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Journal of Medical Laboratory in Infectious and Degenerative Diseases
Published by Universitas dr. Soebandi
ISSN : -     EISSN : 30325447     DOI : https://doi.org/10.36858/jmid.v1i2
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Public Health
Journal of Medical Laboratory in Infectious and Degenerative Diseases is a scientific journal with the scope of research conducted by lecturers, practitioners, and students. The purpose of publishing this journal is to accommodate scientific writings that have the substance of research activities, which are the downstream results of research carried out based on an analysis of the needs of the community for scientific and technological contributions in the fields of Parasitology, Bacteriology, Virology, Hematology, Clinical Chemistry, Immunology, Molecular Biology, Cytohistotechnology, Micology, Clinical Toxicology, and Degenerative Diseases.
Arjuna Subject : Profesi Kesehatan - Teknologi Laboratorium Medis
Articles 25 Documents
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The Relationship Between The Duration Of Zumba Exercise And Total Cholesterol Levels Ahmad, Tasrif
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 2 No. 2 (2024): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v2i2.24

Abstract

Zumba exercise is included in sports that can reduce fat deposits, this is because the energy source needed in exercise apart from burning carbohydrates in the form of glucose is also from burning fat reserves or triglycerides. Stored triglycerides will be converted into fatty acids and glycerol. Glycerol will enter the body's metabolism to be converted into glucose and pyruvic acid. Fatty acids will be broken down together with carbohydrates and oxygen to become energy (ATP) in the mitochondria. Therefore, Zumba exercise is a sport that can reduce cholesterol levels and waist circumference ratio,The aim of this study was to determine the relationship between the duration of Zumba exercise and total cholesterol levels. This research is a type of observational analytical research using a purposive sampling technique with 28 samples obtained from HERCULES FITNES Karanganyar. Measurements of total cholesterol levels were obtained from respondents who filled out a questionnaire and fasted for 8 - 12 hours before taking samples, then the blood samples were taken to the Clinical Laboratory of the National College of Health Sciences to check total cholesterol levels using the Clima MC 15 Photometer. Research results In all samples, cholesterol levels were found to have a value that exceeded the normal limit, namely 205 mg/dl. The conclusion of research conducted on 28 respondents who took part in Zumba exercise at HERCULES FITNES using the Spearman correlation test showed that there was a significant correlation with a P-value of 0.776, meaning that there was a relationship between the duration of Zumba exercise and total cholesterol levels
Differences In High Sensitivity C-Reactive Protein (Hs-Crp) Levels between Active Smokers and Passive Smokers Dwi Niaga, Seftika ; Saktiningsih, Hari
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 2 No. 2 (2024): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v2i2.25

Abstract

Background: Background: High Sensitivity C-Reactive Protein (hs-CRP) is an acute-phase protein produced in the liver in response to inflammation, involving the immune system, blood vessels, and cardiovascular. Purpose: This study aimed to compare hs-CRP levels between active and passive smokers. Methods: This type of research is a quantitative research using a cross-sectional research design and purposive sampling techniques. This study involved 9 active smoker respondents and 9 passive smoker respondents from a population of 24 people in N Village RT 01 RW 04, Bulukerto District, Wonogiri Regency. Results: The results showed that the average hs-CRP level in active smokers was 2.51 mg/L, while in passive smokers it was 0.89 mg/L. The minimum and maximum levels of hs-CRP in active smokers were 0.90 to 4.10 mg/L, while in passive smokers it was 0.30 to 1.80 mg/L (p value 0.024<0.05). Conclusions: There was a significant difference in hs-CRP levels between active smokers and passive smokers.
The Effect of Boiled Mung Bean Seeds on Alanine Aminotransferase Levels in Rats (Rattus norvegicus L.) Induced by NaNO2 dwi ayu pratiwi, nabila; Mufidah, Hartalina; Imroatul Muflihah, Ahdiah; Anggitasari, Wima
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 2 No. 2 (2024): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v2i2.26

Abstract

Background: Sodium nitrite is a chemical compound used in the coloring and preserving process of processed meat. Excess sodium nitrite entering the body can have clinical impacts on health, especially the liver. Disorders of the liver can be identified by increased levels of Alanine Aminotransferase. Mung beans contain antioxidants, a compound that has benefits as a hepatoprotection. Purpose: This study aims to determine the effect of Mung bean stew on Alanine aminotransferase levels in rats (Rattus norvegicus L.) with anemia before and after administration. Method: This research design is an experimental study with quantitative data collection. This study was conducted in June–July 2024. The sample in this study was rats (Rattus norvegicus), which were taken randomly using random sampling techniques. The Mung beans used in this study were Mung beans that had undergone an infusion process. After collecting data, the researcher processed the data using Paired sample-t test analysis, One-Way ANOVA, and Post Hoc Tukey using SPSS. Results: The Paired sample-t test for Alanine Aminotransferase levels in rats (Rattus norvegicus) with anemia showed sig>0.05 in all treatment groups. The test results of the average change in Alanine Aminotransferase levels before and after between groups showed a sig value <0.05. Conclusion: Based on this study, it can be concluded that Based on this research, it can be concluded that there is no effect of boiled Mung beans on Alanine aminotransferase levels.
Comparison of Serum Antibody Titer and Plasma Citrate Using Widal Slide Examination with Different Delay Times Tiara, Tiara Wahyu Norbaity
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 2 No. 2 (2024): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v2i2.27

Abstract

Background: The bacteria Salmonella typhi causes typhoid fever, a life-threatening systemic infection. The clinical symptom of typhoid fever that is definitely found is fever. The diagnosis of typhoid fever can be done by performing a Widal examination for supporting examinations. Serum, plasma, and cerebrospinal fluid are samples used for the Widal tube and slide test. The accuracy of the examination must use serum; this is because the Widal examination is very sensitive to the condition of the specimen. Objective: The purpose of this study was to determine the comparison of serum and plasma citrate antibody titers using the Widal slide examination with a delay time of 5 minutes, 10 minutes, and 15 minutes. Method: This research design is an experimental study with quantitative data collection. This study was conducted in June 2024. The sample in this study were patients with typhoid fever aged 5 to 45 years at the Baladhika Husada Hospital Class III Jember with a sample size of 30 respondents using the purposive sampling technique. After the data was collected, the researcher processed the data using SPSS version 26. The data analysis used was the Kruskal-Wallis test, followed by the Duun test. Results: This study obtained an Asymp. Sig. 1,000 α> 0.05 value, then  was accepted, meaning that there was no comparison of antibody titers in the results of the Widal slide method examination on serum and citrate plasma, which were delayed for 5 minutes, 10 minutes and 15 minutes and the highest age characteristic results were at the age of 16-25 years and gender in men. Conclusion: There was no comparison of antibody titers in the results of the Widal slide method examination on serum and citrate plasma with a delay time of 5 minutes. 10 minutes and 15 minutes.
Effectiveness of The Larvicide Combination Extract of Basil (Ocimum basilicum) Leaves And Soursop (Annona muricata) Leaves Against Aedes aegypti Larva Shafrina Rohma, Hanna; Mufidah, Hartalina; Anggia Destiawan, Rian; Trianggaluh Fauziah, Dina
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 2 No. 2 (2024): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v2i2.28

Abstract

Background: Dengue hemorrhagic fever (DHF) is an acute febrile illness caused by dengue virus infection which is transmitted through the bite of the Aedes aegypti mosquito. An alternative method that can be used is a vegetable larvicide to eradicate Aedes aegypti larvae. Basil leaf extracts (Ocimum basilicum) and soursop leaves (Annona muricata) contain flavonoids, saponins, alkaloids, tannins and essential oils as larvicide compounds. Purpose: This study aims to determine the effectiveness of the larvicidal combination of basil (Ocimum basilicum) and soursop (Nnona muricata) leaf extracts against Aedes aegypti larvae at concentrations of 5%, 10%, 15% and 20%. Methods: This type of research is descriptive quantitative research with an experimental design. This study used 6 samples of Aedes aegypti larvae at each concentration. The treatment stage was carried out by adding a combination of basil (Ocimum basilicum) and soursop leaf (Annona muricata) leaf extracts in concentrations of 5%, 10%, 15% and 20% into an Erlenmeyer flask containing larvae and distilled water. Calculate the number of deaths at 30 minutes, 1 hour, 2 hours and 3 hours. Results: The results of this study showed larval mortality at a concentration of 5%, namely 0 larvae in 30 minutes, 1 larva in 1 hour, 2 larvae in 2 hours and 3 larvae in 3 hours. Larval mortality at a concentration of 10% is 1 larva in 30 minutes, 2 larvae in 1 hour, 3 larvae in 2 hours and 0 in 3 hours. Larval mortality at a concentration of 15% is 2 larvae in 30 minutes, 3 larvae in 1 hour, 1 larva in 2 hours and 0 larvae in 3 hours. Larval mortality at a concentration of 20% was 3 larvae in 30 minutes, 3 larvae in 1 hour and 0 larvae in 2 and 3 hours. Conclusions: The combination of basil (Ocimum basilicum) and soursop leaf (Annona muricata) leaf extracts is most effective as a larvicide at a concentration of 20% with a death time of 30 minutes.
The Effect of Papaya Leaf Extract (Carica papaya L.) on Erythrocyte Values in Anemia-Model Rats Dwi Susanto, Fajar; Yulia Widia Sari, Leny; Imroatul Muflihah, Ahdiah; Wijaya, Anas Fadli; Agustin, Ayu Tri
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.34

Abstract

Background: Anemia remains a significant public health challenge with a global prevalence of 40-88%. Papaya leaf extract (Carica papaya L.) contains bioactive compounds such as flavonoids, vitamin C, and vitamin E that potentially enhance erythrocyte production. Purpose: This study aimed to determine the effect of papaya leaf extract on erythrocyte values in anemia-model rats (Rattus novergicus). Methods: An experimental laboratory study was conducted from April to June 2025 using 25 rats divided into 5 groups: positive control (sodium nitrite), negative control (aquadest), and three treatment groups receiving papaya leaf extract at doses of 100, 200, and 400 mg/kg BW. Anemia was induced using sodium nitrite at 50 mg/kg BW via intraperitoneal injection. Erythrocyte measurements were performed using a hematology analyzer. Data were analyzed using Shapiro-Wilk normality test, Levene's homogeneity test, one-way ANOVA followed by Tukey HSD (α=0.05). Results: Treatment group P3 (dose 400 mg/kg BW) demonstrated the highest erythrocyte value of 12.066±0.84 (10⁶/µL), followed by P1 (11.576±0.71), P2 (11.496±1.19), negative control (10.728±1.01), and positive control (6.220±1.96). ANOVA test revealed significant differences between groups (p<0.001). Conclusions: Papaya leaf extract increases erythrocyte values in anemia-model rats, with 400 mg/kg BW being the most effective dose.
Study Of Use Of Antituberculosis Drugs (OAT) In One Of The Hospitals In Jember District Fitri Amirah Nahdah Salsabilah; Wima Anggitasari
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.38

Abstract

Abstract Background: Tuberculosis (TB) is a long-term infectious disease caused by the bacterium Mycobacterium tuberculosis. Successful management of pulmonary TB will reduce the rate of disease transmission and the risk of death. TB treatment is carried out routinely over a period of time under the supervision of a Drug Companion (PMO).] Purpose: This study aims to identify the type of TB treatment received by patients and the duration of treatment. Methods: This is a descriptive study. Data collection on study subjects was conducted retrospectively using medical records of TB patients undergoing anti-TB treatment (OAT) therapy from January to December 2023. Sampling used a purposive sampling technique, with a sample size of 73. Results: The study showed that the majority of patients were male (60.3%), and the majority were aged 17-25 years (32.9%). Most patients used FDC drugs with a treatment duration of 0-6 months. Conclusions: Most study subjects received anti-TB therapy with a treatment duration of 0-6 months.
The Optimization of a Spray Gel : Formula with Acalypha Leaf Extract (Acalypha wilkesiana Müell. Arg.) Nufus, Galuh Maulidatun; Isnawati, Nafisah
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.39

Abstract

Background: According to research from the Ministry of Health, in 2020 the average was 89.65% and in East Java it was 54.3%, while in Jember 49.6% of people washed their hands properly, one of which was using soap. Hand sanitizer can be used as an alternative to cleaning hands without using soap and running water. One of the plants used as an active ingredient in hand sanitizers is akalifa leaves. Carbopol 940 is a gelling agent that is widely used in spray gel preparations for pharmaceutical products, while TEA is an alkalizing agent. Objective: To identify the effect of carbopol 940 as a gelling agent and TEA as an alkalizing agent on the physical characteristics of akalifa leaf extract spray gel (Acalypha wilkesiana Müell. Arg.). Methods: This study used an experimental method with the Simplex Lattice Design. Research result: Evaluation of the physical properties of spray gel preparations with variations in the concentration of the gelling agent and alkalizing agent produced the best pH value, namely in formula 2 with a pH value of 5.2, the best viscosity value was found in formula 2, namely with a value of 223 cPs, and drying time the best is also found in formula 2 with a value of 3.35 minutes. Conclusion: evaluation of the physical properties of spray gel preparations, variations in the concentration of the gelling agent and alkalizing agent affect pH, viscosity, spraying pattern and drying time.
In-Silico Study Of Bioactive Compounds In Bawang Dayak (Eleutherine palmifolia (L) Merr.) Bulbs On The Main Protease Receptor Of COVID-19 (6LU7) As A Candidate For SARS-CoV-2 Antivirus Drug Septiana, Ulfa Dwi; Wulandari, Septyaningtyas Eka; Kamalia, Nabila; Hezni, Tiara Anjelina; Usman, Mohammad Rofik; Setyaningrum, Lindawati
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.40

Abstract

: The COVID-19 viral disease is a new name given by the World Health Organization (WHO) to patients with the novel COVID-19 virus infection which was first reported from the city of Wuhan, China at the end of 2019. The COVID-19 pandemic is still a major problem in the world health. One antiviral regimen that is widely used to treat moderate to severe Covid- 19 patients is favipiravir. Many studies discuss alternative antiviral therapy for COVID-19 patients from active compounds contained in plants. One of the medicinal plants that has an antiviral effect on CoV-2 is Dayak onion (Eleutherine Palmifolia (L.) Merr). Consuming herbal plants can increase the body's immunity as the main key in preventing the Sars-Cov-2 virus. Purpose: This research aims to determine the effect of anchoring the active compound of Dayak onion bulbs on the growth of the corona virus on the main protease receptor for Covid 19 (6LU7). Methods: This type of research uses a molecular docking research method which consists of docking validation stages, a docking process and continues with docking visualization using Discovery Studio Visualizer and PyRx combined with Autodocktool Results: The results of the molecular docking simulation show that the Lysine sulfate compound has the lowest binding affinity value compared to Favipiravir, namely -4.75 kcal/mol with a Ki value of 96.41 μM and has the same interaction as the positive control ligand on the hydrophobic bond of MET A:165
The Effect of Propylene Glycol and Menthol as Enhancers on the Physical Properties and Skin Irritation Index of Meloxicam Gel Falahi, Asa; Rohman, Anies
Journal of Medical Laboratory in Infectious and Degenerative Diseases Vol. 3 No. 2 (2025): Desember
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jmid.v3i2.41

Abstract

Abstract Background: The drawback of meloxicam when used orally is that it slows the onset time of meloxicam. Other side effects of oral use include gastrointestinal disorders, dyspepsia, nausea, diarrhea, upper gastrointestinal infections, abdominal pain, swelling, and bloating. These side effects have been reported in 15–20% of patients. There is a need to develop a transdermal meloxicam formulation with a modified penetration system. Purpose: This study aims to develop a formulation of meloxicam gel preparations with a direct release system towards the skin barrier and within a period of time is extended by using 10% propylene glycol and 3% menthol as an enhancer to get the optimum formula of meloxicam gel with good physical properties and does not irritate the skin. Methods: This research method is a laboratory experimental study. Gel preparations were made by varying the enhancer agents, namely propylene glycol and menthol. The gel preparations were made by developing the gelling agent to an optimal level. Other additional ingredients were mixed with various enhancer variations. Results: The observed physical properties of the gel included organoleptic characteristics, pH, viscosity, spreadability, and irritation tests. Overall, the test results showed data that met the applicable requirements. All four formulas showed significant differences in each test and did not show signs of skin irritation. Conclusions: The results show that variation concentration of enhancer has an effect to gel form, smell viscosity and spreadability but has no effect to gel colour and pH. All formulas show not irritate the skin.

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