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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 616 Documents
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Skrining fitokimia dan uji aktivitas antioksidan dari ekstrak etanol daun kedondong (Spondias dulcis Soland. ex Forst. fil) dengan metode DPPH Yanti, Rahma; Nasution, Muhammad Amin; Ridwanto, Ridwanto; Nasution, Haris Munandar
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.377

Abstract

Antioxidants are compounds that can ward off free radicals and prevent damage caused by free radicals. Free radicals are unstable and reactive molecules formed from unpaired electrons that can cause damage to the skin. To protect the body's skin from free radicals, it can be overcome by using an antioxidant compound. One is kedondong leaves, which contain polyphenolic compounds known to have antibacterial and antioxidant properties. This study aimed to conduct phytochemical screening and determine the antioxidant activity of ethanol extract of kedondong leaves with the DPPH method. This study was conducted experimentally, where the sample used was kedondong leaves. The stages of research include sample preparation, plant identification, making simplisia, phytochemical screening on kedondong leaf extract and simplisia, then antioxidant activity tests were carried out on kedondong leaf ethanol extract using the DPPH method (1,1-diphenyl -2-picrylhydrazil) at a maximum wavelength of 516 nm, as a positive control vitamin C was used. The research on phytochemical screening showed that ethanol extract of kedondong leaves contains secondary metabolite compounds, namely tannins, saponins, alkaloids, flavonoids, steroids, triterpenoids, and glycosides. In testing, the antioxidant activity of ethanol extract of kedondong leaves showed very strong antioxidant activity with an IC50 of 44.855 μg/ml, and vitamin C had very strong antioxidant activity with an IC50 of 4.44 μg/ml.
Uji kandungan nutrisi nugget daging domba dengan pemanfaatan daun kelor Asmaq, Nur; Warsito, Kabul; Matondang, Syaiful Nasri; Suhut, Anwar
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.379

Abstract

This research aimed to determine the effect of adding Moringa oleifera leaves  on the nutritional value of lamb nuggets. Moringa leaves (Moringa oleifera) is a tropical plant that can quickly grow in low areas such as North Sumatra. This plant contains anticancer and antioxidants, which can be used as a natural ingredient to maintain and improve the quality of lamb nuggets. In this research, Moringa leaves and lamb were processed into nuggets. This research used an experimental method with a completely randomised design with 4 treatments and 4 replications. This research showed that adding Moringa leaves showed a very significant difference (P<0.01) in the water content, pH value and total bacterial colony test.
Formulasi sediaan salep sari kelopak jantung pisang kepok (Musa paradisiaca L) terhadap penyembuhan luka sayat pada tikus putih jantan (Rattuss norvegicus) Fahma Shufyani; Darwin Syamsul
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.383

Abstract

Background: Banana flower petals also have active compounds such as flavonoids, alkaloids and saponins. These active compounds are thought to be able to suppress the growth of bacteria. These compounds can be used to increase the regeneration of epidermal cells and the formation of new blood vessels to speed up healing and wound closure. This research aims to determine the healing effect of cut wounds from banana flower petals (Musa paradisiaca L) extract on male white rats (Rattus norvegicus) and what concentration is most effective in healing cut wounds. This Method research is an experimental study, including collecting samples, making kepok banana heart calyx juice with concentrations of 2%, 4% and 6%, ointment evaluation tests and cut wound healing activity tests on white mice which were grouped into 5 groups with each group consisting of of 5 mice. Statistical analysis included a one-way ANOVA test to see whether there was a significant difference between concentrations and wound healing in white male mice. The results showed that F1 (2% concentration) could heal mice on the 10th day, F2 (4% concentration) could heal mice on the 8th day, F3 (6% concentration) could heal cut wounds on the 7th day, positive control (Betadine Ointment) the mice recovered on the 6th day. The conclusion of this research is that Kepok banana heart petal juice can be formulated as an ointment for healing cuts in male white rats (Rattus norvegicus), with the most effective concentration being a concentration of 6% because it can heal cuts wounds the fastest among other concentrations.
Formulasi dan uji aktivitas antibakteri sediaan salep daging daun lidah buaya (Aloe vera L.) terhadap bakteri Staphylococcus aureus pada penyembuhan luka bernanah Dena, Mutia; Dalimunthe, Gabena Indrayani; Lubis, Minda Sari; Rahayu, Yayuk Putri
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.388

Abstract

Staphylococcus aureus is one of the bacteria that can cause infectious diseases of the skin, one of which is purulent wound disease. Aloe vera (Aloe vera L.) belongs to the family Asphodelaceae, which is a plant known to have antibacterial compounds. The study was conducted experimentally. The independent variable is the concentration of aloe vera leaf flesh, 20%, 30% and 40%. The concentration of aloe leaf meat ointment is 20%, 30%, and 40%. The dependent variables are the antibacterial activity of aloe vera leaf meat ointment preparations against staphylococcus aureus bacteria. The results of the antibacterial Zone of Inhibition (ZOI) value of aloe vera leaf meat against staphylococcus aureus of 8.1 mm (20% concentration); 8.5 mm (concentration 30%); and 10.5 mm (concentration 40%). Antibacterial ZOI value of aloe leaf meat ointment against staphylococcus aureus by 10.6 mm (F1 20%), 11.5 mm (F2 30%), and 12.5 mm (F3 40%). The test results on purulent wounds in rat test animals get moderate healing scores on F1, F2, F3 and K + (gentamicin sulfate 0.1%) strong, so it can be said that aloe vera leaf meat ointment preparations can inhibit antibacterial growth in purulent wound healing even with a moderate category compared to Gentamicin ointment 0.1% with a strong (sensitive) category.  
Penetapan kadar flavonoid total ekstrak kayu kuning dari daerah Samarkilang Aceh Tengah dengan berbagai konsentrasi etanol menggunakan metode spektrofotometri visible Afrizani, Afrizani; Daulay, Anny Sartika; Ridwanto, Ridwanto; Rahman, Fathur
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.391

Abstract

The yellow wood sampled was taken from the Samarkilang area of Central Aceh. The use of yellow wood plants as herbal medicinal ingredients. The chemical compounds contained in Yellow Wood are alkaloids, phenolics, flavonoids, saponins, and tannins. Phenolic compounds and flavonoids have activity as antioxidants. The purpose of this study was to determine the chemical compounds contained in the ethanol extract and to determine the total flavanoid value of the ethanol extract of the yellow wood (Arcangelisia flava (L.) Merr). This research method is an experimental method which includes processing plant materials, making 50%, 70%, and 96% ethanol extracts. Examination of characterization, phytochemical screening and determination of total flavonoid content of the ethanol extract of Kayu kuning using the Uv-Vis spectrophotometry method. Yellow wood extract was prepared by maceration method using various ethanol concentrations of 50%, 70% and 96% the extract obtained was concentrated with a rotary evaporator. Furthermore, the determination of total flavonoid levels was carried out using the Uv-Vis spectrophotometry method. The results of the phytochemical screening on the ethanol extract of Kayu kuning contained groups of chemical compounds such as alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. Determination of total flavonoid content was carried out by determining the maximum wavelength of quercetin, operating time, measuring the quercetin calibration curve and calculating total flavonoid content using the Uv-Vis spectrophotometry method. The results of determining total flavanoid levels in ethanol solvent extract with a concentration of 50% 0,96882 ± 0,2157 mgQE/g, in ethanol solvent extract with a concentration of 70% was 2,6693 ± 11,7041 mgQE/g, and in ethanol solvent extract with a concentration of 96 % is 3,838 ± 1,3036 mgQE/g.
Uji Aktivitas Antibakteri Fraksi Etanol Daun Kelor (Moringa oleifera L.) Terhadap Staphylococcus aureus dan Staphylococcus epidermidis Dewi, Asiska Permata; Darmadi, Darmadi; Yesti, Yulia
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.393

Abstract

Moringa olifera L. is a herbaceous plant that consists of phytochemicals such as flavonoids, saponins cytokinins, acid-caffeoylquinic and contains unsaturated fatty acids such as linoleic (omega 6) and alfalinolenat (omega 3). This research aimed to determine the chemical compound content in the ethanol fraction of Moringa leaves and test its antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis. Phytochemical screening was carried out through a color reaction using a certain reagent; then the antibacterial activity test was carried out using the disc diffusion method with ethanol fraction concentrations of 15%, 30%, 45%, and 60%. The results showed that the compounds contained in the ethanol fraction of Moringa leaves were alkaloid, flavonoid, saponin, and tannin. The diameter of the inhibition zone for S. aureus bacteria is 7.43 mm – 10.16 mm, while for S. epidermidis bacteria is in the range 7.43 mm – 10.48 mm. It can be concluded that the ethanol fraction of Moringa leaves has antibacterial activity against S. aureus and S. epidermidis bacteria.
Evaluasi aktivitas penyembuhan luka fraksi ekstrak etanol daun kirinyuh (Chromolaena odorata (L.) R.M. King & H. Rob) pada luka sayat tikus putih (Rattus norvegicus) Efendi, M. Rifqi; Elisma, Elisma; Zahira, Niken
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.394

Abstract

Kirinyuh (Chromolaena odorata (L.) R.M.King & H.Rob) is a plant from the Asteraceae family traditionally used for wound healing. This research aims to evaluate the wound healing activity of n-hexane, ethyl acetate, and n-butanol fractions derived from kirinyuh ethanol extract (Chromolaena odorata (L.) R.M.King & H.Rob). The study employed a post-test control group design in vivo using white rats (Rattus norvegicus) induced with a 3 cm long and 2 mm deep incision wound. The test formulations were applied twice a day in the morning and evening for 10 days at a dosage of 0.5 g per treatment. Wound healing effects were assessed based on the percentage of wound healing and histopathology of rat skin. The results indicated that all test fractions demonstrated wound-healing effects. The ethyl acetate fraction exhibited the most significant effect on incision wound healing compared to the positive control and the other two fractions, achieving a 75% wound healing percentage. Additionally, histopathological observations of rat skin revealed improved collagen content and epithelial cell thickness in the ethyl acetate fraction. Therefore, the ethyl acetate fraction holds the potential for development as a topical formulation in wound healing.
Analisis penulisan assessment dan plan CPPT apoteker pada pasien community acquired pneumonia (CAP) Rawat inap di rumah sakit X Padang Amelia, Ayu; Nasif, Hansen; Sari, Yelly Oktavia
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.395

Abstract

The Integrated Patient Development Record (CPPT) is a standardized form of documentation used by healthcare professionals to record the development of a patient's condition. It follows the SOAP (Subjective, Objective, Assessment, Plan) method. Inaccurate or incomplete CPPT data can negatively impact the quality of care provided to patients, affecting the effectiveness of their treatment. This study aims to analyze the accuracy of the Assessment and Plan written by pharmacists for inpatient community pneumonia patients in the pulmonary and internal medicine department of X Padang Hospital. The inclusion criteria in this study were medical records of community pneumonia patients with CPPT written by pharmacists. Medical records that met the criteria for inclusion as research subjects were 38 cases. From this study, the results of the analysis of the accuracy of writing the assessment and plan pharmacists were obtained, and none (0%) of the 38 CPPTs analyzed were written correctly.
Analisis penulisan assesment dan plan pada catatan perkembangan pasien terintegrasi terhadap fraktur femur di rumah sakit X Padang Azzahra, Rafifah; Nasif , Hansen; Sari , Yelly Oktavia
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.396

Abstract

Integrated Patient Progress Notes (IPPNs) is an interprofessional documentation of integrated patient development in the form of patient medical records that serves to improve the quality of interprofessional communication in hospitals. Documentation in the form of a complete IPPNs and the accuracy of writing assessments and plans will help establish smooth collaboration between health workers so that good results can be achieved in healing patients. Fracture is a condition of discontinuity of bone structure caused by trauma or pathological conditions. Femur fracture cases are the most common cases and have a high risk if adequate management is not carried out. This study aims to analyze the accuracy of writing assessment and plan on the Pharmacist's IPPNs for femur fractures in Padang X Hospital. This research is a descriptive qualitative study with prospective data collection from purposive sampling. The results of this study showed that there was no assessment on the Pharmacist's IPPNs (0%) which was written correctly from the 39 Pharmacist's IPPNs analyzed and there was no plan on the Pharmacist's IPPNs (0%) which was written correctly from the 39 Pharmacist's IPPNs analyzed. This study shows that there is no accuracy of pharmacists in writing assessments and plans on IPPNs.
Kajian penggunaan obat anti emetik pada pasien lnh di ruang one day care RSUP Dr. M Djamil Padang Nasif, Hansen; Sartika, Lia; Sari, Yelly Oktavia
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.397

Abstract

In the treatment of non-Hodgkin's lymphoma, a combination of chemotherapy drugs (Cyclophospamide, Doxorubicin, Vincristine, and Prednisone) is commonly used. Chemotherapy can lead to side effects such as nausea and vomiting, which can be uncomfortable for patients and may interfere with their treatment. This study aimed to analyze the usage pattern of antiemetics, the compatibility of antiemetics with the emetogenic risk of combination chemotherapy, and the relationship between antiemetic dosage suitability and RINVR scores (Rhodes Index Nausea Vomiting and Retching). The RINVR instrument consists of 8 questions, which evaluates the duration, frequency, amount/volume, and stress related to nausea or vomiting. The study involved 30 patients and data were collected through telephone interviews and patient's medical records. Statistical tests using the independent T test showed mild nausea and vomiting (0-8) for both acute and delayed symptoms against the condition of post-chemotherapy. A normality of RINVR scores was tested and it was determined that the scores were not normally distributed (p<0.05). In bivariate analysis, it was found that the average RINVR scores for both acute and delayed symptoms did not show statistically significant differences (p>0.05). This suggests chemotherapy with emetogenic combination still causes nausea and vomiting even though appropriate antiemetics have been given.

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