cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Risti Graharti
Contact Email
risti.graharti@gmail.com
Phone
+6281369730011
Journal Mail Official
medulla.fkunila@gmail.com
Editorial Address
-
Location
Kota bandar lampung,
Lampung
INDONESIA
Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 972 Documents
 89   90   91   92   93 
Analisis Hubungan Indeks Massa Tubuh dengan Daya Tahan Kardiorespirasi pada Anggota Komunitas Futsal Fakultas Kedokteran Universitas Lampung Ekki Pirmansyah; Berawi, Khairun Nisa; Ramadhian, Muhammad Ricky
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1675

Abstract

Cardiorespiratory endurance is a key indicator of physical fitness, reflecting the efficiency of the heart, lungs, and circulatory system in transporting and utilizing oxygen. Low cardiorespiratory endurance can increase cardiac workload and blood pressure, ultimately elevating the risk of cardiovascular disease. In addition to cardiorespiratory endurance, body mass index (BMI) is another important measure of physical fitness. This study aimed to analyze the relationship between BMI and cardiorespiratory endurance among members of the Futsal Community of the Faculty of Medicine, University of Lampung. This analytic observational study employed a cross-sectional design. A total sampling technique was used, involving 62 student members of the futsal community. The independent variable was BMI, calculated as body weight (kg) divided by height squared (m²). The dependent variable was cardiorespiratory endurance, assessed using the Rockport test. Data were analyzed using the Chi-square test. In this study, most of the participants had a normal BMI (40.32%), while cardiorespiratory endurance levels were predominantly categorized as poor (38.71%) and fair (37.81%). Bivariate analysis yielded a p-value of 0.000, indicating a significant association between BMI and cardiorespiratory endurance among members of the Futsal Community of the Faculty of Medicine, University of Lampung. The direction of the correlation was negative, meaning that an increase in BMI was associated with a decrease in cardiorespiratory endurance.
Faktor Gangguan Ginjal dan Diabetes Melitus yang Mempengaruhi Mortalitas Penderita Sindrom Koroner Akut di RSUD Dr. H. Abdul Moeloek Tahun 2020–2021 Fadhlurrahman, Fadhlurrahman; Yonata, Ade; Karima, Nisa; Kurniati, Intanri
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1676

Abstract

Acute Coronary Syndrome (ACS) is one of the leading causes of cardiovascular mortality worldwide and in Indonesia. Various risk factors have been investigated, yet two important comorbidities that frequently worsen the prognosis are diabetes mellitus and kidney disorders. Diabetes mellitus accelerates atherosclerosis and promotes plaque instability, whereas kidney disorders exacerbate cardiovascular metabolism and restrict therapeutic options due to impaired drug elimination. This study aimed to analyze the influence of diabetes mellitus and kidney disorders on the mortality of ACS patients at Dr. H. Abdul Moeloek General Hospital. An analytic observational study with a cross-sectional design was conducted involving 71 patients diagnosed with ACS during the 2020–2021 period. The main independent variables were diabetes mellitus and kidney disorders, while mortality served as the dependent variable. Data were analyzed using the Chi-Square test, Fisher’s Exact Test, and Odds Ratio (OR) calculations, with a significance level of p < 0.05. The study found an overall mortality rate of 25.3% among ACS patients. A significant relationship was observed between diabetes mellitus and mortality (p = 0.012; OR = 3.1) as well as between kidney disorders and mortality (p = 0.019; OR = 4.0). This indicates that ACS patients with diabetes mellitus have approximately three times higher risk of death, and those with kidney disorders have about four times higher risk compared to those without these comorbidities. In conclusion, diabetes mellitus and kidney disorders are significant predictors of mortality among ACS patients, highlighting the importance of comprehensive management for patients with these conditions in clinical cardiovascular care.
MANAJEMEN ANESTESI PADA PASIEN TUMOR TIROID DEXTRA SUSPEK KEGANASAN: SEBUAH LAPORAN KASUS Salsabila, Indah; Indrawan, Khadafi
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1683

Abstract

Thyroid nodules are excessive growth and structural changes with or without functional changes in one or more parts of the thyroid tissue. The prevalence of thyroid cancer is 4-6% of thyroid nodules ( both of single or multiple nodules). Thyroid cancer is the most common endocrine malignancy with an incidence of 3.1% worldwide. One of the treatments for thyroid cancer is thyroidectomy. Indications for thyroidectomy are thyroid malignancy, obstructive symptoms, retrosternal goiter and Graves' disease unresponsive to medical treatment, recurrent hyperthyroidism, Hashimoto's disease and for cosmetic reasons. Thyroid malignancy poses several difficulties in anesthesia. Airway management in patients who have cancer in the head and neck may experience abnormal changes in the airway anatomy. Therefore, it is necessary to prepare an anesthesia plan as well as appropriate pre-operative, intra- operative and post-operative management so that the operation runs smoothly and safely and reduces morbidity and mortality in patients.
Laporan Kasus : Pasien Anak 8 Tahun dengan Tonsilitis Kronik Eka Putra, Muhammad Rafi; Imanto, Mukhlis
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1690

Abstract

Tonsillitis is one of the most common otorhinolaryngological (ENT) diseases in children, characterized by inflammation of the tonsils caused by recurrent or persistent infections. This condition has significant clinical implications as it may lead to respiratory disturbances, sleep disorders, and a decrease in overall quality of life if not managed comprehensively. Chronic tonsillitis is typically characterized by prolonged symptoms with recurrent episodes, often accompanied by tonsillar hypertrophy and obstructive manifestations. We report a case of an 8-year-old boy who presented with a sore throat that had persisted for three years prior to hospital admission, with worsening symptoms in the past month. The patient’s father reported a sensation of a lump in the throat, visibly enlarged tonsils, and frequent snoring during sleep. Physical examination revealed hyperemia of the soft palate, a midline uvula with edema and hyperemia, hyperemic pharyngeal mucosa, posterior arch that was difficult to assess, hyperemic tonsils with widened crypts and no detritus, and tonsil size graded T3–T2. Based on clinical history and physical findings, the diagnosis of chronic tonsillitis was established. Management of this condition requires a thorough evaluation of recurrence frequency, degree of airway obstruction, and its impact on systemic function to determine the appropriate therapeutic approach, either conservative or surgical, in order to prevent long-term complications.
Penatalaksanaan Holistik Pada Penjahit Perempuan Usia 42 Tahun Dengan Carpal Tunnel Syndrome (CTS) Melalui Pendekatan Kedokteran Keluarga di Wilayah Kerja Puskesmas Natar Utami, Putu Urvasi Ari; Mayasari, Diana; Santika, Maya
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1691

Abstract

Carpal Tunnel Syndrome (CTS) is a peripheral nerve disorder caused by compression of the median nerve at the wrist, classified as a musculoskeletal disorder (MSD) with symptoms such as pain, tingling, and numbness, commonly triggered by ergonomic risk factors in the workplace. The management of CTS requires a comprehensive family medicine-based approach to improve treatment outcomes and the patient’s quality of life. This study aims to implement integrated family medicine principles in examining internal and external risk factors, medical problems, and patient management strategies based on Evidence-Based Medicine (EBM) with a patient-centered, family-oriented, and community-based approach. The research method is a descriptive case report using primary data from interviews, physical examinations, and home visits, as well as secondary data from the medical records of Kedaton Primary Health Center, evaluated holistically through quantitative and qualitative methods. The results showed that a 42-year-old female patient, Mrs. M, with CTS was managed comprehensively with analgesics, vitamins, and poster-based educational interventions; evaluation indicated improved symptoms, increased patient understanding as evidenced by pre- and post-test scores, and enhanced family support. In conclusion, the application of family medicine approaches supports holistic and comprehensive management of CTS patients to identify internal and external risk factors, improve therapeutic success, and enhance patient well-being.
Pengaruh Pemberian Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp) Terhadap Gambaran Sel Hepatosit Tikus Putih Jantan Galur Sprague-Dawley Ruslani, Nada Oktista; Susianti, Susianti; Graharti, Risti; Rudianto, Waluyo
Medula Vol 15 No 3 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i3.1693

Abstract

Syzygium myrtifolium Walp., commonly known as red shoot leaves, is an ornamental plant rich in bioactive compounds such as flavonoids, tannins, and terpenoids, which exhibit antioxidant, anticancer, and antibacterial properties. However, administration at high doses may lead to hepatotoxic effects. The liver plays a central role in drug metabolism and is the first organ exposed to toxic agents, making it highly susceptible to hepatocyte necrosis. This study aimed to evaluate the effect of ethanol extract of Syzygium myrtifolium leaves on liver histopathology in male white rats (Rattus norvegicus). This experimental study employed a post-test only control group design with three groups: control, 2000 mg/kgBW, and 5000 mg/kgBW. The extract was administered orally, and hepatocyte necrosis was assessed using a histopathological scoring system. Statistical analysis included Shapiro-Wilk, Levene’s Test, One Way ANOVA, and post hoc LSD. Histopathological examination revealed normal hepatocytes in the control group, focal necrosis in the 2000 mg/kgBW group, and extensive necrosis in the 5000 mg/kgBW group. Statistical analysis confirmed normally distributed and homogeneous data, while ANOVA indicated significant differences among groups (p=0.001). Post hoc LSD test further demonstrated significant differences between the control and treatment groups as well as between both treatment doses. In conclusion, oral administration of ethanol extract of Syzygium myrtifolium leaves induces hepatocyte necrosis in male white rats, with the severity of liver damage increasing in a dose-dependent manner.
Laporan Kasus : Anensefali Fathul Qadir Kasyfi; Welay, Santri Ditira Welay; Bambang Kurniawan
Medula Vol 16 No 1 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i1.1630

Abstract

Anencephaly is a fetal development disorder characterized by the absence of skull bones accompanied by a lack of most or all of the fetal brain tissue. Anencephaly is a developmental pathology characterized by a fetus that does not have a calvarium, with a lack of most or all of the fetal brain tissue. The number of cases of anencephaly varies, estimated between 0.5–2 per 1000 births. In some cases anencephaly may be caused by chromosomal abnormalities or involve a single gene defect or disruption of the amniotic membrane. One of the genes related to folate metabolism is believed to play a role in the process of anencephaly, one of which is methylene tetrahydrofolate reductase which has been shown to be associated with the risk of NTDs. The causes of this anencephaly are multifactorial including iatrogenic, toxic, metabolic, nutritional and chromosomal. In this case, a 28-year-old patient, G3P1A1 with a gestational age of 25 weeks came to the Obstetrics Polyclinic with no complaints and wanted to be referred to the fetomaternal department of dr. H. Abdul Moeloek Lampung Province, because he was diagnosed with congenital anencephaly in his fetus. Physical and supporting examinations found fetal movement, fetal heart rate 143x/minute, and USG results showed frog eye appearance and laboratory results obtained reactive Anti-HIV. The diagnosis can be confirmed as anencephaly with HIV. The patient terminated her pregnancy vaginally.
Uji Toksisitas Subkronik Ekstrak Kulit Batang Bakau (Rhizophora Apiculata) Terhadap Kerusakan Ginjal Tikus Putih Jantan (Rattus Norvegicus) Galur Sparague Dawley Maulana, Rifadly Yusril; Mustofa, Syazili; Busman, Hendri; Kurniawaty, Evi
Medula Vol 16 No 1 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i1.1652

Abstract

Toxicity testing is a test to detect toxic effects of a substance in a biological system to obtain characteristic dose-response data from the test preparation. Rhizophora apiculata contains compounds such as alkaloids, flavonoids, triterpenoids, steroids, saponins, and tannins. Tannins are active compounds with potential antioxidant properties. This study is an experimental study using a Posttest Only Control Group Design and was conducted over 28 days on 30 rats divided into 5 groups: the control group (K), Treatment Group 1 at 114 mg/kg body weight (P1), Treatment Group 2 at 228 mg/kg body weight (P2), Treatment Group 3 at 456 mg/kg body weight (P3), and Treatment Group 4 at 912 mg/kg body weight (P4). Data were analyzed using the Kruskal-Wallis statistical test and the Mann-Whitney Post Hoc test. Based on the results of the Kruskal-Wallis statistical test, a p-value of 0.000 was obtained. Meanwhile, based on the results of the Mann-Whitney Post hoc statistical test, groups K, P1, P2, P3, and P4 showed significant differences (p<0.05), while groups P2 and P3, which received intervention or treatment, showed insignificant differences. Administration of mangrove bark extract (Rhizophora apiculata) for 28 days had a toxic effect on the kidneys at a dose of 114 mg/kgBW, with toxic effects in the form of tubular edema and glomerular edema. At doses of 228 mg/kgBW, 456 mg/kgBW, and 912 mg/kgBW, Higher doses resulted in more severe toxic effects on the histopathology of the kidneys of Sprague Dawley rats, as evidenced by tubular edema, glomerular edema, Bowman's space edema, and inflammatory cells.
Perkembangan Strategi Pengobatan β-Thalassemia Santhi, Komang Ria Yuliana; Sangging, Putu Ristyaning Ayu; Jausal, Anisa Nuraisa; Ismunandar, Helmi
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1663

Abstract

β-thalassemia is an inherited blood disorder caused by mutations in the β-globin gene that reduce or eliminate β-globin chain synthesis, leading to hypochromic microcytic anemia and significant morbidity worldwide. The disorder is prevalent in South Asia, Southeast Asia, the Mediterranean, the Middle East, India, and Africa, with approximately 1.5% of the global population identified as carriers. Severe complications, including iron overload, skeletal deformities, heart failure, and multi-organ damage, contribute to its substantial global health burden. This narrative literature review synthesizes evidence from PubMed, Cochrane, and Google Scholar to examine conventional and emerging therapeutic strategies for β-thalassemia, with particular emphasis on recent advances in gene therapy. Standard management relies on regular blood transfusions and iron chelation, which remain supportive and are associated with long-term complications. Hematopoietic stem cell transplantation is the only established curative treatment, especially effective in pediatric patients with matched HLA donors, although its availability is limited. Novel pharmacologic agents, such as luspatercept and mitapivat, have demonstrated reductions in transfusion requirements and improvements in hemoglobin production. Additional approaches, including fetal hemoglobin induction and modulation of iron metabolism, show encouraging potential. A major breakthrough is CRISPR-based gene therapy using exagamglogene autotemcel (Casgevy), approved by the FDA and EMA in 2024, with phase 3 trials reporting transfusion independence in more than 90% of patients and significant quality-of-life improvements. Despite persistent challenges related to cost, access, and long-term safety, these advances indicate a paradigm shift toward precision medicine with curative potential for β-thalassemia.
Hubungan Hipertensi dengan Penyakit Jantung Koroner (PJK): Tinjauan Pustaka Worocahyo, Avis Meyvika; Kurniati, Intanri; Damayanti, Putri; Susianti, Susianti
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1694

Abstract

Coronary Artery Disease (CAD) is still one of the leading causes of mortality worldwide, including in Indonesia with a steadily rising prevalence. Hypertension is recognized as a major risk factor, as it accelerates atherosclerosis, induces endothelial dysfunction, and promotes cardiac structural changes that ultimately lead to coronary artery narrowing. This study employed a literature review approach by analyzing scientific articles discussing the association between hypertension and CAD in Indonesia. The findings show a significant relationship between hypertension and CAD, with p-values < 0.05 across multiple studies, and hypertensive individuals found to be more than twice as likely to develop CAD compared to normotensive individuals. Pathophysiologically, chronic hypertension contributes to hemodynamic disturbances, cardiac remodeling, endothelial dysfunction, and activation of the renin-angiotensin-aldosterone system (RAAS), thereby accelerating atherosclerosis and triggering myocardial infarction. These results highlight the importance of early detection and effective management of hypertension as essential strategies for preventing cardiovascular complications.

Page 91 of 98 | Total Record : 972

 89   90   91   92   93 

Filter by Year

2019 2026


Reset
Filter By Issues
All Issue Vol 16 No 3 (2026): Medula Vol 16 No 2 (2026): Medula Vol 16 No 1 (2026): Medula Vol 14 No 10 (2025): Medula Vol 15 No 4 (2025): Medula Vol 15 No 3 (2025): Medula Vol 15 No 2 (2025): Medula Vol 15 No 1 (2025): Medula Vol 14 No 12 (2024): Medula Vol 14 No 11 (2024): Medula Vol 14 No 9 (2024): Medula Vol 14 No 8 (2024): Medula Vol 14 No 7 (2024): Medula Vol 14 No 6 (2024): Medula Vol 14 No 5 (2024): Medula Vol 14 No 4 (2024): Medula Vol 14 No 3 (2024): Medula Vol 14 No 2 (2024): Medula Vol 14 No 1 (2024): Medula Vol 13 No 4.1 (2023): Medula - Edisi Spesial (Special Sense) Vol 13 No 7 (2023): Medula Vol 13 No 6 (2023): Medula Vol 13 No 5 (2023): Medula Vol 13 No 4 (2023): Medula Vol 13 No 3 (2023): Medula Vol 13 No 2 (2023): Medula Vol 13 No 1 (2023): Medula Vol 12 No 4 (2022): Medula Vol 12 No 3 (2022): Medula Vol 12 No 2 (2022): Medula Vol 12 No 1 (2022): Medula Vol 11 No 4 (2021): Medula Vol 11 No 3 (2021): Medula Vol 11 No 2 (2021): Medula Vol 11 No 1 (2021): Medula Vol 10 No 4 (2021): Medula Vol 10 No 3 (2020): Medula Vol 10 No 2 (2020): Medula Vol 10 No 1 (2020): Medula Vol 9 No 4 (2020): Medula Vol 9 No 3 (2019): Medula Vol 9 No 2 (2019): Medula More Issue