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Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 24606065     EISSN : 25483013     DOI : 10.15408/jkv
Core Subject : Science,
Chemistry
Jurnal Kimia Valensi is a biannual and peer-reviewed open access journal published by Department of Chemistry, Faculty of Science and Technology UIN Syarif Hidayatullah Jakarta. This journal covering all aspect of chemistry.
Arjuna Subject : Umum - Umum
Articles 425 Documents
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Synthesis of Antibacterial Coating Film Based on Eugenol-Allyl Eugenol Copolymer with Chitosan-Gelatin Ngadiwiyana, Ngadiwiyana; Dzahabiyyah, Hana Putri; Ismiyarto, Ismiyarto; Sarjono, Purbowatiningrum Ria
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.40944

Abstract

The development of coating film materials based on biopolymers and active antibacterial compounds has attracted attention in the food industries. Food packaging biopolymers can be increased antibacterial properties by adding compound modification of natural ingredients such as eugenol-allyl eugenol copolymer (PEAE). The aims of this study were to synthesize a coating film based on chitosan-gelatin with PEAE and test its antibacterial properties. PEAE synthesis was carried out by polymelirization reaction with the (BF3O(C2H5)2) as catalyst and characterized by FTIR, molecular weight, and solubility. Synthesis of chitosan-gelatin coating films with variations in PEAE concentration of 1.25%, 2.5%, and 3.75% and characterization includes FTIR, SEM, TS, E%, and contact angle. Antibacterial activity is carried out by the turbidimetry method. PEAE was synthesized with the results in the form of brown solids with 94.91% yield, molecular weight of 9,553.98 da, and the melting point of 95-98 °C. Chitosan-Gelatin films with the addition of PEAE produce a thin yellowish film, with a sequential decreased tensile strength, and the percentage value of extension increases with the increase in PEAE concentration. The best antibacterial activity in the film PEAE 2.5, with the percentage of inhibition of Staphylococcus aureus and Escherichia coli of 99.71% and 98.39% respectively.
Low-Cost Adsorbent Development: Sulfuric Acid-Activated Teak Sawdust for Effective Methylene Blue Removal Baunsele, Anselmus Boy; Missa, Hildegardis; Siswanta, Dwi; Naat, Johnson N.; Neolaka, Yantus A. B.; Nitti, Fidelis; Lema, Abner Tonu; Basuki, Rahmat; Rahayu, Rahayu
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.41425

Abstract

The expansion of the global textile industry has resulted in a decline in environmental quality. Environmental pollution resulting from textile dye waste may include heavy metals and dyes, which exhibit carcinogenic and mutagenic effects. Many studies have been done to reduce the harm of dyes. Extensive research has been undertaken to mitigate the detrimental effects of dyes. One cost-effective approach for managing dye pollution is the adsorption of methylene blue using sulfuric acid-activated teak sawdust. Teak wood sawdust, a byproduct of the furniture industry that is abundant and underutilized, contains active sites within its constituent compounds, including cellulose, hemicellulose, and lignin. This study was designed to determine the ability of teak sawdust to adsorb methylene blue. In this investigation, the biosorbent will be characterized using fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and scanning electron microscopy-energy dispersive X-ray (SEM-EDX) to analyze its active sites and surface morphology. Additionally, the study aimed to elucidate the impact of variation contact time, pH solution, and alteration in methylene blue concentration on the adsorption capacity for methylene blue, employing a UV-Vis spectrophotometer for measurement. The research results demonstrated that optimal adsorption occurred at a contact time of 30 minutes and a pH of 6, with the adsorption efficiency reaching 99.67% as a function of contact time. The kinetic study was modeled using a pseudo-second-order approach, with a kinetic constant of 79.71 g mg⁻¹ min⁻¹. The maximum adsorption capacity was 1.351 mg g⁻¹, the n value was 1, and the percentage of methylene blue adsorbed reached 99.88%.
Characterization and Application of Hydroxyapatite From Chicken Egg Shell with Green Template as a Potential Drug Delivery System Irwansyah, Ferli Septi; Nurizal, Abshar Fathur Rochman; Hadisantoso, Eko Prabowo; Zain, Shariffuddin Bin Md
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.41699

Abstract

Hydroxyapatite (HAp) is a calcium phosphate biomaterial widely studied in the medical field because of its good biocompatibility properties. This study aims to identify the effect of increasing variations in banana peel template concentration on the characteristics of hydroxyapatite so that it has the potential as a drug delivery system. This study includes the characterization and application of the potential of the hydroxyapatite drug delivery system with the addition of variations in the concentration of green template. Then, hydroxyapatite was characterized using X-ray diffraction (XRD) and a surface area analyzer (SAA). This study's results indicate that adding a banana peel template affects the characteristics of hydroxyapatite. The higher the template concentration, the smaller the crystallite size, pore size, pore volume, and surface area, but the degree of crystallinity is greater. The results showed that the characterization of hydroxyapatite K15% with a crystal size of 34.73 nm, a degree of crystallinity of 89%, a pore size of 7.2178 nm, a surface area of 30.111 m2/g, and a pore volume of 0.1145 cc/g. The results of the study of the potential of the drug delivery system obtained a loading efficiency value of 67% for ibuprofen. However, the ibuprofen release process results at time intervals tend to be unstable.
Green Synthesis of Zinc Oxide Particles using Banana Peels and Tea Leaves Extracts for Rhodamine B Photodegradation Pratomo, Uji; Fransisca, Natasha; Afriani, Zahra; Sinambela, Ayu Jelita; Zahra, Nazwa Alya; Suwarno, Nelson Indarto; Sumeru, Husain Akbar; Kurnia, Irwan; Primadona, Indah; Edwin, Rudiawan
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.41793

Abstract

Rhodamine B is a widely used dye in the textile sector. However, the wastewater produced during the dyeing process presents a notable source of pollution, contaminating water and posing a threat to aquatic ecosystems due to its presence in liquid waste. Photocatalysis is a technique for breaking down toxic textile dye waste a semiconductor as a catalyst, valued for its high sensitivity and eco-friendly nature. In this research, zinc oxide particles were synthesized via a green synthesis approach using precipitation, employing natural capping agents from banana peel and tea leaf to degrade the synthetic dye of rhodamine B. The catalyst material was characterized using X-ray diffraction (XRD), scanning electron microscope (SEM), and ultraviolet-visible diffuse reflectance (UV-DRS). The photodegradation performance of rhodamine B was determined under UV light exposure for 3 hours. The XRD spectra of ZnO show the specific peaks of 2θ at 31.8°, 34.5°, and 36.3° with a crystallinity value of around 79.50%. The SEM result shows that the morphology of ZnO is in cotton-like form with a minimum band gap of 3.17 eV. The cotton-like ZnO particles demonstrated superior photodegradation efficiency for Rhodamine B, achieving 61.8%, compared to 47.9% with pure ZnO. It suggests that synthesizing ZnO particles with banana peels and tea leaf extracts boosts photodegradation efficiency by up to 20% compared to pure ZnO. This research highlights the potential of utilizing eco-friendly and sustainable methods as a greener approach for reducing waste in environmental applications.
Improvement of Rheological Properties of Modified Asphalt Treated with Residues of Recycled Rubber from Waste Tires and Oxidized by Air Al-Ojar, Roua’a K.; Mahmood, Mahmood E.; Marzena, Salam J.; Jabrail, Fawzi H.
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 10, No. 2, November 2024
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v10i2.41928

Abstract

Asphalt materials loaded with polymer additives have gained particular importance in recent years due to their close association with modification processes and the creation of a clean environment, mainly from plastic wastes in paving and other areas, and they have also caused significant improvement in asphalt properties. It was observed through the research that the rheological properties of the asphalt were improved significantly as added residues of recycled rubber (RRR) from waste tire percentages increased. The observations are apparent from the decrease in permeability of the asphalt and enhance its ductility and elongation. The study focused on modifying the rheological properties of asphalt materials using the residues of the recycled process of rubber (RRR) from waste tires (mainly carbon black, containing residues of rubber extracted from waste tires). The asphalt materials were oxidized in the open system under various conditions of temperature and oxidation time in the presence of a 0.25% (w/w) anhydrous aluminum chloride (AlCl3) catalyst. After determining the optimal conditions for the oxidation process, the added anhydrous AlCl3 catalyst was adjusted to determine its optimal ratio. The modified asphalt samples after oxidation at optimal conditions in the presence of anhydrous AlCl3 catalyst and the recycled rubber (RRR) residues were tested using appropriate measurements. The following measurements of ductility, permeability, softening point, Marshall stability and flow, aging resistance (thin film oven test (TFOT)) and the asphalt content percentages were done, and their results show that the modified asphalt exhibits completely different rheological properties from the original asphalt. The studied N19 and N20 models show availability in paving applications.
Halal Authentication and Metabolite Mapping of Kombucha Products via Gas Chromatography-Mass Spectrometry (GC-MS) and Chemometric Analysis Hermanto, Sandra; Arginia, Della; Mustafidah, Mabrurotul; Fathoni, Ahmad
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.44602

Abstract

The presence of ethanol in fermented beverages is a critical factor in the halal certification process. One of the key parameters for verifying the halal status of such products is the quantification of ethanol content. Kombucha tea, a fermented beverage produced from sugared tea and a Symbiotic Culture of Bacteria and Yeast (SCOBY), naturally contains ethanol as a byproduct of fermentation. This study aims to determine the ethanol content and differentiate the metabolite profiles of kombucha tea using a non-targeted metabolomics approach, based on variations in tea type, storage temperature, and duration. Ethanol levels were measured by gas chromatography, and metabolite profiling was conducted by gas chromatography–Mass Spectrometry (GC-MS), followed by Principal Component Analysis (PCA) to visualize compositional differences and identify characteristic compounds. The results indicated that tea type significantly influenced ethanol production. The ethanol content of kombucha prepared with black tea, green tea, and white tea was 0.1126% w/w ± 0.0003 v/v, 0.1708% w/w ± 0.0053 v/v, and 0.1301% w/w ± 0.0043 v/v, respectively. Green tea kombucha, which exhibited the highest ethanol content, was selected for storage analysis. During storage, ethanol levels increased slightly to 0.1789% w/w ± 0.0008 v/v in the first week, followed by a gradual decline to 0.1478% w/w ± 0.0071 v/v by the fourth week. Metabolomic profiling revealed distinct differences in secondary metabolite composition among the three tea variants, as evidenced by non-overlapping PCA groupings. Key discriminant compounds identified included ethyl acetate, ethyl octanoate, ethylamine, and (E)-2-decenal, which are proposed as characteristic markers for kombucha derived from black, green, and white teas. These findings contribute to understanding kombucha’s biochemical diversity and support halal verification through ethanol quantification and metabolite-based authentication.
Fabrication and Synthesis of Fluorescent Carbon Nanodots from Black Sticky Rice as Probes for detection Mg2+ ions Ngara, Zakarias Seba; Mamut, Anastasia; Pingak, Redi Kristian; Johannes, Albert Zicko; Lerrick, Reinner Ishaq; Refli, Refli
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.45394

Abstract

Herein, fluorescent carbon nanodots (C-dots) with average diameter of 5.51 nm were fabricated from black sticky rice by using carbonization method. These C-dots have been synthesized with magnesium (Mg2+) ions to investigate their potential application as probes for detection Mg2+ ions. The as-obtained C-dots were measured their absorption (Abs), photoluminescence (PL), and FTIR spectra, X-ray diffraction (XRD) patterns and transmission electron microscopy (TEM) image. According to their Abs spectrum, the Abs peak at 276 nm confirmed the presence of C-dots in ethanol solution. Fortunately, the PL peak at 427 nm corresponded to their blue emission color. The XRD patterns and the TEM image confirmed also the formation of amorphous state and monodispersed spherical C-dots, respectively. When the as-prepared C-dots were synthesized with Mg2+ ions, the PL intensities of C-dots quenched as increasing the concentration of Mg2+ ions. A characteristic PL quenching of the C-dots through Mg2+ chelation demonstrated the sensing system up to the detection limit of 2.98 µM. This is the first reporting the application of C-dots as sensors for detection Mg2+ ions. These findings can pave the large opportunity for application of these C-dots in sensing, bioimaging, drug delivery, and so on.
Isolation and Structural Characterization of Biflavonoids from Araucaria hunsteinii and Araucaria columnaris: Chemotaxonomic and Pharmacological Perspectives Sugita, Purwantiningsih; Ningtias, Widya Sekar Ayu; Priandanda, Rafi Chandra; Ilmiawati, Auliya; Kurniawanti, Kurniawanti; Agusta, Dhea Demitri; Dianhar, Hanhan; Rahayu, Dyah Utami Cahyaning
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46173

Abstract

Biflavonoids are a distinctive class of dimeric flavonoids known for their diverse biological activities and chemotaxonomic significance. In this study, two biflavonoids were isolated from the acetone extracts of Araucaria hunsteinii twigs and Araucaria columnaris leaves collected from Bogor Botanical Garden, Indonesia. Chromatographic techniques, including Sephadex LH-20 column chromatography and preparative thin-layer chromatography, were employed for purification, followed by structural elucidation using LC-MS/MS and 1D/2D NMR spectroscopy. The compounds were identified as 4',4''',7,7''-tetra-O-methylcupressuflavone (1) and 7-O-methylcupressuflavone (2). Notably, this is the first report of 7-O-methylcupressuflavone isolated from A. columnaris leaves, providing new chemotaxonomic insights into the genus Araucaria. A literature-based pharmacological analysis revealed promising cytotoxic and α-glucosidase-inhibitory activities of the isolated compounds. These findings contribute to the phytochemical profiling and highlight the pharmaceutical potential of Araucaria-derived biflavonoids.
In-Silico Studies of Potential Anti-Alzheimer Compounds from Spondias dulcis Fathoni, Ahmad; Salma, Aninda; Amilia, Nurul; Rudiana, Tarso
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46175

Abstract

Alzheimer's is a chronic neurodegenerative disease characterized by low levels of acetylcholine and the accumulation of abnormal neuritic plaques, leading to rapid memory decline and cognitive impairment. Compounds found in the kedondong plant (Spondias dulcis) have been reported to exhibit in vitro activity as acetylcholinesterase inhibitors. This study examines the potential of active compounds in Spondias dulcis in their interaction with acetylcholinesterase, an enzyme implicated in the pathogenesis of Alzheimer's disease. The enzyme was obtained from the Protein Data Bank (PDB ID: 4EY7). The test ligands were screened based on Lipinski's rule and docked with the receptor. The results of molecular docking which yielded the five best affinity energy values were followed by ADMET testing (absorption, distribution, metabolism, excretion, and toxicity). The test ligand ellagic acid deoxyhexoside showed binding energy at -11.213 kcal/mol. Molecular dynamics simulations were performed using YASARA with AMBER14 force fields for 50 ns. The test ligand ellagic acid eoxyhexoside showed an MM-PBSA value of -51.277 kcal/mol and exhibited good complex stability with an average total RMSD value of 2 Å and low inter-residue fluctuation values. These findings are consistent with the results obtained from the comparator ligand, donepezil. Therefore, compounds in Spondias dulcis have the potential to act as acetylcholinesterase inhibitors and can be considered for the development of therapies for Alzheimer's disease. 
Exploring Brazilin as a Potential Breast Cancer Therapy via Molecular Dynamics Simulation Targeting ERα, 17β-HSD1, and NUDT5 Receptors Baroroh, Umi; Dasilva, Jasmine Aulia; Sundalian, Melvia; Astriany, Dewi; Ansori, Arif Nur Muhammad; Yee, Jonie C.
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46465

Abstract

Breast cancer remains one of the leading causes of cancer-related mortality worldwide, suggesting the need for novel therapeutic agents with greater efficacy and fewer side effects. Brazilin, a natural flavonoid compound isolated from Caesalpinia sappan L., has shown promising anticancer activity, particularly against breast cancer cells. This study explores the therapeutic potential of brazilin by evaluating its interactions with three key molecular targets: estrogen receptor alpha (ERα), 17β-hydroxysteroid dehydrogenase 1 (17β-HSD1), and Nudix hydrolase 5 (NUDT5). Using molecular dynamics (MD) simulations, the study assesses the stability and binding interactions of complex systems. The results indicate that brazilin forms a stable complex with ERα, demonstrated by a low RMSD (2.6 Å) and strong hydrogen bonding with Glu353, occupancies of 97.8%, and minimal flexibility at the binding site (average RMSF < 2.5 Å). The binding free energy (ΔG Total) for the ERα–brazilin complex was -54.28 kcal/mol, indicating a stronger affinity than the reference ligand 4-hydroxytamoxifen. Brazilin also showed favorable binding with 17β-HSD1 and NUDT5, with binding energies of -39.71 kcal/mol and -23.23 kcal/mol, respectively. These findings suggest that brazilin may modulate critical targets involved in breast cancer progression, particularly in hormone receptor-positive subtypes. Further experimental validation is necessary to confirm its efficacy and optimize its therapeutic potential.

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