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Jurnal Farmasi dan Sains Indonesia (JFSI)
Published by Sekolah Tinggi Ilmu Farmasi Nusaputera
ISSN : 26219360     EISSN : 26863529     DOI : https://doi.org/10.52216
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience
Focus and Scope Jurnal Farmasi & Sains Indonesia is an open-access journal that published twice a year by Sekolah Tinggi Ilmu Farmasi Nusaputera. This journal is a media of research publication on all aspects of pharmaceutical & science that is innovative, creative, original and based on scientific. Articles published in this journal about drug discovery, drug delivery systems and drug development with specific field include: 1. Medicinal chemistry 2. Pharmacology 3. Pharmacokinetics 4. Pharmacodynamics 5. Pharmaceutical analysis 6. Drug delivery systems 7. Pharmaceutical technology 8. Pharmaceutical biotechnology 9. Herbal medicines and active components 10. Clinical evaluation of the medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 24 Documents
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Search results for , issue "Vol 8 No 2 (2025)" : 24 Documents clear
Formulasi Dan Uji Aktivitas Sediaan Face Mist Ekstrak Etanol Daun Jarak Pagar (Jatropha curcas L.) Sebagai Antikosidan Dengan Metode DPPH Raru, Preiscylia; Marzuki, Asnah; Alam, Syamsul
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p15-22

Abstract

Jarak pagar (Jatropha curcas L.) one as an antioxidant. This research aims to obtain a formulation in the form of a stable face mist dosage form and determine the IC50 value of the extra ethanol face mist preparation from jatropha leaves (Jatropha curcas L.) which has potential as an antioxidant. Experimental research method using 96% ethanol solvent, maceration method. The resulting thick extract is rotated, then preparations are made with concentrations of 0.1%, 0.3% and 0.5%, using additional ingredients glycerin as a humectant, propylene glycol as a humectant, sodium benzoate as a preservative, lavender as a fragrance and distilled water. as a solvent. Evaluation of the preparation, namely the cycling test in 6 cycles for 12 days, organoleptic observations obtained in liquid form, pH measurement results were <0.05p, homogeneity tests obtained homogeneous preparations, Viscosity test results were <0.05p, skin moisture and irritation tests were <0.05p. As well as antioxidant testing using the DPPH method using a UV-Vis spectrophotometer. The results of the research can be concluded that Jatropha curcas L. extract can be formulated as a face mist preparation that is physically and chemically stable. The IC50 values ​​using the facial mist preparation formula of Jatropha curcas (Jatropha curcas L.) leaf extract were respectively 17.0276 ppm, 16.5071 ppm, and 13.4743 ppm. The most effective face mist formulation has the highest antioxidant value in formula III.
Variasi Komponen Informasi Obat Pada Etiket Obat Resep Isnenia, Isnenia; Satriawan, Ahmad Bayu
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p23-28

Abstract

Prescription drug label as a means of communication between pharmaceutical staff and patients.  Inadequate prescription drug labels can be a major source of medication errors. This can be exacerbated by the diversity of labels, formats, designs and information components. This study aims to observe prescription drug label in Bandar Lampung City health centers and to determine benefits of prescription drug label. This research was conducted cross-sectional on hypertensive patients regarding prescription drug label and its level of benefit. The results obtained show that there are two materials in prescription drug label. Every health center has a format for prescription drug labels. The label attached to the plastic clip does not contain the identity of the pharmaceutical service facility such as name, address and pharmacist's license. For printed paper labels, this information is a template that will be printed on all label materials that will be used. Information on the date and prescription number, patient name, instructions for use, and time to take the medication is available at all health centers. There is only one health center that has the format for address, date of birth, use, side effects, name of medicine and expiry date. More than 90% of respondents assessed that the labels provided were good and had a high level of benefit. The conclusion is that there are variations in the materials, formats and information components included in the dietetics. Medication labels are considered by patients to have a high level of benefit in the treatment process.
UJI CEMARAN MIKROBA ANGKA LEMPENG TOTAL (ALT) DAN ANGKA KAPANG KHAMIR (AKK) PADA EKSTRAK ETANOL UMBI LOBAK PUTIH (Raphanus sativus L.) Ilham, Kasmal; Solikah, Wahyu Yuliana; Emelda, Emelda; Fauzi, Rizal
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p36-41

Abstract

White radish (Raphanus sativus L.) is a food plant with promising potential for development as a raw material for traditional medicines and functional foods. The microbiological quality of plant extracts is a critical parameter in ensuring product safety, particularly with regard to microbial contamination. By measuring the Total Plate Count (TPC) and Yeast and Mold Count (YMC), this study sought to assess the microbiological contamination of the ethanol extract of white radish tubers.  In order to measure live microorganisms expressed as CFU/g, the experiments were carried out using the pour plate technique on plate count agar (PCA).  The findings demonstrated that the ethanol extract's TPC and YMC values were both less than 1 × 10¹ CFU/g. These values are significantly lower than the maximum limits required by BPOM Regulation Number 29/2023, namely ≤10⁵ CFU/g for TPC and ≤10³ CFU/g for YMC. These findings indicate that the extraction and handling processes produced an extract with minimal microbial contamination. Overall, the results demonstrate that the ethanol extract of white radish meets microbiological safety requirements and is suitable for use as a raw material candidate in the development of traditional medicinal products.
Formulasi Self Nanoemulsifying drug delivery system Enzim Bromelain buah Nanas Ananas comosus Fresiva, Urva; Rochman, M Fatchur; Tianingsih, Flomaria; Pratiwi, Resty; Anugrahi, Amalia
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p9-14

Abstract

The pineapple fruit's bromelain enzyme exhibits pharmacological activity as an antibacterial and anti-inflammatory. The bromelain enzyme was formulated as tablets and powders in earlier research, although this still had the disadvantage of having a higher formulation resistance. Formulating and characterizing SNEDDS of the bromelain enzyme with oil phase, surfactant, and co-surfactant—specifically, clove oil, propylene glycol, and PEG 400—is the goal of this study. The process for creating SNEDDS bromelain enzyme involves combining the carrier in different quantities, adding the enzyme, and evaluating it based on factors including homogeneity, adhesion, spreadability, clarity, and organoleptic characteristics. The active ingredient in the SNEDDS formulation that was obtained was 360 mg of bromelain enzyme per milliliter of SNEDDS. With a 2:5:3 concentration ratio of clove oil, PG, and PEG 400, the transmittance percentage of SNEDDS is 98.54 ± 0.02%, the spreadability is 2.2 cm, the adhesion is 116 seconds, and the pH is 6.48. In comparison to other carrier concentrations, SNEDDS bromelain enzyme SNEDDS with a concentration ratio of 2:5:3 for clove oil, PG, and PEG 400 yields superior characteristic results.
Tingkat Kepatuhan Minum Obat Pasien Tuberculosis Rawat Jalan di RSUD Soehadi Pridjonegoro Kabupaten Sragen Khusna, Khotimatul; Amalina, Syahida Ulya; Qonitah, Fadilah
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p42-50

Abstract

Tuberculosis (TB) is a contagious infectious disease that is still a global health problem, with Indonesia as one of the countries with the highest cases. The success of TB therapy is highly dependent on patient compliance in taking anti-tuberculosis drugs (OAT) regularly. Factors that influence the level of medication compliance in pulmonary TB patients are gender, age, occupation, education, family support, and drug side effects. This study aims to determine the level of compliance of patients taking outpatient pulmonary TB medication at Soehadi Pridjonegoro Regional Hospital, Sragen Regency. This research uses a descriptive method with a quantitative approach. The sample used in the research was 97 respondents. Sampling using techniques purposive sampling. Data was taken using a validated questionnaire created based on the MARS questionnaire (Medication Adherence Rating Scale). The results of the study showed that patients with a high level of compliance were 65 respondents with a percentage of (67%) and moderate compliance was 32 respondents with a percentage of (33%). The conclusion of this research is that patients take outpatient pulmonary TB medication at Soehadi Pridjonegoro Hospital, Sragen Regency with a high level of compliance (67%) with a total of 65 respondents.
Evaluasi Penggunaan Obat Triheksifenidil Sebagai Terapi Adjuvan Pada Pasien Fangguan Afektif Bipolar Di Rumah Sakit Jiwa Provinsi Jawa Barat Cantika, Erika; Putri, Fitria Sulistia; Purwaeni, Purwaeni; S, Encep; Nur, Ice Laila
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p51-56

Abstract

Background: Bipolar affective disorder is a mental disorder that attacks the psychological condition, characterized by mood swings in the form of mania and depression. The high number of mental health cases in Indonesia is one of the challenges of treatment, especially in the pharmaceutical world. Evaluation of drug use is a structured quality assurance program, and provides assurance that the drugs given are appropriate, safe, and effective. Objective: This study aims to evaluate the use of trihexyphenidyl in patients with bipolar affective disorder at the West Java Provincial Mental Hospital. Methods: The research design used was a retrospective observational study with a descriptive cross-sectional approach. The data source used in the study was written information in the medical records of mental patients diagnosed with bipolar affective disorder who received trihexyphenidyl drug therapy at the West Java Provincial Mental Hospital. Results: Based on the results of the study, 93 patients diagnosed with bipolar affective disorder using trihexyphenidyl were obtained, the results of the ANOVA test on the evaluation of drug use showed a significance value of 0.021 <0.05 so that it can be concluded that the data has differences from the research variables. Conclusion: Based on the results of the study, it can be concluded that the evaluation of the use of trihexyphenidyl drugs in patients with bipolar affective disorder is appropriate and in accordance with the rationality of drug use.
OPTIMASI FORMULA TABLET ATTAPULGITE DENGAN KOMBINASI LAKTOSA DAN AVICEL PH 101 TERHADAP MUTU FISIK TABLET MENGGUNAKAN SIMPLEX LATTICE DESIGN Utami, Anisa Tri; Nopiyanti, Vivin; Priyanto, Widodo
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p29-35

Abstract

Attapulgite is one of the drugs from the adsorbent class for anti-diarrhea. In the form of light cream-colored powder and very fine. This study aims to determine the effect of the combination of lactose and avicel PH 101 on the PHysical quality of attapulgite tablets and to obtain the optimum formula. Attapulgite tablets were made by wet granulation and formula optimization using the Simplex Lattice Design method using Design Expert software version 13 to find out the combination of lactose and avicel PH 101. Attapulgite tablets were made into 8 formulas with variations in comparing the proportions of lactose and avicel PH 101 according to the results range of simplex lattice designs. Critical point parameters and optimum formulas were obtained from the response of hardness, brittleness, and disintegration time, and were verified using the one-sample t-test statistical program. The results of this research were variations in concentration of all attapulgite tablet formulas resulting in good PHysical quality of the tablets. The combination of lactose and avicel PH 101 has the effect of increasing hardness, reducing brittleness, and speeding up disintegration time. The proportion of lactose 66,739 mg and avicel PH 101 33,261 mg produces the optimum formula for attapulgite tablets with the best PHysical quality of the tablets.
Hubungan Kepatuhan Minum Obat Anti Tuberkulosis Dengan Keberhasilan Pengobatan Tuberkulosis Pada Pasien Sensitif Obat Di Puskesmas Pamolokan Kabupaten Sumenep Istiqomah, Hamlatul Jamiliyatil; Firmaniar, Rizdyana; Trisno, Zetiawan; Puspitasari, Aldita Cahyani
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p144-149

Abstract

Tuberculosis (TB) is a contagious infectious disease caused by the bacterium Mycobacterium Tuberculosis. Tuberculosis is transmitted through sputum or saliva containing tuberculosis bacilli. Tuberculosis is one of the world's health threats. The purpose of this study was to determine the relationship between adherence to taking anti-tuberculosis drugs and the success of tuberculosis treatment in drug-sensitive patients at the Pamolokan Health Center, Sumenep Regency. This study used a quantitative method with an observational survey approach using a Cross Sectional Research design. The population in this study were all drug sensitive tuberculosis patients undergoing treatment at the Pamolokan Health Center, Sumenep Regency in the January-June period, namely 32 people with total sampling techniques. The results of this study were 30 people as much as (93.75%) had compliant treatment compliance results. Based on the results of the study, it can be concluded that there is a relationship between adherence to taking medication with the success of anti-tuberculosis treatment. It is recommended that family members pay attention to sick family members, provide motivation, care, bring medical treatment and provide support to sick family members.
Uji Efektivitas Gel Ekstrak Etanol Daun Binahong (Anredera cordifolia) Sebagai Penyembuhan Luka Pada Tikus Wistar Jantan (Rattus norvegicus) Siregar, Mardiana; Huda, Nurul; Afika, Ariyati N; Aida, Nur; Syahfitri, Siska; Anglia, Rima; Budyana, Irenia Putri
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p157-162

Abstract

The ethanol extract of binahong leaves contains alkaloids, flavonoids, steroids, tannins and saponins. The compounds contained in the extract have an important role in healing skin incision. The aim of this study was to develop a gel formula for binahong leaf extract (Anredera cordifolia (Ten.) Steenis) with various HPMC gelling agents at concentrations of 2%, 3% and 4%. This study is an experimental study by comparing the effectiveness of incision wound healing in rats in each test group, namely negative control given gel base, positive control given Bioplacenton gel, and the gel formulation of binahong leaf with best stability properties of the gel preparation. The best formula for binahong leaf extract gel is with a concentration of 2% HPMC with consideration of evaluating the physical properties of the gel and the fastest healing effect on burns.
Pengaruh Penggunaan Obat Khelasi Besi Terhadap Perubahan Kadar Ferritin Serum Pada Pasien Thalasemia Di Rumah Sakit Umum Daerah “X” Kota Bekasi Agustiani, Elsya; Futihat, Chilyati Eky; Arianti, Anisa Rachmita; Maifitrianti, Maifitrianti
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p57-65

Abstract

Thalassemia is a blood disorder that is inherited from both parents to their children. Ferritin levels are often elevated due to repeated blood transfusions that cause iron buildup in the body, leading to serious complications if not treated with iron chelation therapy. Iron chelation is a therapeutic method to reduce excessive iron levels in the body that is not bound in plasma and excreted from the body. To see the effect of using iron chelation drugs on reducing serum ferritin levels in patients with thalassemia beta major. Analytical observational research with a retrospective cross-sectional study design using limited secondary medical record data. The sampling technique used consecutive sampling with the inclusion criteria of beta major thalassemia patients with serum ferritin levels ≥1000ng/mL who received a single iron chelation therapy treatment. The effect of iron chelation drug administration in beta major thalassemia patients on reducing serum ferritin levels was analyzed using the Wilcoxon Signed-Ranks Test. In this study, 50 patients met the inclusion criteria. 52% of patients were female, and 40% had an age range of 0-5 years. The most common single iron chelation drug was Deferasirox (85%), with a dose of 250 mg (49%). A total of 6% of patients had decreased serum ferritin levels (≥500ng/mL and <1000ng/mL). However, the results of the data analysis showed that there was no significant decrease in serum ferritin levels after single iron chelation. This study showed that single iron chelation therapy was effective in reducing serum ferritin levels, but not significant (p value>0.05).

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