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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Penentuan konsentrasi hambat minimum dan konsentrasi bunuh minimum ekstrak dan nanopartikel ekstrak daun pepaya (Carica Papaya L.) terhadap Bakteri Cutibacterium acnes Khofifah , Nur; Rahayu, Yayuk Putri; Nasution , Haris Munandar; Miswanda, Dikki
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.720

Abstract

One of the skin diseases that often occurs is acne (Acne vulgaris). Acne is caused by the activity of the Cutibacterium acnes bacteria. Current acne treatment still depends on the use of antibiotics, but long-term use of antibiotics can cause bacterial resistance. Therefore, it is necessary to develop alternative treatments for acne that are effective and safe, one of which is by using medicinal plants. One plant that has potential is papaya leaves (Carica papaya L.). This research aims to determine the minimum inhibitory concentration (MIC) and minimum killing concentration (KBM) of ethanol extract and papaya leaf extract nanoparticles as well as testing antibacterial activity against Cutibacterium acnes bacteria. The research was carried out experimentally. The independent variables are the concentration of papaya leaf extract (6.25% concentration, 12.5% ​​concentration, 25% concentration and 50% concentration), and the concentration of papaya leaf extract nanoparticles (0.625% concentration, 1.25% concentration, 2.5% concentration % and Concentration 5%). The dependent variable is the antibacterial activity of papaya leaf ethanol extract and nanoparticles extract against Cutibacterium acnes. Characterization of the size of the extracted nanoparticles using a Particle Size Analyzer (PSA). The characteristic results for the extract size were 2,203.45 nm while the size of the extract nanoparticles was 330.27 nm. The minimum inhibitory concentration (MIC) value of 1.25% papaya leaf ethanol extract nanoparticles is better than 12.5% ​​papaya leaf ethanol extract, and the minimum lethal concentration (KBM) value of 5% papaya leaf ethanol extract nanoparticles is better than papaya leaf ethanol extract 50% against Cutibacterium acnes bacteria. 5% papaya leaf ethanol extract nanoparticles have the same antibacterial ability as 50% papaya leaf ethanol extract and are sensitive to Cutibacterium acnes bacteria, so it can be said that 5% papaya leaf ethanol extract nanoparticles can reduce the dose concentration of antibacterial compounds up to one-tenth of the time compared to ethanol extract papaya leaves 50% (1:10)
Formulasi eyeshadow kombinasi umbi bit (Beta vulgaris L.) dan rimpang kunyit (Curcuma longa L.) dalam perbandingan ekstrak dan nanoekstrak Sihotang, Laura Indah Restu; Dalimunthe, Gabena Indrayani; Lubis , Minda Sari; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.723

Abstract

Eyeshadow is an eye cosmetic that contains coloring agents to color effects and change the appearance. Some eyeshadow products use synthetic dyes that have a negative impact, so it is important to use safe dyes such as beetroot to produce a red color and turmeric rhizome to produce a yellow color. Turmeric rhizome yellow color. Nanoparticle-based cosmetics have advantages and can penetrate cell walls more effectively. This study aims to determine whether beetroot and turmeric rhizome extracts meet the requirements of nano extracts. Nano extracts determine the color difference at each concentration in the extracts and nano extracts as colorants for eyeshadow preparations, and choose the color of the extracts and nano extracts in eyeshadow preparations with certain concentrations that can meet the physical quality and favored by panels. This research method is True Experimental, and the research design used is a post-test-only control group design. The research design used was a post-test-only control group design. Independent variables are variations in the concentration of the combination of extracts and nano extracts of beetroot and turmeric rhizomes and eyeshadow formulations of various concentrations. Turmeric rhizome and eyeshadow formulations of multiple concentrations. The dependent variables are simplicity characteristics, phytochemical screening, particle uniformity characteristics, nano extract, and various tests. Nano extracts and various physical quality inspection tests of eyeshadow. The results showed that the beetroot and turmeric rhizome extracts met the requirements of nanoextracts with a particle size of beetroot 261 nm and turmeric rhizome 203 nm. Eyeshadow preparations containing a combination of beetroot and turmeric rhizomes in extracts and nano extracts have different colors: F1 is pink, F2 is light brown, F3 is Salem peach, F4 is peach pink, F5 is brown, and F6 is Salem pink. All eyeshadow preparation formulas meet the physical quality requirements, and F5 and F6 are the most preferred formulas for volunteers because they provide attractive colors.
Evaluation of the Implementation of Clinical Pharmacy Services at Kupang City Pharmacy Based on PERMENKES RI Number 73 of 2016 Patty, Yohana Febriani Putri Peu; Parwati, Dian
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.692

Abstract

Clinical pharmacy services in pharmacies are one of the responsibilities that pharmacists must perform. Some of the clinical pharmacy service activities contained in the applicable pharmaceutical service standards are prescription service assessment, dispensing, Drug Information Services (PIO), Counseling, Drug Therapy Monitoring (PTO), Monitoring Drug Side Effects (MESO). The purpose of this study was to determine the suitability of the implementation of clinical pharmacy services in the Kupang City Pharmacy area against the Regulation of the Minister of Health of the Republic of Indonesia Number 73 of 2016. This research method was carried out descriptively with a cross-sectional method. Sample selection was carried out by purposive sampling involving 10 pharmacies that met the inclusion criteria. Data collection was carried out using the interview method using an interview guideline sheet. The results showed that the implementation of clinical pharmacy services in 10 pharmacies in the aspect of reviewing prescription services was 100% (in accordance with the SPKA), the dispensing aspect was 100% (in accordance with the SPKA), the Drug Information Service (PIO) aspect was 100% (in accordance with the SPKA), the counseling aspect was 60% (not in accordance with SPKA). The home pharmacy care aspect, the Drug Therapy Monitoring (PTO) aspect and the Monitoring of Drug Side Effects (MESO) aspect was 100% not implemented by all pharmacy. Conclusion pharmacies in Kupang City have not fully implemented clinical pharmacy services based on the Regulation of the Minister of Health of the Republic of Indonesia Number 73 of 2016.
Formulasi sediaan patch dari ekstrak etanol daun laban (Vitex pinnata L.) sebagai antiinflamasi Rahmi , Ulfa; Dalimunthe, Gabena Indrayani; Yuniarti , Rafita; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.749

Abstract

Laban leaves (Vitex pinnata L.) contain flavonoids, saponins, tannins, and steroids, which have anti-inflammatory potential. This research aims to formulate laban leaves into an anti-inflammatory patch preparation for the back skin of mice induced by 3% carrageenan. Laban leaf simplicia was extracted using the maceration method using 96% ethanol, and patch preparations were made with varying extract concentrations of 5, 7.5, and 10%. The patch preparation is tested organoleptic, pH, weight uniformity, patch thickness, patch moisture, patch crease resistance, and irritation. The anti-inflammatory activity of the patch preparation was analyzed using the inflammatory associate edema method, namely measuring the anti-inflammatory effect using a caliper and 25 test animals, which were divided into 5 groups, namely negative control, positive control, and treatment group with a concentration of 5; 7.5; and 10% with 5 individuals each. The results of several tests that have been carried out are analyzed using the one-way ANOVA program. The results show the anti-inflammatory activity of laban leaves. There was no difference in the percentage of edema inhibition data on the back skin of mice between treatment groups. This shows that the anti-inflammatory patch preparation of Laban leaf extract (Vitex pinnata L.) has anti-inflammatory activity. The formula that provides the most potent anti-inflammatory activity is a patch preparation with an extract concentration of 10%. With an edema inhibition percentage of 59%. 
Penetapan kadar flavonoid total ekstrak etanol 70% dan ekstrak etil asetat daun sambung nyawa (Gynura procumbens (Lour)Merr.) secara spektrofotometri UV-Vis Rahmadani , Adevika; Ridwanto, Ridwanto; Daulay , Anny Sartika; Nasution , Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.751

Abstract

Sambung nyawa leaves (Gynura procumbens L.) are a simplicia with various medicinal properties. One of the chemical compounds in sambung nyawa leaves that plays a crucial role in treatment is flavonoids. Flavonoids in sambung nyawa leaves have benefits as antihypertensive, antioxidant, antihyperglycemic, and anti-inflammatory agents. Different drying methods for simplicia affect the total flavonoid content in the extract.The stages of this research included plant material processing, the preparation of ethanol and ethyl acetate extracts, characterization tests, phytochemical screening, and the determination of total flavonoid content in the ethanol extract and ethyl acetate extract of sambung nyawa leaves using visible spectrophotometry. The extracts of sambung nyawa leaves were made using the maceration method with 70% ethanol and ethyl acetate, and the obtained extracts were concentrated using a rotary evaporator. Total flavonoid content was then determined using visible spectrophotometry. Phytochemical screening of the ethanol and ethyl acetate extracts of sambung nyawa leaves revealed the presence of chemical compounds such as alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The total flavonoid content in the ethanol extract was found to be 6.5149 ± 0.0314 mcg/g of sample, while the ethyl acetate extract had a total flavonoid content of 77.6695 ± 0.1199 mcg/g of sample.
Perbandingan aktivitas antidiabetes ekstrak air dan etanol Muntingia calabura L Folium terhadap mencit jantan Pangondian, Aswan; PS, Nurunnisa; Husein, Saddam; Umaya, Chindy; Athaillah, Athaillah; Chandra, Putra
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.461

Abstract

Muntingia calabura L is an Indonesian herbal plant known as kersen which has the ability to reduce blood sugar levels. M. Calabura has secondary metabolites, namely flavonoids, tannins, triterpenoids, saponins and polyphenols. This study aimed to compare the antidiabetic activities of water and ethanol extracts of M. calabura in male mice. In this study, M. calabura was extracted using the maceration method with 70% ethanol solvent (EEMC) and decoction of Kersen leaves (EDMC). Blood glucose levels were measured at intervals of 15, 30, 45, and 60 minutes using a glucometer after being induced by alloxan induction. Animals were divided into eight groups (positive group, negative group and EEMC group, and EDMC group with doses of 125, 250 and 500 mg/kg BW. The results of the investigation showed that the activity to reduce blood glucose levels during the interval time was significantly different compared to the negative group, and positive control was not significantly different compared to the EEMC 250 mg/kg BW and EDMC 500 mg/kg BW groups. The conclusion of this study was that the EEMC and EDMC groups had decreased blood glucose levels. EEMC 250mg/kg BW and EDMC 500 mg/kg BW groups showed comparable activity to the positive control.
Formulasi hand cream antibakteri berbasis kitosan dan ekstrak daun putri malu (Mimosa pudica L.) Fendy, Fendy; Suryawan, Chinesia Prastialin; Fadila, Rina Fitriana; M.Saad, Nabilatul Rafi’ah; Mubayyinah, Hamidatul; Darmawan, Noviyan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.576

Abstract

CoronaVirus Disease 2019 is a respiratory disease caused by Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) which is transmitted through the air and droplets of fluid. One of the health protocols recommended by the World Health Organization (WHO) is washing hands. Hand-washing activities have limitations because not all places provide them, so the alternative that has been circulating in the community is hand sanitiser. However, the alcohol content and synthetic antibacterials cause dry and irritated skin. The purpose of this study was to create an antibacterial hand cream from putri malu leaf as a utilization of wild plants. Putri malu leaf extract and chitosan were made in the form of nanoparticles, and then an evaluation of the physical characteristics of the hand cream preparation was carried out in the form of pH, organoleptic, homogeneity, and stability observed for 14 days. The antibacterial activity of putri malu leaf extract and hand cream was tested against S. aureus and E. coli. The particle size obtained was 1529.5 ± 42.5 nm. The results of the physical characteristics obtained were pH 6.15; dark orange, odourless, stable at room temperature, and high homogeneity. Antibacterial testing of putri malu leaf extract against S. aureus produced an inhibition zone of 10.27 mm at a concentration of 25% and antibacterial hand cream produced inhibition zones of 23.18 mm and 12.22 mm with an extract concentration of 10% so both are classified as strong antibacterials that are effective against S. aureus and E. coli bacteria.
Efektivitas kinerja pengawasan obat dan makanan di wilayah kerja Balai Besar Pengawas Obat dan Makanan di Bandung Aristawidya, Levina; Zuhrotun , Ade
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.593

Abstract

The increasing demand for drugs and food will have an impact on the production and distribution of drugs and food which is increasingly widespread. The widespread distribution of drugs and food has caused public health problems related to quality and safety that do not meet standards, so that it is necessary to increase drug supervision both pre-market and post-market by the National Agency of Drug and Food Control (NADFC). Therefore, this article aims to determine the effectiveness of the monitoring performance of drug and food production and distribution facilities carried out by one of the Technical Implementation Units of Indonesia NADFC, namely Balai Besar POM in Bandung The method used in this article is descriptive qualitative using primary data from performance reports from the Balai Besar POM in Bandung from years 2020 to 2023. Based on the achievement of performance indicators, the implementation of supervision activities for drug and food production and distribution facilities by the POM Center in Bandung is considered quite effective as evidenced by the Performance Achievement Value which is always above 100% from year to year. The overall achievement value and performance efficiency from 2020 to 2023, respectively, include 104.66%; 101.38%; 107.60%; and 103.82%. However, if we look closely at the realization value per indicator each year, there are several indicators that have not reached the 2020-2024 strategic plan target so that further efforts are needed to improve and maximize the performance achievement value. These efforts can be successful if accompanied by collaboration and synergy of all stakeholders so that the public receives quality and safe drug and food products according to standards.
Karakteristik pasien dan rasionalitas penggunaan obat demam berdarah dengue pada pasien anak rawat inap Lubis, Salmah Handayani Lubis; Dasopang, Eva Sartika; Siahaan , Desy Natalia; Hasanah, Fenny; Ndruru, Mei Kasih Murni; Aisyah , Teti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.633

Abstract

Dengue hemorrhagic fever (DHF) is an infectious disease that can affect children. The main principles of DHF treatment are supportive therapy that can reduce mortality to less than 1%, and maintenance of circulating fluid volume.  This study aims to determine the distribution of the proportion of DHF patients in children based on age, gender, clinical symptoms and the rationality of the use of DHF drugs in pediatric patients treated at Dr. Pirngadi Medan Hospital. This study was a descriptive nonanalytic study with a case study design. The population data in this study were all medical records of pediatric patients diagnosed with DHF who were treated in the period of 2022 at RSUD Dr. Pirngadi Medan.  This study concluded that most pediatric DHF patients were female (47.6%), age 0-35 years (42.7%), clinical symptoms of fever (82%), fever duration of 4 days (82.9%). The most common complaints of pediatric DHF disease were fever (100%), vomiting (81%), nausea (75%). In evaluating the rationality of drug use in the correct dose of analgesic and antipyretic paracetamol administration was obtained 100% (correct dose) and the administration of lactated ringer fluid 85.36% (not correct dose).
Penilaian densitas kolagen pada luka bakar derajat II tikus putih (Rattus norvegicus) yang diterapi dengan krim ekstrak daun melinjo (Gnetum gnemon L.) Srimaryanto, Leonardo Reza; Hidajati , Nove; Triakoso , Nusdianto; Herupradoto, Eduardus Bimo Aksono; Lazuardi, Mochamad; Setiawan, Boedi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.680

Abstract

Second-degree burns are complex traumatic conditions requiring optimal tissue healing interventions. This experimental study investigated the impact of Gnetum gnemon L. leaf extract cream on collagen density in burn wounds. The research was conducted using 20 male Wistar rats (Rattus norvegicus), divided into five groups: negative control, positive control (silver sulfadiazine), and three treatment groups with varying leaf extract concentrations (2.5%, 5%, and 10%). Burn induction was performed on the right gluteal area using a thermostat at 85°C for 5 seconds. Collagen density was evaluated through histopathological analysis using ImageJ with density scores ranging from 0 to 4. Research results demonstrated significant collagen density increases in treatment groups, with the 10% concentration displaying the highest density (score +4). Significant differences between groups were confirmed by statistical analysis (p<0.05). Findings indicate the potential of Gnetum gnemon L. extract as an alternative therapy for improving burn wound healing through collagen density optimization.

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