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JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 468 Documents
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Angiolymphoid hyperplasia with eosinophilia: A potential mimic of kimura’s disease Laila Wahyuningsih; Maria Fransiska Pudjohartono; Hanggoro Tri Rinonce
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art14

Abstract

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare reactive angio-proliferative lesion. ALHE was initially classified as the late stage of Kimura’s disease (KD), although studies later showed that they were two separate clinical entities. Diagnosing ALHE remains a clinical challenge. Here, we report a case of ALHE in a young man and review current literature with an emphasis on how to distinguish ALHE particularly from KD. A 26-year-old man presented with a subcutaneous nodule in right infra-auricular area. Recurrence had occurred after three surgical excisions. Neither enlargement of salivary glands nor lymph nodes were found. Hematological examinations and renal function were normal. The mass was removed surgically. Microscopic examination showed proliferation of vascular channels with accompanying mixed inflammatory infiltrate consisting of lymphocytes, plasma cells, and eosinophils. Based on clinical data and histopathological examination, the patient was diagnosed with ALHE. Several clinical features differ between ALHE and KD, such as gender predilection, hypereosinophilia, IgE levels, and renal involvement. However, clinical features can overlap, so definitive diagnosis relies on histopathological examination. The most important hallmark of ALHE is vascular proliferation with epithelioid endothelial cells. Distinguishing ALHE from KD is important due to the lack of systemic manifestations in ALHE. However, ALHE can be easily mistaken for other diseases due to its rarity. Careful microscopic examination is very important to distinguish ALHE from KD and other mimicking lesions.
Cytotoxicity of ethanolic extract of fruit shells and seeds of Nyamplung (Calophyllum inophyllum L.) on WiDr colorectal cancer cells Irfan Jaen Fathani; Isnatin Miladiyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 2, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss2.art10

Abstract

Background: Colorectal cancer is the 3rd most common type of cancer in the world with unsatisfactory therapeutic effectiveness. One of the efforts being made to overcome this problem is by extracting various new chemotherapy agents, including herbal plants. The Nyamplung plant (Calophyllum inophyllum L.) is reported to contain calophyllolide, triterpene, coumarin, saponin, biflavonoids, benzophenones and neoflavanoids which are potential anticancer agents. Objective: This study aims to determine the cytotoxic activity of ethanolic extract of fruit shells and seeds of Nyamplung (Calophyllum inophyllum L.) on WiDr colorectal cancer cells and their selectivity on normal cells (Vero).Methods: The fruit and seeds of Nyamplung were extracted by maceration with 70% ethanol solvent. The cytotoxic test was carried out by the 3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide (MTT) method, with doxorubicin as a positive control. Data analyzed using Microsoft Excel software using linear regression analysis. The IC50 value and selectivity index were used as indicator of toxicity selectivity.Results: The IC50 value of the ethanolic extract of Nyamplung fruit shells on WiDr was 42.47 µg/ml with a selectivity index of 1.50. Meanwhile, the IC50 value of ethanolic extract of Nyamplung seeds was 1,030.41 µg/ml with a selectivity index of 67,982,414.71. Doxorubicin as a positive control obtained IC50 value on WiDr cells of 3.49 µg/ml with a selectivity index of 764.41.Conclusion: The ethanolic extract of Nyamplung seeds was not cytotoxic against WiDr colorectal cancer cells, while the ethanolic extract of Nyamplung fruit sell was moderate cytotoxic with low selectivity index.
The time administration and cost burden of intravenous immunoglobulin (IVIG) therapy in a 4-year-old girl with Kawasaki disease: A case report Nenden Nursyamsi Agustina; Fitranto Arjadi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art13

Abstract

Kawasaki disease (KD) is an acute systemic vasculitis frequently affecting children under five years old. KD can cause severe complications. It can lead to coronary aneurysms in 15-25% of untreated cases. Intravenous immunoglobulin (IVIG) treatment within ten days of initial onset can reduce the rate of coronary artery aneurysms. However, IVIG administration in Indonesia is currently limited due to its high cost. The case reported a 4-year-old girl with a chief complaint of fever. She complained about a high fever seven days before hospitalization. She also complained about vomiting, cough, joint pain, diarrhea, skin peeling, and rash on her body, palms, and soles. On examination, she looked irritable and sluggish. The temperature was 39.9o C. There were red eyes without discharge, strawberry tongue, oral thrush, and red, dry, cracked lips, swollen neck lymph nodes, and skin rash on her body, palms, and soles. Laboratory testing showed microcytic hypochromic anemia with Hb 7.9 g/dL and leukocytosis 24.230/mm3. Chest X-ray showed perihilar and paracardial infiltrates. Electrocardiogram revealed sinus tachycardia. An echocardiogram showed left ventricle dilatation with trivial mitral regurgitation and no coronary abnormalities were found. She was diagnosed with Kawasaki Disease. She was treated by IVIG 30 gr single dose during 12 hours on day 7 of initial onset, methylprednisolone injection 10 mg/8 hours, paracetamol 150 mg/8 hours, and aspirin 400 mg/8 hours orally and discharged from the hospital with improvement. There weren’t any coronary artery abnormalities found. IVIG administration within ten days of initial onset in KD patients can reduce the risk of coronary artery complications. IVIG administration after day 10 of initial onset can achieve resolution of inflammation but can be insufficient for preventing coronary artery lesions (CALs).
PENGARUH PEMBERIAN PROPOLIS TERHADAP EKSPRESI BDNF DI HIPPOCAMPUS TIKUS YANG DIINDUKSI STRES Kuswati Kuswati; Zainuri Sabta Nugraha; Ety Sari Handayani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art8

Abstract

Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophin secreted by dendrite, which plays a role in differentiation, maturation, neuroplasticity, learning, and memory, which the expression decreases under stress conditions. Propolis contains chrysin which has antioxidant and neuroprotectant effects.Objective: This study aimed to examine the effect of propolis on BDNF expression in the hippocampus of stress-induced rats.Methods: Experimental study using posttest only control group design. The subjects were 25 male Spraque-Dawley rats (Rattus norvegicus), four months old, weighing 200-300 grams. Rats were randomly divided into five groups: group N, did not receive any treatment; group K, received stress treatment; groups P1, P2, and P3, received stress treatment and followed by administered propolis at doses of 100, 150, and 200 mg/kg/day. Social isolation stress was carried out by putting one rat in one cage. Oral propolis administration used oral gavage. In the end, the rats were terminated and brain tissue was collected. Immunohistochemical staining using anti-BDNF antibodies was performed to make histological slides. Observations were made with a light microscope with 1000x magnification in the CA1 area of the hippocampus.Results: There is a significant difference in BDNF expression in the CA1 area of the hippocampus in all groups (p=0.000). The highest BDNF expression was in the P3 group and the lowest in group K.Conclusion: There is an effect of propolis on BDNF expression in the hippocampus of the stress-induced rat. Propolis dose of 100 mg/kgBW/day has increased BDNF expression.
Target protein prediction of Indonesian jamu kunyit asam (Curcumin-tamarind) for dysmenorrhea pain reliever: A network analysis approach Galuh Wening Permatasari; Mochammad Fitri Atho'illah; Wira Eka Putra
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art7

Abstract

Background: Dysmenorrhea is a monthly problem for reproductive-age women before or during menstruation. Dynamic changes of prostaglandins (PGs) and progesterone in the late reproduction cycle regulating signal pathways of PGE2 and PGF2 can contribute to menstrual cramps and other dysmenorrhea symptoms. Curcuma longa and Tamarindus indica (CT) are traditional medicines more preferred by Indonesian women to overcome menstrual pain than painkiller drugs.Objective: This study aims to observe potentially active compounds and detailed mechanism of Curcuma longa and Tamarindus indica (CT) as a pain reliever.Methods: Bioactive compounds in the CT were collected from two databases and then screened by bioavailability and drug-likeness parameter by utilizing SwissADME software. The target proteins and genes associated with dysmenorrhea were retrieved from HitPick and GeneCard database. The possibility of how CT healed dysmenorrhea was predicted by protein-protein interaction (PPI) using STRING Webserver and was visualized by Cytoscape v.3.7.0 and REVIGO.Results: Totally, 147 active compounds were obtained from C. longa and 212 active compounds from T. indica. Respectively, 36 and 66 compounds were obtained from C. longa and T. indica by the ADME screening. Finally, 20 and 22 target proteins were identified in both herbs. Then, an overlap analysis of this study showed that four target proteins had strong interaction with pain-related dysmenorrheaConclusion: This study found possible target proteins of the CT to relieve dysmenorrhea. The target proteins included HSD17B1, ALOX5, GSTM1, and ESR2 genes. Further, these findings are needed to be validated by using in vitro and in vivo approaches.
Initial screening of covid-19 patients based on body mass index, blood glucose level and clinical characteristics Fioni Chandra; Sahna Ferdinand Ginting; Chrismis Novalinda Ginting; Refi Ikhtiari
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 1, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss1.art5

Abstract

Background: Diabetes Mellitus (DM), chronic metabolic disorder characterized by hyperglycemia causing immune response dysfunction and decontrolled pathogens' spread. DM patients are more vulnerable towards infection. Regarding COVID-19 infection, it is essential and urgent to develop initial screening of DM or non-DM patients to establish effective clinical treatment.Objective: Understanding the implementation of initial screening for Diabetes Mellitus based on Blood Glucose Level (BGL) and Body Mass Index (BMI) as guidance in clinical care and how it affects BGL and clinical parameters of DM and non-DM patients indicated positive COVID-19.Methods: This research uses cohort retrospective study. COVID-19 patients in Royal Prima Hospital Medan match the purposive sampling inclusion criteria included in the research for further review through patient’s medical record. 168 samples were divided into 54 DM and 114 non-DM patients. The variables are BMI and BGL. Data will be analyzed using Independent Sample T-Test.Results: Clinical characteristics of COVID-19 patients are dyspneu, chest pain, cough, fever, epigastric pain, etc. Result shows that majority of respondents have normal BMI without DM (72.8%). The Independent Sample T-Test analysis result shows a significant difference in BMI and BGL between DM and non-DM patients.Conclusion: Clinical evidence shows significant differences in BMI and BGL between DM and non-DM patients with COVID-19. Thus, BMI and BGL could be used as the initial screening to develop effective clinical treatment of controlled BGL of DM and non-DM COVID-19 patients based on clinical parameters evaluation.
Urinary tract stones and well water consumption in patients at Zaenoel Abidin Hospital Banda Aceh Vera Dewi Mulia; Jufriady Ismy; Rudy Lusmianda; Hijra Novia Suardi; Suryawati Suryawati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 1, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss1.art6

Abstract

Background: Several remote areas in Aceh lack proper water supply, leading to the citizens to consuming well water for daily needs. The water quality is determined by the concentration of minerals thus affected by location sources. Insufficient monitor of its quality poses risks of health problems, such as urinary tract stones.Objective: This study investigated the incidence of urinary tract stones on patients seeking medical help in Zaenoel Abidin hospital and its association to well water consumption.Methods: Respondents were patients visiting the urological surgery polyclinic at Zaenoel Abidin Regional Hospital and consenting to be research respondents. Sixty respondents were divided into two groups: the patient group suffering from urinary tract stones and those who did not. The disease status was determined based on the diagnosis of a urology specialist and the results of ultrasonography. Analysis of the relationship between well water consumption and the emergence of disease was analyzed statistically.Results: the majority of respondents were from out the city’s capital (Banda Aceh) (48, 80%), men (43, 71.1%), and 45 to 65 years old. Among the patients suffering from urinary tract stones, most of them (63.6%) consumed well water, while only a few of the control group, non-urinary tract stones patients, (36.4%) consumed well water. There is a relationship between well water consumption and the risk of disease (p = 0.038, OR = 3.5)Conclusion: The use of well water for daily water intake contributes to developing urinary tract stones.
Association between severity and locations of primary hyperhidrosis and quality of life among medical students Catherine Patricia Soetedjo; Lorettha Wijaya; Regina Regina; Yunisa Astiarani
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 1, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss1.art4

Abstract

Background: Primary hyperhidrosis is a condition of excessive sweating on certain parts of the body with unknown cause. The severity and location of primary hyperhidrosis vary and are thought to affect the quality of life.Purpose: The study aims to determine the association between severity and locations of primary hyperhidrosis and quality of life in medical students.Methods: This study was conducted on 77 medical students at Atma Jaya Catholic University of Indonesia. Hyperhidrosis Disease Severity Scale (HDSS) questionnaire and Hyperhidrosis Quality of Life Index (HidroQoL) questionnaire were used. Data analysis was performed using Chi-Square.Results: The prevalence of primary hyperhidrosis was 15.33%. Mild-moderate hyperhidrosis was found in 77.9% respondents, while severe-very severe hyperhidrosis was found in 22.1% respondents. The location of hyperhidrosis was found in palmar (66.1%), axillary (28.6%), plantar (1.0%), and other locations such as the face, thigh, and back (9.1%). The score of the daily activity domain (29.65 ± 21.96) was higher than the psychosocial score (27.92 ± 20.46). Data showed that 33.3% of respondents with mild-moderate hyperhidrosis and 82.4% of respondents with severe-very severe hyperhidrosis’ quality of life were affected by their excessive sweating (p=0,000). As many as 34.0% of respondents with palmar hyperhidrosis and 54.5% with axillary hyperhidrosis’ quality of life were all affected by their conditions (p=0,106).Conclusion: We found a significant association between the severity of primary hyperhidrosis and the quality of life, and no significant association between the location of primary hyperhidrosis and quality of life among medical students.
Massive pleural effusion due to heart failure in an undetected diabetic hypertensive patient: A case report Citra Ayu Aprilia; Rizka Dwi Aulia; Arif Eko Wibowo; Evy Novita Permatasari; Samsul Bakhri; Abdurrahman Abdurrahman
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art14

Abstract

Pleural effusion is pathological accummulation of pleural fluid. The most common causes of pleural effusion are cancer, pneumonia, pulmonary embolism and heart failure. Diabetes mellitus and hypertension are two risk factors of heart failure. A 74-year-old male patient came to the emergency room feeling fatigued all over the body since seven days before, dyspneu and notable reduced appetite and weight loss. Initial vital examination revealed an increase in heart rate and blood pressure (BP=140/80 mmHg, 120 bpm). Oxygen saturation was normal and deteriorate from time to time (92.5%). Chest physical examination showed pleural effusion on the right lungs. Laboratory findings noted an elevated blood glucose and mild hypokalemia in patients. ECG result showed old myocardial infact (OMI) anteroseptal and infrequent premature ventricular contraction (PVC). Chest X-Ray revealed a massive pleural effusion on the right lugs, a mediastinal shift and cardiomegaly. The patient were given IVFD RL, gliquidone, Lantus Bisoprolol, B-Complex, and also thoracentesis for the pleural effusion. The underlying pathology largely determines the clinical symptoms of pleural effusion. In this case, the most probable underlying cause is heart failure. The risk factors of heart failure, in this case, are undetected diabetes melitus, hypertension, OMI and arrythmia. Increasing prevention and early detection of chronic illness such as diabetes melitus and hypertension is a very necessary step.
THE EFFECT OF ABO BLOOD GROUP ON COVID-19 IN PREGNANCY Sri Sulistyowati; Nutria Widya Purna Anggraini; Soetrisno Soetrisno; Eric Edwin Yuliantara; Supriyadi Hari Respati; Muhammad Adrianes Bachnas; Wisnu Prabowo; Hafi Nurinasari; Dympna Pramelita; Dewi Setiyawati; Metharisa Sujana; Aldi Firmansyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art6

Abstract

Background: The COVID-19 virus has spread throughout the world and has been declared as a global pandemic by WHO. Some population groups are more susceptible to COVID-19, and one of them is pregnant women. Pregnancy increases risks of the COVID-19, especially thrombotic complications. The SARS-CoV-2 infection may vary widely from asymptomatic to severe infection. Some studies have shown that ABO blood group can be a marker of susceptibility to some disease progression. Objective:This study aims to investigate relationships between the ABO blood group, the COVID-19 infection and its complications in pregnant women at Dr. Moewardi Hospital, Surakarta.Methods: This study was an observational analytic study with a cross-sectional study design involving 40 pregnant women infected with COVID-19 at Dr. Moewardi Hospital, Surakarta. COVID-19 PCR swabs on the women were administered on their oropharynx and nasopharynx, and laboratory examination of the ABO blood group in all samples was performed. Comparative data distribution of blood groups in the population and the global population distribution were calculated by Chi Square Goodness of Fit. Comparative data between ABO blood group distributions, blood parameters and complications (respiratory, thrombotic, other infections, and death) were calculated by Chi square test and then by One-Way ANOVA. Next, correlation tests for the complications of the blood group and the ages applied a multinomial regression.Results: There were significant differences of thrombotic complications on the blood group of pregnant women infected with COVID-19 (p=0.027). Blood type B significantly tended to experience thrombotic complications when compared to other blood groups (p=0.022).Conclusion: The ABO blood group could affect the complication levels in the pregnant women infected with the COVID 19.

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