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Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Published by Universitas Muhammadiyah Surakarta
ISSN : 24773328     EISSN : 28077245     DOI : -
Core Subject : Health, Science, Education, Social, Engineering,
Computer Science & IT Engineering Medicine & Pharmacology Social Sciences Other
The International Summit on Science, Technology and Humanity (ISETH) is organised by Universitas Muhammadiyah Surakarta. This summit aims to provide a platform for researchers and academics to share their research findings with others and meet lecturers and researchers from other institutions and to strengthen the collaboration and networking amongst the participants.
Arjuna Subject : Umum - Umum
Articles 1,013 Documents
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Cytotoxicity of Ethanol Extract, Polar, Semipolar, and Nonpolar Herb Citolod (Isotoma longiflora (L.) C. Presl.) Cells on MCF-7 Cells Haryoto, H; Hapsari, Atikah
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1432

Abstract

Breast cancer is a major cancer suffered and the most cause of death by women in the world. The existing drugs of anticancer are not selective, disturbing the growth of normal cells. It encourages researchers to explore a chemopreventive agent from the nature materials. This study was conducted to determine the cytotoxic activity of ethanol extract, polar fractions, semipolar, and nonpolar herb chitolod (Isotoma longiflora (L) Presl.) on MCF-7 cells. First, herb chitolod was dried, refined, and sieved using mesh number 40 and then macerated using 96% ethanol for 72 hours. Phytochemical screening was conducted with TLC using GF254 silica as stationary phase, n-hexane: ethyl acetate (7: 3) as mobile phase, then the result was visualized on UV 254 nm, 366 nm, and visible light. Anisaldehid, dragendroff, sitoborat, and FeCl3 reagents spray were used as visualizer of TLC spot results. Fractination using KCV method, then cytotoxic test using MTT assay. A result obtained, the ethanol extract of herb chitolod positively contains flavonoids, phenolics, alkaloids, terpenoids, saponins, steroids and tannins. IC50 value of the ethanol extract, polar fractions, semipolar, and nonpolar are 521,05; 213,29; 499,94; and 239,43 µg/mL. This study showed that the ethanol extract, polar fraction, semipolar, and nonpolar of herb chitolod had moderate cytotoxic activity on MCF-7 cells.
Ethanolic Extracts of Mulberry (Morus alba Linn) Leaf Prevent Hyperlipidemia and Oxidative Stress-induced Steatohepatitis in Rats Sari, Wening
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1433

Abstract

Non Alcoholic steatohepatitis (NASH) is associated with the inflammation of fatty liver due to insulin resistance, dyslipidemia and oxidative stress. Treatment of NASH focused on control metabolic disorder and minimizes oxidative stress. White mulberry (Morus alba Linn) leaf has been reported for its anti-cholesterol and antioxidant effect. This study focused on effects of ethanolic extracts of white mulberry (EEM) leaf to total cholesterol, triglycerides and malondialdehyde (MDA) level of a high-fat diet induced steatohepatitis in rats.The experimental animals, male Wistar strain rats, divided into 5 groups. The rats fed high-fat diet to induced NASH and treated by 90, 180 and 360 mg/bodyweight/day of EEM for 21 successive days. The remaining 2 groups served as control, they fed standard and high-fat diet only. At the end of treatment all subjects were sacrificed using decapitation method. Blood was collected and measured for total cholesterol and triglycerides (Randox). Liver tissue was collected for MDA measurement and histopathologic preparation using haematoxylin-eosin staining. MDA level was measured using thiobarbituric acid reactive-substances (TBARS) method for oxidative stress measurement. EEM treatment significantly reduce cholesterol, triglycerides, and MDA levels as compared with high-fat diet control group (p<0.05). This result in line with histopathological finding as indicated by relatively mild hepatocytes cellular damage. It was conclude that EEM might prevent hyperlipidemia and oxidative stress-induced steatohepatitis.
Antioxidant Activity Etanolic Extract from White Mangrove Leaf (Avicennia marina) by FRAP (Ferric Reducing Antioxidant Power) Method Nurany, Asfy; Haryoto, H
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1434

Abstract

White mangrove (Avicennia marina) is one type of mangrove that has potential as a natural antioxidant. Antioxidants are compounds that can eliminate and withstand the effects of negative reactions from free radicals. This aim study to determine the antioxidants of the ethanolic extracts of the mangrove leaves of white mangrove by using the FRAP (Ferric Reducing Antioxidant Power) method. White mangrove leaves (Avicennia marina) were extracted by maceration with 96% ethanol solvent. Then fractionation was carried out, resulting in three fractions : n-hexane, ethyl acetate and ethanol. These three fractions were then tested for antioxidant activity using the FRAP (Ferric Reducing Antioxidant Power) method. This method use a UV-Vis spectrophotometer with a wavelength of 720 nm and the total value of antioxidant activity is calculated based on the absorbance of the data obtained. Based on the calculation results show that ethanol extract, hexane fraction, ethyl acetate and ethanol of white mangrove leaves (Avicennia marina) have antioxidant activity respectively 2.7906; 2.71808; 2.78178 and 2.7854 mgAAE/g extract.
Antioxidant Activity of Mangrove Sonneratia caseolaris L using the FRAP Method Raharjo, Danang; Haryoto, H
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1435

Abstract

Antioxidants are compounds that have an important role in maintaining health because they can ward off free radicals that inhibit oxidation reactions in the body that cause various diseases. Antioxidant compounds are many flavonoid compounds found in mangrove plants. The purpose of this study was to determine the antioxidant activity of red pidada leaves (Sonneratia caseolaris L) using the Ferric Reduction Antioxidant Power (FRAP) method with vitamin C as a comparison. The research process begins with the extraction of red pidada (Sonneratia caseolaris L) leaves with ethanol. The extraction process was carried out by maceration method for 3 x 24 hours @ 24 hours and continued with fractionation. The maserate obtained was then evaporated with a rotary evaporator at a temperature of 40 - 60OC obtained a thick extract, then the fractions obtained were non-polar, semi-polar and polar fractions. The results showed antioxidant activity; ethanol extract, non-polar, semi-polar and polar fractions were 6.37; 5,35; 6.59 and 5.96 mgAAE / g.
Antioxidant Activity of Extract and Fraction from Boesenbergia pandurata Rhizome by FRAP Method Kusumawati, Nursalinda; Haryoto, H
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1436

Abstract

Boesenbergia pandurata is one of the Zingiberaceae families found in Southeast Asia. In Indonesia, this plant which is known as “temu kunci” is widely cultivated by people everywhere included as home plant and used as family medicinal plant. B. pandurata contains flavonoid compounds which have the efficacy of being an antioxidant. Antioxidant is useful to overcome the negative effects of free radicals. Antioxidant test using the FRAP (Ferric Reducing Antioxidant Power) method began with B. pandurataextract using ethanol 96%, then continued with fractionation process of n-hexane, ethyl acetate, and ethanol. Free radical activity using spectrophotometry was seen with a wavelength of 712 nm and the total antioxidant value was calculated based on the absorbance of each samples. The result of study of antioxidant activity from ethanol extract, non-polar, semi-polar, and polar fraction were 37.59; 27.43; 32.93; and 35.68 mgAAE/g.
The Biochemical and Kidney Histopathological Parameters in Hyperoxaluria Rats Treated with Breadfruit Leaf Extract Susilo, Jatmiko; Purnama, Siswanta Jaka; Wahyuni, Ardianti; Purwanto, Bambang; Doewes, Muchsin; Indarto, Dono
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1437

Abstract

Purpose: This study was to analyze the administration of breadfruti leaf extract to changes in biochemical parameters and renal histology in hyperoxaluria rats.Methodology: The experimental study used 6 groups, each of 5 mice that are EG, Normal, Vitamin E, an ethanol extract of breadfruit 100, 200 and 400 mg/kg BW. Blood data for the analysis of biochemical parameters and kidney were taken at the end of the experiment for histological analysis of kidney changes. Results: Research shows that the purified ethanol extract of breadfruit leaf can prevent increases in MDA levels, reduce creatinine and BUN levels, increase body weight, prevent hypertrophy and kidney damage Conclusion: Purified ethanol extract of AA leaves has an antioxidant, nephroprotective activity, protect kidney inflammation, and kidney damage in nephrolithiasis rats and the effective dose is 400 mg/kg BW. The higher the extract dose, the more effective to reduce the biochemical and histopathological parameters in hyperoxaluria rats.Applications/Originality/Value: as a basis for futher studies of molecular biology in the prevention of kidney disorder.
Effect of Green Tea Extract to the Degree of Knee Joint Damage and Nitric Oxide Levels in the Rabbit Osteoarthitis Model Susmiarsih, Tri Panjiasih; Hadi, Restu Syamsul; Sofwan, Achmad; Kuslestari, K; Razari, Intan
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1438

Abstract

Osteoathritis (OA) is characterized by degeneration of articular cartilage, subchondral bone, synovial fluid and synovium. Nitric oxide (NO) is proinflammatory cytokine that play a significant role in the pathogenesis of OA via cartilage and bone degradation by synovial inflammation. Green tea is a novel functional food for treating osteoarthritis and inhibiting the production of inflammatory mediators such as nitric oxide. This study aimed to evaluate the effects of green tea extract to the nitric oxide levels and degree of knee joint damage in the rabbit osteoarthitis model. The Freud’s adjuvant complete was performed to induce OA, as many as sixteen male rabbits (New Zealand white) were randomly divided into four groups: adjuvant injection, adjuvant and green tea (injection), adjuvant and green tea (per oral), and control group. The control group only received drinking water, the Freud adjuvant (0.2 ml) and green tea extract (200 mg/kg bw) were orally and injection administered for eight weeks. The articular cartilage damage was evaluated histologically according to MANKIN score. NO levels were determined by nitric oxide assay. Data was analysed by Chi square test. The result of this study showed the surface structure damage of cartilage increased after adjuvant-induced. Green tea extract decrease significantly (p=0.02) the degree of knee joint damage after adjuvant-induced in rabbit osteoarthritis models. NO levels increased after OA induction. The green tea extract administration (via injection) can significantly (p = 0.038) decrease NO levels compare to adjuvant group. Green tea extract decrease the knee joint damage and NO proinflamantory levels in rabbit of osteoarthritis model
Non Specific and Specific Parameter Standardization of Banana Peel (Musa paradisciata Sapientum) and Andrographis Paniculata Pusmarani, Jastria; Putri, Risky Juliansyah; Dewi, Citra; Purwono, Setyo; Ikawati, Zullies
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1439

Abstract

Purpose: The aim of this study is to standardize the methanol extract of banana peel (Musa paradisciata sapientum) and ethanolic extract of Andrographis Paniculata and Phytochemical screening of banana peel extract and Andrographis PaniculataMethodology: Standardization of the extract conducting with two parameters, they are specific and nonspecific parameters.Results: Content of water solvent of banana peel as many as 47.8% and as many as 35.79% in Andrographis Paniculata. Phytochemical screening result reveals that banana peel extract contains saponin, polyphenol, tannin, flavonoid, and terpenoid. Andrographis Paniculata extract contains alkaloid, steroid, terpenoid, flavonoid and saponin. Non-specific parameter can be observed based on water content, total ash content, non-soluble acid ash content and drying losses. Water content of methanol extract of banana peel as many as 8.47% and Andrographis Paniculata leaves as many as 7.91%. The result of total ash content of banana peel as many as 17.99% and Andrographis Paniculata leaves as many as 17.23%. Ash content of insoluble acid of banana peel as many as 3.15% and Andrographis Paniculata leaves as many as 5.10%. The result of drying loss determination of the extract of plantain peel is 9.37% and sambiloto leaves is8.82%.Applications/Originality/Value: Based on specific and non-specific standardization parameter assay which consist of methanol extract of banana peel and Andrographis Paniculata leaves meet the standardization of quality.
Most Common Learning Style Used by the Students of English Department of Tidar University Riadil, Ikrar Genidal; Nur, Muhammad Rauuf Oktavian
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1440

Abstract

To make a good classroom environment as students’ stimulation, that will make the students active in the teaching and learning process. Understanding the students’ learning styles helps the teacher to teach about the student’s specific favorites. Understand the kind of learning styles can help the teacher developing and also delivering the educational programs. It also will motivate and stimulate students’ in gaining the knowledge. This research pursues to answer two research questions; (1) To know the kind of learning styles used by the students of English Department of Tidar University. (2) To know about the most common learning style used by the students of English Department of Tidar University. Qualitative research is used in this research. This research aims to distinguish the most common used of learning style and used the questionnaire reproduced by O’Brien (1985). The population of this research was the English Department students of Tidar University. However, the researcher used 70 samples from all of the students of English Department of Tidar University.
The Effect of Strategic Orientation on the Competitive Advantage and Business Performance: A Case of Batik SMEs Iriyanto, Setia; Nurhayati, N; Suharnomo, S; Raharjo, Susilo Toto
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1441

Abstract

Purpose: In Indonesia, there is one specific type of SME (Small and Medium-Sized Enterprise) that is part of the nation’s cultural heritage, namely Batik SME (Batik is a traditional fabric). This study aims to determine the effects of Strategic Orientation on the bussiness performance and competitive advantage of SMEs of Batik in Central Java, Indonesia. Methodology: The method of this study was explanatory survey method with a type of decompressionverification study from primary data obtained from SMEs Batik with aand using PLS SEM in analyzing the data of the book. Results: The results of this study indicate that Strategic Orientation with Path coefficient (β) = 0.32 P value <0.001 (<α = 0.05), have a positive effect on Competitive Advantage with coefficient (β) = 0.46, P value <0.001 (<α = 0.05) which implies on the performance of SMEs of Batik.

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