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Hydrogen: Jurnal Kependidikan Kimia
Published by Universitas Pendidikan Mandalika
ISSN : 23386487     EISSN : 26563061     DOI : Prefix 10.33394
Core Subject : Science, Education,
Chemistry Education
Hydrogen: The Chemistry Education Journal published by the Chemistry Education Study Program which contains articles raised from the results of conceptual research and studies in chemistry and chemistry education including education and learning, device development, media and learning models.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 618 Documents
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Quantification of Flavonoid Compounds in Keji Beling Leaves (Strobilanthes Crispa (L.) Blume) Extracted by Ultrasonic Assisted Extraction (UAE) and Maceration Using TLC Densitometry Hasnaeni; Handayani, Selpida; Utami, Fadhillah Resky; Majid, Nini Nirmala
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.17748

Abstract

Keji Beling leaves (Strobilanthes crispa (L.) Blume) contain secondary metabolites such as flavonoids, tannins, saponins, alkaloids, and polyphenols. These secondary metabolites have antioxidant, antidiabetic, and anticancer activities. In this study, flavonoid identification was tested using thin-layer chromatography (TLC), followed by determination of the flavonoid content in Keji Beling leaf extract (Strobilanthes crispa (L.) Blume) using the densitometry method. The extraction methods used were Ultrasonic Assisted Extraction (UAE) and maceration using 70% ethanol solvent, yielding extracts with a yield of 15.143% and 11.092%, respectively.Quantification of flavonoid compounds using quercetin standard showed that the average flavonoid content of keji beling leaf extract using the Ultrasonic Assisted Extraction (UAE) method was 0.057 mg/mL and using the maceration method was 0.156 mg/mL. This study aims to determine the flavonoid content of keji beling extract using the TLC densitometry method.    
Development of Interactive Multimedia on Chemical Bonding Material Iwan; Enawaty, Eny; Masriani
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.18039

Abstract

The limited availability of learning media capable of facilitating students’ understanding of abstract concepts in chemical bonding prompted this research. This study aims to determine the validity level of the developed interactive multimedia and to assess teachers’ and students’ responses toward its use. The research employed a Research and Development (R&D) method using a modified ADDIE model, limited to the development stage. The trial subjects consisted of two chemistry teachers and 9 students for the small-scale test, as well as 30 students from grade XI at SMAN 2 Sekadau for the large-scale test.The validation results from experts indicated that the interactive multimedia was highly valid with an average percentage of 94.17%, consisting of 88.33% for the media aspect, 96.25% for the material and language aspects, and 97.92% for the assessment aspect. Student responses reached an average of 90.69% in the small-scale test and 94.53% in the large-scale test, while teacher responses reached 83.07%.The novelty of this research lies in the use of interactive multimedia equipped with a variety of engaging features, such as ice-breaking activities and educational games, which are rarely implemented in chemical bonding learning at the senior high school level. Therefore, the developed interactive multimedia can be used as a learning medium and further tested for its effectiveness.
Development of Matching Card Media as an Evaluation Tool on Mole Concept Subject Jati, Prameswara Wahyu; Erlina; Lestari, Ira
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.18043

Abstract

This study aims to measure the feasibility level and students' responses to the matching card media that was developed. This type of research is Research and Development with the 4D development model. Data collection techniques in this study used measurement techniques in the form of feasibility tests and student response questionnaires using a Likert scale. The subjects of this study were the matching card media, with trial subjects being XI MIPA 1 students at SMA Negeri 5 Pontianak. Feasibility testing used the Gregory test conducted by two media experts and two graphic design experts. The feasibility test on the developed media met very high criteria with an average score of 1.00 in the material aspect and 1.00 in the graphics aspect. Students' responses to the media in the limited and main field tests were 95.58% and 92.55%, respectively, with very good criteria. Based on the results obtained, it can be concluded that the matching card media as an evaluation tool for the mol concept material is very feasible and received a very positive response. This study contributes to the development of interactive evaluation media for the mole concept material, which can enhance students' understanding, engagement, andmotivation.
The Effect of the Talking Chips Cooperative Model Based on the Quiz Team Strategy on Interest and Learning Outcomes Senta; Enawaty, Eny; Harun, Andi Ifriany
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.18097

Abstract

The Talking Chips learning model is a cooperative approach that uses cards as a tool to regulate speaking turns. Meanwhile, the Quiz Team strategy aims to improve group cooperation through fun activities. This study aims to determine the effect of applying the Talking Chips model based on the Quiz Team strategy on students' interest and learning outcomes. The research was conducted with a quantitative approach using a quasi-experimental method and a post-test only control group design. The study was conducted at SMPN 26 Pontianak City in the even semester of the 2024/2025 academic year with a sample of two eighth grade classes with equal academic abilities. The experimental class received learning using the Talking Chips model based on the Quiz Team strategy, while the control class used conventional learning. The research instruments consisted of a learning interest questionnaire and a post-test learning outcome test.The results showed that the average learning outcome score of students in the experimental class (68.23) was higher than that of the control class (60.16), with a significant difference based on the Mann-Whitney test (Sig. 0.046). The Effect Size value of learning outcomes was 0.52, indicating that the learning model had a moderate effect on learning outcomes. In addition, in terms of learning interest, the experimental class obtained a “Very High” category with an average of 91.8%, while the control class was in the “Fair” category with an average of 69.4%. The t-test showed a significant difference (Sig. 0.000) with an Effect Size value of 2.02, which means that the learning model has a very large effect on learning interest. This study combines the Talking Chips model with the Quiz Team strategy as a cooperative learning approach that has been proven effective in increasing student interest and learning outcomes simultaneously.
In Silico Study of Antidiabetic Activity Mikania Cordata as PPAR- γ Agents Oktavianti, Dian; Masriani; Arief, Ihsanul
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.18110

Abstract

Diabetes mellitus remains a significant global health problem, requiring safer and more effective therapeutic agents. Peroxisome Proliferator-Activated Receptor gamma (PPAR-γ) plays a crucial role in regulating glucose metabolism by enhancing insulin sensitivity, making it a key target in the development of antidiabetic drugs. Pioglitazone, a PPAR-γ agonist from the thiazolidinedione class, has long been used as a conventional therapy; however, its long-term use is associated with side effects such as fluid retention, weight gain, and an increased risk of heart failure. The World Health Organization recommends the development of natural-based drugs with minimal adverse effects. One promising plant candidate is Mikania cordata, which has been reported to possess antidiabetic activity and contains various bioactive compounds, including terpenoids, flavonoids, sterols, and sesquiterpenoids. This study aimed to evaluate the bioactive compounds of Mikania cordata as potential natural PPAR-γ agonists using a molecular docking approach. A total of 36 ligands from M. cordata were docked to the PPAR-γ protein (PDB ID: 2PRG), with Pioglitazone serving as the positive control. Docking was performed using PyRx with the AutoDock Vina system after ligand and protein preparation with UCSF Chimera 1.16. The docking results were analyzed using BIOVIA Discovery Studio Visualizer to identify the interactions between the ligand–protein complexes. The results showed that Cordatolide exhibited the lowest binding affinity (–9.1 kcal/mol), followed by Stigmasterol (–8.9 kcal/mol), both of which were better than Pioglitazone (–8.8 kcal/mol). Interaction analysis revealed that Cordatolide formed two hydrogen bonds with key residues ARG288 and GLY284, accompanied by stable hydrophobic interactions without any unfavorable contacts. Meanwhile, Stigmasterol also showed competitive affinity, although its stability relied solely on hydrophobic interactions without hydrogen bonding. Therefore, Cordatolide demonstrates strong potential as a natural PPAR-γ agonist with fewer side effects compared to conventional therapies. This study provides a novel finding on the potential of M. cordata as a natural PPAR-γ agonist; however, further in vitro and in vivo evaluations are required to confirm its pharmacological activity.
Eco-Friendly Ultrasound-Assisted Synthesis of Silver Nanoparticles Mediated by Tea Leaf Extracts and Their Potential Applications Muliawati, Nindya Tri; Fajar, Malik; Sholeha, Novia Amalia; Ramdhan, Mohamad Alief; Laila, Farida; Sujarnoko, Tekad Urip Pambudi; Yulianti, Wina; Supardan, Atep Dian; Listiasari, Faranita Ratih; Resmeiliana, Ika
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.18213

Abstract

The green synthesis of silver nanoparticles (AgNP) presents notable benefits, such as environmental sustainability, simplicity, cost-effectiveness, and scalability for industrial applications. This study utilized green tea leaves (Camellia sinensis), which are abundant in catechins and polyphenols, as natural reducing and stabilizing agents. Ultrasonic-assisted synthesis was utilized to improve extraction and reduction processes, as acoustic cavitation induced by ultrasonic waves facilitates efficient mass transfer, accelerates nucleation, and enhances nanoparticle dispersion. This method provides an environmentally sustainable and economically viable alternative to conventional AgNP synthesis, enhancing the sustainability of nanoparticle production. The successful synthesis of AgNP was evidenced by the distinct color change of the tea extract from green to brown, accompanied by the formation of a brown colloidal suspension, in accordance with the Surface Plasmon Resonance (SPR) phenomenon. The UV-Vis spectrophotometric analysis confirmed AgNP formation, evidenced by a characteristic absorption peak at approximately 430 nm. The synthesized AgNPs were utilized as a colorimetric sensor for Fe³⁺ ions in aqueous solutions, demonstrating distinct color changes and SPR band shifts upon interaction with the metal. This illustrates their capability as environmentally friendly nanomaterials for the swift and precise detection of heavy metals, aiding in sustainable environmental monitoring. This research integrates ultrasonic-assisted synthesis with green tea extract, presenting a viable approach for the large-scale, environmentally sustainable production of nanoparticles.
Relationship between Cholesterol Levels and Ca 15-3 Tumor Markers in Patients with Carcinoma Mammae Faylori, Adelia Yusnita; Pauzi, Iswari; Fihiruddin
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.17460

Abstract

Breast cancer is the most common malignancy among women worldwide and remains a major cause of cancer-related mortality in Indonesia. Various risk factors, including hormonal, genetic, lifestyle, and metabolic factors, such as elevated cholesterol levels, have been associated with the development and progression of breast cancer. Cholesterol plays a crucial role in cell membrane formation and hormone synthesis, and recent studies have suggested its potential role in tumor growth and metastasis, particularly through the modulation of estrogen receptors and inflammatory pathways. CA 15-3 is a tumor marker widely used for monitoring breast cancer progression and recurrence. However, the correlation between cholesterol levels and CA 15-3 remains underexplored. The research objective is to determine the correlation between total cholesterol levels and the breast cancer tumor marker CA 15-3 in patients diagnosed with breast carcinoma at the Regional General Hospital of West Nusa Tenggara Province (RSUDP NTB). A cross-sectional analytic observational study was conducted using secondary data from the medical records of 33 breast carcinoma patients collected between January to November 2024. Cholesterol and CA 15-3 levels were analyzed using standard laboratory procedures. Data distribution was tested using the Kolmogorov-Smirnov test, and Pearson correlation analysis was applied to evaluate the relationship between cholesterol levels and CA 15-3. Showed that the mean cholesterol level was 214.24 mg/dL, and the mean CA 15-3 level was 41.55 U/mL, both exceeding normal reference values. Pearson correlation analysis demonstrated a very strong and statistically significant positive correlation between total cholesterol and CA 15-3 levels (r = 0.940, p < 0.001), indicating that higher cholesterol levels are associated with increased CA 15-3 concentrations. The study found a significant correlation between cholesterol levels and CA 15-3 in breast carcinoma patients, suggesting that cholesterol may influence tumor activity. Routine monitoring of cholesterol levels may be valuable in the clinical management of breast cancer, especially in assessing disease progression.
Literature Study: Complex Compounds Of Zn (II) EDTA, Mn (II) Netilisophyldithiocarbamate, and Lutesium-177(177lu)-Di-N-Butyl Dithiocarbamate In Industry Nasution, Rida Anastasia; Simatupang, Septania Oniza; Jahro, Iis Siti; Nurfajriani
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.18028

Abstract

This study is a literature review aimed at analyzing the synthesis, characterization, functions, and potential hazards of three types of complex compounds used in industry, namely Zn(II)-EDTA, Mn(II)-N-ethylisopropyldithiocarbamate, and Lutetium-177(177Lu)-Di-n-butyldithiocarbamate. The research method employed was library research, focusing on reviewing various relevant scientific sources from both national and international journals. The results show that Mn(II)-N-ethylisopropyldithiocarbamate functions as a lubricant additive that enhances viscosity and reduces friction at high temperatures; Zn(II)-EDTA acts as an effective anti-algae agent in industrial cooling water systems due to its strong chelating properties; and 177Lu-Di-n-butyldithiocarbamate serves as a radiotracer in industrial process monitoring owing to its high stability and radiochemical purity. Despite their many advantages, these compounds also pose potential toxic and environmental risks if not properly managed. Therefore, further research is recommended to develop more efficient and environmentally friendly synthesis methods and to ensure their application complies with industrial and radiation safety standards.

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