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Lunasin's Mechanism as an Antioxidant and Hypocholesterolemic Agent Santi Widiasari; Sabrina Hayati; May Valzon; Wahyu Ramadhan
International Journal Of Health Science Vol. 5 No. 1 (2025): : International Journal of Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijhs.v5i1.5637

Abstract

Several ways that can help lower cholesterol levels in the blood include using drugs (pharmacotherapy) or by modifying lifestyle and consuming certain foods. One of them is lunasin. Lunasin is a peptide found in soybean plants and is a promising drug candidate because it has broad health effects such as antioxidant, anti-inflammatory, anti-cancer, and lowering blood cholesterol through various mechanisms. This paper aims to examine the role and mechanism of action of lunasin as an antioxidant and its ability to lower blood cholesterol levels due to the unique peptide structure of lunasin as well as the bioavailability of lunasin starting from degradation, absorption, translocation and distribution of lunasin to target organs or target tissues after oral administration . This paper also discusses soybean plants as the main source of lunasin and the optimal content of lunasin in soybeans.
Edukasi Kesehatan Reproduksi Remaja dan Penggunaan Bahan Alam dalam Melindungi Kesehatan Reproduksi pada Siswa SMAN 1 Pekanbaru Saddam Muhdi; May Valzon; Huda Marlina Wati; Larysa Fernenda; Muhammad Al Fatih; Muhammad Nur Faisal Rizky; Reza Rizky Notisa; Rizka Prasetya Putri Dewi
Compromise Journal Community Proffesional Service Journal Vol. 3 No. 1 (2025): Compromise Journal : Community Proffesional Service Journal
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/compromisejournal.v3i1.526

Abstract

Adolescent reproductive health knowledge remains suboptimal due to insufficient access to accurate, evidence-based educational resources. This challenge is further compounded by the dissemination of unreliable information, resulting in misconceptions and improper health practices. This study presents a community-based initiative aimed at enhancing reproductive health literacy among students of SMAN 1 Pekanbaru, with a particular focus on integrating the use of natural resources as a preventive strategy. The program addresses gaps in structured reproductive health education and leverages locally available natural resources to foster sustainable health practices. The initiative encompasses structured activities, including socialization sessions for students and educators, comprehensive training on reproductive health and the utilization of natural resources, and the deployment of technology to facilitate information dissemination. Implemented by a multidisciplinary team from the Faculty of Medicine, Universitas Abdurrab, the program is supported by ongoing mentorship and systematic evaluations using surveys and interviews. This initiative underscores the potential for sustained impact through partnerships with schools, local health agencies, and community organizations. By enhancing awareness and encouraging the adoption of natural, sustainable practices, the program serves as a translational application of research findings, with the potential for scalability to other educational institutions and broader community settings.
EDUKASI TEKNOLOGI INFORMASI DALAM KONSEP SMART VILLAGE DI DESA SEI LEMBU MAKMUR KABUPATEN KAMPAR Sukri Sukri; May Valzon; Salamun Salamun; Muhammad Yazid; Kenepri Kenepri; Siti Juariah
Jurnal Pengabdian Masyarakat Multidisiplin Vol 5 No 3 (2022): Juni
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jpm.v5i3.2492

Abstract

The village area is a location far from the city which has many shortcomings, especially information technology communication. The best development and the fastest and most efficient way of developing information communication is to build from the bottom up at the village level. Every village in Indonesia must be independent and be able to develop themselves to obtain and share information. For this reason, the government has begun to implement a system of development and development from the outskirts or the lowest level, which is called the village and then to the urban area. To support this development, the government created the Smart Village information technology concept. The Smart Village concept has an agenda to strengthen rural management through the use of information and communication technology. In this regard, the Government continues to innovate and be creative to support the Smart Village program. Sei Lembu Makmur Village, Kampar Regency, Riau Province is a village located approximately 45 kilometers from the provincial capital. For this reason, information technology education and data communication through Smart Villages are needed so that village governments can develop Smart Villages independently and community leaders and agencies in the local village area can accept Smart Village development directly in the village.
PENGARUH EKSTRAK ETANOL 96% DAUN KEMANGI (OCIMUM AMERICANUM L) TERHADAP BERAT TESTIS DAN KONSENTRASI SPERMATOZOA TIKUS PUTIH JANTAN (RATTUS NOVERGICUS) May Valzon; Deinike Wanita Marwan
Collaborative Medical Journal Vol 1 No 3 (2018): September
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.715 KB)

Abstract

Kejadian infertilitas pria merupakan 36% dari seluruh kejadian infertilitas di dunia. Sebanyak 27,8% merupakan infertilitas idiopatik yang salah satu penyebabnya adalah reactive oxygen species (ROS). Ekstrak etanol 96% daun kemangi (Ocimum americanum L.) diduga mampu memperbaiki masalah fertilitas karena aktivitas zat yang dikandungnya, yaitu: flavonoid (orientin dan vicenin), zink, boron, dan arginin. Penelitian ini bertujuan untuk menganalisis pengaruh ekstrak etanol 96% kemangi terhadap berat testis dan konsentrasi spermatozoa tikus putih jantan. Dua puluh empat ekor tikus jantan dibagi secara acak menjadi empat kelompok, masing-masing terdiri dari 6 tikus. Kelompok A, B, C akan diberikan ekstrak kemangi oral setiap hari selama 20 hari dengan dosis 50 mg/kgBB/hari, 100 mg/kgBB/hari, dan 200 mg/kgBB/hari, sedangkan kelompok D adalah kontrol. Semua kelompok diberikan makan dan minum ad libitium selama 20 hari. Tepat pada hari ke-21 dilakukan pengangkatan testis dan pemeriksaan berat testis dan konsentrasi spermatozoa. Data yang diperoleh akan dianalisis secara kuantitatif dengan one way anova. Terdapat perbedaan bermakna rata-rata berat testis di dalam dan antar kelompok, tetapi tidak ditemukan perbedaan signifikan antar kelompok kontrol dan kelompok A dan B. Terdapat perbedaan bermakna rata-rata konsentrasi spermatozoa di dalam dan antar kelompok perlakuan, kecuali pada antara kelompok kontrol dengan kelompok A dan kelompok A dengan kelompok B. Penulis menyimpulkan bahwa pemberian ekstrak etanol 96% kemangi dapat meningkatkan berat testis dan konsentrasi spermatozoa.
PENGGUNAAN SCIATIC FUNCTIONAL INDEX (SFI) DAN TIBIAL FUNCTIONAL INDEX (TFI) DALAM PENILAIAN REGENERASI MOTORIS SARAF TEPI May Valzon; Ayu Permata
Collaborative Medical Journal Vol 3 No 1 (2020): Januari
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (200.916 KB) | DOI: 10.36341/cmj.v3i1.1094

Abstract

Regenerasi motorik saraf tepi dapat dinilai dengan menggunakan Sciatic Function Index (SFI) dan Tibial Function Index (TFI). Namun, studi komprehensif mengenai aspek anatomi dan metodologis pengukuran belum memadai. Penelitian ini bertujuan membandingkan penggunaan TFI dan SFI dalam menilai pemulihan fungsi motorik saraf tepi. Penelitian ini menggunakan desain posttest only with control group. Delapan belas tikus Wistar jantan dibagi menjadi tiga kelompok. Kelompok I, nervus ischiadicus dicederai 5mm proksimal terhadapat bifurkasi nervus ischiadicus kaki belakang kanan. Kelompok II, nervus tibialis dicederai 5mm proksimal dari tempat bercabang nervus cutaneous surae medialis kaki belakang kanan dan kelompok III sebagai kontrol negatif. SFI dan TFI diamati pada minggu II, IV, VI, dan VIII dan dianalisis. Hasil penelitian ini menunjukkan terdapat perbedaan yang signifikan antara nilai varians SFI dan TFI pada pengamatan minggu III, IV, dan VI (p-value < 0,05). Penggunaan TFI sebagai metode penilaian regenerasi motorik saraf tepi lebih baik dari pada penggunaan SFI yang ditunjukkan oleh nilai varians yang lebih kecil.
PERUBAHAN HISTOPATOLOGI AORTA AKIBAT PAPARAN ASAP KEBAKARAN BIOMASSA GAMBUT PADA MODEL MENCIT (Mus musculus) May Valzon; Widya Rizkika Islami
Collaborative Medical Journal Vol 6 No 2 (2023): Mei
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/cmj.v6i2.3784

Abstract

Indonesia is one of the countries that often experiences large-scale forest and peatland fires. The biggest disaster after the tsunami that occurred in Indonesia has occurred since the last dozen years, especially in Riau, Kalimantan. The smoke produced from these forest fires can worsen the air which will be inhaled and entered through the lungs so that it can enter the blood vessels and circulate throughout the body. It gives a direct effect by some of the components contained in the particles, such as endothelial damage to blood vessels due to particulate matter. Short-term exposure will cause acute atherothrombosis, ischemia, regulation of the inflammatory response as well as a decrease in blood vessel diameter. Meanwhile, long-term effects will occur such as local inflammation to atherogenesis. This study aims to analyze changes in the diameter of the aortic lumen and the presence or absence of endothelial foam cells. using a true experimental study with a posttest approach with control group on 6 mice that received exposure to fire smoke, 6 mice that did not get exposure or as a control for 10 days. Based on Fisher's test, it was found that exposure to peat burning smoke for 10 days caused the formation of foam cells on the aortic wall.
EFEKTIVITAS PENGGUNAAN VIDEO PEMBELAJARAN ANATOMI TERHADAP KESIAPAN MAHASISWA KEDOKTERAN MENGIKUTI PRATIKUM ANATOMI SISTEM REPRODUKSI PRIA: (Studi pada mahasiswa kedokteran Universitas Abdurrab) May Valzon; Tasha Haviva Suhaila; Huda Marlina Wati
Collaborative Medical Journal Vol 7 No 2 (2024): Mei 2024
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/cmj.v7i2.5165

Abstract

Background: The competencies that medical students must have at the academic level are the realm of biomedical science, medical humanities, clinical medical science and public health science, by paying attention to the principles of scientific method and curriculum principles. Biomedical science is a branch of medical science consisting of anatomy, physiology, and biochemistry. Anatomy is a medical language that is very important for medical students to study the normal body structure starting from the shape, size, location, supporting elements and their relationship with the surrounding structure. Evaluation of medical education institutions shows that less time is spent studying anatomy. In addition, the material and limitations of props such as guidebooks that do not have high image quality make it difficult for students to understand the material contained in the book. These day, thanks to technological innovations, there have been many changes in the teaching and learning process. Advances in computer and smartphone technology allow the development of various multimedia learning environments, including video learning that can be repeated on smartphones, besides that multimedia can increase working memory capacity. Objectibve: Analyse the effectiveness of male reproductive sistem anatomy practicum learning videos to improve student learning achievement in anatomy learning in medical students. Method:This research method is an experimental method with a cross-over design. The population of this research is second-year students of the 2023/2024 academic year, the Faculty of Medicine, Abdurrab University with the total sampling method. Results: The results of the Mann-Whitney comparative test showed that there was no significant difference between the group using video learning media and the group using the module learning media (P-value = 0.518). The average percentage of external male reproductive sistem kuis given treatment using modules and videos was 68.63 and 69.03. Meanwhile, the average percentage of kuis of the internal male reproductive sistem given treatment using modules and videos is 73.57 and 68.00. Conclusion: The use of video is no more effective as a medium for learning anatomy practicums, especially in learning the male reproductive system module at the Faculty of Medicine, Abdurrab University.
Co-Authors Agus Jamal Agusmai, Riski Ahmad Naufal, Ahmad alif maulana Amelia Elvarani Aprilianti, Risa Arif Budianto Arzi Putra Persada Asiska Permata Dewi Asma Ul Husna Aulia Izzati, Aulia Ayu Permata ayuningtiyas, ratih Bagus Pramono, Kurnia Cheok Ng, Siew Deinike Marwan Deinike W Marwan Dewi Sartika Siagian Dheana Salsabiela Eddya Dinda Lestari Dona liazarti Dona Liazarti Dona liazarti Donaliazarti Else Chandra Else Chandra Farras, Aqil Fino Hidayat, Arya Fitrianti Hari Kusryanto Hasikin, Khairunnisa Huda Marlina Wati Imron Khoiri, Muhammad Ismaningsih ismaningsih, ismaningsih Isna Wardaniati Juni Nurma Sari Jusman, Yessi Kenepri Kenepri Kusuma Wardani, Kharisma Laila Indah Fitriya Larysa Fernenda Lasiah Susanti Liazarti, Dona Madona, Putri Maratis Solehah, Nurul Marwan, Deinike Wanita Muga Hapdy Daulay Muhammad Al Fatih Muhammad mahrus zain Muhammad Nur Faisal Rizky Muhammad Yazid Mukhammad Fathkhur Rozaq Nanda Utami, Putri Nurmaliza, Nurmaliza Oktariani, Eva Pratiwi, Denia Prista Indria Nawang Wulan Rahmatika Hasanah, Atin Raja Alya Zahra Reza Rizky Notisa Rini Hariani Ratih Riski Agusmai Rizka Prasetya Putri Dewi Sabrina Hayati Saddam Muhdi Safardi, Hakim Salamun Salamun Samosir, Nova Relida Santi Widiasari Santi Widyasari Santi Widyasari Siagian, Dewi Sartika Sinaga, Grace Krisdayanti Siregar, Uli Astuti Siti Juariah Siti Muawanah Sitimuawanah Sri Wahyuni Sukri Sukri Tasha Haviva Suhaila Ulhusna, Nissa Uly Astuti Siregar Uly Astuti Siregar Ummi Azizah Nasution Utami, Putri Nanda Wahyu Ramadhan Widya Ade Putri Sinaga Widya Rizkika Islami Wiwi Sartika Zein, Renni Hidayati