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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 289 Documents
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Pengaruh PENGARUH PEMBERIAN JUS KOMBINASI DAGING BUAH NANAS (Ananas comusus (L.) Merr.) DAN UMBI LOBAK PUTIH (Raphanus satius L.) TERHADAP PENURUNAN KADAR ASAM URAT TIKUS PUTIH JANTAN HIPERURISEMIA Kurniawati, Reka; Rasyad, Ade Arinia; Lely, Nilda; Imanda, Yunita Listiani
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art19

Abstract

Background: Hyperuricemia is defined as a condition in which serum uric acid levels exceed 7 mg/dL in men and 6 mg/dL in women. First-line management typically involves lifestyle modification and non-pharmacological interventions. One such intervention includes the administration of a combination juice made from pineapple flesh (Ananas comosus (L.) Merr.) and white radish (Raphanus sativus L.), both of which contain flavonoids capable of inhibiting xanthine oxidase activity. Objective: This study aimed to investigate the effect of the combination of pineapple and white radish juice on serum uric acid levels in male Wistar rats with hyperuricemia. Methods: The study employed a pre- and post-test control group design involving five groups (n = 5 per group). Group I served as the negative control and received a placebo; Group II served as the positive control and received allopurinol; Group III received pineapple juice; Group IV received white radish juice; and Group V received a combination of both juices. Serum uric acid levels were measured before and after the treatment period, and the percentage reduction was calculated. Statistical analysis was performed using the Kruskal-Wallis test followed by the Mann-Whitney U test for pairwise comparisons. Result: The percentage reductions in uric acid levels were as follows: negative control group, 39.8%; positive control group, 49.67%; pineapple juice group, 34.75%; white radish juice group, −5.12%; and combination juice group, 15.5% (p<0.05). Conclusion: In conclusion, administration of pineapple juice alone demonstrated a greater reduction in uric acid levels than the combined juice.
Innovation of microemulsion of mangosteen fruit rind extract (Garcinia mangostana L.) as an antidiabetic agent for nephropathy Mahmudah, Rifa’atul; Salsahbila; Prasilya, Sindi; Amelia, Resty; Rahayu, Maghfira Dwi; Rasyid, Fitriani
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art20

Abstract

Background: Diabetes mellitus (DM) is a global health concern with a rising prevalence. Chronic kidney disease (CKD), affecting up to 40% of DM patients, is a severe complication. Mangosteen rind extract (MRE), containing bioactive compounds such as xanthone and α-mangostin, exhibits antidiabetic and nephroprotective potential, enhanced through microemulsion formulations that improve solubility, stability, and bioavailability.Objective: To evaluate the effectiveness of microemulsions containing MRE as antidiabetic and nephroprotective agents.Method: Microemulsion formulations were evaluated for organoleptic properties, pH, viscosity, homogeneity, and particle size. Effectiveness testing was conducted on male Wistar rats divided into five groups: a negative control, a positive control, and three treatment groups receiving MRE doses of 25, 50, and 100 mg/kgBW. Blood glucose levels and nephroprotective parameters were analyzed using one-way ANOVA and LSD post hoc tests (p>0.05).Results: The microemulsion met physical criteria, including optimal pH, stable viscosity, good homogeneity, and appropriate particle size. MRE significantly reduced blood glucose levels and improved kidney function, with the 100 mg/kgBW dose being most effective.Conclusion: MRE microemulsions are effective in lowering blood glucose levels and providing nephroprotective benefits, offering potential therapy for DM and diabetic nephropathy.
Optimizing collagen tripeptide and sucrose composition in nutricosmetic gummy candy Agung, Nia; Luthfi, Salsabila; Darsih, Cici; Rumiyati, Rumiyati; Dian Laksitorini, Marlyn
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art17

Abstract

Background: The rising prejuvenation trend has fueled demand for anti-aging functional foods. While sucrose is essential for gummy texture, excessive sugar content can inhibit collagen activity. Research on balancing these components to preserve bioactivity remains limited. This study addresses this gap by optimizing a formula that balances sucrose and collagen tripeptide levels, ensuring ideal physical properties without compromising the collagen’s antiaging efficacy.Objective: This study aims to obtain the optimum formula for collagen tripeptide gummy candy and to determine the effect of sucrose and collagen tripeptide compositions on pH, organoleptic, moisture content, syneresis, texture, and sensory attributes.Method: The gummy candy formula was optimized using the Simplex Lattice Design (SLD) method in Design Expert ver. 13. Verification of the optimal formula was conducted using a one-sample t-test and the Wilcoxon signed-rank test to compare predicted and actual values.Results: The results showed that the composition of sucrose and collagen tripeptide significantly affected the physicochemical properties and sensory acceptance of gummy candy. The optimum formula was obtained at a combination of 2.152% collagen tripeptide and 33.848% sucrose. Conclusion: The amount of collagen tripeptide in the formulation affects the physicochemical properties of the gummy, and thus more research needs to be conducted to increase the amount of collagen tripeptide that can be released.
Analgesic effect of combined white turmeric (Curcuma zedoaria) and red ginger (Zingiber officinale Rosc. var. rubrum) ethanolic extracts in mice Sasongko, Heru; Tri Utami, Diyah; Farida, Yeni; Riza Zulaika, Hanifah; Mayta Vannesa Putri, Petrisia
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art16

Abstract

Background: Analgesics are widely used to relieve pain without causing loss of consciousness. However, prolonged use may lead to serious adverse effects, leading to the need for safer natural alternatives. White turmeric (Curcuma zedoaria) contains curcumin, while red ginger (Zingiber officinale Rosc. var. rubrum) contains gingerol, both of which possess analgesic properties.Objective: This study evaluated the analgesic activity of combined ethanol extracts of white turmeric and red ginger using writhing and hot plate tests in mice.Methods: The experimental design consisted of seven groups: negative control (CMC-Na), positive controls (mefenamic acid and tramadol), single extracts of white turmeric (500 mg/kg) and red ginger (600 mg/kg), and three extract combinations (25:75, 50:50, and 75:25). In the writhing test, pain was induced using 0.6% acetic acid, while the hot plate test measured responses to thermal stimulation. Data were analyzed using one-way ANOVA followed by the LSD post hoc test.Results: The combination containing 75% white turmeric extract (315 mg/kg) and 25% red ginger extract (150 mg/kg) showed the strongest analgesic activity among all treatment groups.Conclusion: The combination of white turmeric and red ginger ethanol extracts demonstrated effective analgesic activity, with the 75:25 combination producing the most potent effect in mice.
Formulation of spray gel and the evaluation of anti-inflammatory activity or effect to relieve diaper rash Utami, Tri Fitri Yana; Tajudin, Tatang; Indratmoko, Septiana; Yunadi, Frisca Dewi; Rinanda, Intan Frisshin
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art12

Abstract

Background: Diaper rash requires topical preparation that minimizes friction on inflamed infant skin. A spray gel was selected for hygienic, low-contact application, while peppermint oil, Virgin Coconut Oil (VCO), and lemon oil were combined for their complementary anti-inflammatory, skin-barrier-supporting, and antioxidant properties.Objective: This study aimed to formulate and evaluate an anti-inflammatory spray gel containing peppermint oil, VCO, and lemon oil, with a focus on the relationship between formula composition, physical quality, and in vitro anti-inflammatory activity. Method: This laboratory-based experimental study prepared seven spray gel formulations using Carbopol-940 and HPMC as gel-forming agents. Data were collected through organoleptic observation, homogeneity, pH, spray pattern, adhesion-spreadability, mechanical stability, and anti-inflammatory activity testing using the bovine-serum-albumin method for inhibiting protein denaturation. The data were analyzed descriptively, while anti-inflammatory activity was assessed based on percentage inhibition and IC₅₀ values. Results: The results indicated that all formulations were homogeneous, mechanically stable, and had pH values ranging from 5.38 to 6.98. All formulations demonstrated anti-inflammatory activity, with Formula F3 showing the strongest effect, indicated by the lowest IC₅₀ value of 1.933 µg/mL. Conclusion: These findings suggest that spray gel containing natural bioactive ingredients has potential as a topical anti-inflammatory candidate for diaper rash and contributes to the development of natural-based pharmaceutical formulations.
The potential of fungus Ceratobasidium sp. as a source of pharmaceutical bioactive compounds: a scoping review Triastuti, Asih; Wahyu Wardana, Andika; Tsurayya, Faiqoh; Pramisandi, Amila; Ilyas, Muhammad
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art13

Abstract

Background: Endophytic fungi are considered promising sources of novel bioactive compounds with diverse pharmacological activities, including antimicrobial, antioxidant, and anticancer effects. Among these fungi, Ceratobasidium sp. has attracted growing interest due to its metabolic diversity, although its bioactive potential remains insufficiently explored. Objective: This review aimed to evaluate the potential of secondary metabolites derived from Ceratobasidium sp. based on isolation studies and biological activity assessments. Methods: A narrative scoping review was conducted using literature retrieved from Google Scholar, PubMed, and ScienceDirect databases. Eligible studies included published journal articles and master's thesis manuscripts between 2005 and 2025. Results: Twelve studies met the inclusion criteria. Several Ceratobasidium sp. isolates demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, antifungal activity against Candida albicans and Aspergillus niger, and cytotoxic effects against A549, MCF-7, and HeLa cell lines. Identified metabolites included 4-methoxycinnamate, farnesol, benzoic acid, cyclopeptides, and saturated fatty acids, which exhibited antiproliferative, antioxidant, and enzyme-modulating mechanisms. Conclusion: Ceratobasidium sp. shows promising potential as a source of bioactive secondary metabolites with antibacterial, antifungal, and anticancer activities. Nevertheless, the available evidence remains limited, and further studies are required to confirm these findings and evaluate their relevance for pharmaceutical development.
Sodium carboxymethyl cellulose corn husks: synthesis and characterization using isopropanol–isobutanol solvent mixtures for carboxymethylation reaction Larasati, Erna; Cahyani, Intan Martha; Bagiana, I Kadek
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art15

Abstract

Background: Corn husks are an underutilized agricultural waste containing 44.08% cellulose, making them a promising raw material for sodium carboxymethyl cellulose (NaCMC) production.Objective: This study investigated the effect of different isopropanol–isobutanol solvent ratios (5:95, 20:80, and 35:65) on the physicochemical properties of NaCMC synthesized from corn husks and identified the optimum solvent ratio.Method: α-Cellulose was obtained through delignification with 4% NaOH followed by bleaching with 5% NaOCl. Alkalization was performed using 30% NaOH before carboxymethylation with sodium monochloroacetate (NaMCA). The resulting NaCMC was characterized for organoleptic properties, pH, moisture content, bulk density, yield, melting point, viscosity, degree of substitution, FTIR spectra, and SEM morphology. Data were analyzed using SPSS 23.0 at a 95% confidence level.Results: Solvent ratio significantly affected most physicochemical properties of NaCMC, except solubility, pH, melting point (20:80 vs. 35:65), and degree of substitution (5:95 vs. 35:65). The 20:80 isopropanol–isobutanol ratio produced NaCMC with characteristics most comparable to commercial NaCMC.Conclusion: The isopropanol–isobutanol solvent ratio significantly influenced the physicochemical characteristics of corn husk NaCMC, with the 20:80 ratio producing the most favorable product.
Jamur Endofit dari Kratom (Mitragyna speciosa): Sumber Potensial Senyawa Antimikroba Astuti, Puji; Andini, Hana Trisna
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art11

Abstract

Background: Endophytic fungi are known as promising sources of bioactive secondary metabolites with potential antimicrobial properties. Kratom (Mitragyna speciosa Korth.) possesses antimicrobial properties; however, the antimicrobial potential of its associated endophytic fungi remains largely unexplored.Objective: This study aimed to isolate endophytic fungi from kratom plants and evaluate their antimicrobial potential through the agar plug diffusion method as a preliminary screening assay.Method: Endophytic fungi were isolated from healthy kratom plants collected in West Kalimantan, Indonesia. A total of 37 pure isolates were obtained and screened against S. aureus, B. subtilis, P. aeruginosa, S. typhimurium, E. coli, and C. albicans using the diffusion method with agar plugs. Antimicrobial activity was evaluated by measuring inhibition zone diameters. Results: The isolates exhibited varying antimicrobial activities against the tested microorganisms. Isolate MS-D4 demonstrated the strongest antibacterial activity against S. aureus, B. subtilis, P. aeruginosa, and S. typhimurium, although the inhibition zones remained lower than the positive control. No inhibitory activity was observed against E. coli or C. albicans.Conclusion: Endophytic fungi associated with M. speciosa exhibited selective antimicrobial activity and represented promising alternative sources of antimicrobial compounds. Isolate MS-D4 showed the greatest antibacterial potential and warrants further investigation through quantitative antimicrobial assays.
Gold nanoparticles as drug nanocarriers: therapeutic applications, safety, and translational challenges Salsadila, Ummu; Prabowo, Muhammad Hatta; Istikharah, Rochmy
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art14

Abstract

Background: Gold nanoparticles (AuNPs) are promising drug nanocarriers due to tunable physicochemical properties, surface functionalization, colloidal stability, and biological interactions. These characteristics may improve drug delivery and therapeutic efficacy.Objective: This review aimed to evaluate AuNP-drug conjugation strategies, therapeutic applications, safety profiles, and challenges that remain for clinical implementation. Methods: A narrative review was performed using PubMed. This review summarized the in vitro and in vivo studies published in English from 2014 to 2025 on AuNP loading or conjugation with drugs. We excluded reviews, conference abstracts, duplicate studies, and studies that did not have relevant therapeutic or safety outcomes.Results: AuNP-based systems exhibit superior therapeutic efficacy in antibacterial, antiviral, antifungal, antidiabetic, and anticancer applications. The effects are associated with enhanced stability of the drug, cellular uptake, accumulation at the target site, controlled release, membrane disruption, and modulation of oxidative stress. Efficacy and safety are affected by particle size, morphology, surface charge, coating, and functionalization. However, differences in synthesis, characterization, experimental models, toxicity assessment, biodistribution, and clearance limited comparison among studies.Conclusion: AuNPs are versatile nanocarriers with high therapeutic potential, but standardization of the production processes, long-term safety evaluation, and regulatory guidelines are still required.

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