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All Journal Alchemy : Journal of Chemistry Jurnal Surya Medika INKUIRI : Jurnal Pendidikan IPA Jurnal Analis Kesehatan Jurnal Biomedika Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Jurnal Peduli Masyarakat Indonesian Journal of Global Health research Jurnal Farmasi Journal of Nursing and Health (JNH) Akper Yakpermas Banyumas Jurnal Kesehatan Kusuma Husada Jurnal Farmasetis Journal of Environment and Sustainability Education GEMASSIKA: Jurnal Pengabdian kepada Masyarakat Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Wimpy, W
Sekolah Tinggi Ilmu Kesehatan Nasional
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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ANALISIS KADAR RETIKULOSIT BERDASARKAN KATEGORI KADAR TIMBAL DARAH PADA PEROKOK AKTIF Safira, lLaurentia Filda; Wimpy, Wimpy
Journal of Nursing and Health Vol. 10 No. 2 (2025): Journal of Nursing and Health
Publisher : Yakpermas Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52488/jnh.v10i2.473

Abstract

Evaluation of Blood Mercury Levels and Creatinin Levels in Indonesian Traditional Gold Miners in Central Java Wimpy, Wimpy; Widhiyastuti, Endang; Puspitasari, Lala
Indonesian Journal of Global Health Research Vol 6 No 4 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i4.3519

Abstract

Based on the world gold council data in 2024, Indonesia is the eighth largest gold producing country in the world. More than 200 gold mining locations spread throughout Indonesia, but gold mining processes in Indonesia especially in Central Java are still carried out traditionally. The importance of this research is that traditional gold mining can lead to health issues such as mercury poisoning and impaired kidney function wich is characterized by the increased of creatinine levels Purpose : to evaluate the blood mercury levels and creatinine levels in Indonesian traditional gold miners in Central Java. Methods : This research uses a cross-sectional analitycal method. The number of samples in this research was 20 gold miners as respondents using a quota sampling technique. Data on blood mercury level results were obtained by examining blood mercury levels with a mercury analyzer and creatinine levels were obtained by examining serum creatinine with a photometer. The spearman’s rho test is used to test the correlation between blood mercury and creatinine levels. Results : As many as 19 out of 20 respondents had mercury levels of more than 20 µg/L, exceeding the threshold set by NCBI but they all had creatinine levels that were still within normal limits according to the NCBI limits wich is less than 1,2 mg/dL. The results of the Pearson correlation test obtained a sig. value (2 tailed) 0,962 where it can be concluded that there is no correlation between blood mercury levels and creatinine levels in.
Blood mercury levels and PCR-based GSTP1 and GSTT1 gene profiles in artisanal gold miners: A cross-sectional study Wimpy, Wimpy; Silviani, Yusianti; Hidayati, Nur; Aribowo, Daffina Ramadhani Putri; Septiani, Erni Dwi; Masykuri, Mohammad
Journal of Environment and Sustainability Education Vol. 4 No. 1 (2026)
Publisher : Education and Development Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62672/joease.v4i1.159

Abstract

Mercury (Hg) exposure from artisanal and small-scale gold mining (ASGM) remains a major public health concern, particularly in communities where mercury amalgamation is still widely practiced. Chronic mercury exposure is known to induce oxidative stress and may interfere with detoxification pathways involving glutathione S-transferase enzymes, including GSTP1 and GSTT1. This study aimed to assess blood mercury levels and PCR-based GSTP1 and GSTT1 gene profiles among artisanal gold miners in Central Java. A cross-sectional descriptive study was conducted using whole blood samples from 10 adult males, consisting of 5 artisanal gold miners and 5 non-miner controls. Blood mercury concentrations were measured spectrophotometrically, while GSTP1 and GSTT1 gene profiles were evaluated using polymerase chain reaction (PCR). Blood mercury levels in miners ranged from 20.244 to 67.987 µg/L, exceeding the recommended reference value of <20 µg/L, whereas control subjects showed levels below the threshold. PCR analysis demonstrated expected GSTP1 and GSTT1 bands in all control samples. In contrast, miner samples showed variations in PCR band patterns, including larger than expected amplicons for GSTP1 and absence of GSTT1 amplification in two samples, which may indicate altered gene profiles associated with mercury exposure. In conclusion, artisanal gold miners exhibited elevated blood mercury levels alongside variations in GSTP1 and GSTT1 PCR profiles. Although the small sample size limits definitive genetic interpretation, these findings suggest that combined biomonitoring of mercury burden and detoxification-related gene profiles may provide useful preliminary indicators for assessing susceptibility to mercury exposure in ASGM settings.
Co-Authors Afita Indah Puspitasari. Aminuyati Andika Travel Nasruminalloh Andita, Anung Aprillia Dwi Yanti Ardy Prian Nirwana, Ardy Prian Aribowo, Daffina Ramadhani Putri Avicka Clara Yoan Claristya Bayutama, Yudistira Bella Amalia Rizky Wahyudi Cornelia Candra Ayu Prameswari Dewi Kumala Dewi Saroh Didik Wahyudi Dwi Utami, Hesti Enny Listiawati Enny Listiawati Enny Listiawati enny listiawati, enny Hendri Hermawan Adinugraha Kadam, Lencana Nurfi’ah Kartika Pertiwi Kusumawardani, Dinda Dwi Lencana Nurfi’ah Kadam Livana PH livana ph Luluk Damayanti Mardiyono Melati Putri Utami Mohammad Masykuri Mulatningtyas, Zevanya Nur Hidayati Nur Hidayati Nurdianto, Sefri Odelia Christiana Utami Oksani, Trifena Wening Oktaviana Puteri Megawati Paramita, Adelia Putri Pramuditha, Zevanya Mulatningtyas Purwati Purwati Puspitasari, Lala Putri, Nonik Restu Putrie Prameswari Ratna Sari Reraska Reraska Reynandar Wilda Muhammad Rhomadona, Rahma Dewi Risnawati, Wahyu Roby Fauzan Samsulaga Safira, lLaurentia Filda Santi Santi Sariningtyas, Rahma Novita Septiani, Erni Dwi Septiyan, Erni Dwi Shafa Sabela Ramadhani Sintia Aisyah Nur Said Stefanus Khrismasagung Trikusumaadi, Stefanus Khrismasagung Suharyanto Suharyanto Tri Harningsih Tri Harningsih Tri Harningsih Tri Harningsih Tri Harningsih, Tri Trifena Wening Oksani Umi Rahmawati Violyn Christiana Wardani, Tatiana Siska Whella Thalitha Larassati Widhiyastuti, Endang Wijayanti Arum Pradita Yaniarty, Setyo Yesti Nanda Sisvitara Yolandita Shintaini Auliya Yusianti Silviani Yusianti Silviani Zafira, Azalia Putri