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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Optimasi gelling agent dan humektan dalam formula gel antioksidan ekstrak daun pepaya (Carica papaya Linn.) menggunakan metode simplex lattice design Pratiwi, Puspa Dwi; Gusti, Diah Riski; Angraini, Resti Indah
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.430

Abstract

Papaya leaf (Carica papaya L.) have very strong antioxidant activity with IC50 value 21.08 ppm. C. papaya L. leaf can be formulated in gel preparation. The physical properties of gel and its effectiveness as an antioxidant can be affected by excipients, so it is necessary to optimize the formula. The aims of this research were to find the concentration of sodium carboxy methyl cellulose (Na-CMC) as gelling agent and glycerin as humectant to get optimal formula with the best physical properties and measure its antioxidant activity. Simplex lattice design (SLD) method was chosen for formula optimization with Na-CMC range 0.5-4% and glycerin 10-13.5%. The optimal formula was determined based on pH value, spreadability, stickiness and viscosity then determined for antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The results of this research were optimal formula with Na-CMC concentration 1.853% and glycerin 12.147%. The antioxidant activity of the optimal formula was decreased from the extract activity, with an IC50 value 21.08 ppm (very strong) to 61.70 ppm (strong). It can be concluded that the optimal formula for papaya leaf (C. papaya L.) extract gel preparation can be obtained with combination of Na-CMC and glycerin using the SLD method with strong antioxidant value.
Analisis cemaran mikroba pada daging ayam broiler di beberapa pasar tradisional di Kota Binjai Surbakti, Junaidi Lapiga; Purwosiswoyo, Purwosiswoyo; Putra, Andhika; Sinaga, Kurniawan
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.431

Abstract

Broiler chickens are a source of protein consumed by the wider community, have relatively affordable prices and are very common in traditional markets. The city of Binjai has a high level of demand for broiler chicken meat, so it is important to know the level of safety in consuming broiler chicken meat in terms of microbial contamination. This research aims to analyze microbial contamination in broiler chicken meat in several traditional markets in Binjai City. This research uses a descriptive method to determine the presence of bacterial contamination in broiler chicken meat. Research parameters include observation of the number of microbial colonies and analysis of Salmonella sp. microbial contamination. and E. coli. The research results showed that the number of microbial colonies in the three markets met SNI requirements and was negative in the Salmonella sp. contamination test but contamination occurred in the Escherichia coli contamination test.
Strategi efektif pencegahan nyeri saraf kejepit melalui gerakan senam yoga Sulaiman, Sulaiman
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.110

Abstract

Pinched nerve pain is a prevalent ailment among the populace of Indonesia. Many endured adversity between the ages of 30 and 45. In general, males exhibit a higher prevalence rate. Pain in the belly, groyne, and limbs is something that people who are impacted by this nerve will describe as being present. This study aimed to determine whether or not regular yoga acrobatics could alleviate nerve pain in patients suffering from nerve pain. Semi-experimental methods are employed in this study. Nerve pain affected sixty individuals who comprised the population of this study. Utilising purpose sampling as a sampling method. Regular yoga and gymnastics participation reduces nerve pain by 66.33 percent, in accordance with the results of this research. According to the findings of this study, participating in regular yoga practice results in a substantial reduction in nerve closures (p = 0.000).
Pengaruh variasi konsentrasi terhadap uji sifat fisik dan stabilitas freeze- thaw cycling pada formula sediaan gel kombinasi ekstrak daun kelor dan ekstrak daun jeruk nipis Juliana, Intan; Fatmawati, Annisa; Munir, Muhammad Abdurrahman; Emelda, Emelda; Rahmawati, Feti
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 1 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i1.188

Abstract

Moringa leaves are a major source of antioxidant compounds due to their high content in carotenoids, ascorbic acid, glucosinolates and other bioactives. Lime contains elements of useful chemical compounds, such as alkaloids, polysaccharides, flavonoids, and essential oils. This study aims to obtain a gel formula that is physically stable and stable during storage using the Freeze-Thaw Cycling method from Moringa leaf extract and lime leaf extract. This research is a laboratory experimental research. Gel preparation was carried out with varying concentrations of Moringa leaf extract and lime leaf extract F1 (75%:25%), F2 (50%:50%), and F3 (25%:75%). Testing the physical properties of the gel includes organoleptic, pH, homogeneity, viscosity, spreadability, adhesion and syneresis. The stability test carried out was a stability test using the Freeze-Thaw Cycling method for 3 cycles by observing the stability to be carried out where each cycle observed physical changes in the gel including organoleptic, homogeneity and pH. The results of gel preparations of the combination of ethanol extract of moringa leaves and lime leaves of formulations 1, 2, and 3 with differences in the concentration of the active substance were declared stable, because there was no significant change from organoleptic observations, homogeneity, pH, adhesion and spreadability. However, statistical tests stated that the 4℃ temperature adhesion test obtained a p value (<0.05) and a 40℃ temperature p value (>0.05), while the 4℃ and 40℃ temperature spreadability test obtained a p value (<0. 05).
Formulasi sediaan lotion poliherbal minyak alpukat (Persea americana) dan ekstrak seledri (Apium graveolens L) sebagai pelembab kulit Bylla, Salsa; Salman, Salman; Sari, Nurmala; Sihotang, Supran Hidayat; Indriana, Meutia
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.249

Abstract

Background: avocado oil contains vitamins A, D, E and lecithin. This content is efficacious to moisturise and regenerate the skin, and it is a natural sunscreen that protects the skin from UV rays. The flavonoid content in celery can neutralise free radicals and prevent premature aging. Then, this plant can be processed and used as a cosmetic preparation in the form of lotion. Polyherbs are cosmetic products that contain one or more herbal substances. This study aimed to determine whether avocado oil (Apium graveolens L) and celery (Persea americana) in polyherbal lotion preparation extracts can provide skin moisture. Methods: the method used is experimental by making celery extraction by maceration using 96% ethanol solvent and concentrated with a rotary evaporator and avocado oil as a combination lotion preparation of 1.5%, 2%, 2.5% and 3% concentrations. As blanks used lotion base. Tests on lotion preparations include homogeneity tests, pH measurements, determination of emulsion type, stability, irritation to volunteers, liking/hedonics, moisture effectiveness compared with existing preparations, using the Skin Analyzer Detector tool, and antioxidant activity tests. Result: the results of the study showed that all lotion preparations were homogeneous, had a pH of 6.2-5.9, emulsion type M/A and were stable during storage of 4 weeks. Lotion preparations of avocado oil and celery extract with a concentration of 3% can provide the best moisturising effect on the skin after 4 weeks. All polyherbal lotion preparations of avocado oil and celery extract do not irritate the skin; celery ethanol extract and avocado oil have antioxidant activity in the "medium" category with an IC50 value of 143 ppm. Polyherbal lotion preparations with a concentration of 3% show effectiveness as the best moisturiser.
Pengaruh ball milling pada dispersi padat ibuprofen dengan pembawa HPMC terhadap ukuran partikel dan kecepatan disolusi kapsul Nining, Nining; Gusmayadi, Inding; Romansyah, Febri
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 1 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i1.250

Abstract

One factor that greatly influences the active drug solubility is particle size. Ibuprofen is a non-steroidal anti-inflammatory that is poorly water-soluble, potentially slowing its drug dissolution. Milling is one way to reduce particle size and help to enhance drug dissolution. This research aims to study the milling process effect on the particle size of ibuprofen and the capsule dissolution rate. Micrometer-sized ibuprofen (P1) is processed to nanometer size using the wet-milling method for 15 hours (P2) and 20 hours (P3) using HPMC (Hydroxy Propyl Methyl Cellulose) as a stabilising polymer. All particles were evaluated for particle size, and FTIR was tested and formulated into capsules. The powder mass was evaluated for flow properties. Capsule evaluation was also carried out, which included a disintegration time test, weight uniformity test, and dissolution test. The three particles have sizes of 40.6 µm (P1), 438.9 ± 20.9 nm (P2), and 267.1 ± 4.1 nm (P3). FTIR test results show compatibility between ibuprofen and HPMC. The disintegration time test results and capsule weight uniformity met the compendial requirements. Based on the dissolution test, the three formulas showed significant differences (sig p 0.0002 < 0.05) in the per cent dissolution. Obtained Q60 F1-F3 respectively were 99.61 ± 8.75%; 110.03±5.97%; and 115.95 ± 3.34%. The conclusion obtained is that the milling process has a significant effect on the dissolution percentage of ibuprofen.
Analisis pengaruh pelayanan IGD terhadap kepuasan pasien di rumah sakit Omni Cikarang tahun 2021 Safuranti, Aristya Maulida; Fitriani, Arifah Devi; Nasution, Ramadhani Syafitri
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 1 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i1.256

Abstract

Background: The Emergency Room (IGD) is one of the service units in hospitals that provides first aid. Emergency services provided must meet good service quality. Patients are satisfied with the services of nurses in the ER if the patient's expectations are met. According to WHO, health systems should strive to make improvements in six areas or dimensions of quality. Objectives: To analyze the effect of emergency services on patient satisfaction at OMNI Cikarang Hospital in 2021. Method: This type of research is an analytical survey method with a cross sectional approach. The research was carried out at OMNI Cikarang General Hospital. The population of this study were emergency room patients with the number of samples in this study as many as 92 people through the calculation of the slovin formula. Sampling using accidental sampling technique. Data analysis used univariate, bivariate and multivariate analysis. Results: Showed that the respondents who were satisfied were 40 people (43.5%) and 52 people (56.5%) were not satisfied with the emergency room service. The results of the chi-square statistical test showed that the variables of effectiveness, efficient, accessible, acceptable, impartial and safe had an influence on patient satisfaction with a p value of <0.05. Simultaneous test results showed that the effectiveness factor was the most dominant factor influencing patient satisfaction in the OMNI Cikarang Emergency Room. Conclusion: There is an effect of effectiveness, efficiency, access, acceptable, impartial and safe has an effect on patient satisfaction in the ER OMNI Cikarang. It is recommended to health workers to always improve better services in order to increase patient satisfaction as users of health services.
Efektivitas latihan range of motion (ROM) terhadap gangguan otot pada pasien stroke di lingkungan desa Kotasan Galang Butar-butar, Maria Haryanti; Saputra, Heri; Bangun, Herianto; Zebua, Arianus; Maryanti, Endang
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.264

Abstract

Background: Stroke sufferers suffer from unmovable muscle disorders that are the result of cerebral bleeding. muscle contractions necessary to perform daily activities and a decrease in blood supply to the brain as a result of stroke. Objective: function of the musculoskeletal system with the effectiveness of a range of motion training (ROM) against muscle disorders in stroke patients in the neighborhood of Kotasan Galang village. Methods: The research type is quasi-experimental, using one-group pretest and posttest design approaches. The research intervention was by doing ROM exercises. (Range of motion). The population of stroke patients who experienced muscle disorders of patients using Wilcoxon's trial was 22 patients. Result: Muscle disorders before and after performing the ROM action obtained the minimum muscle disorder value on scale 2 and the maximum muscle disturbance value on scale 4 with an average of 3.20. Conclusion: There is the effectiveness of range of motion (ROM) exercises against muscle disorders in stroke patients in the neighborhood of Kotasan Galang Village.
Uji aktivitas antibakteri ekstrak etanol dan berbagai fraksi daun rimbang (Solanum torvum Swartz) terhadap Bakteri staphylococcus aureus. Sari, Devi Purnama; Kusumastuti , Melati Yulia; Safriana, Safriana
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.281

Abstract

Traditional medicine is now seen as an opportunity for modern medicine because it is considered safer and believed to have complementary or synergistic effects, making traditional medicine beneficial. Rimbang leaves (Solanum torvum Swartz) are plants that can be utilized in traditional medicine. This study aims to determine whether ethanol extracts and various fractions of rimbang leaves have antibacterial activity against Staphylococcus aureus bacteria. Phytochemical screening results show that ethanol extract and ethyl acetate fraction of rimbang leaves contain secondary metabolites including alkaloids, flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides. The ethanol fraction consists of alkaloids, flavonoids, saponins, and glycosides, while it does not include steroids/triterpenoids. The n-hexane fraction only contains alkaloids and steroids/triterpenoids. The antibacterial activity against Staphylococcus aureus at a dose of 500 mg/ml shows that ethanol extract has an average inhibition zone of 14.83 mm, ethyl acetate fraction has an average of 21.67 mm, and ethanol fraction has an average inhibition zone diameter of 8.17 mm.
Efek antidiabetes minuman GEMAR (Germinated Black Rice) pada tikus model diabetes melitus Pasaribu, Sudana Fatahillah; Chandra, Putra; Irwanto, Reno; Anggraini, Citra Dewi; Herviana, Herviana
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.315

Abstract

Type 2 diabetes mellitus (T2DM) is a degenerative disease caused by increased blood glucose levels. Therapeutic recommendations for treating T2DM are the implementation of healthy lifestyle and pharmacological interventions. Germinated Black Rice contain high levels of fiber, anthocyanins and flavonoids. Functional beverage products Germinated Black Rice (GEMAR) is expected to help improve blood glucose levels and body weight in T2DM sufferers. This study aims to analyze the effect of beverage GEMAR at doses of 3.8 and 7.6 g/200 gBW on fasting blood glucose and body weight in T2DM rats. Laboratory experimental research method with design pre-posttest control group design. Samples of 30 male Wistar rats were divided into 5 groups. The results of the study found that the fasting blood glucose (GDP) of the acarbose drug group, P1 (GEMAR 3.8 g/200 g BW) and P2 (GEMAR 7.6 g/200 g BW) were significantly different (p<0.001) compared to the negative control group. GDP reducing effect of acarbose drug treatment (148%), P1 (177%), and P2 (128%). Body weight in the acarbose, P1 and P2 drug groups were significantly different (p<0.001) compared to the negative control. The improved effect of the drug groups acarbose (4%), P1 (7%), and P2 (5%) compared with adaptation. This research concludes that GEMAR P1 and P2 functional beverage can reduce GDP levels and improve body weight T2DM rats.

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