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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Formulasi sediaan pelembab bibir mengandung ekstrak kulit buah pisang raja (Musa paradisiaca L) Siregar , Runisya Maugin Utami; Yuniarti, Rafita; Lubis, Minda Sari; Nasution, Muhammad Amin
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.674

Abstract

Lip balm is a care product that can keep your lips moist, which is a type of ointment used to treat dry and chapped lips. The benefit of using lip balm for lips is to regulate lip moisture. Lip balms are generally clear or colorless, although recently colored variants have also been created. To find out whether the extract of plantain peel (Musa paradisiaca L) can be formulated in the form of lip balm preparations. The purpose of this study was to determine whether lip balm preparations could be used as moisturizers. To find out lip balm preparations well made and of good physical quality. This research method is experimental. Collection of plants was carried out purposively, ie without comparison with other areas. The sample used was the skin of fresh ripe plantains obtained from the Simpang Limun market in Medan. This study included quality inspection preparations, moisture effectiveness test preparations, irritation tests on formulations and hedonic tests on variations in preparations made. The results of this study indicate that extracts of plantain peel (Musa paradisiaca L) with concentrations of 1%, 3%, 5%, 10%, and 15% can be formulated in the form of lip balm preparations. Formula 5 with a concentration of 15% showed the best lip balm preparation by fulfilling the requirements for physical quality, effectiveness and safety. With a preference value of 5 (like very much), has a melting point of 57'C and has a pH of 5.9 so it does not cause skin irritation and is stable at room temperature storage for 28 days. Lip balm preparations made using cocoa butter base are safe to use and meet the standards..
Review : Identifikasi senyawa bioaktif utama dalam daun leilem (Clerodendrum minahassae) dan potensi farmakologis Sambou , Christel
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.696

Abstract

Clerodendrum minahassae leaves contain various bioactive compounds, including flavonoids, alkaloids, saponins, and phenolic acids, contributing to their pharmacological activity. This study aims to identify the main bioactive compounds in Leilem leaves (Clerodendrum minahassae) and their pharmacological potential through a literature review of various relevant scientific sources. The methodology employed includes systematic observation and meta-analysis. This review article describes the compounds present in Leilem leaves and evaluates their pharmacological activities, thereby enhancing the understanding of this underexplored medicinal plant. The findings indicate that Leilem leaves hold substantial potential as a source of bioactive molecules with diverse pharmacological properties. Based on a review of multiple scientific research articles, it can be concluded that Leilem leaves exhibit considerable efficacy in antimicrobial, anti-inflammatory, and antioxidant activities, as well as in reducing blood glucose levels.
Formulation of nanocream whitening preparation from a combination of yam starch (Pachyrhizus erosus L.) and rice starch (Oryza sativa L.) Nur, Hijrotun; Dalimunthe, Gabena Indrayani; Rani, Zulmai; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.698

Abstract

Whitening cosmetics have become a popular choice in modern society, with the perception that beauty is associated with white skin. The high market demand is an opportunity for cosmetic business actors but it also increases the risk of illegal cosmetic production containing hazardous materials such as hydroquinone. One of the cosmetic ingredients that is often found in whitening creams containing hydroquinone, which is effective in removing dark spots, has the risk of serious side effects. Therefore, it is advisable to find a safe, natural alternative for long-term skin whitening. Jicama starch and rice water starch are natural choices for whitening cosmetics. Nanoparticle-based cosmetics are superior to micro-scale cosmetics. The objective of the research was to determine whether a combination of jicama starch and rice water starch whitening cream can meet the characteristic requirements of a nano cream, to determine all concentrations of jicama starch and rice water starch whitening nano cream that meet the physical quality requirements and to determine all concentrations of jicama starch and rice water starch whitening nano cream have different effectiveness. This research method was True Experimental with Post Test Only Control Group Design research design. The independent variables are variations in the concentration of yam starch and rice water starch. The dependent variables were sample characteristics, characteristics of the whitening nano cream formulation and nano cream effectiveness test. The results showed that yam starch and rice water starch had effectiveness as whitener with a concentration of f3 (5:5) water content of 55.67%, sebum of 16% and pigment of 15.67%. The whitening cream met the characteristics of a nano cream with particle sizes of f0: 134.04, f1: 1849.20, f2: 147.64 and f3: 188.14 nm. Yam starch and rice water starch in the preparation of the whitening nano cream meet the physical quality requirements.
Analisis kuersetin pada ekstrak benalu teh (Scurrula oortiana Dans.) secara kuantitatif Silvyana, Annysa Ellycornia; Reubun, Yonathan Tri Atmodjo; Warti, Lia; Simangunsong, Lidia Octaviani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.575

Abstract

Indonesia has a variety of plants that are useful as medicine. One is the Tea Mistletoe plant (Scurrula oortiana Dans.). This plant contains flavonoid compounds that are effective as antioxidants, especially in the form of quercetin. Quercetin in the tea mistletoe plant can prevent cell damage caused by free radicals, where cells need this antioxidant to avoid the harmful effects of excessive reactive oxygen species (ROS) production and prevent damage to immune cells. This study aims to analyze the levels of quercetin in Tea Mistletoe extract using quantitative analysis methods such as thin-layer chromatography and UV-Vis spectrophotometry. Tea Mistletoe powder was extracted by maceration with 96% ethanol solvent and then concentrated using a rotary evaporator and water bath. The thick extract obtained was then tested for phytochemical screening and specific and non-specific parameters. Analysis of flavonoid quercetin compounds was carried out using a thin layer chromatography method using a mobile phase of a mixture of chloroform, ethyl acetate, and n-butanol with a ratio of 5:4:1 and a stationary phase of Silica Gel GF₂₅₄. Determination of flavonoid levels was carried out using UV-Vis spectrophotometry at a wavelength of 428 nm. The results of this study indicate that the Mistletoe Tea plant contains flavonoids, alkaloids, steroids, tannins, saponins, phenolics, and glycosides. All test parameters meet the specified requirements. The thin layer chromatography test showed the Rf value of the Mistletoe Tea extract of 0.78. The linearity test showed a correlation value (r) = 0.9988 with a total flavonoid compound content of 372.250 mg QE/g extract, or a percentage of 37.225%.
Analisis efektivitas biaya dan profil penurunan kadar glukosa darah penggunaan metformin dan glimepirid pasien diabetes melitus tipe 2 di RSUD R. Syamsudin, SH. Honifa, Honifa; Rokhmah , Nisa Najwa; Zunnita, Oktaviana; Elina, Elina
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.600

Abstract

Hyperglycemia caused by abnormalities in insulin secretion and insulin function is a hallmark of a metabolic disorder known as diabetes mellitus (DM). The choice of alternative medications for DM varies significantly, making it essential to consider cost to ensure that the selected drug remains affordable while providing the best therapeutic effect. The purpose of this study is to examine the glucose-lowering profile and identify the most cost-effective antidiabetic drug for use in type 2 diabetes patients in the outpatient unit at RSUD R. Syamsudin, SH. Kota Sukabumi. This non-experimental study uses a descriptive design by reviewing the medical records of outpatients from the pharmacy department. Random blood glucose levels and medication costs are the parameters used. The results of the study showed that the use of the antidiabetic drug glimepiride, which is the most cost-effective drug for type 2 diabetes mellitus patients, demonstrated an average blood glucose reduction of 26.92% for patients using metformin and 22.97% for patients using glimepiride.
Uji penghambatan enzim α-glukosidase ekstrak etanol daun karas tulang (Chlorantus erectus) Arly Syahputri , Janies; Haryoto, Haryoto
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.642

Abstract

Karas tulang plant (Chloranthus erectus) is a medicinal plant that has been used in several areas such as China and Southeast Asia. There has been no research regarding the potential of bone karas leaves as an antidiabetic through inhibiting the α-glucosidase enzyme from the ethanol extract of bone karas leaves. Inhibition of the α-glucosidase enzyme can work due to the presence of phytochemical compounds, such as flavonoids, saponins, tannins and quinones. This is because the phytochemical compounds contained therein can act as antidiabetic agents to prevent hyperglycemia in diabetes sufferers. This research aims to identify chemical compounds and the activity of the α-glucosidase enzyme in the ethanol extract of leaves contained in karas bone leaves. The thin layer chromatography method was used to screen phytochemical chemicals for alkaloids, flavonoids, saponins and tannins. The ELISA reader 405 nm method was used to test the inhibition of the α-glucosidase enzyme. The substrate used was p-NPG while the comparison used was acarbose tablets. The results of this research were that the IC50 value for the extract was 30.541 ????g/mL while for acarbose it was 3.873 ????g/mL. From these results it can be concluded that the inhibitory power of the α-glucosidase enzyme is in the active category, while that of acarbose is in the very active category.
Formulasi dan uji sifat fisik granul effervescent ekstrak kunyit asam (Curcuma longa-Tamarindus indica). Kautsari, Farah Widya; Emha, Maulida Rahmawati
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.669

Abstract

Empirically, turmeric tamarind is used to relieve pain and inflammation and ease menstrual cramps. However, conventional herbal preparations are currently less popular, especially among teenagers. Effervescent turmeric tamarind formulations are an innovative, practical pharmaceutical preparation with the advantage of a pleasant taste, which helps disguise the bitter flavor of turmeric. This product also provides a refreshing effect due to the acid-base reaction that produces carbon dioxide (CO2). This study aims to evaluate the physical test of effervescent turmeric tamarind granules. This experimental study formulates three turmeric-tamarind effervescent granule formulas by varying the turmeric extract dosage (Curcuma longa) to 250 mg, 500 mg, and 750 mg. The evaluations performed include organoleptic tests, water content, flow properties and angle of repose, dissolving time, and pH testing. The results showed that turmeric extract (Curcuma longa) and tamarind (Tamarindus indica) can be formulated into effervescent granules—the three formulas with different variations of turmeric extract produced good physical quality test results. Variations in the concentration of turmeric extract did not affect the physical quality of the granules.
Formulasi masker wajah serbuk nano teh celup bekas dan aktivitas antibakteri terhadap Propionibacterium acnes dan Staphylococcus epidermidis Matondang , Fikriyah Hafni; Lubis, Minda Sari; Yuniarti , Rafita; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.685

Abstract

The increase in the cosmetic industry has caused a variety of facial mask products to circulate on the market, making it difficult for consumers to find one that suits their skin condition. Masks from well-known brands are easy to get, but some cause skin problems. Since ancient times, Indonesians have used plants as medicines and cosmetic ingredients for skin care. Tea can be processed into new active ingredients such as antioxidants, antibacterials, and anti-aging for cosmetics. Nanoparticle-based cosmetics are superior to micro-scale cosmetics. The objective of the research was to determine whether used tea bag powder meets the characteristic requirements as nanopowder, to determine whether used tea bag nanopowder in facial mask preparations meets the physical quality requirements, and to determine whether used tea bag nano powder facial mask preparations has antibacterial activity against Propionibacterium acnes and Staphylococcus epidermidis. This research method was true experimental with post test only control group design research design. The independent variables are tea bag powder and nanopowder and powder face mask formulation variations. The dependent variables are the characteristics of the simplicia, secondary metabolites, nanopowder characteristics, powder face mask formulation, and antibacterial activity test. The results showed that tea bag powder and nanopowder contained alkaloid, steroid, flavonoid, saponin, and tannin compounds. The inhibitory activity of the used tea bag nano powder mask on Propionibacterium acnes was 11.3 mm on Staphylococcus epidermidis, which was 11.2 mm. The tea bag powder used meets the characteristics of a nanopowder with a particle size of 684 nm. I used a tea bag nanopowder to prepare a face mask that meets the physical quality requirements.
Pembuatan nanoekstrak dari kulit buah jeruk kasturi (Citrus microcarpa) dan formulasinya sebagai pasta gigi Hasibuan , Fika Miah Sasmitha; Dalimunthe, Gabena Indrayani; Lubis , Minda Sari; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.694

Abstract

Dental caries is a common oral health problem among the Indonesian population, and its primary cause is the bacterium Streptococcus mutans. The peel of the Kasturi orange (Citrus microcarpa) fruit has been known to contain antibacterial properties, which may help prevent the occurrence of dental caries. This study aims to evaluate the toothpaste formulation with the active ingredient of nano-extract from kasturi orange peel (Citrus microcarpa). The extract of Kasturi orange peel was obtained through a maceration method, followed by phytochemical screening that identified the presence of flavonoids, steroids, alkaloids, saponins, glycosides, and essential oils. The extract was then processed into a nano-extract, and its particle size was measured using a Particle Size Analyzer (PSA) with a dynamic light scattering technique. The nano-extract was formulated into toothpaste at concentrations of 7.5%, 10%, and 12.5%, and its antibacterial activity was tested. Physical evaluations showed that the toothpaste maintained its shape, color, odor, and taste during storage, was homogeneous, had a pH within the acceptable range (4.5–10.5), viscosity within the required range (20,000–50,000 cps), and passed organoleptic testing (color, aroma, taste, and texture) on respondents.
Kandungan protein tempe kedelai yang berbeda bahan pengemas primer dan parameter penyimpanan Pujiastuti, Nurkholifah; Santoso, Broto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.718

Abstract

Soybean tempeh products are in great demand by most Indonesian people. The most of producers use plastic as packaging material, but some of them use natural materials such as banana leaves and teak. Soybean tempeh packaged with leaves is more popular with the public than plastic because it has a distinctive aroma and a savory taste. This study aims to determine the differences in protein content in soybean tempeh with different primary packaging materials with raw soybeans as a comparison. The three tempeh packages were produced using raw soybeans and under the same conditions. The protein content of the samples was determined by the Lowry reaction at a wavelength of 748.5 nm. This method has been determined for its validity through repeatability, linearity, and accuracy tests. Together with raw soybeans, samples that had been stored in the freezer were measured for their protein content at two different times. The Lowry method used is valid because all parameters have met the acceptance requirements where r2 linearity = 0.9954-0.9972 (> 0.9950); %RSD repeatability = 0.291-0.768 (<2%); and %recovery accuracy = 98.769-101.118% (80-120%). The average results of the protein content of raw soybeans, plastic-packaged soybean tempeh, banana leaves, and teak leaves on the 11th day were 5.531-7.967% while on the 35th day it was 5.881-7.972%. The results of the One-Way ANOVA statistical test with sig = 0.0001 (p <0.05) so it can be said that there is a significant difference between soybean tempeh with different primary packaging materials.

Page 36 of 66 | Total Record : 654

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