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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 18 Documents
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Search results for , issue "Vol 12, No 2 (2025)" : 18 Documents clear
Decoction of Cocos nucifera Linn. : Antioxidant Activity, Total Phenolics, and Flavonoids Contents Salim, Reny; Taslim, Tuty; Selonni, Fita; Verawaty, Verawaty; Dewi, Irene Puspa
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.45058

Abstract

Young coconut husk is one of the wastes that can be processed as a source of herbal medicine. Previous research on young coconut husk has provided information about its tannin content, antioxidant activity, and other bioactivities. This study aims to measure antioxidant activity and total phenolic and flavonoid contents from young coconut husk decoction. The determination of antioxidant activity and total phenolic and flavonoid contents used successively were DPPH, Folin-Ciocalteu, and aluminium chloride methods. The antioxidant activity test of young coconut husk decoction revealed an IC50 value of 47.69 µg/mL. The analysis of total phenolic and flavonoid content in the decoction showed 46,43 mg GAE/gram of husk powder and 4.04 mg RE/gram of husk powder, respectively. Collectively, young coconut husk extracted by decoction has strong antioxidant activity and can be used as a source of phenolics and flavonoids.
Phytochemical Screening And Antioxidant Activity Test of Lupun Root (Poikilospermum suaveolens (Blume) Merr) from South of Borneo Mardiana, Lia; Milanda, Tiana; Hadisaputri, Yuni Elsa; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.51350

Abstract

Lupun root is the local name for Poikilospermum suaveolens (Blume) Merr. in the Aranio region, South of Borneo, Indonesia. P.suaveolens is a medicinal plant traditionally used to treat various ailments and to enhance the body’s immune function. This study aimed to investigate the secondary metabolites and antioxidant capacity of the ethanol extract derived from the root of Lupun (P. suaveolens). Samples were collected from Aranio, South Borneo. Extraction was performed by maceration using 96% ethanol. The analysis included phytochemical screening and evaluation of antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay measured by a UV-Vis spectrophotometer. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, and phenolic compounds in the Lupun root extract. The antioxidant assay showed an IC50 value of 20.44 µg/mL, indicating strong antioxidant potential of the ethanol extract. These results highlight the plant’s promise as a candidate for pharmaceutical development.
Formulation of a Spray Gel Containing Asiaticoside and Niacinamide Combination for Anti-acne Nurdianti, Lusi; Gustaman, Firman; Kurniady, Fabillah; Setiawan, Fajar; Firmansya, Ardianes
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.50520

Abstract

Asiaticoside is one of the compounds of the triterpenoid group that functions as an antibacterial by forming a complex with cell membranes that pass through hydrogen bonds, then destroying the permeability of bacterial cell walls. Spray gel is considered a more practical and safer form of gel preparations due to its use, which can minimize microorganism contamination. This study aims to determine the effect of variations in the concentration of asiaticoside combined with niacinamide on its physical properties and antibacterial activity. This research method was carried out experimentally to manufacture spray gel preparations with variations in asiaticoside concentrations of 0%, 1%, 2%, 3%, and 4%. Spray gel preparations were tested for physical properties, stability, and antibacterial activity using the good diffusion method by producing preparations that meet the requirements of physical properties testing, did not cause irritating effects on the skin, good stability and results of antibacterial activity of spray gels produce different inhibitory zone diameters of 1.73 mm ± 2.00 (F0); 5.21 mm ± 1.25 (F1); 6.38 mm ± 1.01 (F2); 12.57 mm ± 4.73 (F3) and 16.20 mm ± 5.04 (F4). The five formulas exhibit good physical properties, stability, and antibacterial activity against Propionibacterium acnes. 
Uniformity Test of Total Flavonoid Content in Antidiabetic Capsules from Ethanol Extract of Purple Sweet Potato Leaves (Ipomoea batatas L.) Suhendi, Jessica Rianty; Dewi, Ni Kadek Santi Maha; Warditiani, Ni Kadek; Arisanti, Cokorda Istri Sri; Wirasuta, I Made Agus Gelgel
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.53962

Abstract

The ethanol extract of purple sweet potato leaves (Ipomoea batatas L. or “IBL”) has antidiabetic activity, and the total flavonoid (KTF) is designated as the quality marker (Q-marker) in capsule manufacturing. This research aims to develop KTF As a Q-marker for OHT capsules from ethanol extract of IBL leaves as antidiabetic. KTF Q-marker determination involves: (1) Identification of the absorption peak of the quercetin-AlCl3 complex, (2) Method verification, and (3) Testing OHT capsule content uniformity. The Quersetin-AlCl3 complex provides a bathochromic shift in band I from 380 nm before being reacted towards 430 nm after complex formation. The method verification test resulted in a correlation coefficient of 0.998, intraday RSD of 0.76-2.00%, and interday RSD of 0.87-1.96%, and accuracy of return in the range 82.88-91.83%. The consistency test results of the capsule content of the four bets obtained a ratio of the content of 10 capsules of each bet of 100% and RSD value in the range of 3.22-4.57% The establishment of KTF with a method in accordance with the FHI has met the verification requirements, showing that the method can be used and potentially as a quality control in the manufacture of IBL leaf capsules on a production scale.
Enhancement of Losartan Transdermal Transport Through Incorporation into Chitosan Nanoparticles Efiana, Nuri Ari; Nugroho, Akhmad Kharis; Martien, Ronny
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.49978

Abstract

Losartan, an antihypertensive agent, has low oral bioavailability. Therefore, developing a design for transdermal delivery of losartan is interesting. This study aims to enhance losartan in vitro transport by incorporating it into chitosan nanoparticles. Transdermal transport studies were conducted using two experimental groups: the pretreatment group using oleic acid and propylene glycol, and the group without pretreatment. The results showed that losartan incorporated into chitosan nanoparticles resulted in a significantly higher amount of drug being transported than the losartan solution (control) in both experimental groups. In the experiment without pretreatment, the amount of losartan from the control could not be detected in the receptor compartment until 28 hours. In contrast, losartan was detected at 16 hours of transport from chitosan nanoparticles. In pretreatment, chitosan nanoparticles exhibited 6.6fold higher losartan transport than the control. In addition, losartan chitosan nanoparticles showed significant increases in steady-state flux and transport efficiency by 3.3 and 6.6 times higher than the control, respectively. It can be concluded that the incorporation of losartan into chitosan nanoparticles can increase its transdermal transport.
Prospective Anti-Aging Benefits of Mackerel Scad Collagen Peptides Through Anti-Hyaluronidase Activity Herawati, Elisa; Agnesia, Pipin
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.56450

Abstract

The increased activity of the hyaluronidase enzymes speeds up the degradation of hyaluronic acid in the skin, leading to reduced elasticity and the formation of fine wrinkles, eventually contributing to skin aging. Mackerel scad (Decapterus macarellus) is a promising candidate as a skin anti-aging substance due to its particular amino acid composition. Native collagen and collagen peptides from mackerel scad skin were extracted using pepsine soluble collagen and hydrolysis with collagenase II enzyme. The amino acid profile of collagen was determined using HPLC analysis. An anti-hyaluronidase activity test was done using the spectrophotometry assay to express the content of N-acetyl glucosaminoglycan, and IC50 was calculated. Results showed that mackerel scad collagen contains 17 amino acids, with the highest content of glutamic acid, 8.20%; aspartic acid, 6.70%; glycine, 5.37%; arginine, 4.24%; and proline, 3.84%. The collagen from the extraction results had relatively low anti-hyaluronidase activity (IC50 326.05 ± 6.77 ppm). However, when it was broken down into smaller collagen peptides, the anti-hyaluronidase activity increased to IC50 100.78 ± 0.17 ppm. This indicated that the hydrolysis of collagen into collagen peptides with a smaller molecular weight increased its capacity to inhibit hyaluronidase. These findings suggest that D. macarellus collagen peptides have the potential to inhibit skin aging by inhibiting hyaluronidase enzyme activity.
Eficacy Red Ginger in Reduce The Risk of Covid-19 Severity in COPD Patients: A Review Lorensia, Amelia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.51076

Abstract

Chronic obstructive pulmonary disease (COPD) is a major global health problem and has an impact on increasing healthcare costs and decreasing productivity. Patients with COPD have a higher prevalence of coronary ischemia and other factors that put them at higher risk for COVID-19-related complications. A strong immune system can help increase the body's resistance so as to reduce the risk in the midst of the COVID-19 pandemic. The use of natural therapy in the treatment of chronic diseases is an opportunity for Indonesia as a tropical country that has many variations of plants that have the potential to become herbal medicines. Red ginger (Zingiber officinale var. rubrum) is one of the most widely consumed medicinal plants in Indonesia. Red ginger has greater anti-inflammatory and antioxidant content than other types of ginger. The antioxidant and anti-inflammatory effects of red ginger in addition to helping reduce the effects of reducing the risk of COVID-19 severity, can also help improve lung function. The preparation of red ginger that has been used in the community is steeping. Therefore, red ginger has the potential to effectively reduce the risk of COVID-19 severity in COPD patients with anti-inflammatory and antioxidant effects in reducing NF-B and the effectiveness of improving lung function.
Effectiveness Test of Spray Gel Hand Sanitizer with Carbomer 940 as a Preventive Product in Emergency Conditions Sutiswa, Shandra Isasi; Aji, Nur; Yulia, Nunung
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.45186

Abstract

Hand sanitizer is known for its ability to kill germs quickly due to its alcohol content, making it more effective than washing hands with soap and water. However, excessive use of alcoholbased sanitizers can cause skin irritation and dryness. Alcohol is polar and volatile, leading to rapid skin dryness and reduced effectiveness. To address this, gelling agents like Carbomer 940 are added to spray gel formulations. Carbomer 940 offers high stability and low toxicity, thereby enhancing the gel’s antibacterial properties. This study aims to develop an innovative spray gel hand sanitizer using Carbomer 940. The research method used was a pure experiment, evaluating the % inhibition of microbial growth on agar media. Results showed that the spray gel with 0.05% Carbomer 940 had superior effectiveness, with 60.77% inhibition, compared to the control group using the WHO formula, which achieved 33.11%. Additionally, the spray gel had a pH of 6.5 ± 0.2, a viscosity of 135.10, and an average spray weight of 0.027 ± 0.000 g, demonstrating optimal physical quality. In conclusion, the spray gel hand sanitizer with 0.05% Carbomer 940 was more effective at inhibiting microbial growth than the WHO standard formula.
Nanoemulsion of Nagasari (Mesua ferrea L.) Leaf and Its Activity Against Staphylococus aureus Suhesti, Tuti Sri; Muslimah, Annisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.49866

Abstract

Nagasari leaves (Mesua ferrea L.) contain special chemicals to fight S. aureus. Nanoparticle technology can improve the solubility, stability, and bioavailability of the phytochemicals found in herbal medicines. The nanoemulsion produces small particle sizes. It has a large surface area. This research aims to determine the physical stability of Nagasari leaf ethanol extract nanoemulsion (EDN) with variations of Virgin Coconut Oil (VCO) as the oil phase during storage and its activity. Nanoemulsions were produced using 1%, 2%, and 3% VCO concentrations. The physical properties and stability of the preparations were characterised. The nanoemulsion was tested for activity against S. aureus. Chloramphenicol was used as a positive control. The results showed that the nanoemulsion containing 1% VCO produced the best physical properties: a particle size of 23.137 ± 7.63 nm, a polydispersity index (PDI) of 0.203 ± 0.013, and a zeta potential of -18.9 ± 0.086. A VCO concentration of 1% produces good nanoemulsion stability. The F1 nanoemulsion exhibited an average inhibition zone diameter of 16.75 mm (strong), the EDN provided an inhibition zone diameter of 8.70 mm (medium), and the positive control exhibited an inhibition zone diameter of 24.30 mm (very strong).
The Development of Nano-mist Spray Propolis as Antioxidant Suryaman, Ine Suharyani; Sulastri, Lela; Rizikiyan, Yayan; Wathoni, Nasrul; Suhandi, Cecep; Noviani, Lusy; Rahmasari, Yuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i2.52433

Abstract

Propolis is a lipid-based compound from honeybees composed of plant wax, resin, and pollen. Due to its poor water solubility, its application is limited to lipid-based formulations with low bioavailability. This study aimed to develop a water-based propolis nano-mist spray with improved dispersion and evaluate its antioxidant activity. The nano-mist formulation was prepared using soy lecithin and Tween 80 in a phosphate buffer base. Evaluations included organoleptic characteristics, pH, particle size, zeta potential, and antioxidant activity by DPPH method. The propolis extract contained flavonoids, alkaloids, and tannins. The resulting spray showed a light brown color, a pH of 6.87 ± 0.03, particle size of 272.13 ± 4.25 nm, and zeta potential of -0.433 ± 0.35 mV. Antioxidant testing revealed moderate activity with an IC₅₀ value of 83.63 ± 11.88 ppm. This study supports the potential of nano-mist spray as a promising delivery system for propolis with antioxidant properties suitable for cosmetic and pharmaceutical applications.

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