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All Journal Pendas : Jurnah Ilmiah Pendidikan Dasar JURNAL FARMASIMED (JFM) Jurnal Ilmiah Pendidikan Citra Bakti Indo-MathEdu Intellectuals Journal Sibatik Journal : Jurnal Ilmiah Bidang Sosial, Ekonomi, Budaya, Teknologi, Dan Pendidikan Jurnal Kependidikan JURNAL PENGABDIAN AGRO AND MARINE INDUSTRY Al-Qalam: Jurnal Kajian Islam Dan Pendidikan Jurnal Ilmiah Pendidikan Citra Bakti
Amelia, Fatma
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Social Sciences Other

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Journal : JURNAL FARMASIMED (JFM)

 1 
Anti-Inflammatory Potential of Combined Turmeric Rhizome Extract (Curcuma longa L.) and Hydroxyapatite in Male White Mice (Mus musculus) Ritonga, Ahmad Hafizullah; Amelia, Fatma; Herlina, Herlina; Aritonang, Barita; Harefa, Karnirius
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/garnbm90

Abstract

Inflammation is a protective response of the body to tissue injury that needs to be controlled to prevent further damage. The use of nonsteroidal anti-inflammatory drugs is effective; however, it has the potential to cause side effects, so safer alternatives are needed. Turmeric rhizome (Curcuma longa L.) is known to have anti-inflammatory activity, while hydroxyapatite (HA) is biocompatible and has the potential to enhance the effectiveness of the combination. This study aims to evaluate the anti-inflammatory potential of the combination of turmeric rhizome ethanolic extract and HA in male white mice (Mus musculus). This research method uses an experimental design with an acute inflammation model induced by intraplanar injection of 1% carrageenan. A total of 25 mice were divided into five groups: negative control (0.5% Na-CMC), positive control (diclofenac sodium), and three treatment groups at 0.5%, 1%, and 1.5%. Edema volume was measured every 1 hour for 6 hours and analyzed using the Kruskal-Wallis test followed by a post hoc test. The results of this study showed that all treatment groups exerted anti-inflammatory effects compared to the negative control, as indicated by decreases in edema volume and the percentage of inflammation and increases in the percentage of inhibition of inflammation, with the 1.5% concentration showing the most optimal effect. These findings indicate that the combination of turmeric rhizome ethanolic extract and HA has potential as an effective anti-inflammatory agent in male white mice.
Co-Authors Amalia Rizki Lailatul Khilwa Aritonang, Barita Arju Mushaffa Azizah, Farida Nur Azmi, M. Ulul Azmi, M.Ulul Chusnul Chotimah Conia, Astri Fadillah Fadillah Fakhri, Wafiq Abdillah Herlina Herlina Imam Junaris Islam, Muhammad Thoriqul Karnirius Harefa Khilwa, Amalia Rizki Lailatul Ludviana, Vieke Mar'atus Sholikhah MS, Yusnadi Mushaffa, Arju Nur Azizah, Farida Pricilia, Yolanda Rizki Lailatul Khilwa, Amalia Salamah Noorhidayati Salma Nadhirroh Fatma Yuthi Sholikhah, Maratus Sholikhah, Mar’atus Silaen, Azwa Fazira Subaedah, Siti Suci, Delli Suriana Suriana Ulul Azmi, M. Willia, Seri Zaini Fasya