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INDONESIA
Indonesian Journal of Pharmacy and Natural Product
Published by Universitas Ngudi Waluyo
ISSN : 26563215     EISSN : 26156903     DOI : 10.35473
Core Subject : Health,
Medicine & Pharmacology
This journal is aimed as promoting principled approach to research on pharmacy that covers a broad range of topics engaging a good relationship in theoretical and practical. This journal covers: Pharmacology Pharmacognosy Analytical Chemistry Pharmaceutical Technology Social and Management Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 151 Documents
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Pengaruh Pemberian Ibuprofen dan Paracetamol Terhadap Penurunan Nyeri Disminorhea di Pondok Pesantren X: The Effect of Giving Ibuprofen and Paracetamol on Reducing Dysminorhea Pain at X Islamic Boarding School Isma Oktadiana
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.236 KB) | DOI: 10.35473/ijpnp.v6i01.2154

Abstract

Dysmenorhea is menstrual discomfort that women feel during menstruation, particularly if it started while they were teenagers. If this condition is not addressed, it will have an effect on these teenagers. The goal of this study was to ascertain whether giving young women between the ages of 12 and 17 years old Ibuprofen 200 mg and Paracetamol 500 mg as pharmacotherapy would have any effect on alleviating the discomfort associated with dysmenorrhea. This study's experimental data collection method used a one group pretest-post test design without a comparison group. The value that the respondent provided in the form of pretest and post-test with Wilcoxon test. Purposive sampling was used for the sample process, while chi-square was used for analysis. The results of the Wilcoxon test, which produced a significance value of 0.000<0.05, demonstrated that there was a therapeutic effect of using Paracetamol 500 mg and NSAIDs, it means that there is a difference in the intensity of menstrual pain felt by respondents before and after therapy. The conclusion of this study is a significant effect on the administration of ibuprofen and paracetamol on reducing the intensity of menstrual pain in teenagers at X Islamic Boarding School ABSTRAK Disminorhea merupakan nyeri menstruasi yang dialami oleh wanita pada masa menstruasi terutama yang sudah dialami pada usia remaja, dimana jika hal ini tidak terobati akan berdampak pada remaja tersebut. Tujuan penelitian ini adalah untuk mengetahui pengaruh farmakoterapi pemberian Ibuprofen 200 mg dan Paracetamol 500 mg terhadap penurunan nyeri disminorhea pada remaja putri usia 12-17 tahun.  Metode pengambilan data dalam penelitian ini dilakukan secara eksperimental dengan rancangan one group pretest-post test tanpa kelompok pembanding. Pengaruh dari penelitian ini akan dilihat dari nilai pretest dan postest dengan uji Wilcoxon. Teknik pengambilan sampel dengan cara purposive sampling dan dianalisis menggunakan chi-square. Hasil penelitian menunjukan bahwa terdapat pengaruh terapi penggunaan obat Paracetamol 500 mg dan NSAID yaitu ibuprofen 200 mg sebelum dan sesudah terapi, yang dapat menurunkan disminorea pada remaja putri, dibuktikan dengan uji Wilcoxon yang menghasilkan nilai signifikansi 0,000 <0.05 artinya terdapat perbedaan intensitas nyeri menstruasi yang dirasakan responden saat sebelum terapi dan sesudah pemberian terapi. Kesimpulan penelitian ini adalah bahwa terdapat pengaruh signifikan pada pemberian ibuprofen dan parasetamol terhadap penurunan intensitas nyeri menstruasi pada remaja di Pondok Pesantren X.
Uji Aktivitas Antioksidan Fraksi Daun Melinjo (Gnetum Gnenom L.) Menggunakan Metode CUPRAC (Cupric Ion Reducing Antioxidant Capacity) : Antioxidant Activity of Fraction From Gnetum Gnenom L.Leaves Using Cuprac (Cupric Ion Reduxing Antioxidant Capacity) Methods Windi Susmayanti; Azmi Rahmadani
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.962 KB) | DOI: 10.35473/ijpnp.v6i01.2178

Abstract

Free radicals are highly reactive and unstable molecules because have unpaired electrons, which was formed from the results of the body's metabolism caused by an unhealthy lifestyle. Free radicals can be overcome by synthetic or natural antioxidants, but synthetic antioxidants have a bad impact if used continuously, so natural antioxidants are developed from melinjo leaves (Gnetum gnenom L). The research purpose is to determine the potential of natural antioxidants that could be developed as drug candidates. Methods used include preparation of 96% ethanol extract by maceration and using water, n-hexane and ethyl acetate by fractionation. Ethanol 96% extract and melinjo leave fractions were tested for phytochemical screening and antioxidant activity using the CUPRAC (Cupric Reduxing Antioxidant Capacity) method. The results showed that ethanol 96% extracts and melinjo leaf fractions contained flavonoids, polyphenols/phenolic, alkaloids, steroids, terpenoids, and tannins. The antioxidant activity test showed the IC50 of the 96% ethanol extract was 60.689 ppm, the IC50 of the ethyl acetate fraction was 59.7951 ppm, the IC50 value of the water fraction was 67.915 ppm indicating a strong antioxidant due to the phenol compound or -OH group attached. IC50 The n-hexane fraction of 117.235 ppm showed moderate antioxidant because it was suspected to contain compounds that have long carbon chains that affect antioxidant activity ABSTRAK Molekul radikal bebas bersifat reaktif dan tidak stabil yang disebabkan elektronnya tidak berpasangan terbentuk dari hasil metabolisme tubuh karena pola hidup tidak sehat. Radikal bebas dapat diatasi dengan antioksidan sintesis maupun alami, namun antioksidan sintesis memiliki dampak buruk jika dipakai secara terus menerus, maka dikembangkan antioksidan alami dari daun melinjo (Gnetum gnenom L). Penelitian ini bertujuan mengetahui potensi antioksidan alami yang akan dikembangkan sebagai kandidat obat. Metode yang digunakan meliputi metode maserasi dalam pembuatan ekstrak etanol 96% dan metode fraksinasi dalam  pembuatan fraksi menggunakan air, n-heksana, etil asetat. Ekstrak etanol 96% dan fraksi daun melinjo diujikan skiring fitokimia dan aktivitas antioksidan dengan metode Cuprac (Cupric ion Reduxing Antioxidant Capacity). Hasil menunjukkan bahwa ekstrak etanol 96% dan fraksi-fraksi daun melinjo mengandung senyawa polifenol/fenolik, alkaloid, flavonoid, steroid, triterpenoid, dan tannin. Uji aktivitas antioksidan menunjukkan IC50 ekstrak etanol 96% sebesar 60,689 ppm, IC50 fraksi etil asetat sebesar 59,7951 ppm, nilai IC50 fraksi air sebesar 67,915 ppm  menunjukkan antioksidan kuat karena senyawa fenol atau gugus -OH yang terikat. IC50 Fraksi n-heksana sebesar 117,235 ppm menunjukkan antioksidan sedang karena diduga mengandung senyawa yang memiliki rantai karbon panjang dan belum murni yang mempengaruhi aktivitas antioksidan.
Analisa Kadar Flavonoid Fraksi Etil Asetat Ekstrak Etanol Tanaman Sawi Langit (Vernonia Cinerea L) dengan Metode Spektrofotometri Visible: Analysis Flavonoid Content Of The Ethyl Acetate Fraction Of the Sawi Langit (Vernonia Cinerea L) Ethanol Extract Using Visible Spectrophotometry Method ELLY MULYANI; Herlina; Melani Nahdiadwi
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.949 KB) | DOI: 10.35473/ijpnp.v6i01.2187

Abstract

Sawi Langit (Vernonia Cinerea L) is a weed that grows wild with great potential as a medicinal plant. The purpose of this study was to determine the content of flavonoid compounds and to determine the levels of flavonoids from the ethyl acetate fraction of the ethanol extract of Sawi Langit using spectrophotometry vis. The method of this study is simplicia was extracted with 70% ethanol using the maceration method, then fractionated with n-hexane, ethyl acetate, and water (4:1:5). Thin layer chromatography test using butanol: acetic acid: water as the eluent (4:1:5). Then the concentration of the ethyl acetate fraction of the extract Sawi Langit was determined using the spectrophotometric method vis. The results of this study are identification of the ethyl acetate fraction of the ethanol extract of Sawi Langit (Vernonia cinerea L.) using layer chromatography (TLC) showed positive for containing flavonoids at a value (Rf 0.71) and quercetin standard (Rf 0.73) with a difference of 0.02. Vis spectrophotometry results in the wavelength range of 400-800 nm, showed an absorption peak at 424nm. The results showed that the flavonoid content of the Ethyl Acetate Fraction of Ethanol Extract of Mustard Greens (Vernonia Cinerea L) was 0.819%. Flavonoid compounds contained can be antioxidants and can reduce the risk of cancer, inflammation to antibacterial. ABSTRAK Sawi langit (Vernonia Cinerea L) merupakan gulma yang tumbuh liar berpotensi besar sebagai tanaman obat. Tujuan Penelitian ini adalah mengetahui kandungan senyawa flavonoid dan mengetahui kadar flavonoid dari fraksi etil asetat ekstrak etanol sawi langit menggunakan spektrofotometri vis. Metode penelitian ini adalah simplisia diekstraksi dengan pelarut etanol 70 % menggunakan metode maserasi, kemudian difraksinasi dengan n-heksan, etil asetat, dan air (4:1:5). Uji kromatografi lapis tipis (KLT) menggunakan eluen butanol: asam asetat : air (4:1:5). Kemudian dilakukan penetapan kadar fraksi etil asetat ekstrak sawi langit dengan metode spektrofotometri vis. Hasil identifikasi fraksi etil asetat ekstrak etanol sawi langit (Vernonia cinerea L.) menggunakan KLT menunjukkan positif mengandung flavonoid dengan nilai Rf  0,71 dan nilai Rf baku pembanding quersetin adalah 0,73, dengan selisih 0,02. Hasil spektrofotometri visible pada range panjang gelombang 400-800 nm, menunjukan puncak serapan pada 424 nm. Hasil penelitian didapatkan kadar flavonoid Fraksi Etil Asetat Ekstrak Etanol Sawi Langit (Vernonia Cinerea L) sebesar 8,2 %. Senyawa flavonoid yang terkandung dapat menjadi antioksidan dan dapat mengurangi resiko penyakit kanker, peradangan hingga antibakteri.
Studi Potensi Interaksi Obat Pasien Covid-19 di Rumah Sakit Umum Daerah Kota Mataram: Study on The Potential Drug Interactions in COVID-19 Patient at the Mataram City General Hospital Dwi Monika Ningrum; Putri Ramdaniah; Denih Agus Setia Permana; Deny Hariyadi
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.136 KB) | DOI: 10.35473/ijpnp.v6i01.2202

Abstract

Covid-19 or Coronavirus disease 2019 is an acute respiratory disease caused by the Severe Acute Respiratory Syndrom Coronavirus (SARS CoV-2), which entered Indonesia in early 2020. Data on Covid-19 in West Nusa Tenggara Province (NTB) in November reported 4,550 cases. Covid-19 can cause disorders in the respiratory system, acute pneumonia to death, so researchers conducted this study which aims to see how potential drug interactions exist in patients who get Covid-19 therapy while being treated at the Mataram City Hospital for the January-December 2021 period. This research is a descriptive study conducted to get an idea of whether there are potential drug interactions that occur by conducting research objectively. Data obtained from primary data, namely medical records of patients diagnosed with Covid-19 and treated in isolation rooms. Obtained as many as 95 medical record data of Covid-19 patients in the period January - December 2021. This research is a descriptive study conducted to get an idea of whether there are potential drug interactions that occur by conducting research objectively. Data obtained from primary data, namely medical records of patients diagnosed with Covid-19 and treated in isolation rooms. As many as 95 medical record data for Covid-19 patients were obtained in the period January – December 2021. Of the 95 patients obtained, it was found that the category of drug interactions with drugs based on severity was 5.26%, moderate interactions were 42.10%, and major interactions were 3.15%.  The conclusion of this study is that the most common potential drug interactions were found with moderate severity with a percentage of 42.10% of 95 patients. ABSTRAK Covid-19 atau Coronavirus disease 2019 merupakan suatu penyakit pernapasan akut yang disebabkan oleh Severe Acute Respiratory Syndrom Coronavirus (SARS CoV-2), yang masuk ke Indonesia di awal tahun 2020. Data Covid-19 di Provinsi Nusa Tenggara Barat (NTB) pada bulan November dilaporkan sebanyak 4.550 kasus. Covid-19 dapat menyebakan gangguan pada sistem pernapasan, pneumonia akut hingga kematian, sehingga peneliti melakukan penelitian ini yang  bertujuan untuk melihat bagaimana potensi adanya interaksi obat pada pasien yang mendapatkan terapi Covid-19 selama di rawat di RSUD Kota Mataram periode Januari-Desember 2021. Penelitian ini merupakan penelitian deskriptif yang dilakukan untuk mendapatkan gambaran apakah ada potensi interaksi obat yang terjadi dengan melakukan penelitian secara objektif. Data diperoleh dari data primer yaitu rekam medis pasien yang terdiagnosa Covid-19 dan dirawat di ruang isolasi. Diperoleh sebanyak 95 data rekam medis pasien Covid-19 pada periode Januari – Desember 2021. Dari 95 pasien yang diperoleh, ditemukan diperoleh kategori interaksi obat dengan obat berdasarkan keparahan yaitu interaksi minor sebanyak 5,26% , interaksi moderate 42,10% , dan interaksi mayor sebanyak 3,15%.  Kesimpulan penelitian ini adalah potensi interaksi obat yang paling banyak ditemukan yaitu dengan tingkat keparahan moderate dengan persentase sebesar yaitu 42,10% dari 95 pasien.
Pengaruh Ekstraksi dan Konsentrasi Etanol terhadap Kadar Flavonoid Total dan Aktivitas Antioksidan Ekstrak Jahe Emprit (Zingiber officinale var. Amarum): Effect of Ethanol Extraction and Concentration on Total Flavonoid Content and Antioxidant Activity of Emprit Ginger Extract (Zingiber officinale var. Amarum) Avian Tri Wahyudi; Tri Minarsih
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.334 KB) | DOI: 10.35473/ijpnp.v6i01.2208

Abstract

Ginger emprit or Zingiber officinale var. Amarum contains flavonoids which have pharmacological activities such as antioxidants. Extraction of metabolites through a method using a solvent affects the levels of compounds and the level of pharmacological activity. The purpose of this study was to analyze the effect of different maceration treatments and ethanol concentrations on total flavonoid levels and antioxidant activity of Emprit Ginger extract. The research method in this test begins with collecting samples of Ginger Emprit obtained from Temanggung. Extraction was carried out by maceration and remaceration methods. Determination of total flavonoid content using UV-Vis spectrophotometric method. Testing of antioxidant activity using the DPPH method, absorbance was measured using UV-Vis Spectrophotometry. This test resulted in total flavonoid content of Ginger Emprit extract: maceration-ethanol 70%: 0,674 mgQE/g, remaceration-ethanol 70%: 0,659 mgQE/g, maceration-ethanol 96%: 0,601 mgQE/g, remaceration-ethanol 96%: 0,643 mgQE /g. The results of the determination of the antioxidant activity of the sample with  parameter IC50 value for each treatment, on the maceration-ethanol 70% method: 56,58 ppm; remaceration-ethanol70%: 22,1 ppm ; maceration-ethanol 96%: 87,7 ppm; remaceration-ethanol 96%: 67,42 ppm.  Based on these results, the Independent-Samples Kruskal-Wallis Test Summary statistical test with variations in extraction methods and solvents did not provide a significant difference in total flavonoid levels with a sig value of 0.447 > 0.05, but resulted in significant differences in the antioxidant activity of emprit ginger extract with a value sig of <0.05 ABSTRAK Jahe emprit Zingiber officinale var. Amarum mengandung flavonoid yang memiliki aktivitas farmakologis diantaranya sebagai antioksidan. Penyarian metabolit melalui suatu metode dengan menggunakan pelarut mempengaruhi kadar senyawa dan tingkat aktivitas farmakologisnya. Tujuan penelitian ini adalah untuk menganalisi pengaruh perbedaan perlakuan proses maserasi dan konsentrasi etanol terhadap kadar flavonoid total dan aktivitas antioksidan ekstrak Jahe Emprit. Metode penelitan pada pengujian ini diawali dengan pengumpulan sampel Jahe Emprit diperoleh dari Temanggung. Ekstraksi dilakukan dengan metode maserasi dan remaserasi. Penetapan kadar flavonoid total menggunakan metode spektrofotometri UV-Vis. Pengujian aktivitas antioksidan menggunakan metode DPPH, diukur absorbansi menggunakan Spektrofotometri UV-Vis. kadar flavonoid total ekstrak Jahe Emprit denganmetode maserasi (etanol 70%) 0,674 mgQE/g , remaserasi (etanol 70%) 0,659 mgQE/g, maserasi (etanol 96%) 0,601 mgQE/g, dan remaserasi (etanol 96%) 0,643 mgQE/g. nilai IC50 sampeldiperoleh hasil pada metode maserasi (etanol 70%) sebesar 56,58ppm); remaserasi (etanol 70%) 22,1 ppm ; maserasi (etanol 96%) 87,7 ppm; dan remaserasi (etanol 96%) sebesar 67,42 ppm. Berdasarkan hasil tersebut, dilakukan uji statistik Independent-Samples Kruskal-Wallis Test Summary  variasi metode ekstraksi dan pelarut tidak memberikan perbedaan signifikan pada kadar flavonoid total dengan nilai sig sebesar 0,447 > 0,05, namun menghasilkan perbedaan signifikan pada aktivitas antioksidan ekstrak jahe emprit dengan nilai sig sebesar < 0,05
Pengetahuan dan Persepsi Apoteker Terhadap Penggunaan Obat Off-Label di Indonesia: Pharmacist's Knowledge and Perception of Off-Label Drugs Use in Indonesia Dwi Aulia Ramdini; Sarmoko; Ihsanti Dwi Rahayu; Muhammad Iqbal; Ramadhan Triyandi; Dika Pramita Destiani
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.807 KB) | DOI: 10.35473/ijpnp.v6i01.2219

Abstract

Off-label drugs are generally used in clinical practice but require close monitoring by health workers, especially pharmacists. Pharmacists need knowledge regarding the potential benefits and dangers of off-label medications to ensure the safety of drug users. This study aims to determine pharmacists' knowledge and perceptions of using off-label drugs in Indonesia. The study design used in this study was a cross-sectional study with an analytic observational approach using off-label drug-related questionnaires conducted online. Results of this study a total of 174 pharmacist respondents filled out a complete questionnaire with the result that 86% of the respondents had good knowledge regarding off-label drugs, and the rest were classified as poor (14%). Pharmacist respondents said they focused on safety (96.55%), efficacy (86.55%), medication history (72.99%), cost efficiency (61.49%), and also the target population (32.76%) in the use of off-label drugs. Based on factor analysis, the experience of preparing off-label drugs was significantly related to respondents' knowledge (p=0.041). In contrast, the factors of gender (p=0.777), age (p=0.677), last education (p=0.801), and years of service (p=0.541) there is no significant relationship. Conclusions of this study is The majority of pharmacist respondents in this study had good knowledge regarding the use of off-label drugs and agreed that pharmacists play an important role in monitoring the side effects of off-label use. In addition, almost all pharmacist respondents perceived that drug safety was the dominant factor for the consideration of off-label drug use. ABSTRAK Obat off-label umumnya digunakan dalam praktik klinis, namun dalam penggunaannya diperlukan pemantauan yang ketat oleh tenaga kesehatan, khususnya oleh apoteker. Pengetahuan terkait manfaat dan bahaya obat off-label diperlukan apoteker dalam menjamin keamanan dan keselamatan penggunaan obat. Penelitian ini bertujuan untuk mengetahui pengetahuan dan persepsi apoteker terhadap penggunaan obat off-label di Indonesia. Metode penelitian yang digunakan adalah studi cross-sectional dengan pendekatan observasional analitik melalui penggunaan kuesioner terkait obat off-label yang dilakukan secara online. Hasil penelitian sebanyak 174 responden apoteker terdapat 86% responden memiliki pengetahuan yang baik terkait obat off-label, dan sebagian lainnya tergolong kurang baik (14%). Responden apoteker menyatakan memiliki fokus terhadap faktor keamanan (96,55%), kemanjuran (86,55%), riwayat pengobatan (72,99%), efisiensi biaya (61,49%), dan target populasi (32,76%) dalam penggunaan obat off-label. Berdasarkan analisis faktor, pengalaman menyiapkan obat off-label berhubungan signifikan terhadap pengetahuan responden (p=0,041), sedangkan faktor jenis kelamin (p=0,777), umur (p=0,677), pendidikan terakhir (p=0,801), dan masa kerja (p=0,541) tidak terdapat hubungan signifikan. Kesimpulan penelitian ini adalah mayoritas responden apoteker memiliki pengetahuan yang baik terkait penggunaan obat off-label dan menyetujui bahwa apoteker berperan penting dalam monitoring efek samping penggunaan off label. Selain itu, hampir keseluruhan responden apoteker memiliki persepsi dimana faktor pertimbangan penggunaan obat off-label yang dominan adalah faktor terkait keamanan obat.
Ekstrak Daun Binahong (Anredera Cordifolia (Ten).Steenis) Sebagai Kandidat Terapi Antiinflamasi pada Inflamasi Kolon: Binahong Leaf Extract (Anredera Cordifolia (Ten).Steenis) as A Candidate of Anti-Inflammatory Therapy in Colon Inflammationolia Tri Fitri Yana Utami; Nikmah Nuur Nikmah; Melinda Prahesti
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (542.403 KB) | DOI: 10.35473/ijpnp.v6i01.2221

Abstract

Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease that occurs in the gastrointestinal tract, remitting and relapsed with definite causes that are not yet clearly known. Binahong leaf extract (Anredera cordifolia (Ten.) Steenis ) has been shown to provide anti-inflammatory effects. The aim of this study was to determine the effect of binahong leaf extract on colon inflammatory conditions in mice with 3% acetic acid-induced UC. The research method used is pure experimental research. The test animals used were 30 male mice (mus musculus), randomly divided into 6 groups which were given different treatments. Normal group (CMC-Na 1%), negative control group (3% acetic acid and 1% CMC-Na), positive group (3% acetic acid and dexamethasone 2 mg/kg BW s.c), and 0.728 mg binahong leaf extract , 1,456 mg, 2,912 mg. UCinduction was given for 5 days and continued with extra treatment variations which were observed for 7 days. The results showed that there was an improvement starting from the 4th day after giving the treatment. The conclusion of this study showed that there was an effect of binahong leaf extract on UC conditions. There was an increase in body weight, normal stool consistency, and no presence of blood (significant p<0.05) ABSTRAK Inflammatory Bowel Disease (IBD) ialah penyakit inflamasi kronis yang terjadi didalam  saluran cerna, bersifat remisi dan relaps dengan penyebab pasti yang sampai saat ini belum diketahui secara jelas. Ekstrak daun binahong (Anredera cordifolia (Ten.) Steenis ) terbukti mampu memberikan efek antiinflamasi. Tujuan penelitian ini mengetahui pengaruh ekstrak daun binahong terhadap kondisi inflamasi kolon pada mencit kondisi KU yang diinduksi asam asetat 3%. Metode penelitian yang digunakan yaitu penelitian eksperimental murni. Hewan uji yang digunakan yaitu 30 ekor mencit jantan ( mus musculus ), dibagi menjadi 6 kelompok secara acak yang diberi perlakukan berbeda. Kelompok normal (CMC-Na 1%), kelompok kontrol negatif (asam asetat 3 % dan  CMC-Na 1%), kelompok positif (asam asetat 3 % dan dexametason  2 mg/kg BB s.c), dan ekstrak daun binahong dosis 0,728 mg, 1,456 mg, 2,912 mg. Induksi KU diberikan selama 5 hari dan dilanjutkan perlakuan variasi ekstrak diamati selama 7 hari. Hasil penelitian menunjukkan bahwa terjadi perbaikan dimulai dari hari ke 4 setelah pemberian perlakuan. Kesimpulan penelitian ini menunjukan bahwa adanya pengaruh ekstrak daun binahong pada kondisi KU. Terjadi kenaikan berat badan, konsistensi feses normal, dan tidak ada keberadaan darah (siginfikan p<0,05)
Penentuan Nilai Sun Protecting Factor dan Uji Stabilitas Krim Ekstrak Daun Waru Laut (Hibiscus tiliaceus L.): Determination of Sun Protecting Factor Value and Cream Stability Test Waru Laut Leaf Extract (Hibiscus tiliaceus L.) Monica Kristiani; Arsita; Meida Maharani
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.887 KB) | DOI: 10.35473/ijpnp.v6i01.2222

Abstract

Exposure to UV light can trigger the formation of free radicals. Free radicals can be inhibited by antioxidant compounds. Sea hibiscus leaf extract contains flavonoids which functions as an antioxidant. Antioxidant compounds can be made into sunscreen cream, because they can stick to the surface of the skin for a long time and are easier to clean with water. Sunscreen cream also has an effectiveness level based on the measurement of the Sun Protecting Factor (SPF) value. The SPF value indicates the ability of the sunscreen to provide skin protection in the sun without the skin experiencing erythema. This study aims to evaluate the physical stability of cream preparations of sea waru leaf extract. The research method is explorative experimental research. The research design used is the One Case Study Design. The cream was made using one formula with three replications, then tested for physical characteristics, stability tests, and determined the SPF value. The test results of sea hibiscus leaf extract cream showed that the cream met the physical characteristics requirements, having an SPF value for cream base of 1.87 (minimum protection) while for sun waru leaf extract cream was 6.37 (extra protection). In the stability test, the cream preparations of sea hibiscus leaf extract had good physical stability during storage, this was indicated by the mixing of the oil phase and the water phase in the cream preparations of sea hibiscus leaf extract with light stirring.   ABSTRAK Paparan sinar UV dapat memicu terbentuknya radikal bebas. Radikal bebas dapat  dihambat  oleh  senyawa antioksidan.  Ekstrak  daun  waru  laut mengandung senyawa flavonoid yang berfungsi sebagai  antioksidan. Senyawa antioksidan dapat dibuat menjadi sediaan krim tabir surya, karena mampu melekat pada permukaan kulit dalam waktu yang cukup lama dan lebih mudah dibersihkan dengan air.  Krim tabir surya juga memiliki   tingkat efektifitas berdasarkan pengukuran nilai Sun Protecting Factor (SPF). Penelitian ini bertujuan untuk mengevaluasi stabilitas fisik sediaan krim ekstrak daun waru laut. Metode penelitian ini adalah penelitian eksperimental eksploratif.  Rancangan penelitian yang digunakan yaitu One Case Study Design.  Krim dibuat menggunakan satu formula dengan tiga kali replikasi, selanjutnya dilakukan uji karakteristik fisik, uji stabilitas dan penentuan nilai SPF. Hasil pengujian krim ekstrak daun waru laut menunjukkan krim memenuhi syarat karakteristik fisik, memiliki nilai SPF untuk basis krim sebesar 1,87 (proteksi minimal), sedangkan untuk krim tabir surya ekstrak daun waru laut sebesar 6,37 (proteksi ekstra). Pada uji stabilitas sediaan krim ekstrak daun waru laut memiliki stabilitas fisik yang baik selama penyimpanan, hal ini ditunjukkan dengan tercampurnya kembali fase minyak dan fase air pada sediaan krim ekstrak daun waru laut dengan pengadukan ringan. 
Formulasi dan Uji Stabilitas Fisik Sediaan Permen Jeli Ekstrak Wortel (Daucuscarota L.): Formulation and Physical Stability Tests of Carrot Extract Jelly Candy (Daucus carota L.) Resti Hayu Ningtyas; Agitya Resti Erwiyani
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (700.301 KB) | DOI: 10.35473/ijpnp.v6i01.2223

Abstract

Carrots contain vitamin A and β-carotene which help maintain eye health. The content of carotenoids in carrots can protect DNA, protein, and fat from oxidative damage and plays a role in maintaining the normal function of the immune system, skin, mucous membranes, and eye vision function. Carrots are formulated in the form of jelly candy as an eye supplement. The aim of this study was to evaluate the characteristics and physical stability of carrot extract jelly candy preparations. Jelly candy was made with various concentrations of gelatin as a jelly former of 8%, 10%, 12%, 14%, 16%, and 18%. Tests for physical characteristics were carried out including organoleptic tests, weight uniformity, pH, water content, and panelist tests. A stability test was observed at room temperature for 7 days. The jelly candy has a characteristic orange color, star shape, distinctive mango aroma, and sweet taste. Jelly candy has a pH of 5 with a weight in the range of 4.17 g - 4.94 g. The water content in each jelly candy is in the range of 38.67% - 48.03%. The panelist test had the highest elasticity at a concentration of 14%, the most attractive color, and shape at a concentration of 18%, smell and taste at a concentration of 8%, 10%, 14%, 16%, and 18% had the same score. The results of the stability test for 7 days showed that the jelly candy experienced a decrease in weight and pH uniformity, mold growth on the surface of the candy, and the water content did not meet the requirements. ABSTRAK Wortel memiliki kandungan vitamin A dan β-karoten yang membantu menjaga kesehatan mata. Kandungan karotenoid dalam wortel dapat melindungi DNA, protein, dan lemak dari kerusakan oksidatif serta berperan dalam mempertahankan fungsi normal sistem imun, kulit, membran mukosa, dan fungsi penglihatan mata. Wortel diformulasi dalam bentuk permen jeli sebagai suplemen mata. Tujuan penelitian ini mengevaluasi karakteristik dan stabilitas fisik sediaan permen jeli ekstrak wortel. Permen jeli dibuat dengan variasi konsentrasi gelatin sebagai pembentuk jeli sebesar 8%, 10%, 12%, 14%, 16%, dan 18%. Pengujian karakteristik fisik dilakukan meliputi uji organoleptis, keseragaman bobot, pH, kandungan air, dan uji panelis. Uji stabilitas dilakukan pengamatan pada suhu kamar selama 7 hari. Permen jeli memiliki karakteristik warna orange, berbentuk bintang, aroma khas mangga dan rasanya manis. Permen jeli memiliki pH 5 dengan bobot berada pada rentang 4,17 g - 4,94 g. Kandungan air pada masing-masing permen jeli berada pada rentang 38,67% - 48,03%. Uji panelis kekenyalan tertinggi pada konsentrasi 14%, warna dan bentuk yang paling menarik pada konsentrasi 18%, bau dan rasa pada konsentrasi 8%, 10%, 14%, 16%, 18% memiliki skor yang sama. Hasil uji stabilitas selama 7 hari menunjukkan permen jeli mengalami penurunan pada keseragaman bobot dan pH, serta kandungan air tidak memenuhi persyaratan.
Kajian Peresepan Obat yang Berpotensi Tidak Tepat Berdasarkan Kriteria STOPP Versi-2 Pada Pasien Geriatri : Evaluation of Potentially Inappropriate Prescribing with version-2 STOPP Criteria in Geriatric Patients Citra Yuliyanda Pardilawati; Nara Safitri; Rasmi Zakiah Oktarlina; Muhammad Iqbal
Indonesian Journal of Pharmacy and Natural Product Vol. 6 No. 01 (2023): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (187.838 KB) | DOI: 10.35473/ijpnp.v6i01.2225

Abstract

Potentially inappropriate prescribing (PIP) is a drug prescription without a proper clinical indication. The tools used to identify PIP in the geriatric patient is the STOPP criteria. The STOPP criteria evidently to improve treatment suitability, reduce medical costs, and reduce the occurrence of adverse drug reaction. The aim of this study is to evaluate the potentially inappropriate prescribing in geriatric patients using the STOPP criteria. This study is observational study used a cross-sectional approach. The sampling technique is purposive sampling. The research samples were medical records of geriatric patients aged more than 60 years old in outpatient installations at one of the hospitals in Bandar Lampung for the period January - June 2022. The samples were 96. The highest number of patients was in the age group of 60-69 years with 77 patients (80.2%). Male patients were 58 patients (60.4%) and the patients who get more than equal to 5 medicine were 79 patients (82.3%). PIP events occurred in 5 (5.2%) patients. PIP occurred in five patients, with the incident of the use of non-steroidal anti-inflammatory drugs used concurrently with anticoagulant drugs for two incidents, the use of opioids as first-line painkillers for two incidents, and one incident of the use of non-steroidal anti-inflammatory drugs for patients with uncontrolled hypertension. ABSTRAK Peresepan obat yang berpotensi tidak tepat atau Potentially inappropriate prescribing (PIP) merupakan peresepan obat tanpa indikasi klinis yang tepat. Salah satu alat yang dapat digunakan untuk mengidentifikasi PIP pada pasien geriatri adalah kriteria STOPP. Kriteria STOPP terbukti dapat meningkatkan kesesuaian pengobatan, mengurangi biaya pengobatan, dan mengurangi terjadinya reaksi obat yang merugikan. Tujuan dari penelitian ini yaitu untuk mengevaluasi kejadian potentially inappropriate prescribing (PIP) pada pasien geriatri menggunakan kriteria STOPP. Penelitian ini adalah penelitian observasional dengan pendekatan cross-sectional. Teknik pengambilan sampel menggunakan purposive sampling. Sampel penelitian adalah rekam medis pasien yang berusia lebih dari 60 tahun di instalasi rawat jalan salah satu rumah sakit di kota Bandar Lampung periode Januari – Juni tahun 2022. Jumlah sampel dalam penelitian ini adalah 96. Jumlah pasien paling banyak terdapat pada kelompok usia 60 – 69 tahun sebanyak 77 pasien (80.2%). Pasien laki-laki sebanyak 58 pasien (60.4%), dan pasien yang mendapatkan ≤ 5 obat sebanyak 79 pasien (82.3%). Kejadian PIP terjadi pada 5 (5.2%) pasien. Kejadian PIP terjadi pada 5 pasien diantaranya adalah penggunaan obat antiinflamasi non-steroid yang digunakan bersamaan dengan obat antikoagulan sebanyak 2 kejadian, penggunaan opioid sebagai antinyeri lini pertama sebanyak 2 kejadian dan penggunaan obat antiinflamsi non-steroid pada pasien dengan hipertensi tidak terkontrol sebanyak 1 kejadian.

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