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INDONESIA
Indonesian Journal of Health Science
Published by PT WIM Solusi Prima
ISSN : -     EISSN : 28091167     DOI : https://doi.org/10.54957/ijhs
Core Subject : Health,
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary
Indonesian Journal of Health Science is a place for disseminating research results in the field of health, including, but not limited to topics of public health, environmental health, occupational health, pharmacy, nutrition, epidemiology, medical laboratories, physiotherapy, or other general health.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 330 Documents
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Patterns of antithyroid drug use in hyperthyroid patients at the outpatient pharmacy of hospital x from January to December 2023 Faadiyah, Rif'aa Naflah; Adiana, Sylvi; Rochjana, Anna Uswatun Hasanah
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1788

Abstract

Hyperthyroidism is a condition characterized by increased production and secretion of thyroid hormones by the thyroid gland. This condition is indicated by a significant increase in triiodothyronine (T3) and thyroxine (T4) levels, which is generally caused by an autoimmune response that attacks the thyroid gland. This study aims to determine the pattern of use of hyperthyroid drugs based on medical record data and outpatient BPJS prescriptions at Hospital X during the period January to December 2023. This research is an observational study with a quantitative approach using descriptive methods, and data collection is done retrospectively. Results based on patient characteristics based on age, dominated by the age group with a range of 26-35 years as many as 56 people (29.47%) and gender dominated by women as many as 148 people (77.89%). Results based on the pattern of use of antithyroid drugs in hyperthyroid patients show that based on the type of drug, propylthiouracil (PTU) is more widely used in patients with hyperthyroidism as much as 124 uses (65.26%) and the class of drugs used in hyperthyroid patients with Thionamide group, obtained a percentage of 100%.
Phytochemical screening and standardization of ethanol extract of Guava Leaves (Psidium guajava L.) with specific and non-spesific parameters Biadi, Sukma Dwyastati; Arianti, Varda; Adrianto, Dimas; Maulina, Devi
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1837

Abstract

This study aims to conduct phytochemical screening and standardization of guava leaf ethanol extract (Psidium guajava L.) originating from Gunung Putri, Bogor Regency, West Java. The extract was derived by means of maceration procedure utilizing 96% ethanol as the extraction medium, and phytochemical analysis confirmed the presence of flavonoids, alkaloids, tannins, saponins, terpenoid/steroid compounds, as well as glycosides. Quality evaluation based on specific and non-specific parameters showed results that met the standards: drying loss of  (<10%), total ash content of (<8,4%), specific gravity of 0.99 g/mL, water content of 5.2% (<10%), and negative heavy metal contamination. These results indicate that guava leaves from the Gunung Putri area have a phytochemical profile and extract quality that are suitable for the development of standardized herbal preparation raw materials. Geographical aspects also contribute to the validity of the results and can be a reference for standardization based on plant growing areas.
Factors associated with the practice of clean and healthy living behavior among households in Ranombupulu Village Karimuna, Siti Rabbani; Fatrisya, Waode Mitha; Yunawati, Irma; Dewi, Sri Tungga
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1899

Abstract

Clean and Healthy Living Behavior (PHBS) is an essential preventive health strategy to improve community well-being; however, its implementation remains suboptimal in several rural areas. This study aimed to describe the implementation of PHBS and analyze the relationship between knowledge, education level, income, and age with household PHBS status in Ranombupulu Village. A descriptive analytic design with a cross-sectional approach was used, involving 81 respondents selected through purposive sampling. Data were collected using a structured questionnaire and analyzed using the Chi-square test. The results showed that only 45.7% of households properly implemented PHBS. Statistical analysis revealed no significant relationship between PHBS status and knowledge (p=0.952), education level (p=0.990), income (p=0.781), or age (p=0.890). The study concludes that PHBS implementation remains low and is not influenced by sociodemographic characteristics. Continuous health education and improved community support and facilities are recommended to strengthen PHBS adoption.
Standard procedures for care and management of children with reactive syphilis at Kardinah Regional Hospital, Tegal City, 2025 Ridlo, Ahmad; Khoeroh, Himatul
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1943

Abstract

Background: Syphilis or king lion disease is a sexually transmitted infection (STI) caused by the Treponema Pallidium bacteria. This disease begins with a painless sore, usually found on the genitals, rectum or mouth. Based on data from the Central Java Department, there were 368 cases of syphilis throughout 2024, Tegal Regency, which is a city in Central Java, contributed 4 cases of syphilis, 2 of which were in pregnant women who underwent examination at Kardinah Regional Hospital. Objective: The purpose of this study was to provide care and management of childbirth cases with reactive syphilis at Kardinah Regional Hospital according to standards. Research Method: The method in this study used a descriptive qualitative method with a case study approach through subjective, objective, assessment and planning elements. Data were collected through observation, in-depth interviews, physical and supporting examinations, KIA books, and medical records. The main informants were determined by purposive sampling technique, namely mothers giving birth with reactive syphilis who were giving birth at Kardinah Regional Hospital, while additional informants were husbands, families, midwives in the VK room and obstetricians. Results: Based on the care and management of childbirth with reactive syphilis cases, there was no significant difference in the assistance of normal vaginal delivery provided there were no vaginal lesions and scabs on the body or canker sores in the mouth or lips.  
The effects of Mangifera indica L. leaf extract on sperm function Shari, Amalia; Novitasari, Ludira Dwi
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1965

Abstract

Male infertility remains a global health problem, contributing to approximately 50% of all cases of infertility in couples. One of the main factors causing decreased sperm quality is oxidative stress, which can damage cell membranes, reduce motility, and impair sperm viability. Mango leaves (Mangifera indica L.) are known to contain various bioactive compounds, such as mangiferin, flavonoids, tannins, saponins, triterpenoids, and steroids, which have strong antioxidant activity and potentially provide protection to germ cells in the testes. This paper aims to examine the effect of mango leaf extract on sperm function through parameters of motility, viability, and cellular protection mechanisms against oxidative stress. The results of the study indicate that antioxidant compounds in mango leaves play a role in neutralizing reactive oxygen species (ROS), maintaining membrane integrity, and supporting spermatogenesis. Thus, mango leaf extract has the potential to be a natural phytotherapeutic agent to improve sperm quality and support male reproductive health.
Level of knowledge of the Menteng community RT 010 RW 009 Menteng Village regarding the use of mefenamic acid tablets as an NSAID analgesic Rahmadani, Azrizah; Fakhriah, Amalina; Arianti, Varda; Maulina, Devi
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1969

Abstract

Mefenamic acid, a meclofenamate derivative, is a type of NSAID that inhibits the formation of the cyclooxygenase enzyme. This cyclooxygenase enzyme converts arachidonic acid into prostaglandins. Therefore, if this drug is given as a pain reliever to children or adolescents during their growth period, it will disrupt the longitudinal growth process of their bones. This study aims to evaluate the level of public knowledge in RT 010 RW 009, Menteng Village, Central Jakarta, regarding the use of mefenamic acid tablets as an NSAID analgesic. The method used is descriptive with a quantitative approach and involved 64 respondents selected based on inclusion criteria. The results show that the average level of public knowledge is in the sufficient category (63,20%). Respondents are predominantly in the 17–25 year age group with a vocational high school education level. Only 35.90% of respondents have received direct education from health workers. This finding emphasizes the importance of more intensive educational interventions from health institutions so that the public uses drugs appropriately and wisely.
Skrining fitokimia dan standarisasi ekstrak etanol pada Daun Kelor (Moringa Oleifera L.) dengan parameter spesifik dan non spesifik asal Bogor Anaswa, Zahra; Arianti, Varda; Adrianto, Dimas; Maulina, Devi
Indonesian Journal of Health Science Vol 5 No 6 (2025)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v5i6.1972

Abstract

Penelitian ini bertujuan untuk melakukan skrining fitokimia dan standarisasi ekstrak Daun Kelor (Moringa oleifera L.) (Moringa oleifera L.) dengan parameter spesifik dan non spesifik asal Bogor, Jawa Barat. Dengan mengetahui kandungan metabolit sekunder dan parameter standar yang dapat digunakan sebagai acuan untuk penelitian selanjutnya. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol. Hasil penelitian menunjukkan bahwa ekstrak Daun Kelor (Moringa oleifera L.) memiliki kandungan metabolit sekunder yang lengkap, seperti alkaloid, flavonoid, tanin, saponin, steroid dan glikosida. Parameter standar yang diperoleh adalah rendemen 18,1%, kadar sari larut etanol 24,4%, kadar air 5,2%, kadar abu 6,05%, susut pengeringan 5,2%, bobot jenis 0,94 g/ml, cemaran logam tidak terdeteksi dan cemaran mikroba hasilnya negatif. Perbedaan kuantitatif dengan studi di wilayah lain seperti India dan Afrika dapat dipengaruhi oleh iklim, tanah, dan varietas lokal. Kondisi agroklimat tropis basah di Bogor, Indonesia, dapat memengaruhi kadar senyawa aktif dalam Daun Kelor (Moringa oleifera L.) . Penelitian ini berkontribusi pada data fitokimia Daun Kelor (Moringa oleifera L.) asal Bogor, Indonesia, yang belum banyak dieksplorasi dalam studi terdahulu.
Studi etnozoologi pemanfaatan hewan yang digunakan oleh penyehat tradisional sebagai pengobatan di Kecamatan Manna Kabupaten Bengkulu Selatan Dewi, Novita Rahma; Putri, Dwi Kurnia; Slamet, Samwilson; Ikhsan, Ikhsan; Handayani, Dian; Rahmawati, Suci
Indonesian Journal of Health Science Vol 5 No 6 (2025)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v5i6.1992

Abstract

Etnozoologi merupakan ilmu yang mempelajari hubungan antara manusia, biota dan lingkungan sekitar yang meliputi tentang pengetahuan masyarakat mengenai sumber daya hewan yang dapat dimanfaatkan sebagai hewan obat. Tujuan dari penelitian ini adalah untuk memperoleh data hewan apa saja yang digunakan oleh penyehat tradisional, bagian yang digunakan, cara pengolahan, cara penggunaan, aturan pakai, penyakit yang dapat diobati dan efek samping dari hewan obat sebagai alternatif pengobatan tradisional yang digunakan oleh penyehat tradisional di Kecamatan Manna Kabupaten Bengkulu Selatan. Penelitian ini menggunakan metode penelitian deskriptif kualitatif, dengan pendekatan observasional deskriptif. Dari hasil wawancara yang sudah dilakukan terdapat sebanyak 24 jenis hewan obat yang digunakan sebagai pengobatan tradisional di Kecamatan Manna Kabupaten Bengkulu Selatan. Dari 17 orang penyehat tradisional yang ada di Kecamatan Manna Kabupaten Bengkulu Selatan didapatkan bagian-bagian hewan yang digunakan sebagai pengobatan tradisional, yaitu seluruh bagian dari hewan, lendir, air liur, daging, minyak dan juga hati. Cara pengolahannya direbus, dipanggang, disop, dan dimakan langsung. Cara penggunaannya ditempelkan langsung ke kulit, diminum, dimakan secara langsung. Penyakit yang dapat disembuhkan dengan menggunakan hewan obat tersebut meliputi sakit digigit lipan, untuk menyedot darah kotor, sesak nafas, kejang-kejang, malaria, malaria tipes, luka setelah operasi, batuk, batuk menahun, batuk disertai sesak nafas, bisul ditelapak kaki, anak-anak yang masih kencing dalam celana (ngompol), digigit ular, gatal-gatal, angin duduk, sakit mata, kekurangan gizi, kesat (terlambat tumbuh kembang anak), sulit hamil dan asma.
Immunothrombosis as a bridge between innate immunity and hemostasis: A narrative review of emerging mechanisms Maulana, Anang Rizky; Nuriah, Cici; Kencana, Faradiyan
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.1993

Abstract

Background: Immunothrombosis is an evolutionarily conserved host defense mechanism integrating innate immunity and hemostasis to limit pathogen dissemination through localized thrombus formation. While physiologically protective, dysregulated immunothrombosis contributes to thrombo-inflammatory diseases. Objective: This narrative review summarizes emerging cellular and molecular mechanisms linking innate immunity and coagulation, with emphasis on their pathological and therapeutic implications. Methods: A narrative literature review was conducted using Scopus-indexed journals retrieved from PubMed, Scopus, and ScienceDirect, prioritizing review articles and landmark original studies published between 2013 and 2025. Main Findings: Immunothrombosis is orchestrated by neutrophils, platelets, monocytes, endothelial cells, and complement systems through mechanisms including neutrophil extracellular trap (NET) formation, tissue factor expression, inflammasome activation, and immune–coagulation crosstalk. Conclusion: Immunothrombosis represents a fundamental biological bridge between innate immunity and hemostasis, offering novel therapeutic targets in thrombo-inflammatory disorders.
Spatio-temporal analysis and correlational study of environmental factors on tuberculosis incidence in Kendari City Yasmin, Dhira Fijri; Lestari, Hariati; Handayani, Listy
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.2001

Abstract

Tuberculosis (TB) in Kendari City has shown an increasing trend, highlighting the need for spatial analysis to identify high-risk areas. This study analyzed the spatiotemporal patterns of TB incidence and their correlation with environmental factors (population density, households with smokers, temperature, humidity, and rainfall) during 2020–2024 using an ecological study design and secondary data. The results indicate that TB cases increased from 567 in 2020 to 1,111 in 2024, with high-risk clusters consistently observed in Abeli District, while Nambo District remained in the low-risk category. Among all variables, only temperature showed a significant correlation with TB incidence (p = 0.005; r = 0.361). These findings emphasize the importance of spatiotemporal mapping to support the identification of priority areas for TB control.

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