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All Journal Jurnal Ilmu Manajemen Jurnal Teknik Kimia USU Biology, Medicine, & Natural Product Chemistry MPI (Media Pharmaceutica Indonesiana) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA ALCHEMY Jurnal Penelitian Kimia Jurnal Ilmiah Manajemen "E M O R" JAB (Jurnal Akuntansi & Bisnis) Stability: Journal of Management and Business CARADDE: Jurnal Pengabdian Kepada Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Analis Farmasi Oetoesan-Hindia: Telaah Pemikiran Kebangsaan Community Empowerment Advance Sustainable Science, Engineering and Technology (ASSET) Bioscientia Medicina : Journal of Biomedicine and Translational Research JAF (Jurnal Analis Farmasi) Jurnal Ilmu Manajemen SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT SWAGATI: Journal of Community Service Jurnal Sains dan Kesehatan Advance Sustainable Science, Engineering and Technology (ASSET) Berita Biologi
Marlina, Dian
Universitas Setia Budi
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Comparing Conventional and Modern Methods for The Phycocyanin Extraction from Spirullina sp Dian Marlina; Desi Purwaningsih; Reny Pratiwi; Ryan Werytama Saputra; Widiastuti Setyaningsih; Supriyono Supriyono
Advance Sustainable Science Engineering and Technology Vol. 6 No. 3 (2024): May - July
Publisher : Science and Technology Research Centre Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v6i3.907

Abstract

Spirulina platensis, a blue-green algae abundant in tropical regions, is rich in minerals, vitamins, fibers, and pigments, with low nucleic acid content. It has unique chromoproteins called phycobiliproteins, notably phycocyanin, used in various applications. This study aims to optimize phycocyanin extraction using different solvents (distilled water and sodium phosphate buffer pH 6.7) and methods (freeze-thaw and sonication). Spirulina platensis biomass was extracted in both solvents, then some of them was freeze for 24 and 48 hours followed by thawing overnight. The other was sonicated for 2.5 minutes, 50 Hz then soaked for 1, 2, and 3 hours. All of the samples were centrifuged at 6000 rpm for 10 minutes and the absorbance was measured using a UV-Vis spectrophotometer at wavelengths of 280, 620, and 650 nm. with freeze-thawing for 48 hours yielded the highest phycocyanin concentration (0.55%), with a yield of 11.07 and purity of 0.21. Sonication improved phycocyanin concentration, yield, and purity significantly, yielding 1.108, 25.85, and 0.26, respectively.
PKM PEMANFAATAN LIMBAH ANORGANIK UNTUK ALAT DESTILASI SEDERHANA Novita, Mega; Dewanto, Febrian Murti; Harjanta, Aris Trijaka; Herlambang, Bambang Agus; Marlina, Dian; Purwaningsih, Desi; Kusumo, Haryo
SWAGATI : Journal of Community Service Vol. 1 No. 1 (2023): March
Publisher : Universitas AMIKOM Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24076/swagati.2023v1i1.1030

Abstract

Sampai saat ini, Indonesia masih kesulitan menangani persoalan sampah. Oleh karena itu, perlu dilakukan perubahan paradigma yang memandang sampah sebagai sumber daya yang memiliki nilai ekonomis dan dapat dimanfaatkan. Kkhususnya limbah anorganik seperti kaleng dan plastik banyak dimanfaatkan untuk pembuatan kriya logam, campuran beton, bahan pembuatan MMC (Metal Matrix Composites) dan bahan dasar koagulan. Untuk mendukung warga Desa Doplang meningkatkan nilai jual komoditi bunga sedap malam, Teknologi Tepat Guna (TTG) alat destilasi/ penyulingan sederhana dari limbah anorganik dibuat. Metode yang digunakan adalah dengan pendekatan community development, empowerment dan community engagement. Setelah melakukan perijinan ke mitra, sosialisasi tentang potensi limbah anorganik dan pelatihan pembuatan alat destilasi sederhana dilakukan. Alat destilasi sederhana berhasil dibuat dengan memanfaatkan limbah organik. Dari kegiatan ini, warga Desa Doplang diharapkan mampu mengekstrak minyak atsiri bunga sedap malam menjadi produk turunannya.
EVALUASI SISTEM MANAJEMEN SUMBER DAYA MANUSIA PADA PENEMPATAN KERJA PEGAWAI DI SEKRETARIAT DPRD KABUPATEN MAGELANG Asiyah, Siti Dwi; Marlina, Dian
Jurnal Ilmiah Manajemen Emor (Ekonomi Manajemen Orientasi Riset) Vol. 5 No. 1 (2021): Juni
Publisher : Universitas Muhammadiyah Luwuk Banggai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32529/jim.v5i1.592

Abstract

Salah satu sumber daya yang penting dalam manajemen adalah sumber daya manusia atau human resources. Pentingnya sumber daya manusia ini, perlu disadari oleh semua tingkatan manajemen. Bagaimanapun majunya teknologi saat ini, namun faktor manusia tetap memegang peranan penting bagi keberhasilan suatu instansi. Penelitian ini bertujuan untuk mengevaluasi sistem manajemen SDM pada perencanaan, pengorganisasian, pengarahan, dan pengendalian terhadap penempatan kerja pegawai di Sekretariat Dewan Perwakilan Rakyat Daerah (DPRD) Kabupaten Magelang. Jenis penelitian ini menggunakan pendekatan studi kasus dengan metode deskriptif kualitatif yaitu pengamatan, wawancara mendalam (indepthinterview) dan observasi serta theoretical sampling yang digunakan dalam penelitian ini adalah purposive sampling. Hasil penelitian menunjukkan bahwa sistem manajemen sumber daya manusia pada penempatan kerja pegawai di Sekretariat DPRD Kabupaten Magelang belum maksimal dikarenakan masih ada kekurangan tenaga kerja/pegawai yang mengakibatkan penempatan kerja yang tidak sesuai job description. Perlu mengatur kembali sumber daya manusia yang sesuai dengan tupoksi masing-masing jabatan. Perlu segera dilakukan pelatihan untuk manajemen kinerja secara berkala dan berkesinambungan agar sistem manajemen sumber daya manusia di Sekretariat DPRD Kabupaten Magelang lebih baik.
Optimization of Papaya Leaf Extract Cream Using Stearic Acid and Triethanolamine via Simplex Lattice Design Siwi, Andini Prabandaru; Priyanto, Widodo; Novita, Mega; Marlina, Dian
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 1 (2025): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i1.7468

Abstract

Papaya leaves (Carica papaya L.) are known to contain bioactive compounds such as flavonoids, alkaloids, tannins, and saponins, which exhibit antiseptic, anti-inflammatory, antifungal, and antibacterial properties, making them promising for topical pharmaceutical preparations. However, achieving optimal physical characteristics in cream formulations requires careful selection and proportioning of emulsifiers. This study investigates the effect of varying ratios of stearic acid and triethanolamine on the physical properties of creams containing ethanol-extracted papaya leaf extract. The extract was obtained via maceration using 96% ethanol and confirmed to contain active compounds through phytochemical screening and thin-layer chromatography. Eight formulations were developed using a Simplex Lattice Design (SLD) with stearic acid concentrations ranging from 15–17% and triethanolamine from 2–4%. Physical evaluations included tests for pH, viscosity, adhesion, and spreadability. All formulations met standard of cream quality requirements, but the optimal formula was identified at 15.20% stearic acid and 3.79% triethanolamine, offering the most desirable physical characteristics. This formulation strategy demonstrates the potential for producing effective and stable papaya leaf creams, with implications for natural-based dermatological product development. Submitted: 05-05-2025, Revised: 18-06-2025, Accepted: 25-06-2025, Published regularly: June 2025
MENDOBRAK PANDEMI MELALUI WIRAUSAHA DENGAN PENDEKATAN PLANNED BEHAVIOR THEORY Mayang, Anissa; Marlina, Dian; Ratnawati, Shinta
JURNAL ILMU MANAJEMEN Vol. 19 No. 1 (2022): JUNI 2022
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.976 KB) | DOI: 10.21831/jim.v19i1.44756

Abstract

Dari adanya Covid-19 ini akan berdampak pada perekonomian di indonesia, kinerja ekonomi menjadi lemah kemudian berdampak pada kondisi ketenagakerjaan. Kewirausahaan berkontribusi pada pertumbuhan ekonomi karena dianggap sebagai cara untuk menciptakan berbagai jenis pekerjaan baru. Penelitian ini merupakan penelitian kuantitatif yang bertujuan untuk melihat pengaruh antara variabel motivasi terhadap perilaku berwirausaha yang dimediasi oleh intensi. Data primer dikumpulkan melalui penyebaran kuesioner kepada 140 mahasiswa Universitas Tidar angkatan 2017. Instrumen penelitian yang digunakan menggunakan skala likert dengan ukuran 1 sampai 5 dan menggunakan teknik analisis data dengan analisis regresi dan uji sobel untuk menguji mediasi. Hasil penelitian menunjukkan t-hitung sebesar 6,254 lebih besar dari t-tabel 1,655, dari hasil tersebut dapat membuktikan bahwa variabel intensi berwirausaha dapat memediasi hubungan antara motivasi berwirausaha terhadap perilaku berwirausaha. Menandakan bahwa mahasiswa angkatan 2017 Universitas Tidar dapat melakukan kegiatan wirausaha dengan motivasi untuk membuka usaha yang didasari oleh intensi berwirausaha yang kuat.
MENDOBRAK PANDEMI MELALUI WIRAUSAHA DENGAN PENDEKATAN PLANNED BEHAVIOR THEORY Mayang, Anissa; Marlina, Dian; Ratnawati, Shinta
JURNAL ILMU MANAJEMEN Vol. 19 No. 1 (2022): JUNI 2022
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jim.v19i1.44756

Abstract

Dari adanya Covid-19 ini akan berdampak pada perekonomian di indonesia, kinerja ekonomi menjadi lemah kemudian berdampak pada kondisi ketenagakerjaan. Kewirausahaan berkontribusi pada pertumbuhan ekonomi karena dianggap sebagai cara untuk menciptakan berbagai jenis pekerjaan baru. Penelitian ini merupakan penelitian kuantitatif yang bertujuan untuk melihat pengaruh antara variabel motivasi terhadap perilaku berwirausaha yang dimediasi oleh intensi. Data primer dikumpulkan melalui penyebaran kuesioner kepada 140 mahasiswa Universitas Tidar angkatan 2017. Instrumen penelitian yang digunakan menggunakan skala likert dengan ukuran 1 sampai 5 dan menggunakan teknik analisis data dengan analisis regresi dan uji sobel untuk menguji mediasi. Hasil penelitian menunjukkan t-hitung sebesar 6,254 lebih besar dari t-tabel 1,655, dari hasil tersebut dapat membuktikan bahwa variabel intensi berwirausaha dapat memediasi hubungan antara motivasi berwirausaha terhadap perilaku berwirausaha. Menandakan bahwa mahasiswa angkatan 2017 Universitas Tidar dapat melakukan kegiatan wirausaha dengan motivasi untuk membuka usaha yang didasari oleh intensi berwirausaha yang kuat.
Kuantifikasi Flavonoid dan Analisis Aktivitas Antioksidan Ekstrak Daun Nilam (Pogostemon cablin) Menggunakan Uji DPPH Anggraini, Natasya Dila Putri; Pramukantoro, Ganet Eko; Novita, Mega; Marlina, Dian
Jurnal Teknik Kimia USU Vol. 14 No. 2 (2025): Jurnal Teknik Kimia USU
Publisher : Talenta Publisher (Universitas Sumatera Utara)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jtk.v14i2.20795

Abstract

Patchouli leaves (Pogostemon cablin) are known to contain flavonoid compounds with potential antioxidant properties. However, comparative data on flavonoid content and antioxidant activity across different extract fractions of patchouli leaves remain limited. To address this gap, the present study was conducted to analyze the total flavonoid content and evaluate the antioxidant activity of the ethanol extract and three solvent fractions—n-hexane, ethyl acetate, and wáter using the DPPH method as an indicator of free radical scavenging activity. The extraction was carried out through maceration, followed by fractionation. The determination of flavonoid content employed a colorimetric method based on the aluminum chloride reaction, while antioxidant activity was assessed using the DPPH assay. The results revealed that the ethyl acetate fraction contained the highest flavonoid concentration (1.615 ± 0.0591%) and exhibited very strong antioxidant activity, with an IC₅₀ value of 17.3909 ± 0.1327 μg/mL. These findings suggest that the ethyl acetate fraction holds significant potential as a natural antioxidant agent, with possible applications in the pharmaceutical field or nutraceutical-based health products.
Variations of Tween Surfactant and Propylene Glycol Cosurfactant in Topical Microemulsion Formulation on The Penetration of Ibuprofen Fitrianingsih, Sri; Widodo, Gunawan Pamudji; Marlina, Dian
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.5785

Abstract

ABSTRACTIbuprofen is a derivative of propionic acid, a class of non-steroidal anti-inflammatory drugs (NSAIDs). Ibuprofen has side effects on the gastrointestinal tract. So that topical use can be a solution to reduce the side effects of oral use because of the release of topical drugs through the stratum corneum which makes it selective in certain places. The preparation chosen was a topical microemulsion because it is more thermodynamically stable and has no effect on the gastrointestinal tract. This study aims to determine the effect of the ratio of surfactant concentrations of various ratios of tween 20:tween 80 and cosurfactant propylene glycol to the penetration rate of ibuprofen across the membrane and to determine the physical characteristics of topical microemulsions. Selection of tween surfactant and propylene glycol cosurfactant because it has high physical stability. This research is an experimental study, namely by making four formulations with various ratios of surfactant and cosurfactant with a difference of 2.5% in each formulation of topical ibuprofen microemulsion with a concentration of 5% ibuprofen using variations of surfactant tween 20 and tween 80, cosurfactant propylene glycol with black cumin oil phase. Evaluation of the preparation by organoleptic test, pH test of the preparation, examination of the type of emulsion, particle size measurement, microemulsion release test in vitro using the Franz diffusion method. The results show that the concentration ratio of surfactant tween 20:tween 80 and cosurfactant propylene glycol can affect particle size, pH and penetration velocity (flux) in Franz diffusion. The results of the study showed that in F1 using surfactant tween 20:tween 80 with a concentration of 71.6% (6:4) had the smallest particle size of 11.5 nm and the largest flux value was 128.45 g.cm-2.H- 1. In conclusion, variations in surfactant and cosurfactant concentrations can affect the pH of the preparation, particle size, penetration speed (flux). The results obtained that the cumulative percent and penetration speed of all formulas had significant differences (p0.05).
Hydrogen bonding investigation of poly(3-hydroxybutyrate) / glycol chitosan blends studied by infrared and terahertz spectroscopies Marlina, Dian; Sato, Harumi
Advance Sustainable Science, Engineering and Technology Vol 1, No 1 (2019): May-October
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v1i1.4879

Abstract

Poly(3-hydroxybutyrate) (PHB)/glycol chitosan (GC) polymer blend was developed as one of the new biopolymer materials. Effects of different PHB / GC concentrations were analysed as a function of the blend compositions by using Fourier transform infrared (FTIR) and terahertz (THz) spectroscopies to investigate the changes in the higher-order structure and bonding of hydrogen. The higher-order structure and hydrogen bonding monitored in this study include the crystalline structure and (C=O…H-C) hydrogen bonding of PHB. The FTIR and THz spectra showed that PHB's higher-order structure transforms into the less-order structure by adding GC without altering the crystalline structure and PHB's intramolecular (C = O ... H-C) hydrogen bonding with increasing GC concentration. Because of the addition of GC, the intensity ratio of THz bands figure out the crystalline dynamics of PHB, the helical structure deformation occurs first followed by the weakening of intramolecular (C = O ... H-C) hydrogen bonding within PHB-PHB molecules. Keywords: Chitosan, higher-order structure, hydrogen bonding, low-frequency vibrational spectroscopy
Optimization of Papaya (Carica papaya L.) Leaf Extract Emulgel Formulation using Simplex Lattice Design for Topical Application Nurfiana Rachmawati; Siti Aisiyah; Mega Novita; Dian Marlina
ALCHEMY Jurnal Penelitian Kimia Vol 21, No 2 (2025): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.21.2.101792.432-441

Abstract

Papaya (Carica papaya L.) leaf extract is rich in bioactive compounds with antioxidant, anti-inflammatory, and wound healing effects, making it a promising candidate for topical applications. However, there are challenges in formulating an effective and stable system. This study aimed to optimize the formulation of Papaya leaf extract emulgel using the simolex lattice design (SLD) method with various concentrations of Carbopol 940, Olive oil, and Tween 80. Eight formulations were evaluated for pH, viscosity, spreadability, and physical stability. This study showed that the optimal formulation of 1.0% Carbopol 940, 15% olive oil, and 10% Tween 80, which produced an emulgel with pH 6.1, viscosity of 4.580 cP, and spreadability of 6.8 cm, which are acceptable according to pharmaceutical standards. The above formulation showed good physical stability over 28 days of storage. In conclusion, the SLD method can be applied to developing typical herbal-based products and standardized for better effectiveness and stability.
Co-Authors 12.520.20.206 Shinta Ratnawati, 12.520.20.206 Achmad Solechan Amanda, Nathasya Gracya Ana Indrayati Anak Agung Istri Sri Wiadnyani Anggraini, Natasya Dila Putri Aris Tri Jaka Harjanta, Aris Tri Arsyeni Destra Anarchy Arsyandi Asiyah, Siti Dwi Bambang Agus Herlambang, Bambang Desi Purwaningsih Desi Purwaningsih Dwinata Rahayuningsih Emmellia Yunitha Febrian Murti Dewanto Fitrianingsih, Sri Ghani Nurfiana Fadma Sari Gunawan Pamudji Widodo Haryo Kusumo Haryo Kusumo Ira Juliani Anwar Iswandi Iswandi Jason Merari Peranginangin Kusumo, Haryo Lumbantungkup, Gebi Evelin mayang, anissa Mega Novita Mega Novita Misnovita, Ghina Salsabila Muhamad Ansory, Hery Nabilah Nauli Jehan Nilawati, Anita Novitarini Nur Anggreini Dwi Sasangka Nurfiana Rachmawati Pramukantoro, Ganet Eko Prasetyanto, Panji Kusuma Priyanto, Widodo Purwaningsih, Avianti Eka Dewi Aditya Puspitasari, Ismi Putri, Cinthiya Ekwinta Rahmadita, Ivony Reny Pratiwi Rifki Hermana Ryan Werytama Saputra Santi Kartika Dewi, Lensa Erliana Sato, Harumi Senowarsito, Senowarsito Sephia Febriyanti Setiawan, Anang Kuncoro Rachmad Siti Aisiyah Siwi, Andini Prabandaru Supriyono Supriyono Sutomo Sutomo Takad Bagas Aji Prasetyo Titik Sunarni Vivin Nopiyanti Widiastuti Setyaningsih