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INDONESIA
Jurnal Farmasi Galenika
Published by Universitas Bhakti Kencana
ISSN : 24069299     EISSN : 25794469     DOI : https://doi.org/10.70410/jfg
Core Subject : Health,
Medicine & Pharmacology Public Health
The aim of JFG is to become a media for the publication of articles on Pharmaceutical and related practice-oriented subjects in the pharmaceutical sciences and technology. The scope of the journal is Pharmaceutical sciences, its research and its application. The journal aims to cover the latest outstanding developments in the field of Pharmaceutical science and Technology but not limited to the following branches: Pharmaceutics Pharmaceutical technogy International Regulatory Validation Techniques Industrial Pharmacy Nanotechnology Novel Drug Delivery Systems Quality Control Quality Assurance BioTechnology Bioinformatics Proteomics Biochemistry Pharmacognosy Herbal technology Pharmacology Toxicology Pharmacy Practice Pharmacoinformatics Phytochemistry Pharmaceutical Analysis Chiral Chemistry Synthetic Chemistry Drug Development Clinical Pharmacy Pharmacogenomics Pharmacetical Engineering
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 201 Documents
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Antimicrobial Candidate From Ethanol Extract And Ethyl Acetate Fraction Of Betadin (Jatropha multifida L.) Leaves Which Actively Inhibits Clinical Isolates Of Human Skin Pathogenic Bacteria And Fungi Faroliu, Goldha; Adriani, Nova; Wulandari, Sarah
JURNAL FARMASI GALENIKA Vol 12 No 3 (2025): Jurnal Farmasi Galenika Volume 12 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i3.405

Abstract

Betadin leaf (Jatropha multifida L.) is an ornamental plant in Indonesia and is rarely used, but its leaf sap has been reported to accelerate wound healing due to skin infections. This has the potential to be used for the development of new antimicrobial agents. The extraction method was carried out by maceration using 96% ethanol and fractionation with ethyl acetate. Extracts and fractions analyzed for the presence of various phytochemical constituents. Antibacterial assay used disc diffusion (Kirby-Bauer's) method towards Propionibacterium acnes, Staphylococcus epidermidis, Corynebacterium diphtheriae, Microsporum canis and Epidermophyton floccosum. Ethanol extract of Betadin leaves contained Alkaloids, Flavonoids, Phenolics, Steroids, Terpenes, Saponins, while the ethyl acetate fraction contained Alkaloids, Phenolics, Terpenes. J. multifida leaf ethanol extract has strong activity towards Microsporum canis and Epidermophyton floccosum, and has weak activity towards Propionibacterium acnes, Staphylococcus epidermidis, and Corynebacterium diphtheriae. While J. multifida leaf ethyl acetate fraction has strong activity towards Propionibacterium acnes, Microsporum canis and Epidermophyton floccosum, and has weak activity towards Staphylococcus epidermidis, and Corynebacterium diphtheriae. Based on the results of this study can be concluded that both the ethanol extract and the ethyl acetate fraction of Betadin leaves (Jatropha multifida L.) had the ability to inhibit the growth of bacteria and fungi, then can be antimicrobial candidate of herbal medicine
Pengaruh Leaflet Terhadap Pengetahuan Pasien Tentang Dagusibu Obat Antibiotik di Puskesmas Sungai Ulin Fitriah, Rahmayanti; Permatasari, Rr. Ghinaa; Ramadhani, Syahrizal; Sajidah, Ainun
JURNAL FARMASI GALENIKA Vol 12 No 3 (2025): Jurnal Farmasi Galenika Volume 12 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i3.411

Abstract

The high use of antibiotics can trigger resistance. Currently, people often make mistakes in obtaining, using, storing and disposing of drugs properly.This is one of the consequences of the lack of accurate information and the very low level of public education. Providing education on the use of antibiotics is important so that patients get maximum drug effectiveness and prevent resistance. This study aims to determine the effect of leaflets on patient knowledge about DAGUSIBU (Get, Use, Store, Discard) antibiotics at Sungai Ulin Public Health Center, Banjarbaru City. The type of research used was a pre-experiment with a one group pretest–post test research design. Sampling used a purposive sampling technique on 87 respondents. The pretest was given before education and the posttest was given 2 weeks after education. From the research results, the average value of the patient's pretest knowledge was 65.99% and the posttest was 87.83%. The statistical test method used was the Wilcoxon Signed Rank Test with an Asymp. Sig 2 tailed result of 0.000. This shows a significance value of <0.05, which means that the alternative hypothesis is accepted, where there is a significant difference in knowledge between before and after the intervention was given through leaflet media.
Pengaruh Ekstrak Daun Landep (Barleria prionitis L.) Terhadap Glukosa Darah Postprandial dan Histopatologi Pankreas Tikus Yang Diinduksi Aloksan Sabrina, Salsa; Amin, Muhammad Saiful; Yety Lindawati , Novena
JURNAL FARMASI GALENIKA Vol 12 No 3 (2025): Jurnal Farmasi Galenika Volume 12 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i3.415

Abstract

Indonesia ranks second in diabetes mellitus with 20.4 million sufferers in 2024 and will increase to 28.5 million in 2025. This condition shows the urgency of finding new alternative antidiabetic candidates that can help reduce the number of sufferers. Landep leaves contain flavonoids, saponins, tannins, triterpenoids, and phenolics, which have potential as antidiabetic agents. This study aims to determine the effect of landep leaf extract administration on postprandial blood glucose levels and histopathological improvements in the pancreas in alloxan-induced rats. This experimental study used 25 alloxan-induced rats divided into 5 groups: negative control (CMC-Na 1%), positive control (Metformin 9 mg/200g rat body weight), and landep leaf extract at doses of 100, 200, and 400 mg/kg body weight. Treatment was administered for 14 days. Data analysis was performed using SPSS with ANOVA. The results showed that landep leaf extract at a dose of 400 mg/kg BW had a significant effect on reducing postprandial blood glucose spikes (p=0.634) compared to the positive control metformin, as well as a significant effect on improving the area of the islets of Langerhans (p=0.978) compared to the positive control. Thus, landep leaf extract has an effect on reducing postprandial blood glucose spikes and provides an improvement in the histopathology of the pancreas of alloxan-induced rats.
Formulasi Dan Evaluasi Fisik Lipstik Dari Ekstrak Kulit Umbi Bit (Beta vulgaris L.) Eryani, Mikhania Christiningtyas; Aditama, Agnis Pondineka Ria; Husni, Patihul; Permatasari, Lina Putri
JURNAL FARMASI GALENIKA Vol 12 No 3 (2025): Jurnal Farmasi Galenika Volume 12 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i3.417

Abstract

Lipstick is a cosmetic used to add color to the lips. Natural dyes that can be used as a lipstick component are beet (Beta vulgaris L.) skin extract. The skin of beet contains betacyanin which can give color to the lips. This study aims to determine the effect of varying concentrations of beet skin extract on the physical properties of lipstick. There are 3 lipstick formulas used with a 1% (F1), 2% (F2), and 3% (F3) concentration of beet skin extract. The research results show that F1 is pink, F2 is red, and F3 is dark red. The entire formula has even spreadability. The pH values of F1, F2, and F3 are 4.9±0.173, 5±0.3, and 5.3±0, respectively. The melting points of F1, F2, and F3 are 50.66±1.15°C, 52.66±1.15°C, and 53.66±0.58°C, respectively. The conclusion of this study is that variations in the concentration of beet extract affect the color, pH, and melting point of lipstick but do not affect the spreadability of lipstick.
Pengembangan Sediaan Losio Ekstrak Buah Naga Putih Husni, Patihul; Budianto, Muhamad Oke; Baitariza, Ardian; Eryani, Mikhania Christiningtyas; Febryanto, Hery Diar; Januarti, Melinda
JURNAL FARMASI GALENIKA Vol 12 No 3 (2025): Jurnal Farmasi Galenika Volume 12 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i3.419

Abstract

White dragon fruit (Hylocereus undatus) is a tropical fruit from a type of cactus plant that contains various powerful antioxidants. The purpose of this study was to obtain the best lotion formula containing extract of white dragon fruit based on physical evaluation. Three lotion formulas (F1, F2, F3) containing 7,5% white dragon fruit extract were prepared in this study. Physical assessment of the lotion preparation included organoleptic tests, homogeneity, pH determination, and viscosity evaluation. The results showed that the preparation was in the form of a liquid and homogeneous lotion with a white color and a rose odor. The pH of the preparation was around 5.2-6.5 with a viscosity between 1200-1800 cps. F3 is the best lotion formula based on physical evaluation during four weeks of storage with a composition of 7.5% white dragon fruit extract, 1% glycerin, 0.05% triethanolamine, 3% liquid paraffin, 0,3% methyl paraben, 2% dimethicone, 2% stearyl alcohol, 1.5% glycerol monostearate, 3% virgin coconut oil, 0.1% disodium edetate, 3% cetyl alcohol, 0.2% titanium dioxide, parfum qs, and aquadest ad 100%.
Pengaruh Ekstrak Air Herba Ceplukan (Physalis angulata L.) Terhadap Kadar Kreatinin Pada Tikus Model Hewan Gagal Ginjal dan Diabetes Melitus Rachmawan, R. Lucky; Choirunnisa, Anna; Rustaman, Nayla Nazza
JURNAL FARMASI GALENIKA Vol 13 No 1 (2026): Jurnal Farmasi Galenika Volume 13 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i1.418

Abstract

Diabetes mellitus is a metabolic disease characterized by elevated blood glucose. Untreated hyperglycemia can lead to the production of free radicals and increased oxidative stress, which play a key role in the destruction of pancreatic beta cells and microvascular complications, such as kidney failure. Physalis angulata L. is known to have antihyperglycemic activity and contains antioxidants that have the potential to protect kidney function. This study aims to determine the effect of single administering aqueous extract of ceplukan herb and in combination with metformin on creatinine levels in rat models of kidney failure and diabetes mellitus. The test animals, male Wistar rats, were given renal failure induction treatment using the ischemic reperfusion method and given alloxan 150 mg/kgBW to induce diabetes mellitus and were given a single treatment of ceplukan herb water extract 7 mg/kgBW and a combination of ceplukan herb water extract 3.5 mg/kgBW with metformin 22.5 mg/kgBW given orally for 21 days. The results of the study showed that a single administration of ceplukan herb water extract showed the highest percentage of creatinine inhibition (55.84%) compared to the combination group (50.55%) in rats as animal models of kidney failure and diabetes mellitus. Therefore, it can be concluded that a single administration of ceplukan herb water extract is more effective in reducing creatinine levels in rats as animal models of kidney failure and diabetes mellitus.
Pengembangan Lotion Anti Nyamuk Ekstrak Daun Kenikir (Tagetes erecta L.) Dengan Variasi Konsentrasi Setil Alkohol Eryani, Mikhania Christiningtyas; Rashati, Dewi; Falahi, Asa; Husni, Patihul; Agustin, Eka Yulia
JURNAL FARMASI GALENIKA Vol 13 No 1 (2026): Jurnal Farmasi Galenika Volume 13 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i1.423

Abstract

The use of chemical-based mosquito repellents has excellent repellent power, but their use can cause hypersensitivity and irritation. In Indonesia, there are several plants that contain essential oils and have mosquito repellent effects. One of them is cosmos (Tagetes erecta L). Cosmos leaf extract is formulated into a lotion preparation so that it can adhere to the skin for a longer time, thus providing longer-lasting mosquito repellent properties. This research aims to determine the effect of varying cetyl alcohol concentrations on the physical properties of lotion. There are 3 lotion formulas used with cetyl alcohol concentrations of 2% (F1), 2.5% (F2), and 3% (F3). The research results show that F1 has a thick texture and brownish-yellow color, F2 has a thick texture and green color, and F3 has a very thick texture and green color. All formulas are homogeneous. F1, F2, and F3 had pH values of 7.5±0, 7.5±0, and 7.9±0, respectively. F1, F2, and F3 have respective viscosities of 20±0 dPas, 30±0 dPas, and 35±0 dPas. F1, F2, and F3 had spreadability values of 8.48±0.51 cm, 7.81±0.05 cm, and 7.10±0.37 cm, respectively. The conclusion of this study is that variations in cetyl alcohol concentration affect the texture, color, pH, viscosity, and spreadability of the lotion.
Sunscreen Activity Test of Tahongai (Kleinhovia hospita L) Leaves Infusion use UV-Vis Spectrophotometry Method Butar-Butar, Maria Elvina Tresia; Sianturi, Sister; Leswana, Nurillahi Febria; Muh. Taufiqurrahman
JURNAL FARMASI GALENIKA Vol 13 No 1 (2026): Jurnal Farmasi Galenika Volume 13 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i1.425

Abstract

Excessive frequency and duration of UV exposure causes adverse effects, including erythema, pigmentation, premature aging, and even skin cancer. Therefore, additional protection is required, such as the use of sunscreen. The development of natural active ingredients is necessary to reduce the negative impact of sunscreen products. Tahongai (Kleinhovia hospita L) contains flavonoid compounds that have the potential as sunscreens due to the presence of chromophore groups that can absorb UVA and UVB rays. The purpose of this study was to determine the potential of tahongai leaf infusion as a sunscreen. The test method of sunscreen activity was carried out in-vitro using UV-Vis spectrophotometry. The sunscreen activity test was carried out by calculating the percent transmission value (%Te), the percent transmission value of pigmentation (%Tp), and the SPF value. The results of the calculation of %Te, %Tp, and SPF values, as well as the sunscreen category at a concentration of 0.5 g are %Te of 3.368 (extra protection), %Tp of 1.248 (sunblock), and SPF value of 21.945 (ultra protection). Tahongai leaf infusion has potential as an active ingredient for sunscreen products and still requires further in vivo research to ensure its effectiveness as well as the duration of its protection
Pengaruh Variasi Konsentrasi Cocamidopropyl Betaine Pada Karakteristik Fisik Sampo Ekstrak Kering Teh Hijau Husni, Patihul; Silviya, Rini; Hasanah, Uswatul; Eryani, Mikhania Christiningtyas; Dewi, Mayang Kusuma; Putriana, Norisca Aliza; Januarti, Melinda
JURNAL FARMASI GALENIKA Vol 13 No 1 (2026): Jurnal Farmasi Galenika Volume 13 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i1.435

Abstract

Hair growth–promoting preparations are used to prevent hair damage problems. Compounds contained in green tea extract have activity as hair growth promoters. This study aimed to obtain data on the effect of variations in cocamidopropyl betaine concentration on the physical characteristics of shampoo containing dry green tea extract. The formulations were prepared in three formulas (F1, F2, and F3) containing different concentrations of cocamidopropyl betaine (8.25%, 8.5%, and 8.75%). The research stages included formulation followed by physical evaluation, including organoleptic properties, homogeneity, pH, viscosity, and foam stability. The results showed that the shampoo preparations were viscous liquids, brown in color, with a characteristic odor, pH of 7–8, viscosity of 250–300 cPs, and foam stability of 15–20 cm. The conclusion of this study is that variations in cocamidopropyl betaine concentration affect the physical characteristics of shampoo containing dry green tea extract. The concentration of cocamidopropyl betaine greatly influences the physical stability of the shampoo, with F3 as the best formula based on physical evaluation, which contains 8.75% cocamidopropyl betaine.
Aktivitas Antibakteri Fraksi Etil Asetat Daun Sirsak (Annona muricata L.) Terhadap Staphylococcus aureus dan Escherichia coli Secara In Vitro Pamungkas, Barolym Tri; Yulita, Victoria; Ibrahim, Arsyik
JURNAL FARMASI GALENIKA Vol 13 No 1 (2026): Jurnal Farmasi Galenika Volume 13 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i1.437

Abstract

The widespread emergence of antimicrobial resistance has intensified the search for plant-derived antibacterial agents as therapeutic alternatives. Soursop (Annona muricata L.) is widely recognised in Indonesian ethnomedicine as a plant effective against infections, owing to its rich and diverse secondary metabolite profile. This study was designed to examine the growth-inhibitory capacity of the ethyl acetate leaf fraction of soursop against pathogenic bacteria Staphylococcus aureus and Escherichia coli in vitro, while concurrently identifying the fraction concentration producing the greatest inhibitory effect. Antibacterial testing employed the agar diffusion disc technique at three fraction concentrations: 10%, 20%, and 40% (w/v). The resulting inhibition zone diameters were subjected to one-way ANOVA and Duncan's Multiple Range Test. All concentrations successfully suppressed the growth of both test organisms; the maximum inhibition was recorded at 40%, with mean inhibition zone diameters of 4.49 mm for S. aureus and 4.06 mm for E. coli. Statistical analysis confirmed a highly significant treatment effect (Fcount = 21.02; p<0.01). Accordingly, the ethyl acetate fraction of soursop leaves demonstrates dose-dependent antibacterial potential worthy of further development.

Page 20 of 21 | Total Record : 201

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