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INDONESIA
INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY
Published by Universitas Nahdlatul Ulama Surabaya
ISSN : 26846748     EISSN : 26569825     DOI : https://doi.org/10.33086/ijmlst
Core Subject : Health, Social,
Health Professions Social Sciences
Contributions will be considered for publication in Indonesian Journal of Medical Laboratory Science and Tehnology (IJMLST) concern kind from research, involvement and theory to functioning matters, education and training. The very wide spectrum of its topics includes: dosimeter, instrument enlargement, specialized measuring techniques, epidemiology, biological effects (in vivo and in vitro) and risk and environmental impact assessments.
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Articles 113 Documents
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Potential of ethanolic extracts from seed kernel Indonesian cultivars mangoes as an anti-multidrug-resistant (MDR) Escherichia coli Ariyadi, Tulus; Qayimah, Sitti; Assa’diyah, Lulu’ Nur; Asyiah, Asyiah; Pratiwi, Hanum Adisty; Khairunnisa, Afifah; Hikmah, Annisa Nurul; Kusmita, Lia; Mutmainah, Mutmainah; Mukaromah, Ana Hidayati
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i2.5837

Abstract

Escherichia coli is a type of bacteria that often found in wound infections. The use of antibiotics to treat these uncontrolled infections has resulted in the emergence of multi-drug resistant (MDR) strains of pathogenic bacteria.  This rapid increase in MDR E. coli strains has led to significant morbidity and mortality in human populations. Consequently, the exploration of natural antibacterial agents is urgently needed. One promising resource is mango extract, which is recognised for its antibacterial properties and is obtained through solvent extraction using 96% ethanol. This study aimed to determine the antibacterial activity of seed extracts from seven different mango cultivars (Mangifera indica L.), against MDR E. coli. The study focused on determining the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) using dilution method. The concentrations examined for both MIC and MBC were 5, 10, 50, and 100 mg/mL. The results indicate that the mango seed extract exhibit significant antibacterial activity against MDR-E. coli., with the kweni cultivar showing the largest inhibition zone measuring 23.25 mm. The ethanol extract from the kweni seeds yielded the most favorable results, with an MIC value of ≥0.078 mg/mL and an MBC value that ranged from 1.25-10 mg/mL. In conclusion, mango seed extract, particularly from the kweni cultivar, has substantial potential to be developed as an effective antibacterial agent against MDR-E. coli.
Effect of subacute toxicity of mosquito coil smoke inhalation on lung histology and blood hematology parameters in Wistar rats Sri Rahayu, Mulyati; Wahyuni, Sri
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i2.6046

Abstract

Mosquito coils are made from incense products and are designed to repel insects using pyrethrins and pyrethroids as their main active ingredients. However, the use of these coils poses significant public health and ecological risks due to the emitted toxic fumes. These fumes can have long-term damaging effects on humans and the environment. This study aimed to investigate the effects of various durations of subacute exposure to mosquito coil smoke (MCS) on lung histology and blood hematology in white male Wistar rats (Rattus norvegicus). Rats were divided into four groups (n = 6): control; P1, P2, and P3, exposed to MCS for 5, 7, and 9 h per day, respectively, for 21 days. Hematological blood analyses (red cell count (RBC), hemoglobin (Hb), and hematocrit (Hct)) were performed, and lung histopathology was evaluated using Manja Roenigk's criteria. The group exposed to MCS for 9 h/day showed a significant decrease in mean body weight (185.00 ± 9.59) (p = 0.008) compared with the control group. All treated groups had normal Hb and Hct levels and RBC indices, with no significant differences compared with the control group. The 9-hour exposure group had significantly lower lung weights than the control group (p<0.05), and all treatment groups showed significant differences in lung weight (p<0.05). Histopathological analysis revealed significant loss of alveolar septal integrity, leading to alveolar lumen rupture and development of emphysema. This study provides clear evidence of emphysema due to subacute allethrin-based MCS inhalation, although it did not affect hematological parameters in rats.
Molecular identification and antibacterial activity of endophytic bacteria from Bambusa vulgaris leaves as antibacterial potential against phatogenic microoganism Malau, Jekmal; Mierza, Vriezka; Mulki, Munir Alinu; Urbaningrum , Lestari Mahardika; Hasna, Vina Luthfiana; Debora, Priscinya Christiana
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i2.6538

Abstract

The increasing prevalence of antibiotic-resistant bacteria poses a critical global health concern, necessitating the exploration of novel antibacterial solutions. Endophytic bacteria, which colonize plant tissues without causing harm, have gained attention as potential sources of bioactive metabolites. This study aimed to isolate and characterize endophytic bacteria from Bambusa vulgaris leaves and evaluate their antibacterial potential against pathogenic microorganisms. Leaf samples were collected from Bekasi, West Java, and subjected to a surface sterilization process prior to bacterial isolation. A total of 12 bacterial strains were successfully obtained and screened for antibacterial activity against Bacillus subtilis, Propionibacterium acnes, Pseudomonas aeruginosa, and Staphylococcus epidermidis using the agar well diffusion assay. Three isolates exhibited notable inhibitory activity, with P8 demonstrating the strongest antibacterial effects against B. subtilis, P. acnes, and S. epidermidis. The two most potent isolates, P8 and K3, were characterized via 16S rRNA gene sequencing. Genomic DNA extraction was performed, followed by Polymerase Chain Reaction (PCR) amplification using the universal primers 27F (5′-AGAGTTTGATYMTGGCTCAG-3′) and 1492R (5′-GGTTACCTTGTTACGACTT-3′). Sequencing and The Basic Local Alignment Search Tool (BLAST) analysis confirmed that isolate P8 exhibited 100% similarity to B. subtilis strain LZH-H1, whereas isolate K3 shared 99.85% similarity with Pantoea stewartii subsp. indologenes strain SR2-12. These findings suggest that endophytic bacteria from B. vulgaris endohytic bacteria hold promise as potential sources of antibacterial compounds. Further research is necessary to purify and characterize these bioactive metabolites for potential pharmaceutical applications.
STAT3, but not Ki-67, expression is independently associated with tumor progression in colorectal carcinoma: A comparative immunohistochemical biomarker analysis Wedharga, I Gede Putu Adhi; Willianto, Vincentius Michael; Theodora, Imelda; Parengkuan, Irene; Novita, Bernadette Dian
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i2.7711

Abstract

The insidious progression of colorectal carcinoma (CRC) at early stages often hampers timely screening and diagnosis, resulting in delayed intervention and poor clinical outcomes. Ki-67 and Signal Transducer and Activator of Transcription 3 (STAT3) have been widely studied for their roles in tumor proliferation and survival. However, comparative studies assessing their clinicopathological relevance in CRC progression remain limited, and their relative contributions to tumor aggressiveness are unclear. This study aimed to evaluate the clinicopathological significance and association of Ki-67 and STAT3 expression with tumor aggressiveness, focusing on their roles in tumor infiltration and size as indicators of CRC progression. Thirty-eight formalin-fixed, paraffin-embedded (FFPE) CRC tissue specimens were collected from patients undergoing surgical resection for this cross-sectional study. Ki-67 and STAT3 expression were assessed using immunohistochemical (IHC) staining. Clinicopathological data were retrieved from medical records. Protein expression was quantified using inverted mean gray values via digital image analysis. Ki-67 and STAT3 expression levels significantly correlated with tumor infiltration (Ki-67: r = 0.322, p = 0.049; STAT3: r = 0.429, p = 0.007) and size (Ki-67: r = 0.425, p = 0.008; STAT3: r = 0.452, p = 0.004). No significant correlation was found between Ki-67 and STAT3 (r = 0.225, p = 0.175). Only STAT3 was independently associated with infiltration (OR per 1-standard deviation: 4.11, p = 0.043) and size (OR per 1-SD: 3.41, p = 0.047). While both markers are associated with CRC progression, only STAT3 shows an independent association with tumor aggressiveness, underscoring its role beyond cell proliferation and suggesting broader involvement in tumor invasion and progression pathways.
Acute oral toxicity and dose-dependent histopathological effects of Indonesian Ciplukan (Physalis angulata L.) extract in Sprague-Dawley rats Sylviningrum, Thianti; Inayati, Nor Sri; Setiawati, Setiawati; Arjadi, Fitranto; Novrial, Dody
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i2.7921

Abstract

The growing global interest in herbal medicines underscores the importance of safety assessments for traditional plants. Physalis angulata L. (Ciplukan) demonstrates therapeutic potential, yet data on Indonesian extracts remain limited. This study evaluated the acute oral toxicity and determined the median lethal dose (LD50) of Indonesian Ciplukan extract. Twenty-five female Sprague-Dawley rats were divided into five groups (n=5): control (aqueous), and four groups that received extract at 100, 400, 800, or 1200 mg/kg body weight. Over 14 days, researchers monitored clinical signs, body weight, food intake, and organ weights in accordance with Acute Oral Toxicity (OECD Test Guideline 425). Major organs were examined histopathological using the modified International Harmonization of Nomenclature and Diagnostic Criteria. No mortality or significant behavioral changes were observed at any dose. Rats maintained normal body weight gain and food intake. The LD50 was determined to be exceeded 1200 mg/kg, indicating favourable acute safety. However, histopathological analysis revealed significant dose-dependent necrotic changes (p < 0.05) in the lungs, kidneys, liver, and spleen at doses of 400 mg/kg and above. Liver and spleen damage were detected first at this threshold. These findings indicate an LD50 above 1200 mg/kg body weight for Indonesian Ciplukan extract, supporting its acute safety. Nonetheless, subclinical organ toxicity occurred at doses of 400 mg/kg or higher, emphasizing the need for dose optimization in phytomedicine. The study provides regulatory-grade toxicological data to support evidence-based standardization of Indonesian herbal medicines and highlights the necessity for further research on sub chronic and chronic toxicity to establish safe therapeutic doses.
Genetic diversity in the E6 and E7 gene of human papillomavirus type 16 among cervical cancer patients in Riau Province, Indonesia Savira, Maya; Rachmadina, Rachmadina; Mahargyarani, Azza Enggar; Admiral, Muhammad Zhafran; S, Donel; Sofian, Amru; Razali, Renady Reza; Ilmiah, Zidny; Farniga, Analdi
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.6652

Abstract

Cervical cancer mostly occurs due to persistent high-risk human papillomavirus (HPV), with type 16 being the most frequent. In Indonesia, cervical cancer ranks second in mortality, with a fatality rate of 57%. The E6 and E7 genes of HPV-16 play crucial roles in the virus’s oncogenic transformation, leading to cervical cancer. This study was conducted to determine the prevalence and genetic diversity of the E6 and E7 genes of HPV-16 in Riau Province, Indonesia. There were 37 HPV-positive samples analyzed using the MY09/11 primers. This was followed by the amplification of the E6 and E7 genes. Nineteen samples were detected as HPV-16, thirteen of which were coinfected with HPV-18. Seven E6 and E7 sequences were aligned compared with the reference sequence NC_001526.4. The most common nucleotide changes in the E6 gene, 7318A>G, was detected in 30.7% of samples, leading to an amino acid change from 65N>S. Three nucleotide changes were identified in the E7 gene of sample 89: two synonymous (7831T>C, 7837T>G) and one non-synonymous (7989A>G), resulting in an amino acid change of 29N>S. The most frequent E7 nucleotide change, 7708G>A, was found in 80% of samples. Phylogenetic analysis revealed that HPV-16 isolates from Riau have close kinship with the European lineage, with 57.1% (E6) and 85.7% (E7). In conclusion, the incidence of cervical cancer in Riau Province caused by HPV-16 is 52.8% and 7318A>G and 7708G>A are the most common genetic diversity. Furthermore, the majority of HPV-16 isolates in Riau Province show close kinship with the European lineage.
Characterization of Aedes sp. larvae: Detection of dengue, Japanese encephalitis and West Nile virus with knockdown resistance mutations in Mulyorejo, Surabaya, Indonesia Prasasti, Adelia Gita; Sucipto, Teguh Hari; Kurniawan, Muhammad Ridho Hafid; Fauziyah, Shifa; Riris, Anak Agung Istri Dalem Cinthya; Djurumana, Yohana; Hapsari, Nafisah Nurul; Farihah, Neni Isna; Wijayanti, Alvia Rachma; Kusumawati, Nita; Hariyono, Hariyono; Wardhani, Puspa
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.6654

Abstract

Indonesia recorded the highest dengue mortality rate in Asia in 2022, with 45,387 cases and 432 deaths.  This study aimed to investigate the coexistence of arboviruses and insecticide resistance mechanisms in Aedes vectors mosquitos’ populations in Mulyorejo District, Surabaya, during the early monsoon season of 2021. A cross-sectional survey was conducted in January 2021, and Aedes larvae were collected and reared to adulthood under laboratory conditions. A total of 309 Aedes larvae (comprising 65% Aedes aegypti and 35% Aedes albopictus) were collected from 36 breeding sites, identified, and georeferenced using QGIS software. RNA extraction and RT-PCR assays were performed to detect Dengue virus (DENV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and knockdown resistance (KDR) mutations. Results showed seven samples positive for DENV-2 and seven for JEV, with two samples (codes 9 and 12) exhibiting co-infection with both viruses, while no WNV was detected. The detection of JEV in Aedes larvae is a notable finding, suggesting a potential secondary vector role for these species in the study area, as Culex mosquitoes are the primary vectors of JEV. Mutations at codons 1016 (V1016G) and 1534 (F1534C), associated with pyrethroid and DDT resistance, were detected in eight and seven samples, respectively. These findings confirm the circulation of DENV-2 and JEV in local Aedes populations, highlighting the presence of KDR mutations that confer insecticide resistance. The results underscore the urgent need for integrated vector management in Surabaya, combining arbovirus surveillance, insecticide resistance monitoring, and community-based source reduction to mitigate arboviral disease transmission.
Antidyslipidaemic effect of Ipomoea batatas L. extract with increased PCSK-9 levels in atherosclerotic rats Yasa, I Wayan Putu Sutirta; Jawi, I Made; Mahendra, Agung Nova; Wiradana, Putu Angga; I Gede Widhiantara
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.7260

Abstract

Atherosclerosis is the largest cause of mortality worldwide, and Low-Density Lipoprotein (LDL) is a primary risk factor for this illness. The purpose of this research was to determine the effect of purple sweet potato (Ipomoea batatas L.) extract on cholesterol, LDL, PCSK9, and MDA levels in rats fed a high-cholesterol diet. This true experimental study used a randomised pre-test-post-test control group design. Wistar rats were randomly assigned to three groups. Purple sweet potato extract (PSPE) was prepared by 24-hour maceration with 70% ethanol. All rats were fed a high-cholesterol diet for 14 days, followed by pre-test measurements of cholesterol, LDL, PCSK9, and MDA on day 15. Rats were then randomly divided into control (no treatment), PSPE (200 mg/day), and Simvastatin (0.9 mg/kg BW) groups. After one month of treatment, post-test analyses were performed for all parameters. The results showed an increase in serum cholesterol, LDL and MDA levels in rats fed a high-cholesterol diet (p<0.05) compared to the PSPE and Simvastatin groups. The high-cholesterol diet also resulted in a significant (p<0.05) decrease in PCSK9 when compared to the PSPE and Simvastatin groups. In the PSPE group there was a decrease in cholesterol, LDL, and MDA, and PSPE (p<0.05) compared to the control group. In the Simvastatin group, the increase in PCSK9 was very low compared to the PSPE group. PSPE has antidyslipidaemic activity by reducing total cholesterol status, LDL, and oxidative stress while promoting PCSK-9 function. Further research is still needed to provide a comprehensive understanding of the mechanism of action of PSPE as an antioxidant source in patients with atherosclerosis.
Computational Modeling of a Novel CTX-M β-Lactamase Escherichia coli Isolated from Yogyakarta, Indonesia Using I-TASSER Kinasih, Anggiresti; Retnaningrum, Endah
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.7267

Abstract

Extended-spectrum β-lactamases (ESBLs), especially those of the CTX-M family, significantly contribute to antibiotic resistance in Escherichia coli. While CTX-M variants are well-characterized in clinical settings, their structural features in foodborne E. coli remain underexplored, particularly in countries like Indonesia. This study aimed to predict and validate the three-dimensional (3D) structure of a novel CTX-M β-lactamase protein from an E. coli isolate (D4DU2-ESBL-EC) culture collection at Laboratory of Microbiology, Universitas Gadjah Mada (UGM). This study reports a novel CTX-M variant from E. coli D4DU2, a locally strain originated from raw chicken meat in Yogyakarta traditional market that has been shown to adapt and thrive in Sleman Regency, Indonesia. Based on phylogenetic and structural analyses, E. coli D4DU2 evolutionary link to Indian CTX-M-15, with distinct mutations at W253L, P254A amino acid near the active site. The 3D structure of D4DU2 CTX-M β-lactamase was predicted using I-TASSER and validated using PROCHECK. Ramachandran analysis showed 78.4% of residues in the most favored regions, 20.5% in allowed regions, and only 1.2% in disallowed regions, confirming high stereochemical quality. These findings highlight potential local adaptation and emergence of a unique ESBL-producing E. coli strain. This study provides a reliable model for CTX-M β-lactamase from foodborne E. coli in Indonesia, supporting One Health-based surveillance and intervention strategies. Overall, this study demonstrates that I-TASSER, complemented by PROCHECK validation, offers a valuable in silico approach for the structural characterization of ESBL proteins from foodborne bacterial isolates in resource-limited contexts
Association between postnatal maternal serology and congenital cytomegalovirus infection in neonates with jaundice Wardhani, Puspa; Pamungkas, Joko; Husada, Dominicus; Ernawati, Ernawati; Purnami, Nyilo; Fitriah, Munawaroh; Prasetyani, Reni
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.7737

Abstract

Congenital cytomegalovirus (CMV) infection is one of the most prevalent infections at birth and can lead to severe health complications in neonates. Timely detection is crucial. However, polymerase chain reaction (PCR) testing is often unavailable in numerous healthcare settings. In such cases, maternal CMV antibody testing may assist in identifying at-risk infants. In the development of diagnostic methods to date, there is no single method for detecting CMV infection in pregnant women at all stages of pregnancy. This study examined the relationship between maternal CMV serology after delivery and congenital CMV infection in newborns presenting with symptoms including jaundice, prematurity, or low birth weight. Urine samples from neonates within the first 21 days of life were analyzed for CMV DNA via PCR, while maternal IgG and IgM antibodies were assessed within three weeks after delivery. A total of 87 neonates were examined, with 28 (32.2%) testing positive for CMV DNA. Neonatal jaundice was significantly associated with CMV infection, whereas prematurity and low birth weight were not. Maternal CMV IgM positivity was significantly correlated with neonatal CMV PCR positivity, while maternal IgG did not exhibit a significant relationship. In conclusion, maternal CMV IgM positivity post-delivery may assist in identifying newborns requiring confirmatory PCR testing, particularly in healthcare environments with constrained diagnostic resources.

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