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SARIYANTO, IWAN
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Evaluating Alpha-Glucosidase Inhibitory Activity and Toxicity of Cacao Pod Husk (Theobroma cacao L.) Fractions Iwan Sariyanto; Hartanti
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 6 (2025): December 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i6.18654

Abstract

This study aimed to evaluate the anti-diabetic and cytotoxicity potential of ethyl acetate and acetone fractions from cocoa pod husk (Theobroma cacao L.). The cacao pod husks were extracted and fractionated using ethyl acetate and acetone solvent. The alpha-glucosidase inhibitory activity was determined using Saccharomyces cerevisiae alpha-glucosidase with p-nitrophenyl-α-D-glucopyranoside (pNPG) substrate. Toxicity was evaluated against Artemia salina larvae to determine the Lethal Concentration (LC50). The results showed that the ethyl acetate fraction and acetone fraction had LC50 values of 202.31 ppm and 360.07 ppm, respectively, indicating potential cytotoxic activity. Both fractions demonstrated weak alpha-glucosidase inhibitory activity, with inhibition percentages below 50% at the highest tested concentration (60 ppm), preventing the determination of IC50 values. These findings suggest that while the fractions possess bioactive potential indicated by toxicity, they may not be effective alpha-glucosidase inhibitors under the tested conditions.
Co-Authors Anggraini, Yetti Ardini, Dias Dias Ardini Dina Dwi Nuryani Dinutanayo, Wimba Widagdho Enro Sujito Enro Sujito Filia Yuniza Hartanti Hartanti Hartanti Hartanti Hartanti, Hartanti Heriyansyah Heriyansyah Ika Fitria E Makhdalena Makhdalena, Makhdalena Mei Ahyanti Mulyani, Roza murwanto, bambang Musiana, Musiana Musiana, Musiana - Nawasari Indah Putri S. Oktaviani, Ika Prayudhy Yushananta Pudji Rahayu Putri, Nawasari Indah Riyanto Riyanto Siti Julaiha Siti Julaiha Sujito, Enro Yetti Anggraini Yetti Anggraini Yetti Anggraini Yetti Angraini Yulia Novika J Yulida Fithri