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All Journal Jurnal Ilmu Manajemen Jurnal Teknik Kimia USU Biology, Medicine, & Natural Product Chemistry MPI (Media Pharmaceutica Indonesiana) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA ALCHEMY Jurnal Penelitian Kimia Jurnal Ilmiah Manajemen "E M O R" JAB (Jurnal Akuntansi & Bisnis) Stability: Journal of Management and Business CARADDE: Jurnal Pengabdian Kepada Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Analis Farmasi Oetoesan-Hindia: Telaah Pemikiran Kebangsaan Community Empowerment Advance Sustainable Science, Engineering and Technology (ASSET) Bioscientia Medicina : Journal of Biomedicine and Translational Research JAF (Jurnal Analis Farmasi) Jurnal Ilmu Manajemen SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT SWAGATI: Journal of Community Service Jurnal Sains dan Kesehatan Advance Sustainable Science, Engineering and Technology (ASSET) Berita Biologi
Marlina, Dian
Universitas Setia Budi
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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ANTIOXIDANT ACTIVITY PROFILING OF RED BAJAKAH TAMPALA (Spatholobus littoralis Hassk) FRACTIONS USING THE DPPH RADICAL SCAVENGING METHOD Amanda, Nathasya Gracya; Sari, Ghani Nurfiana Fadma; Novita, Mega; Marlina, Dian
Berita Biologi Vol 24 No 3 (2025): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2025.11322

Abstract

Indonesia’s rich biodiversity harbors numerous plants with medicinal properties, including Red Bajakah Tampala (Spatholobus littoralis Hassk.), which has long been used in traditional medicine for its therapeutic benefits. Despite its promising ethnomedicinal reputation, scientific validation of its antioxidant potential remains limited. This study aims to evaluate the antioxidant properties of Red Bajakah Tampala and identify key bioactive compounds responsible for its bioactivity. The plant's antioxidant capacity was assessed using the DPPH assay, and the chemical composition was analyzed through phytochemical screening and thin-layer chromatography (TLC). The ethyl acetate fraction exhibited the strongest antioxidant activity, with an IC₅₀ value of 12.87 ppm, followed by the n-hexane fraction (24.08 ppm) and the water fraction (57.23 ppm). Phytochemical screening revealed the presence of flavonoids, tannins, triterpenoids, phenols, and saponins, which contribute to the plant's antioxidant effects. These findings provide scientific evidence supporting the traditional use of Red Bajakah Tampala as a natural antioxidant, with implications for its potential use in therapeutic and cosmetic applications. Further research into the molecular mechanisms and practical applications of Bajakah-based formulations is recommended.
Anti-Acne Activity of Robusta Green Coffee Bean Extract against Cutibacterium acnes Putri, Cinthiya Ekwinta; Puspitasari, Ismi; Novita, Mega; Marlina, Dian
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7857

Abstract

Acne vulgaris, a common chronic skin disorder, is primarily caused by the overgrowth of Cutibacterium acnes and often treated with synthetic agents that may cause side effects and resistance. The increasing demand for therapeutics with improved safety profiles and natural alternatives has encouraged the exploration of herbal remedies, including robusta green coffee beans (Coffea canephora). This study aimed to evaluate the anti-acne activity of robusta coffee bean ethanol extract against C. acnes. The extract was prepared through maceration and subsequently evaluated using to phytochemical screening, thin layer chromatography, and in vivo testing on New Zealand rabbits. Results confirmed the presence of flavonoids, alkaloids, tannins, steroids, and triterpenoids. In vivo assays demonstrated that the 75% extract concentration achieved a 96.69% reduction of acne lesions, comparable to the positive control at 99.35%, while lower concentrations showed moderate activity. These findings highlight the potential of robusta coffee bean extract as a promising natural anti-acne agent. The study implies that robusta extract can be further developed into herbal-based dermatological formulations, although future research should focus on isolating active compounds and conducting clinical trials for broader application.
Formulation and Evaluation of Spirulina-Based Gel with Varying Carbopol Concentrations for Anti-Acne Activity against Staphylococcus epidermidis Emmellia Yunitha; Anita Nilawati; Mega Novita; Dian Marlina
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.699-705

Abstract

Spirulina platensis is a blue-green microalga known for its antibacterial properties, offering potential as a natural alternative in acne treatment. Acne vulgaris, often caused by Staphylococcus epidermidis, requires effective topical solutions. Gels are favored for their non-greasy texture, ease of application, and good skin absorption. This study aimed to formulate and evaluate anti-acne gels containing 25% Spirulina extract with varying Carbopol concentrations (0.5%, 1%, 1.5%). Each formulation was assessed for physical properties, stability over 21 days, and antibacterial activity against S. epidermidis. All gel formulations met quality standards for pH, homogeneity, viscosity, spreadability, and adhesiveness. The gel with 0.5% Carbopol (FI) showed the best spreadability, ideal viscosity, and good adhesiveness, along with the highest antibacterial activity, exhibiting an inhibition zone of 16.5 mm—comparable to tetracycline. In conclusion, Spirulina-based gel with 0.5% Carbopol offers an effective, stable, and natural anti-acne option. These findings highlight the potential of Spirulina as a bioactive agent in topical formulations and encourage further research for clinical applications in acne management.
Karakterisasi Cocrystal Glibenklamida Dengan Variasi Pelarut dan Uji Stabilitas Termal Setiawan, Anang Kuncoro Rachmad; Iswandi, Iswandi; Marlina, Dian
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 7, No 3 (2022)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v7i3.59893

Abstract

Glibenklamida termasuk dalam Biopharmaceutical Classification System (BCS) kelas II yaitu kelarutannya rendah. Kelarutan dapat ditingkatkan dengan dengan mengubah glibenklamida menjadi bentuk cocrystal. Penelitian bertujuan mengetahui karakteristik kristal dan pengaruh termal terhadap cocrystal glibenklamida yang dibuat dengan variasi pelarut aceton, etanol dan pelarut acetonitril-aceton, dan untuk mengetahui peningkatan kelarutan cocrystal glibenklamida. Cofomer yang digunakan asam oksalat dalam perbandingan equivalensi molar 1:1 dibuat dengan metode solvent evaporasi, menggunakan variasi pelarut aceton (F1), etanol (F2) dan pelarut campuran acetonitril-aceton (F3). Karakteristik cocrystal menggunakan Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Fourier Transform Infrared (FTIR), Differential Thermal Analysis (DTA), Differential Scanning Calorimetry (DSC), Thermal Gravimetric Analysis (TGA) dan uji kelarutan. Hasil penelitian cocrystal yang dibuat dengan variasi pelarut aceton (F1), etanol (F2) dan pelarut campuran acetonitril-aceton (F3) pada difraktogram XRD memiliki intensitas kristalisasi sudut 2θ: (F1) 5230,55; (F2) 4115,12 dan (F3)3404,17. Hasil spektra FTIR cocrystal pada gugus NH (F1) 3398,72 cm-1 (F2) 3381,36 (F3) 3404,51, pada gugus C=O (F1)1641,42 cm-1; (F2) 1433,17 cm-1; (F3) 1437,64 cm-1. Analisis termal DTA menunjukan titik leleh pada suhu 141-169,90C. Nilai entalpi (ΔH) dari DSC glibenklamida murni -38,0044 J/g; (F1) -12,14874 J/g; (F2) -38,8612 J/g; (F3) -5,8400 J/g. Hasil uji kelarutan terjadi peningkatan pada F1 6,75-12,65%, F2 7,40-12,52% dan F3 5,46-10,75%. Kesimpulan dari penelitian ini, cocrystal glibenklamida yang dibuat dengan variasi pelarut F1, F2 dan F3 memiliki perbedaan karakteristik kristal dan karakteristik terhadap pengaruh termal, cocrystal yang dibuat dengan pelarut aceton mempunyai peningkatan kelarutan yang paling tinggi sebesar 12,65 % pada medium pelarut dapar pH 4,5.
Microencapsulation of Phycocyanin from Spirulina platensis by Freeze-Drying: Optimization of Maltodextrin–Soy Protein Matrices for Enhanced Stability and Antioxidant Functionality Dian Marlina; Ryan Werytama Saputra; Takad Bagas Aji Prasetyo; Hery Muhamad Ansory; Siti Aisiyah; Desi Purwaningsih
Advance Sustainable Science Engineering and Technology Vol. 8 No. 2 (2026): February-April
Publisher : Science and Technology Research Centre Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v8i2.2726

Abstract

Phycocyanin, a natural blue pigment from Spirulina platensis, exhibits strong antioxidant activity but is highly unstable under light, heat, and pH variations, limiting its practical applications. This experimental study addresses the lack of systematic optimization data on maltodextrin–soy protein isolate (SPI) wall matrices for phycocyanin microencapsulation via freeze-drying. Phycocyanin was extracted using phosphate buffer and encapsulated at different maltodextrin:SPI ratios (9:1, 8:2, and 7:3). Each formulation was analyzed in triplicate (n = 3) for encapsulation efficiency (EE), phycocyanin retention, moisture content, particle size, and antioxidant activity (DPPH assay). The 8:2 ratio exhibited the best performance with EE of 88.5%, phycocyanin content of 0.710 mg·mL⁻¹, and particle size of 70.2 µm. Moderate antioxidant activity was observed (IC₅₀ = 102.29 ppm). ANOVA confirmed that the polymer ratio significantly affected all parameters (p < 0.05). Overall, the optimized maltodextrin–SPI microcapsules enhanced the stability and antioxidant functionality of phycocyanin under laboratory conditions, supporting their potential application as bioactive ingredients in functional food and pharmaceutical formulations.
Characterization of microencapsulated Saga Leaves Extract (Abrus precatorius L.) and Analgetic Activity Tests in Male Mice (Mus musculus) Nabilah Nauli Jehan; Titik Sunarni; Dian Marlina
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.280-289

Abstract

Background: Saga leaves are one of the plants that have analgesic activity. Saga leaves contain phenol compounds, flavonoids, tannins, alkaloids, and saponins. Phenol has instability with oxygen, light, and high temperatures. Therefore, the microencapsulation process is necessary. Microcapsule characterization in this study included encapsulation efficiency, particle size, distribution value and morphology. Objective: This research was to determine the characterization of microcapsules and the analgesic activity of saga leaf extract microcapsules in male mice. Methods: The microencapsulation process conducted in this study was carried out using the spray drying method. Saga leaf extract was coated with the coating material in the ratio of 1:20. Several ratios of maltodextrin (MD) and soy protein isolate (SPI) (100%:0%); (75%%:25); (50%:50%); (25%:75%) were applied as the coating material. The encapsulation efficiency was determined by comparing the total phenol content of the extract and microcapsule. Particle size and distribution values were tested using a particle size analyzer. Microcapsule morphology was seen using scanning electron microscopy. Analgesic activity test using the tail-flick method with mice as test animals. Data analysis in this study used one-way ANOVA. Results: The encapsulation efficiency obtained was 31.40-80.29%. The particle size obtained in the microcosm was 17.70-30.90 µm. The distribution value obtained was 1.42-2.45. The morphology of the microcapsule obtained was round and had wrinkles. The analgesic activity obtained in this study resulted in significantly different pain inhibition values before and after microencapsulation. Conclusion: The characteristics of microcapsule preparations are well-known, and the analgesic activity of various microcapsules was 42.43-57.15%.
Freeze-Dried Phycocyanin Microcapsules: Effect of Maltodextrin-Soy Protein Ratios on Encapsulation Efficiency and Particle Properties Siti Aisiyah; Ira Juliani Anwar; Dian Marlina; Ana Indrayati; Desi Purwaningsih
Advance Sustainable Science Engineering and Technology Vol. 8 No. 3 (2026): May - July
Publisher : Science and Technology Research Centre Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v8i3.2759

Abstract

Natural pigments such as phycocyanin are highly sensitive to environmental conditions and therefore require stabilization to broaden their applications in functional products. This study aimed to evaluate the effect of varying ratios of maltodextrin and soy protein isolate (SPI) on the physical properties and encapsulation performance of freeze-dried phycocyanin microcapsules. Phycocyanin was extracted using phosphate buffer and encapsulated in three formulations with different maltodextrin–SPI proportions. The obtained microcapsules were characterized using UV–Vis spectrophotometry and particle size analysis (PSA) to determine encapsulation efficiency (EE), yield, moisture content, purity index, and particle size distribution. All experiments were performed in triplicate (n = 3), and data were analyzed using one-way ANOVA (p < 0.05). The formulation with a higher proportion of maltodextrin exhibited the best performance, achieving high EE (≈96%), low moisture content, and uniform particle size. These findings highlight that optimizing biopolymer combinations can enhance the quality and stability of phycocyanin microcapsules, demonstrating potential applications in functional food and pharmaceutical formulations.
AKTIVITAS ANTIOKSIDAN, PENENTUAN TOTAL FENOLIK DAN FLAVONOID FRAKSI DAN EKSTRAK DAUN KUNYIT (Curcuma longa L.) Dwinata Rahayuningsih; Dian Marlina; Vivin Nopiyanti
Jurnal Analis Farmasi Vol 10, No 2 (2025): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v10i2.20437

Abstract

Antioksidan adalah senyawa kimia yang menyumbangkan elektron ke radikal bebas agar menjadi tidak reaktif. Antioksidan alam yang bisa dimanfaatkan yaitu daun kunyit (Curcuma longa L.). Kandungan flavonoid dalam daun kunyit bertindak sebagai antioksidan. Penelitian ini bermaksud untuk mengetahui aktivitas antioksidan, kadar fenolik total dan flavonoid total pada fraksi n-heksana, etil asetat dan air ekstrak daun kunyit. Daun kunyit dimaserasi menggunakan etanol 96%. Ekstrak yang didapatkan dilanjutkan difraksinasi dengan n-heksana, etil asetat dan air serta dilakukan aktivitas antioksidan dengan DPPH. Fraksi dan ekstrak dianalisis kadar flavonoid total dengan AlCl3 dan fenolik total dengan folin-ciocalteu, Pengujian menggunakan spektrofotometri UV-Vis. Hasil pengujian antioksidan dengan IC50 ekstrak, fraksi n-heksana, etil asetat dan air yaitu 41,11 ± 0,09, 130,62 ± 0,07, 32,35 ± 0,03, 100,30 ± 0,2 ppm. Kadar flavonoid total pada ekstrak, fraksi n-heksana, etil asetat dan air  sebesar 39,79 ± 0,33, 10,38 ± 0,26, 42,00 ± 0,56, 12,91 ± 0,14 mg QE/g. Kadar fenolik total pada ekstrak, fraksi n-heksana, etil asetat dan air sebesar 140,74 ± 0,21, 55,41 ± 0,19, 303,86 ± 0,99, 63,88 ± 0,56 mg GAE/g.
AKTIVITAS ANTIOKSIDAN, PENENTUAN TOTAL FENOLIK DAN FLAVONOID FRAKSI DAN EKSTRAK DAUN KUNYIT (Curcuma longa L.) Dwinata Rahayuningsih; Dian Marlina; Vivin Nopiyanti
Jurnal Analis Farmasi Vol 10, No 2 (2025): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v10i2.20437

Abstract

Antioksidan adalah senyawa kimia yang menyumbangkan elektron ke radikal bebas agar menjadi tidak reaktif. Antioksidan alam yang bisa dimanfaatkan yaitu daun kunyit (Curcuma longa L.). Kandungan flavonoid dalam daun kunyit bertindak sebagai antioksidan. Penelitian ini bermaksud untuk mengetahui aktivitas antioksidan, kadar fenolik total dan flavonoid total pada fraksi n-heksana, etil asetat dan air ekstrak daun kunyit. Daun kunyit dimaserasi menggunakan etanol 96%. Ekstrak yang didapatkan dilanjutkan difraksinasi dengan n-heksana, etil asetat dan air serta dilakukan aktivitas antioksidan dengan DPPH. Fraksi dan ekstrak dianalisis kadar flavonoid total dengan AlCl3 dan fenolik total dengan folin-ciocalteu, Pengujian menggunakan spektrofotometri UV-Vis. Hasil pengujian antioksidan dengan IC50 ekstrak, fraksi n-heksana, etil asetat dan air yaitu 41,11 ± 0,09, 130,62 ± 0,07, 32,35 ± 0,03, 100,30 ± 0,2 ppm. Kadar flavonoid total pada ekstrak, fraksi n-heksana, etil asetat dan air  sebesar 39,79 ± 0,33, 10,38 ± 0,26, 42,00 ± 0,56, 12,91 ± 0,14 mg QE/g. Kadar fenolik total pada ekstrak, fraksi n-heksana, etil asetat dan air sebesar 140,74 ± 0,21, 55,41 ± 0,19, 303,86 ± 0,99, 63,88 ± 0,56 mg GAE/g.
Sustainable Digital Transformation in Healthcare: Challenges and Directions in the Society 5.0 Era Haryo Kusumo; Dian Marlina; Achmad Solechan
Advance Sustainable Science Engineering and Technology Vol. 7 No. 1 (2025): November-January
Publisher : Science and Technology Research Centre Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v6i4.876

Abstract

This study conducts a comprehensive literature review on the digital transformation required by health service institutions during the Society 5.0 era. Utilizing articles related to digital transformation and health services, the study presents qualitative data simplified into descriptive narratives to draw meaningful conclusions. The method employed is a qualitative literature review. The review identifies significant challenges, including big data utilization, data security, privacy concerns, and the implementation of cloud computing systems. Furthermore, the research synthesizes current trends and proposes actionable recommendations for overcoming these challenges, such as adopting Health 5.0 and fostering integrated Community 5.0 systems. The study underscores the importance of maintaining the human aspect amidst technological advancements. Future research directions are outlined, focusing on the "big data-based society" within Society 5.0 to explore innovative solutions, mitigate barriers, and ensure sustainable digital transformation in healthcare services.
Co-Authors 12.520.20.206 Shinta Ratnawati, 12.520.20.206 Achmad Solechan Amanda, Nathasya Gracya Ana Indrayati Anak Agung Istri Sri Wiadnyani Anggraini, Natasya Dila Putri Aris Tri Jaka Harjanta, Aris Tri Arsyeni Destra Anarchy Arsyandi Asiyah, Siti Dwi Bambang Agus Herlambang, Bambang Desi Purwaningsih Desi Purwaningsih Dwinata Rahayuningsih Emmellia Yunitha Febrian Murti Dewanto Fitrianingsih, Sri Ghani Nurfiana Fadma Sari Gunawan Pamudji Widodo Haryo Kusumo Haryo Kusumo Ira Juliani Anwar Iswandi Iswandi Jason Merari Peranginangin Kusumo, Haryo Lumbantungkup, Gebi Evelin mayang, anissa Mega Novita Mega Novita Misnovita, Ghina Salsabila Muhamad Ansory, Hery Nabilah Nauli Jehan Nilawati, Anita Novitarini Nur Anggreini Dwi Sasangka Nurfiana Rachmawati Pramukantoro, Ganet Eko Prasetyanto, Panji Kusuma Priyanto, Widodo Purwaningsih, Avianti Eka Dewi Aditya Puspitasari, Ismi Putri, Cinthiya Ekwinta Rahmadita, Ivony Reny Pratiwi Rifki Hermana Ryan Werytama Saputra Santi Kartika Dewi, Lensa Erliana Sato, Harumi Senowarsito, Senowarsito Sephia Febriyanti Setiawan, Anang Kuncoro Rachmad Siti Aisiyah Siwi, Andini Prabandaru Supriyono Supriyono Sutomo Sutomo Takad Bagas Aji Prasetyo Titik Sunarni Vivin Nopiyanti Widiastuti Setyaningsih