi, Yardi; Suryani, Nelly; Novitri, Suci Ahda; Hasan, Delina; Anwar, Vidia Arlaini
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

A pharmacy is a place where pharmacists do their pharmaceutical work, serving directly and responsibly for patients who need their professional services. One form of direct service is the provision of drug information and counseling. The purpose of this study was to describe the drug information services provided by pharmaceutical personnel in the South Tangerang area pharmacy for patients who redeemed prescriptions using antibiotics. Patient simulation method was used to collect data to 100 pharmacies that were randomly selected based on data in the city health office. Recommendations were obtained from the South Tangerang branch of the Indonesian Pharmacists Association while ethical clearance was obtained from the ethical committee of the Faculty of Medicine, University of Indonesia. The results of this study indicate that 85% percent of pharmaceutical personnel who provide drug information for simulated patients are non-pharmacists. The most widely conveyed drug information items were the frequency of drug use delivered by 82% of pharmacists, received by the intended use (61%) and time of use (44%). Not related to pharmacy officers who submit the following information: drug interactions and ways to prevent them, side effects of drugs and how to prevent them; food and drinks that must be avoided as well as how to store drugs. As many as 49% of pharmacists provide additional antibiotics requested by patients without a prescription. Drug information points provided by pharmacy staff specifically by pharmacist had not been maximally delivered.

Analysis of the Entrapment Efficiency of Thymoquinone in Microcapsules of Black Cumin Seed Oil (Nigella sativa L.) Using High Performance Liquid Chromatography Ofa Suzanti Betha; Supandi, Supandi; Addina Syahida; Boy Reynaldi Noor; Nelly Suryani; Sabrina Dahlizar; Yuni Anggraeni; Barita J. Siregar; Zilhadia
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.27545

Thymoquinone is the main active compound found in black cumin seed oil (Nigella sativa). This study intends to analyze the efficiency of its absorption in microcapsules by the ionic gelation of cross-linked alginate and the CaCl2 method, and loading with black cumin seed oil in a concentration of 20%. Thymoquinone was used as a marker to establish quality standards for this microcapsule preparation. Analysis of thymoquinone in microcapsules was performed using a pre-optimized, high-performance liquid chromatography method. Method optimization utilized an Acclaim® Polar Advantage II (C18) column with a flow speed of 1.5 mL/min, a UV detector wavelength of 252 nm, and an injection volume of 20 μL with an isocratic system on a methanol eluent composition: water (70:30). This method revealed a good linearity value (r = 0.9997) in the range of 0.5 – 500 μg/ml. The detection and quantitation limits were 8.67 μg/mL and 28.9 μg/mL, (%diff) was about -1.864 to 1.562, precision (% RSD) was 0.052 to 0.113%, and the recovery was 98.135 to 101.563%. The results of this method validation were then applied to determine thymoquinone loading in black cumin seed oil microcapsules. The results of the absorption efficiency value of black cumin seed oil microcapsules by the ionic gelation alginate and CaCl2 method, which contained 20% oil concentration in the formula, were 81.769%.

The Effect of Gelatin and Propylene Glycol on the Penetration Rate of Asiaticoside from Centella asiatica (L.) Urb Leaf Extract Geleaf Extract Gel Dahlizar, Sabrina; Anggraeni, Yuni; Munfarikhatin, Atina; Suryani, Nelly; Betha, Ofa Suzanti; Zilhadia; Fajriah, Sofa; Septama, Abdi Wira; Handayani, Maulina; Herdini
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/w7prk175

Centella asiatica (L.) Urb. is a plant known for its potential in scar treatment due to the presence of asiaticoside, a compound capable of promoting skin cell tissue repair. However, the large molecular size of asiaticoside hinders its penetration through the skin. This study aims to evaluate the effect of gelatin and propylene glycol on the transdermal penetration of asiaticoside from a gel formulation containing Centella asiatica leaf extract. Four different formulations were tested: a control (F1, without gelatin or propylene glycol); one with 15% propylene glycol (F2); one with 4% gelatin (F3); and one with 4% gelatin and 15% propylene glycol (F4). The physical characteristics of the formulations were assessed using several parameters: organoleptic properties, pH, homogeneity, centrifugation, spreadability, viscosity, and rheological behaviour. Penetration studies were performed using a Franz Diffusion Cell with a Whatman No. 1 membrane (pre-coated with Spangler solution) for 360 minutes. The penetration data were analyzed using Liquid Chromatography–Tandem Mass Spectrometry (LC–MS/MS) with a C18 BEH column (2.1 × 50 mm; 1.8 μm particle size). The results showed that each formulation exhibited distinct characteristics. The study findings indicated that both gelatin and propylene glycol, as well as their combination, significantly influenced the penetration of asiaticoside in the gel formulation. Propylene glycol, functioning as a penetration enhancer, was found to increase the penetration of asiaticoside in both gelatin-based and liquid formulations.

Quantitative Study of Antibiotic Usage in Pneumonia Patients: Systematic Literature Review Hasan, Delina; Saibi, Yardi; Suryani, Nelly; Musdja, Muhammad Yanis; Arlaini, Vidia; Dzdzikra D.A, Dzdzikra D.A
Eduvest - Journal of Universal Studies Vol. 4 No. 1 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i1.996

Pneumonia caused more than 2,56 million deaths in 2017 worldwide. With the high number of pneumonia sufferers, the use of antibiotics will also increase. This study aims to describe the quantity of antibiotic use in pneumonia patients using the Systematic Literature Review method. The literature search was conducted through the PubMed, Sciencedirect, Mendeley, BMC, and Google Scholar databases. The literature used is a journal of the last 10 years that discusses the use of antibiotics in pneumonia patients calculated by the ATC/DDD system. Of the total 19 journals included in the study, 8 journals were from Indonesia. A total of 5 journals discussed antibiotics used in CAP (Community-Acquired Pneumonia), 2 journals in HAP (Hospital-Acquired Pneumonia), 2 journals in VAP (Ventilator-Associated Pneumonia), 2 journals were non-specific, and the remainder covered several types of pneumonia. The class of antibiotics with the highest DDD value is fluoroquinolones, with an average use of 41,81 DDD/100 patient-days; 17,29 DDD/100 bed days; and 0,0696 DDD/1000 inhabitants per day, and third-generation cephalosporins, with an average use of 15,86 DDD/100 patient-days and 28,31 DDD/100 bed days. The antibiotic with the highest DDD value was levofloxacin, with an average use of 31,29 DDD/100 patient-days; 12,22 DDD/100 bed days; and 0,0612 DDD/1000 inhabitants per day, and ceftriaxone, with an average use of 12,51 DDD/100 patient-days and 26,33 DDD/100 bed days. The most widely used antibiotics in the treatment of CAP and HAP are third-generation cephalosporins, while penicillin is the most commonly used in VAP.

A retrospective descriptive cross-sectional study of Oral Dosage Form Administered in The Form of Suspension to ICU Patients at Hospital X Suryani, Nelly; Anwar, Vidia Arliani; Saibi, Yardi; Dhilasari, Estu Mahanani; Dahlizar, Sabrina; Betha, Ofa Suzanti; Komala, Ismiarni; Azzahra, Afifah Nurnishrina
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.41341

Patients in the intensive care unit were often very sick and had lost consciousness. Because they had trouble swallowing, individuals with reduced awareness frequently depended on enteral tubes (NGT) for their daily medical and nutritional requirements. Since not all medications were accessible in parenteral forms, patients who relied on enteral tubes often had issues, including drug stability. Many problems arose in clinical usage when the medication was crushed or suspended and put into the NGT, including drug obstruction in the enteral tube and a reduction in drug stability as a result of the dose form being altered, making the drug unstable. Thus, this study aimed to ascertain the stability of oral suspension medications given to intensive care unit patients. The medical records of intensive care unit patients who had received oral medication therapy at X Hospital in Jakarta were examined retrospectively using a cross-sectional, descriptive approach. According to the statistics, coated tablets accounted for 68% of the most frequently used oral medication preparations. It was highly likely that crushing the coated tablets and administering them via NGT had resulted in tube obstruction. Additionally, 59.26% of the medications used had exhibited hygroscopic qualities, and several had been readily hydrolyzed. Based on these findings, it was concluded that oral medications, particularly crushed-coated tablets, could negatively affect drug stability. Active substances with hygroscopic properties and those prone to hydrolysis were also identified as potential contributors to instability.

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