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INDONESIA
CHEMPUBLISH JOURNAL
Published by Universitas Jambi
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Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry
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Articles 126 Documents
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Molecular Docking Study of Chalcone Analogue Compounds with Hydroxy and Methoxy Subtituents as Bcl-2 Inhibitors Frimayanti, Neni; Dona, Rahma; Solihin, Tabah
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.17487

Abstract

Molecular docking study of 6 chalcone analogues with protein target from the crystallographic structure modeling of Bcl-2 protein with PDB code 2W3L was carried out using computational media using the Molecular Operating Environment (MOE) program. The aim of this study is to determine the potentiality of the 6 chalcone analogue compounds as Bcl-2 inhibitors using molecular docking studies. In this study, venetoclax was used as positive control. Based on docking results, binding free energy was used as information to know which wheather chalcone analogue compounds are active or not as Bcl-2 inhibitors. According to the docking results that have been carried out, it showed that the 6 chalcone analogue compounds have no potential as Bcl-2 inhibitors. Due to the superimposition of the 6 compounds that did not stick to the positive control and most importantly the binding free energy values ​​(S) of the 6 chalcone analogue compounds were higher than the binding free energy values ​​of the positive control (Venetoclax).
KARAKTERISTIK FISIK EDIBLE FILM DENGAN VARIASI PEKTIN KULIT PISANG TANDUK DAN MINYAK ATSIRI CENGKEH Sari, Myra Wardati; Nissa, Berta Khairun
Chempublish Journal Vol. 6 No. 2 (2021): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

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Abstract

Banana plants have high production of fruit, this is compared straight about waste of banana peels. To overcome this problem, utilizing pectin of banana peel waste as an ingredient for making edible films. Clove essential oil can be used as additive in edible films as an antimicrobial that can inhibit food-destroying microorganisms. The purpose of this study was to determine the characteristics of the edible film of the pectin of the banana peel with the addition of clove essential oil with reference to the Japan Industrial Standard (JIS) Vol. 2: 1707. The method used in this research is banana peel pectin extraction, with variations in pectin concentration 0; 4; 6; 8 grams and clove essential oil 0.2; 0.4; 0.6 mL. The best edible film products that meet the JIS standard values ​​are sample B4 with a composition of 3 grams of pectin in banana peel and 0.6 mL of clove essential oil with a thickness value of 0.23 mm; the tensile strength value is 0.46 Mpa, the percent elongation is 48%, and the water vapor transmission rate (WVTR) is 6.78 g/m2/day. The appearance of the edible film produced is clear brown in color due to the influence of the color of banana peel pectin and clove essential oil. Based on these results, it can be concluded that the edible film produced meets the main parameter standards given by JIS which is used as a reference.
PENDEKATAN PEMBELAJARAN KIMIA BERBASIS KEARIFAN LOKAL PADA KEBUDAYAAN BETAWI Firdaus, Risha Nurfitri; Mulyanti, Sri; Alawiyah, Nur
Chempublish Journal Vol. 6 No. 2 (2021): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

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Abstract

Keanekaragaman budaya yang unik setiap daerah belum maksimal dalam pembelajarankimia SMA di masing-masing daerah. Masih jarang pembelajaran kimia yangmenghubungkan konsep dengan kebudayaan lokal. Pembelajaran kimia berbasis kearifanlokal kota Jakarta merupakan pengetahuan yang memadukan pengetahuan lokal dengankimia di wilayah Jakarta. Tujuan dari penelitian ini adalah mengkaji kearifan lokal (birpletok, asinan betawi, dan gabus pucung) serta mengetahui penerapan pendekatan kearifanlokal dalam pembelajaran kimia. Metode penelitian menggunakan kajian studi literatur.Kompetensi pengetahuan kebudayaan daerah kota Jakarta dapat diimplementasikan padapembelajaran kimia Kelas X pada topik penerapan kimia dalam kehidupan sehari-hari. Halini karena kearifan lokal kota Jakarta dapat memanfaatkan rempah-rempah yang adadisekitar kita menjadi sebuah kuliner ciri khas dan didalam nya terdapat proses kimia.Pemanfaatan rempah-rempah misalnya pada pembuatan bir pletok yang di dalamyaterdapat pembelajaran kimia mengenai materi benzena. Asinan betawi, ciri khas dari asinanbetawi ini dikenal dengan rasa yang asam dan pedas oleh karena itu rasa asam nya termasukke dalam pembelajaran kimia pada materi asam basa. Selanjutnya gabus pucung yangdikenal dengan kuahnya yang hitam dari biji kluwak yang terdapat senyawa tanin sehinggamasuk kedalam materi benzena. Pentingnya penelitian Pendekatan Kearifan lokal ini dapatmengukur literasi dan berpikir kritis peserta didik.
Analisis Pembuatan Susu Kedelai dengan Gula Kulit Singkong (SKGKS) Terhadap Kadar Nutrisi dan Uji AKtivitas Anti Bakteri Coliform Nur Latifah, Rais
Chempublish Journal Vol. 6 No. 2 (2021): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

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Abstract

Milk is one of the nutrients needed by the body. Milk can come from animal milk or vegetable milk. Soybean has a protein content equivalent to cow's milk which is about 3.5 g/100 g with a lower fat composition of 2.5 g/100 g. The sugar in the manufacture of vegetable milk is made from cassava peel waste. This research uses an enzymatic method that is able to hydrolyze starch in cassava peel. The resulting sugar is applied in the manufacture of low-fat soy milk that can be consumed by children to adults. The production of soy vegetable milk in this study was divided into two types of milk samples. The manufacture of soy milk begins with processing soybeans into soy juice. There are two types of soy milk in this study, type I is soy milk with a composition ratio between soybeans and water of 1:10, namely SKGKS I. While type II soy milk is soy milk with a composition ratio between soybeans and water of 1:35, namely SKGKS II. Both types of milk were analyzed for nutritional content and tested for anti-bacterial activity. The results showed that SKGKS 2 had a higher nutritional value than SKGKS 1. The nutritional content of SKGKS 2 was 11.56 g carbohydrates/mL milk and 2.93% milk protein. SKGKS II has a lower fat content than SKGKS 1, which is 1.23 g of fat/mL of milk. SKGKS types I and II showed a pH range of 6.74-7.12 with a storage time of 9 days. SKGKS II has a higher fiber content of 18.56 g with a food fiber content of 12.34 g. The results of the bacterial test showed that the two milk samples did not exceed the microbial contamination and were in accordance with the requirements of the Indonesian National Standard (SNI) No. 06.8-7388-2009.
Pewarnaan Preparat Apus Tipis Malaria (Plasmodium vivax Dan Plasmodium falcifarum) Menggunakan Ekstrak Murbei Sebagai Pengganti Eosin Pada Komposisi Giemsa Riyadi, Sandra Amalia; Fadhilah, Fitri
Chempublish Journal Vol. 6 No. 2 (2021): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i2.22464

Abstract

Malaria is caused by the plasmodium parasite and still a threat to Indonesia. The main examination is staining of thick and thin smear preparations using Giemsa. Because giemsa is expensive, its waste is difficult to decompose, toxic and rare. Therefore, there is a need for new inventions to utilize the potential of natural components like mulberry fruit, which contains anthocyanins for coloring agents, to lessen the impact and risk of giemsa. The purpose of this study was to determine the effect of macerated ethanol extract of mulberry with a ratio of 1:3 (w/v) as an alternative to eosin in Giemsa on staining of thin blood smears of malaria, as well as knowing the best concentration in staining. This type of experimental research by observing the clarity of shape, color of parasites P.vivax, P.falcifarum, erythrocyte cells also compared with 3% giemsa as a control. This study consisted of 32 samples, 8 repetitions and 4 treatments namely P1 (3% Giemsa control), Giemsa modified mulberry eosin P2 (20%), P3 (30%), P4 (40%). The quality of the preparations was assessed based on the clarity and contrast of the colors. Kruskal-Wallis and Mann-Whitney data analysis techniques were used. The results showed that mulberry extract could be an alternative dye to replace eosin in the composition of giemsa on malaria thin smear preparations. The most effective concentration was 30% which could give the Plasmodium nuclei the same quality of staining as the control, while for the erythrocytes the staining quality was not the same as the control.
Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies Fikriansyah, Muhammad; Nelson, Nelson; Latief, Madyawati; Tarigan, Indra Lasmana
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.23726

Abstract

Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population. Research for alternative anticancer drugs is still being done, including anticancer from plants. One of the plants that have the potential to be developed as an anticancer alternative is the sungkai plant. Sungkai leaves contain many bioactive compounds, one of which is the clerodane-type diterpenoids, peronemins, A2 (1), A3 (2), B1 (3), B2 (4), B3 (5), C1 (6), and D1 (7). The aim of this study was to initial screen the potential of seven Peronemins compounds in Sungkai leaves extract as anticancer candidates. Initial screening was carried out by predicting in-silico anticancer activity of the seven compounds. Dihydrofolate reductase inhibitor (DHFR inhibitor) is one of the anticancer activity screening approaches. DHFR Inhibitor activity from perenomins derivatives with pIC50 values ​​of 0.785 (A2), respectively; 0.785 (A3); 0.799 (B2); 0.799 (B3); 0.799 (C1 and D1). In addition, from compounds 1,2,3,4,5 peronemin derivatives have potential anticancer activity through interaction with the target protein Voltage-gated potassium channel subunit while compounds 6, 7 also have biological activity potential anticancer on target protein Dihydrofolate reductase.
Calcium Reduction Using Variations of Thickness and Retention Time of Cocoa Shell Activated Carbon Muadifah, Afidatul; Santoso, Arif; Ngibad, Khoirul; Martha, Rahma Diyan; Kholifah, Siti Nurriyatul
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.24768

Abstract

High levels of hardness can lead to increased cases of kidney stones. Hardness levels can be reduced by using activated carbon from the cocoa rind as an adsorbent. The purpose of this research was to determine the variation of activated carbon thickness and optimum retention time in reducing the calcium content of dug well water, to determine the percent decrease in calcium ion levels at the optimum variation, and to determine the significance of the difference in the decreased in calcium levels between the treatment groups. The research method used the principle of adsorption of activated carbon from cocoa shells to calcium ions, which are activated by KOH. There were ten treatment samples with different variations of activated carbon thickness and retention time. The results showed that the thickness of activated carbon of 60 cm with a retention time of 50 minutes had the optimum ability to reduce the calcium content of dug well water. The percentage decrease in calcium levels reached 89,041 % with a decreased concentration of 234 ppm. The result of the statistical test showed a significance value of 0,05. The conclusion of the research is that activated carbon of cocoa shells can reduce calcium levels to the levels of soft water hardness, with variations in activated carbon thickness and retention time having a significant effect.
Anticaries Potential of Temu Kunci-Serai Ethyl Acetate Extract Combination: In Vitro and Molecular Studies Approach Priyadi, Muhammad; Saputra, Rizki Rachmad
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.26098

Abstract

Dental caries is one of the problems in dental disorders suffered by many people. There have been many ways of handling such as using temu kunci and lemongrass plants. This study aims to determine the antibacterial activity of caries in vitro and predict the mechanism of action of the bacteria that cause caries Streptococcus mutans.  Temu kunci and lemongrass were extracted using ethyl acetate solvent. antibacterial tests against Streptococcus mutans were carried out using diffusion tests with a combination treatment of temu kunci: serai extracts 5% b/v: 5% b/v, 5% b/v: 10% b/v, and 10% b/v: 5% b/v. The positive control used amoxicillin and DMSO as a negative control. Potency as an anticaries drug of drived compound from Temu Kunci and Serai were evaluated by molecular docking using glucosyltransferase (3AIC). The results showed that the combination of temu kunci and serai with concentration 10% b/v: 5% b/v has potential as anticaries against Streptococcus mutans. Molecular studies depicted that Panduratin A, Isopanduratin, and 1,3-O-di-p-coumaroylglycerol have great activity toward 3AIC, respectively. Especially for Panduratin A and Isopanduratin, those compound depicted great and similar binding affinity (-8.4 kcal mol-1) that lower than Acarbose as native ligand  (-8.3 kcal mol-1). Furthermore, those compound binding similarity ilustrated activity mechanism similarly with native ligand toward receptor. Additionally, the profiling drug-target interaction suggested Temu Kunci’s derived compounds have great potential as anticaries treatment.   
Immobilization of Dibenzalacetone on TiO2 Surface and its Potential as Anti-UV Material Ariefin, Mokhamat; Alfanaar, Rokiy
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.26109

Abstract

Sunlight has been known to provide many benefits to human life. However, behind these benefits, there are some negative effects along with the destruction of the ozone layer and the environment on earth. One of them is exposure to ultraviolet (UV) rays which can cause several diseases such as skin cancer. One way to overcome this is by using sunscreen substances. In this study, dibenzalacetone immobilization on TiO2 has been carried out for anti-UV applications. Based on the test results using UV-Vis spectrometry, TiO2, and dibenzalacetone both have anti-UV properties with maximum peaks at wavelengths of 335 nm and 346 nm with absorbance values of 0.871 and 1.197. Immobilization of TiO2 with dibenzalacetone gives an absorbance with a value of 1.221 at a wavelength of 329. These results indicate that TiO2 immobilization with dibenzalacetone provides better anti-UV A properties than TiO2 because of the higher absorbance value.
Microbial Test: Combination of Kefir Milk, Star Fruit, and Red Ginger Wardani, Kartika Arum; Chamidah, Nurul
Chempublish Journal Vol. 7 No. 2 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i2.26019

Abstract

One of drinks with high nutritional value and good for health is milk kefir. The advantage of milk kefir compared to yogurt (another fermented beverage) they are richer with  probiotics. Goat's milk kefir contains more nutrients than cow's milk. To increase the production of sweet star fruit plants, the innovation of kefir milk drink combined with sweet star fruit juice and red ginger juice can be used as an alternative health drink that can increase body immunity. Each ingredient has the same benefits such as having antioxidant, antibacterial, anti-inflammatory, antiviral and immunomodulatory activities. In this study, researchers wanted to know the microbiological quality of the combination of milk kefir, sweet star fruit Juice and red ginger. The study was conducted from February to May 2021. Microbiological tests carried out were Methylene blue test, MPN test and total plate count test. The research design used a completely randomized design which focused on one factor, namely the concentration of red ginger extract (control concentration 0%, 4.5%, 6%, 7.5%). This experiment was used with replicas 3 times. The results showed that kefir fermented goat milk with the addition of sweet star fruit juice and ginger juice was good for consumption, namely in treatment group 1 (containing 20% ​​star fruit juice and 4.5 percent red ginger juice).

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