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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 269 Documents
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Formulasi dan Uji Penetrasi Sediaan Gel Transfersom yang Mengandung Kojyl 3 Amino Propil Fosfat sebagai Pencerah Kulit Andini, Septia; Jufri, Mahdi; Djajadisastra, Joshita
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2948

Abstract

Kojyl 3 APPA is a compound used for skin lightening. Kojyl 3 APPA has a good solubility in water. This causes the hydrophilic nature kojyl 3 APPA difficult to penetrate through the skin. Transfersom is a carrier system that can improve the effectiveness of drug penetration. This study aims to formulate, characterize and evaluate transfersom preparations containing kojyl 3 APPA. Further more transfersom formulated in a gel formulation. Preparation gel was tested its physical stability and in vitro penetration test against non transfersom kojyl 3 APPA. Transfersom gel formulation is physically proven stable at room temperature, low temperature and high temperature storage. In vitro penetration tests showed that kojyl 3 APPA penetration loaded in transfersom gel was 11,16% while for non transfersom gel 8,02%
Efek Ekstrak Campuran Kulit Batang Pulai (Alstonia scholaris) dan Meniran (Phyllanthus niruri) pada Mencit Swiss Webster yang Diinfeksi Plasmodium berghei Intan, Putri Reno; Winarno, M. Wien; Prihatini, Nita
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2949

Abstract

Pulai and meniran is one of the medicinal plants that have been studied as a possible antimalarial drugs. This study aims to evaluate the antimalarial activity of a mixture of pulai bark and meniran extracts as antimalarial drugs. Acute toxicity tests was performed using male and female Wistar rats each 25 animals with four doses of treatment. Antimalarial test using 72 mice were divided into six dose groups: group CMC, DHP, dose mixture of 1330; 443.34; 147.78 mg/kg bw and doses of pulai groups 1330 mg /kg bw. All the mice were infected with Plasmodium berghei (D0) and given the extracts orally for 14 days. Giemsa blood stainning taken on days D1-D7 and D14 were analyzed for percentage of parasitaemia, lymphocytes, monocytes and granulocytes. Results of acute toxicity test (LD50) values obtained from extract mixture was more than 14285 mg/kg bw, are classified as non-toxic materials. The most effective dose of the test antimalarial obtained from the percentage of parasites reducing and leukocytes differential, was 147.78 mg/kg. A mixture of pulai bark and meniran extract can be considered to be used as an alternative drug in the treatment of malaria. Further research is needed to isolate and characterized the active ingredients which have the effect of antimalarial to be recommended as an antimalarial drug in the future.
Sarana dan Prasarana Rumah Sakit Pemerintah dalam Upaya Pencegahan dan Pengendalian Infeksi di Indonesia Herman, Max Joseph; Handayani, Rini Sasanti
Jurnal Kefarmasian Indonesia VOLUME 6, NOMOR 2, AGUSTUS 2016
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v6i2.2950

Abstract

Nosocomial infections is an important issue around the world. Hospitals are required to provide qualified, efficient and effective service to ensure patient safety. The Ministry of Health has revitalized prevention and control of infection program (PPI) in hospitals which is one of the cornerstones towards patient Safety. The purpose of this study is to identify the preparedness of hospitals to implement the PPI program. The data source is Health Facility Research of 2011 which was done by National Institute of Health Research and Development. The aspects examined include facility, infrastructure, human resource, organization, guidelines, compliance in prescribing, the availability of clean water and hospital sewage treatment. The results show that many hospitals are not yet ready to conduct PPI, especially in terms of infrastructure, clean water sterilization and processing waste, mostly hospitals of classes C and D. Sewage treatment is important in the control or prevention of spread of antimicrobial resistance. This program gives many benefits especially in preventing the occurrence of total resistance or back to the era before antibiotics. The PPI program does require a large fee such that hospital management often disapproves, although the result of available cost analysis indicates that PPI is highly cost-effective.
Potensi Fraksi Etil Asetat Ekstrak Daun Gambir (Uncaria gambir Roxb.) sebagai Antihiperlipidemia Yunarto, Nanang; Elya, Berna; Konadi, Laurentia
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i1.2959

Abstract

Hyperlipidemia is the main risk factor for atherosclerosis and coronary heart disease. Ethyl acetate fraction of gambier leaves extract (Uncaria gambir Roxb.) contains catechin secondary metabolites which have potency to be used as antihyperlipidemic. This study aimed to examine the antihyperlipidemic effect of ethyl acetate fraction of gambier leaves extract in vivo. Thirty six males of Sprague Dawley strain, 2,5 months old, were randomly divided into six groups: normal group, negative group (distilled water), positive group (simvastatin 2 mg/200 g bw), dose I (5 mg/200 g bw fraction), II (10 mg/200 g bw fraction) and III (20 mg/200 g bw fraction) groups. Rats were induced with high cholesterol and saturated fat feeds for 28 days, except in the normal group. Furthermore, rats were given the treatment for 28 days. The results showed when compared than negative control, dose III reduced of total cholesterol, triglycerides, LDL levels and increased HDL level (p
Profil Disolusi Tablet Amlodipin dan Perbandingan Kadar Dua Produk Generik dengan Produk Inovator Alegantina, Sukmayati; Isnawati, Ani
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i1.3029

Abstract

Amlodipine is an antihypertensive and antianginal drug belonging to the class of dihydropyridine calcium antagonist (calcium ion antagonist). Amlodipine patent term expired in 2007, thus nowadays some national pharmaceutical manufacturers produce amlodipine as generics and branded generics medicine. In order to determine the quality of generic amlodipine, dissolution profile and contents of two generic amlodipine were studied by comparing them with their innovator product. The dissolution test was carried out using a type 2 (paddle) and the dissolved content was determined by using UV spectrophotometer, whereas amlodipine content tablet was determined by using HPLC (High Performance Liquid Chromatography). The results showed that all of the three tablets met the FDA requirements of dissolution, i.e.within 30 minutes they should be dissolved not less than 85%. All of the three tablets had the same dissolution profile p=0,521 (CI=95%), whereas both the generic and branded generic tablet compared to the innovator product had similar or comparables profile , (f2>50). The content of all three tablets are not significantly different with p=0,08 (CI = 95%). The highest content of amlodipine was found in amlodipine a tablet with an average content of 102,69%.
Selektivitas Medium Cystine Tellurite Blood Agar (CTBA) terhadap Beberapa Isolat Bakteri Sariadji, Kambang; Sunarno, Sunarno; Puspandari, Nelly; Muna, Fauzul; Rukminiati, Yuni
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i1.3030

Abstract

Cystine tellurite blood agar (CTBA) medium is a selective medium for Corynebacterium diphtheriae culture. The presence of tellurite is a selectivity of this medium to inhibit the others bacteria. Others medium were used as a selective medium for the culture of Corynebacterium diphtheriae were tinsdale and Hoyle medium, but was recommended by the World Health Organization (WHO) were CTBA and hoyle medium. However, information about the selectivity of medium was recommended by WHO is still limited. The aims of study to determine the selectivity of medium against a number of others species bacteria on CTBA. A number of 24 isolates contains of different species Corynebacterium spp and others species were regrown, then all isolates were cultured in CTBA medium, incubated for 24 – 48 haours at 37°C. The growthing of colony in CTBA were observed. The results showed that 7 isolates for Corynebacterium species can grow well on medium CTBA, 5 isolates from different species showed growth in CTBA medium including Staphylococcus aureus, Streptococcus pneumoniae, Enterobacter sakazakii , Klebsiella pneumoniae and Candida albicans. Meanwhile the rest 12 isolates showed no growthing on CTBA medium. Therefore it can be concluded that the selectivity of the CTBA medium has limited capabilities
Studi Docking Molekuler Catechin Gallate, Epicatechin Gallate, Gallocatechin Gallate, dan Epigallocatechin Gallate Isnawati, Ani; Adelina, Rosa
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 1, FEBRUARI 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia has the second biggest natural in the world. This natural resources could be used as raw material for drug if well managed. As we know, 96% of raw material in Indonesia are imported which caused the price of drugs are expensive. In order to overcome the problem, it is essential to conduct research about Indonesian plants which are potential as dyslipidemia drug. The molecular docking study is one of insilico studies that is used to screen compounds based on their working mechanism to protein. In this study, catechin gallate, epicatechin gallate, gallocatechin gallate and epigallocatechin gallate were docked using Moleculer Operating Environtment (MOE). Software in order to determine their affinity and interaction with HMG-CoA reductase enzyme which has a role in cholesterol/fat metabolism. This research used simvastatin and atorvastatin as the standard drug for dyslipidemia. The result of molecular docking showed that Gibbs values of simvastatin, atorvastatin, catechin gallate, epicatechin gallate, gallocatechin gallate and epigallocatechin gallate were -6,4974; -8,543; -9,5736; -10,6395; -10,4765; and -10,598. The results stated that four cathechin derivates have an inhibiting energy better than simvastatin and atorvastatin. These are potential as dyslipidemia drugs candidate.
Uji Klinik Keamanan Ramuan Jamu Penurun Kolesterol Zulkarnain, Zuraida; Triyono, Agus; Ardiyanto, Danang; Saryanto, Saryanto
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i1.3186

Abstract

Research on the safety of Jamu (herbal medicine) formula is important to guarantee its use in community. The Jamu Saintification development program has been resulted a cholesterol-lowering herb containing of 7 plants. This study aimed to determine the safety of the cholesterol-lowering herb. This study is a phase one of clinical trial with a pre-post group design, a single arm, involving 50 subjects with mild hypercholesterolemia without any complications and comorbidities. The intervention was conducted for 28 days at the Hortus Medicus Herbal Medicine Research House (RRJ) in 2014. Outcome parameters included clinical signs and symptoms, liver function laboratory tests (SGOT, SGPT), renal function (ureum, creatinine) and routine blood counts (hemoglobin, leukocyte, platelets, hematocrit). Subjects were requested to boil the herb everyday and drank it twice a day. The data were analyzed descriptively and statistically using SPSS. The results showed increasing in bowel frequencies of 92% subjects and abdominal pain in bowel movements of 34% subjects. These effects were still in a normal range and can be tolerated by the subjects. The paired t test analysis showed no differences in average laboratory parameters on day (D)-14 and D-28 compared to the baseline (p > 0.05). The cholesterol-lowering herbal medicine does not change the function of the liver, kidneys and blood, with mild side effects of increasing the frequencies of bowel movements and stomachaches.
Penentuan Aktivitas Antioksidan dan Antidiabetes Ekstrak Daun Matoa (Pometia pinnata J.R. Forst. & G. Forst.) secara In Vitro Wulandari, Lestyo; Nugraha, Ari Satya; Himmah, Ulfa Aliyatul
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 2, AGUSTUS 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i2.3196

Abstract

Matoa (Pometia pinnata J.R. Forst. & G. Forst.) Matoa (Pometia pinnata J.R. Forst. & G. Forst.) is one of the plants that is used as a traditional medicine for diabetes mellitus due to an imbalance between the amount of ROS and antioxidants in the body. Therefore, it was carried out in vitro to see the antioxidant and antidiabetic activity in matoa leaf extract. The extraction of matoa leaves was carried out using the ultrasonication method for 30 minutes with methanol, ethanol, and ethyl acetate as solvents. Antioxidant activity is release through DPPH free radical inhibition, through the antidiabetic potential released by inhibiting the work of the α-amylase enzyme. Phytochemical test results showed the presence of secondary metabolites in the form of flavonoids, polyphenols, tannins, alkaloids, and terpenoids. The results of the research on methanol, ethanol, and ethyl acetate extracts of matoa leaves showed high antioxidant activity with IC50 values of 6.416 ± 0.176 ppm, 8.622 ± 0.066 ppm, and 170.637 ± 4.441 ppm, respectively, but they were less potent than vitamin C as a comparison which is 1.646 ± 0.015 ppm. Inhibition of the α-amylase enzyme showed IC50 values of 91.037 ± 0.750 ppm, 105,166 ± 2,423 ppm, and 785,436 ± 11,740 ppm in each of the methanol, ethanol, and ethyl acetate extracts while the IC50 value of acarbose as a comparison was 23,479 ± 0.347 ppm. The statistical data analysis of Pearson correlation showed that it had a positive relationship between the antioxidant and antidiabetic activity of matoa leaf extract as seen from the R-value of 0.998. The higher antioxidant activity, so the higher potential for inhibition of α-amylase enzyme.
Penggunaan Metode Hybrid e-Learning untuk Praktikum Imunologi Farmasi di Fakultas Farmasi Universitas Gadjah Mada Ikawati, Muthi'; Hermawan, Adam; Sahid, Muhammad Novrizal Abdi; Kristina, Susi Ari; Sasmito, Ediati
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i1.3332

Abstract

Laboratory work of Pharmaceutical Immunology, Faculty of Pharmacy UGM aims to provide skills of applying antigens, antibodies, and immunological techniques in pharmaceutical; and ideally each student should be able to perform it completely. However, the limitation of time and facilities making the learning process ineffective. An innovative learning method such as hybrid e-learning is expected to increase the learning effectiveness. Learning materials and online quizzes/discussions were uploaded and carried out using elisa.ugm.ac.id (eLisa), respectively, combined with on-site works in the laboratory. The method was evaluated by examination scores and final grades. Student participations in online quizzes increased from first to fourth quiz (average participation rate 98.86±0.87%). Compared to the conventional method applied in 2016 (n=207), the examination average score did not increase; however, the percentage of students whose score is 90-100 were higher in the hybrid e-learning. The average final grade of the hybrid e-learning was 81.43±0.70; whereas the conventional method of 2016 was 80.22±5.22. More than 80% students (n=48) expressed easiness in following courses and were satisfied with the online learning materials’ quality. Hence, the hybrid e-learning results positive effects in increasing the effectiveness of the learning process. Development of more interactive online platforms is needed to optimize the learning process.

Page 11 of 27 | Total Record : 269

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