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INDONESIA
JOURNAL OF Pharmacy and Tropical Issues
Published by Indonesian Public Health-Observer Information Forum
ISSN : 28074319     EISSN : 28074122     DOI : https://doi.org/10.56922/pti.v4i2
Core Subject : Health,
Medicine & Pharmacology
Jurnal penelitian dibidang kesehatan meliputi ilmu keparmasian. Penelitain sesuai tren pengobatan sesuai sumber alam di negara tropis. Pengembangan obat dan pendistribusian kepada pelanggan, dan sesuai aturan Badan Pengawas Obat dan Makanan (BPOM) - Republik Indonesia
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 98 Documents
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Hubungan kepatuhan minum obat terhadap kontrol tekanan darah pada pasien lansia Ni Made Diah Dwipayani; Ni Made Suastini; I Made Wiracana
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 3 (2026): July Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i3.3644

Abstract

Background: Hypertension is one of the most common chronic diseases among the elderly, requiring long-term treatment adherence to achieve optimal blood pressure control. Poor adherence to antihypertensive therapy can lead to uncontrolled blood pressure and increase the risk of cardiovascular complications. Purpose: To determine the relationship between medication adherence and blood pressure control in elderly patients with hypertension. Method: A quantitative design with a cross-sectional approach was employed. A total of 47 respondents were selected using the total sampling technique. Data were collected using the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire and patient medical records. Data analysis was performed using descriptive statistics and the Chi-Square test. Results: The majority of respondents demonstrated moderate to high levels of medication adherence and controlled blood pressure. Statistical analysis revealed a significant association between medication adherence and blood pressure control p-value=0.007 (p<0.05). Higher levels of patient adherence to antihypertensive medication were associated with better blood pressure control. Conclusion: Medication adherence plays a crucial role in achieving optimal blood pressure control in elderly patients with hypertension. Increased medication adherence is associated with better blood pressure control.   Keywords: Blood Pressure Control; Elderly; Hypertension; Medication Adherence; MMAS-8.
Analisis kepatuhan penggunaan obat antihipertensi pada pasien hipertensi Johan Andrian; Ade Maria Ulfa; Dessy Hermawan
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 3 (2026): July Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i3.3667

Abstract

Background: Hypertension is a condition where systolic blood pressure is ≥140 mmHg or diastolic blood pressure is ≥90 mmHg, requiring long-term treatment to prevent complications. The success of hypertension therapy is influenced by patient compliance with antihypertensive medication. Purpose: To analyze adherence to antihypertensive medication use among hypertensive patients.. Method: This observational study used a cross-sectional design. The study location was the Bunut Inpatient Community Health Center in Pesawaran Regency. A sample of 130 hypertensive patients was obtained using a purposive sampling technique. Adherence data were obtained using the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire and analyzed using the Chi-Square test with a 95% confidence level (α=0.05). Results: The study showed that most patients were female (6.7%), aged <65 years (69.2%), had less than a high school education (79.2%), were employed (61.5%), had incomes below the minimum wage (UMP) (76.9%), had uncontrolled blood pressure (80.8%), and had a history of hypertension for >12 months (63.8%). The level of compliance with antihypertensive medication use was low, with 13.1% being compliant and 86.9% being non-compliant. Conclusion: There was a significant association between education (p=0.000), income (p=0.000), blood pressure (p=0.014), and history of hypertension (p=0.037) with adherence to antihypertensive medication use. Meanwhile, gender, age, occupation, belief in treatment, and clarity of drug information were not significantly associated with adherence to antihypertensive medication use. Suggestion: Patients are expected to commit to adhering to their treatment and attending regular health check-ups to ensure therapeutic success. To support this, community health centers (Puskesmas) need to optimize patient education, monitoring, and communicative medication counseling. Meanwhile, future researchers are advised to examine other factors influencing patient adherence to provide a more comprehensive overview.   Keywords: Antihypertensives; Hypertension; Medication Compliance.
Kajian etnomedisin masyarakat desa Putri Yohana Roswita Lusi; Tadeus Andreas Lada Regaletha; Matias Nataniel Kolobani; Yendris Krisno Syamruth
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 3 (2026): July Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i3.3673

Abstract

Background: Plant-based ethnomedicine practices remain a vital part of rural public health systems. Knowledge regarding the use of medicinal plants is passed down through generations, yet it has not been scientifically documented, placing it at risk of being lost as times change. Purpose: To identify the types of medicinal plants, the plant parts used, preparation methods, modes of administration, and the types of ailments treated by the village community. Method: This is a descriptive qualitative study employing an ethnographic approach. It was conducted in Camplong 2 Village, Fatuleu District, Kupang Regency, East Nusa Tenggara Province. Data were collected through observation, in-depth interviews, and documentation involving three key informants and 27 additional informants. Data analysis was performed through data reduction, data presentation, and conclusion drawing. Results: Forty seven species of medicinal plants utilized by the community were identified. The plant part most frequently used was the leaf (59%), the dominant preparation method was boiling (57%), and the most common method of administration was oral consumption (54%). These medicinal plants were used to treat 34 types of ailments categorized into 10 groups, with the category comprising fever and general bodily complaints being the most prevalent (19%). Conclusion: Village communities continue to maintain plant-based ethnomedicine practices rich in local knowledge. The diversity of medicinal plant species, along with the methods of their preparation and use, demonstrates that traditional medicine still plays a vital role in maintaining community health.   Keywords: Ethnomedicine; Medicinal Plants; Traditional Medicine.
Ekspresi protein pada pasien tuberkulosis kanker jaringan kelenjar getah bening dan non kelenjar getah bening Lendawati Lendawati; Hasti Primadilla Krismaningrum
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 2 (2026): June Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i2.3681

Abstract

Background: Mycobacterium tuberculosis in patients with tuberculosis has mechanisms that induce tumor formation and contribute to the development of cancer. In more than 80% of cases, TB primarily affects the lungs and other tissues, leading to chronic inflammation. Inflammation has long been associated with the development of cancer. T lymphocytes from patients with active tuberculosis secrete high levels of vascular endothelial growth factor (VEGF). VEGF is also secreted by CD4+ T lymphocytes treated with purified tuberculin protein derivative (PPD). Purpose: To determine protein expression in tuberculosis patients with lymph node and non-lymph node TB tissue. Method: This experimental study employed immunohistochemistry. Data were analyzed using one-way ANOVA followed by the Tukey HSD test. Research data were statistically analyzed using the Mann–Whitney test. Results: Non-lymph node tuberculosis exhibits a lower cellular immune response, with the H-score method providing an accurate quantitative assessment of CD4 expression. Conclusion: CD4 protein expression based on H-score was significantly higher in lymph node tuberculosis. Suggestion: Further research correlating CD4 expression with other specific immune biomarkers is needed to clarify the immune response profile in tuberculosis.   Keywords: CD4; Immunohistochemistry; Lymph Node; Tissue; Tuberculosis.
Efektivitas range of motion sebagai terapi pendukung dalam meningkatkan kemampuan activity of daily living pasien stroke Dedek Saiful Kohir; Sulastri Sulastri; Virginia Syafrinanda; Made Marsela Dwi Natalia
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 2 (2026): June Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i2.3696

Abstract

Background: Stroke patients often experience a decline in their ability to perform Activities of Daily Living (ADL) due to impaired motor function. Range of Motion (ROM) therapy is a non-pharmacological intervention that can help improve motor function and independence in stroke patients. Purpose: To determine the effect of ROM therapy on ADL ability in stroke patients. Method: This study employed a quantitative, quasi-experimental design using a non-equivalent control group approach. The independent variable was ROM therapy, while the dependent variable was the ADL ability of stroke patients. The sample consisted of 36 respondents selected via purposive sampling. The study was conducted from March to May 2026. Data were collected using the Barthel Index observation sheet and subsequently analyzed using the Wilcoxon test, paired t-test, and Mann-Whitney U test. Results: Research indicates an effect of ROM therapy on ADL ability in stroke patients, with a p-value of 0.000 (<0.05). Conclusion: This study demonstrates that ROM therapy contributes to improved ADL capabilities in stroke patients.   Keywords: Activities of Daily Living; Dependence; Independence; Range of Motion; Stroke
Formulasi dan uji stabilitas sediaan body scrub ekstrak ubi jalar ungu (Ipomoea batatas l.) dan bunga telang (Clitoria ternatea l.) dengan variasi konsentrasi trietanolamin Anissa Fitriani; Yovita Endah Lestari; Vito Zhafran Octonariz
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 3 (2026): July Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i3.3707

Abstract

Background: Exposure to free radicals and accumulation of dead skin cells can cause dull skin and premature aging. Purple sweet potato (Ipomoea batatas L.) and butterfly pea flower (Clitoria ternatea L.) contain anthocyanins and flavonoids that possess strong antioxidant activity and have the potential to be developed into Body scrub preparations. Purpose: To formulate a Body scrub containing purple sweet potato and butterfly pea flower extracts and evaluate the effect of triethanolamine (TEA) concentration on physical stability and antioxidant activity. Method: This experimental study used four formulations containing different TEA concentrations, namely 0% (F1), 1% (F2), 2% (F3), and 3% (F4). Physical evaluations included organoleptic test, homogeneity, pH, spreadability, adhesiveness, irritation test, and cycling test stability. Antioxidant activity was determined using the DPPH method and expressed as IC₅₀ values. Results: Formulations F2, F3, and F4 showed good physical stability and met the requirements of topical preparations, while F1 showed instability due to the absence of emulsifier. Antioxidant activity testing demonstrated IC₅₀ values of 10.31 ppm (F1), 11.20 ppm (F2), 13.63 ppm (F3), and 32.68 ppm (F4), indicating very strong antioxidant activity. Increased TEA concentration tended to increase pH and reduce antioxidant activity. Conclusion: Variation of TEA concentration affected the physical stability and antioxidant activity of Body scrub preparations. Formula F3 containing 2% TEA provided the most optimal balance between physical stability and antioxidant effectiveness.   Keywords: Antioxidant; Body Scrub; Butterfly Pea Flower; Purple Sweet Potato; Triethanolamine.
Kunjungan antenatal care dan dukungan keluarga berhubungan dengan kekurangan energi kronik Roslina Roslina; Nelly Indrasari; Amrina Octaviana; Nurlaila Nurlaila
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 2 (2026): June Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i2.3709

Abstract

Background: Chronic energy deficiency (CED) during pregnancy can disrupt the mother’s nutritional reserves and fetal growth. Antenatal care (ANC) visits and family support are modifiable factors related to healthcare and the household. Purpose: To analyze the crude association between ANC visits and family support and the incidence of KEK among pregnant women. Method: This focused secondary analysis used data from a 2024 parent study involving 100 pregnant women who received care at a midwife’s private practice. KEK was defined as an upper arm circumference <23.5 cm. ANC visits were categorized as 0–3 times and >3 times; family support was categorized as absent and present. The p-value for the chi-square test refers to the parent study, while the crude prevalence ratio (PR) and 95% confidence interval (CI) were calculated from the available 2×2 frequency table. Results: Eccentricity was reported in 33.0% of respondents. The proportion of eccentricity was higher among mothers with 0–3 ANC visits compared to those with >3 visits (46.7% vs. 12.5%; PR=3.73; 95% CI: 1.57–8.85; p<0.001). KEK was also higher among mothers without family support than among those who received support (55.6% vs. 20.3%; PR = 2.74; 95% CI: 1.55–4.82; p < 0.001). Conclusion: Limited ANC visits and a lack of family support are associated with a higher prevalence of stunting. The findings support strengthening nutritional screening, scheduled ANC follow-ups, and counseling that involves the family. A cross-sectional design and unadjusted analysis cannot be used to draw conclusions about cause-and-effect relationships.   Keywords: Antenatal Care; Chronic Energy Deficiency; Family Support; Independent Midwifery Practice; Pregnancy.
Efektivitas biogenik silver nanopartikel (AgNPs) dalam sediaan gel terhadap pertumbuhan Propionibacterium acnes dan bakteri patogen luka Shabina Adinia Yonny; Ratna Purwaningrum; Mala Kurniati; Dwi Marlina Syukri
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 3 (2026): July Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i3.3749

Abstract

Background: Acne and wound infections are health issues frequently caused by pathogenic bacteria such as Propionibacterium acnes, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii. Rising antibiotic resistance is driving the development of alternative antibacterial agents. Purpose: To determine the effectiveness of biogenic silver nanoparticles (AgNPs) in gel preparations synthesized using Eucalyptus pellita leaf extract against the growth of Propionibacterium acnes and wound pathogenic bacteria. Method: This was an experimental laboratory study using a post-test-only control group design. Antibacterial activity was tested using the well-diffusion method. The results showed that the AgNP gel inhibited the growth of all tested bacteria. The largest inhibition zone diameter was observed against Propionibacterium acnes, measuring 26.67 ± 2.309 mm. Results: The two-way ANOVA test showed a significant difference between bacterial types and treatment groups (p<0.001). Conclusion: Biogenic silver nanoparticles (AgNPs) in gel formulations exhibit antibacterial activity and have the potential to be developed as alternative antibacterial agents.   Keywords: AgNPs; Antibacterial; Eucalyptus Pellita; Propionibacterium Acnes; Wound Pathogenic Bacteria.
Pengaruh pemberian ekstrak kulit pisang kepok (Musa paradisiaca L.) terhadap kondisi metabolik pada mencit model diabetes melitus tipe 2 Putri Binta Fadillah; Yesi Nurmalasari; Ratna Purwaningrum; Mala Kurniati
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 3 (2026): July Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i3.3753

Abstract

Background: Type 2 diabetes mellitus is a chronic metabolic disorder characterized by impaired insulin function, elevated blood glucose levels, and abnormal lipid profiles, including HDL. Purpose: To determine the effect of Musa paradisiaca L. (Kepok banana) peel extract on random blood glucose (RBG) and HDL levels in a type 2 diabetes mellitus mouse model. Method: A true experimental study with a pretest-posttest control group design. A total of 20 male mice were divided into four groups: normal control, negative control, positive control, and treatment group, each consisting of five mice. The negative control, positive control, and treatment groups were induced with alloxan. The positive control group was given metformin, while the treatment group was given kepok banana peel extract for 14 days. The data were analyzed using normality and homogeneity tests, one-way ANOVA, and the Games-Howell post hoc test. Results: The treatment group showed the greatest reduction in GDS, with a ΔGDS of 112.4 mg/dL, followed by the positive control at 99.6 mg/dL, the negative control at 4.8 mg/dL, and the normal control at 1.4 mg/dL. The ANOVA test showed a significant difference in ΔGDS between groups (p=0.031), but the Games-Howell test did not show significant differences between pairs of groups: KN vs K- (p=0.973), KN vs K+ (p=0.222), KN vs P (p=0.170), K- vs K+ (p=0.266), K- vs P (p=0.200), and K+ vs P (p=0.996). HDL levels in the treatment groups were 88.39 ± 22.98 mg/dL, with no significant differences between groups (p=0.788). Conclusion: Kepok banana peel extract tends to lower GDS, but has no significant effect on HDL.   Keywords: Alloxan; Banana Peel Extract; Glucose Disposal System; High-Density Lipoprotein; Type 2 Diabetes Mellitus.
Hubungan antara kepatuhan penggunaan obat dengan keberhasilan terapi pada pasien hipertiroid usia produktif Neng Widiyah Hikmah Syaripah; Mala Kurniati; Veronica Ela Rimawati; Toni Prasetia
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 3 (2026): July Edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i3.3786

Abstract

Background: Hyperthyroidism is an endocrine disorder caused by the excessive production of thyroid hormones, which can lead to complications if not properly managed. Treatment success in patients with hyperthyroidism is influenced by medication adherence. Purpose: To determine the relationship between medication adherence and treatment success in patients of productive age with hyperthyroidism. Method: This was an analytic observational study with a cross-sectional design. The study sample consisted of 54 respondents selected using purposive sampling. Adherence levels were measured using the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire, while treatment success was assessed based on thyroid hormone test results and clinical symptom improvement recorded in patient medical records. Data analysis was conducted using univariate and bivariate methods, employing the chi-square test. Results: The results show that the respondents' mean TSH levels decreased from 6.87 mIU/L to 3.21 mIU/L following therapy. The majority of respondents demonstrated adherence levels ranging from low to high and achieved successful therapeutic outcomes. There is an association between medication adherence and therapeutic success in patients with hyperthyroidism. Conclusion: Medication adherence is associated with therapeutic success in hyperthyroid patients of working age. The higher the level of patient adherence to treatment, the greater the therapeutic success achieved. Suggestion: Ongoing education, monitoring, and support from healthcare professionals are required to improve patient adherence.   Keywords: Health Belief Model; Hyperthyroidism; Medication Adherence; MMAS-8; Treatment Success.

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