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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 12 Documents
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Search results for , issue "Vol 29, No 2 (2024)" : 12 Documents clear
Clinical Trial of Bawang Dayak Leaves Capsules (Eleutherine americana) in Active Smokers Wahdaningsih, Sri; Untari, Eka Kartika; Rizkifani, Shoma
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.86496

Abstract

Smoking is an unhealthy behavior, particularly for the respiratory system's health due to the free radicals found in cigarette smoke. Eleutherine americana or Bawang Dayak has antioxidant properties which can neutralize the harmful free radicals penetrating the body. Additionally, malondialdehyde (MDA) is one of the stress oxidative biomarkers often applied to identify reactive stress. This study was conducted to determine the effect of Malondialdehyde on active smokers who consumed Bawang Dayak Leaves capsules. This study was a pre and post-test design involving 30 smokers who met the inclusion. The participants consumed 1 capsule containing 400 mg Bawang Dayak leaves extract for 7 days. The subject's blood was taken before and after the consumption of the capsules for MDA examination. The results of this study were that the MDA level between before and after Bawang Dayak capsules consumed statistically significant. Moreover, MDA pre and post-test level respectively were 12.074 nmol/ml and 11.869 nmol/ml. The usage of Bawang Dayak leaves capsules for a week can reduce MDA levels and likely has an antioxidant potential for active smokers.
Formulation of Microemulsion of Cayenne Pepper (Capsicum Frutescens L.) Ethanol Extract and Hair Growth Activity Test Anggraini, Deni; Sandi, Nofri Hendri; Djohari, Meiriza
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87206

Abstract

Cayenne pepper contains capsaicin, which exhibits properties that promote hair growth. Microemulsion is an oil and water dispersion system with a particle size of 10-200 nm which can be used topically as a drug delivery system through the scalp to stimulate hair growth. The microemulsion was made with olive oil and tween 80 as surfactants and stirred using a magnetic stirrer at 1000 rpm for 3 minutes. The ethanol extract of cayenne pepper was prepared in microemulsions at three different concentrations: 0.1%, 0.2%, and 0.3%. Microemulsion tests included organoleptic tests, specific gravity, pH, viscosity, freezing and thawing stability tests, and hair growth activity tests on rabbits. The results showed that the microemulsion of cayenne pepper ethanol extract at concentrations of 0.1%, 0.2%, and 0.3% was quite stable with a clear appearance and a particle size ranging from 27.7 nm to 167.8 nm. The microemulsion of cayenne pepper ethanol extract at a concentration of 0.2% was the most effective in enhancing hair growth, achieving a hair growth length of 1.27 over a 30-day period. A two-way ANOVA statistical test showed that the hair length of rabbits using microemulsion was significantly different from the hair length of negative control animals at p<0.05.
Calophyllum inophyllum: A Comprehensive Analysis of its Ethnobotanical, Phytochemical, and Pharmacological Properties Farida, Sofa; Jenie, Riris Istighfari; Fakhrudin, Nanang
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87488

Abstract

Nyamplung (Calophyllum inophyllum L.) is reported to have ethnomedicinal benefits in traditional medicine systems. Leaves, fruit, seeds, flowers, stems, roots and essential oils are the parts that are often used. Previous scientific studies revealed that this plant part is a valuable resource of secondary metabolites and exhibits a wide range of biological activities. The purpose of this review is to deliver thorough and detailed insights into the traditional uses, chemical ingredients, biology, and pharmacological studies as scientific evidence about the useful efficacy of C. inophyllum in the development of modern medicine. Traditional use shows C. inophyllum is widely used to treat skin diseases, wounds, boils, vaginal discharge, bleeding, gonorrhea, chronic bronchitis, sore eyes, heatstroke, and headaches. C. inophyllum is rich in phenols, polyphenols, flavonoids, xanthones, coumarins, and terpenoids. Several research results show that C. inophyllum possesses a multitude of pharmacological properties including anti-cancer, anti-inflammatory, antimicrobial, antioxidant, antiplatelet, antiviral, and antidiabetic activities.
Anti-psoriatic and Anti-inflammatory Potentials of Phytochemicals from Curcuma longa against Interleukin-17A and Inducible Nitric Oxide Synthase: An In Silico Study Abdul-Hammed, Misbaudeen; Olajide, Monsurat; Adedotun, Ibrahim Olaide; Afolabi, Tolulope Irapada; Abdul-Razaq, Roqeebah; Ismail, Ubaedah; Abdullateef, Muhminah Folake; Adebayo, Zainab Omowumi
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87528

Abstract

Psoriasis is a chronic autoimmune cell-mediated inflammatory skin disease that affects approximately 125 million people worldwide. Turmeric has been long known for its potent anti-inflammatory activities. In this study, in silico studies were used to evaluate the efficacy of isolated phytochemicals from turmeric in the treatment of psoriasis. One hundred and fifteen phytochemicals from this plant and two standard medications (Flurandrenolide and Triamcinolone), active ingredients used in some topical steroid creams were evaluated for their inhibitory properties against Interleukin-17A (IL-17A) and Inducible NOS (iNOS) receptor using a computer-aided drug design approach. The binding scores and inhibitory efficiencies were obtained via virtual screening. ADMET SAR-2 website was used to conduct the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) analysis, the Molinspiration and SwissADME tools were used to investigate the drug-likeness characteristics and oral bioavailability of the selected compounds respectively. Other analyses of the selected compounds include bioactivity, activity spectra for substances (PASS) prediction, binding mode, and molecular interaction. The results revealed that Bisabolone (−9.3 kcal/mol), Curcumanolide B (−8.6 kcal/mol), (E)-sesquisabinene hydrate (−8.5 kcal/mol), and procurcumadiol (−8.3 kcal/mol) are potential inhibitors of iNOS receptor, while hop-17(21)-en-3-ol (7.6 kcal/mol) is a potential inhibitor of IL-17A receptor. These compounds have better ADMET properties, binding affinities, drug-likeness, PASS properties, bioactivities, oral bioavailability, good binding mechanism, and interactions with the active site of the target receptor when compared with Flurandrenolide and Triamcinolone. As a result, this preliminary investigation suggests that these phytochemicals should be studied further to design novel psoriasis therapeutics.
Methyl Jasmonate Elicitation Enhanced Biomass, Phenolic, and Flavonoid Production of Adventitious Root Culture of Gynura procumbens in Balloon Type Bubble Bioreactor Wijayanti, Ely Tri; Kusuma, Dannis Yuda; Kristanti, Alfinda Novi; Wibowo, Anjar Tri; Sugiharto, Sugiharto; Sugiarso, Djarot; Manuhara, Yosephine Sri Wulan
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87736

Abstract

Secondary metabolites in the medicinal plant Gynura procumbens have various beneficial pharmacological activities. However, the limited availability of these beneficial compounds has constrained the possibilities for therapeutic applications. Exogenously applied methyl jasmonate (MeJa) as an elicitor has been reported to trigger the accumulation of secondary metabolites in plant tissues cultured in vitro. This study aimed to assess how varying periods of MeJa elicitation affect the growth and accumulation of phenolic and flavonoid compounds in adventitious root cultures of G. procumbens within a balloon-type bubble bioreactor (BTBB). Adventitious roots were induced from leaf and stem explants obtained from established in vitro shoots. Upon transfer to the BTBB, the cultures were supplemented with 100 µM MeJa and sampled at 1, 2, 3, and 4 weeks. The results revealed that including MeJa in the culture medium significantly boosted growth and the accumulation of phenolic and flavonoid compounds in G. procumbens. The highest biomass and concentrations of phenolic and flavonoid compounds were observed after 3 weeks of elicitation. These findings highlight the potential of MeJa elicitation for enhancing the production of valuable bioactive compounds in G. procumbens adventitious root cultures, showcasing its utility for industrial applications.
Determination of Anticancer from EtOAc Fraction of Spatholobus Littoralis Hassk and of Molecular Structure Prediction Iskandar, Dodi; Widodo, Nashi; Warsito, Warsito; Masruri, Masruri; Rollando, Rollando; Afthoni, Muhammad Hilmi; Ichsan, Ichsan; Hermansyah, Adi
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.88894

Abstract

In recent years, the search for new anticancer drugs from local plants in Indonesia has become an interesting topic for research. One of the typical Indonesian local plants that have been used by the community as an anticancer traditional medicine (jamu) is Spatholobus littoralis Hassk (SLH) or better known as Bajakah. The native Dayak people of Kalimantan have used it for years for the treatment of breast cancer. In this study, the separation of single compounds from the ethyl acetate fraction of SLH stems was carried out, their molecular structure was analyzed, and anticancer bioactivity was tested. The isolation used the preparative HPLC method. The elucidation of the isolates from the ethyl acetat fraction used LCMS-MS, FTIR, and NMR. Anticancer bioactivity was determined using the MTT bioassay. The result is the acquisition of two isolates; it has been predicted that both are pseudobaptinin. The anticancer IC50 of the pseudobaptinin was 62.85 ppm, and Pseudobaptinin with impurities was 145.60 ppm.
Moringa oleifera Leaves Ethanol Extract Inhibits HT-29 Cells and COX-2 Expression Predictably Through PPARγ Activation Tedjo, Aryo; Aprilliyani, Ifana; Kusmardi, Kusmardi; Megawati, Ajeng; Noor, Dimas Ramadhian
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.89037

Abstract

Colorectal cancer is the second leading cause of death among all cancer cases worldwide. Cancer cells often exhibit overexpression of cyclooxygenase-2 (COX-2), producing prostaglandin E2 (PEG2) and subsequent inflammation and neoplasia. Moringa oleifera is rich in bioactive compounds such as polyphenols, flavonoids, and saponins, known for their anti-inflammatory and antioxidant properties. This study aimed to investigate the inhibitory effects of M. oleifera leaves ethanol extract on COX-2 expression in HT-29 cells. Dried M. oleifera leaves (5 g) were ethanol-macerated for 24 hours, yielding a 10 mg ethanol extract. MTT inhibition is used for immunocytochemistry evaluation of COX-2 expression. Molecular docking of phenolic compounds from the extract on PPARγ indicated an agonistic potential. The ethanol extract of M. oleifera leaves demonstrated anticancer activity with an IC50 value of 114.8 µg/ml, with a significant reduction in COX-2 expression observed at a dose of 100 ppm, resulting in an H-score of 111.83 ± 2.21. Peroxisome proliferator-activated receptor-gamma (PPARγ) activity is thought to be the first step in suppressing COX-2 expression. Three phenolic compounds found in M. oleifera are predicted to be PPARγ agonists: rutin, naringin, and hesperidin, according to the molecular docking simulations.
Antioxidant Activity of Hydroalcoholic Extract of Puguntano Herbs and Andaliman Fruits by Cuprac Methods Satria, Denny; Dalimunthe, Aminah; Sitorus, Panal; Waruwu, Syukur Berkat; Vadhila, Mumtaz; Wahyu, Muhammad
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.90337

Abstract

Free radical damage to the body can be prevented and repaired using antioxidants. Various natural ingredients native to Indonesia contain antioxidants, which are needed to improve people's health at an affordable cost. Puguntano (Picria fel-terrae) and Andaliman (Zanthoxylum acanthopodium DC.) are natural ingredients that can be used as antioxidants. This research determined the antioxidant activity and differences in IC50 values of hydroalcoholic extracts from Puguntano (Picria fel-terrae Lour) herbs and Andaliman (Zanthoxylum acanthopodium Fruits). Hydroalcoholic extracts were prepared by maceration using 90%, 80%, 70%, 60% and 50% ethanol. Antioxidant capacity was measured using the CUPRAC method, and quercetin was used as a positive control. The results were showed that the IC50 value for hydroalcoholic extracts of Puguntano herbs (27.02 ± 0.15 µg/mL, 25.94 ± 0.22 µg/mL, 25.12 ±0.15 µg/mL, 22.07 ± 0.23 µg/mL, and 23.86 ±0.18 µg/mL) and for Andaliman fruits (41.65 ± 0.30 µg/mL, 36.59 ± 0.40 µg/mL, 34.13 ± 0.44 µg/mL, 25.46 ± 0.30 µg/mL, 25.39 ± 0.30 µg/mL) respectively and quercetin 2.21 ± 0.02 µg/mL. Hydroalcoholic extracts of Puguntano herbs and Andaliman fruits have antioxidant activity, with each concentration having an IC50 of less than 50 µg/mL. The test sample's antioxidant activity is indicated by its lower IC50 value.
The Hepatoprotective Effect of Moringa oleifera Leaves on Male Wistar Rat Induced Streptozotocin-Nicotinamide Bachri, Moch Saiful; Nurani, Laela Hayu; Edityaningrum, Citra Ariani; Ma'ruf, Muhammad; Sulistyorini, Dwi Agustin; Amelia, Rizki; Hidayati, Sholihatil; Sulistyawati, Rini; Guntarti, Any
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.90806

Abstract

Diabetes mellitus is a disease characterized by uncontrolled increases in blood sugar levels, which can cause complications in the liver. Disorder liver disease can be seen from the increasing SGOT, SGPT activity, and the number of necrosis cells in the liver. Moringa leaves contain the flavonoid quercetin with antidiabetic and antioxidant activity. This research aimed to determine the effect of administering the ethyl acetate fraction of Moringa leaves on SGOT activity, SGPT, and liver histopathology in rat induced by streptozotocin and nicotinamide. Moringa leaves macerated with 80% ethanol and fractionated with ethyl acetate were used. The research subjects were 30 rats divided into six groups. The rats were induced with streptozotocin at a dose of 65 mg/kgBW and nicotinamide 100 mg/kgBW for five days, then treated for ten days. Serum SGOT and SGPT activity were measured using a Microlab 300 Semi-Automated at a wavelength of 340 nm. Histopathological observations were carried out when the rats were dislocated, their livers were taken, and then preparations were made using Hematoxylin Eosin (HE) staining. Data were analyzed using the SPSS One Way ANOVA method, followed by the Tukey test with a confidence level of 95%. The results of the study showed that administration of Ethyl Acetate Fraction of Moringa oleifera (EA-MO) could reduce the levels of SGOT, SGPT, and the number of liver necrosis cells in rats induced by streptozotocin and nicotinamide.
Antibacterial Activity of Pasak Bumi Stem (Eurycoma longifolia J.) Extract against Salmonella typhi Sirait, Christine; Hanasia, Hanasia; Martani, Natalia Sri; Ysrafil, Ysrafil; Fatmaria, Fatmaria
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.91168

Abstract

Typhoid fever is caused by consuming food or water contaminated with Salmonella typhi. The disease develops from bacterial infection through the consumption of contaminated sustenance and drink. The bacterium can cause bacteremia, which is bacteria living in the blood, penetrating the mucosal epithelium of the small intestine and entering the lymphatic flow. Therefore, this study aimed to assess the potential inhibitory effect of ethanol extracts derived from stems of Eurycoma longifolia (pasak bumi) on the growth of Salmonella typhi bacteria. Compounds such as alkaloids, saponins, flavonoids, terpenoids, and tannins in pasak bumi stems possessed antibacterial properties. Extracts were made using 96% ethanol at varying concentrations (10%, 20%, 30%, 40%, 50%) with distilled water and chloramphenicol as negative and positive control. The result showed that pasak bumi stem extracts inhibited Salmonella typhi, with increasing efficacy at higher concentrations and statistical analysis reported significant differences between all treatment groups (p<0.001). Average zone diameter was 0 mm and 23.10 mm for negative and positive control, as well as 2.75 mm, 4.10 mm, 5.24 mm, 6.98 mm, and 8.55 mm for 10%, 20%, 30%, 40% and 50% extracts, respectively. This study provided verification of antibacterial effects of pasak bumi stem ethanol extracts against Salmonella typhi.

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