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All Journal Jurnal Ilmu Manajemen Jurnal Teknik Kimia USU Biology, Medicine, & Natural Product Chemistry MPI (Media Pharmaceutica Indonesiana) Jurnal Ilmiah Manajemen "E M O R" JAB (Jurnal Akuntansi & Bisnis) Stability: Journal of Management and Business CARADDE: Jurnal Pengabdian Kepada Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research FITOFARMAKA: Jurnal Ilmiah Farmasi Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Analis Farmasi Oetoesan-Hindia: Telaah Pemikiran Kebangsaan Community Empowerment Advance Sustainable Science, Engineering and Technology (ASSET) Bioscientia Medicina : Journal of Biomedicine and Translational Research JAF (Jurnal Analis Farmasi) Jurnal Ilmu Manajemen SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT SWAGATI: Journal of Community Service Jurnal Sains dan Kesehatan Advance Sustainable Science, Engineering and Technology (ASSET)
Marlina, Dian
Universitas Setia Budi
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AKTIVITAS ANTIOKSIDAN, PENENTUAN TOTAL FENOLIK DAN FLAVONOID FRAKSI DAN EKSTRAK DAUN KUNYIT (Curcuma longa L.) Rahayuningsih, Dwinata; Marlina, Dian; Nopiyanti, Vivin
Jurnal Analis Farmasi Vol 10, No 2 (2025): JURNAL ANALIS FARMASI
Publisher : Program Studi Analisis Farmasi dan Makanan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v10i2.20437

Abstract

Antioksidan adalah senyawa kimia yang menyumbangkan elektron ke radikal bebas agar menjadi tidak reaktif. Antioksidan alam yang bisa dimanfaatkan yaitu daun kunyit (Curcuma longa L.). Kandungan flavonoid dalam daun kunyit bertindak sebagai antioksidan. Penelitian ini bermaksud untuk mengetahui aktivitas antioksidan, kadar fenolik total dan flavonoid total pada fraksi n-heksana, etil asetat dan air ekstrak daun kunyit. Daun kunyit dimaserasi menggunakan etanol 96%. Ekstrak yang didapatkan dilanjutkan difraksinasi dengan n-heksana, etil asetat dan air serta dilakukan aktivitas antioksidan dengan DPPH. Fraksi dan ekstrak dianalisis kadar flavonoid total dengan AlCl3 dan fenolik total dengan folin-ciocalteu, Pengujian menggunakan spektrofotometri UV-Vis. Hasil pengujian antioksidan dengan IC50 ekstrak, fraksi n-heksana, etil asetat dan air yaitu 41,11 ± 0,09, 130,62 ± 0,07, 32,35 ± 0,03, 100,30 ± 0,2 ppm. Kadar flavonoid total pada ekstrak, fraksi n-heksana, etil asetat dan air  sebesar 39,79 ± 0,33, 10,38 ± 0,26, 42,00 ± 0,56, 12,91 ± 0,14 mg QE/g. Kadar fenolik total pada ekstrak, fraksi n-heksana, etil asetat dan air sebesar 140,74 ± 0,21, 55,41 ± 0,19, 303,86 ± 0,99, 63,88 ± 0,56 mg GAE/g.
AKTIVITAS ANTIOKSIDAN, PENENTUAN TOTAL FENOLIK DAN FLAVONOID FRAKSI DAN EKSTRAK DAUN KUNYIT (Curcuma longa L.) Rahayuningsih, Dwinata; Marlina, Dian; Nopiyanti, Vivin
Jurnal Analis Farmasi Vol 10, No 2 (2025): JURNAL ANALIS FARMASI
Publisher : Program Studi Analisis Farmasi dan Makanan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v10i2.20437

Abstract

Antioksidan adalah senyawa kimia yang menyumbangkan elektron ke radikal bebas agar menjadi tidak reaktif. Antioksidan alam yang bisa dimanfaatkan yaitu daun kunyit (Curcuma longa L.). Kandungan flavonoid dalam daun kunyit bertindak sebagai antioksidan. Penelitian ini bermaksud untuk mengetahui aktivitas antioksidan, kadar fenolik total dan flavonoid total pada fraksi n-heksana, etil asetat dan air ekstrak daun kunyit. Daun kunyit dimaserasi menggunakan etanol 96%. Ekstrak yang didapatkan dilanjutkan difraksinasi dengan n-heksana, etil asetat dan air serta dilakukan aktivitas antioksidan dengan DPPH. Fraksi dan ekstrak dianalisis kadar flavonoid total dengan AlCl3 dan fenolik total dengan folin-ciocalteu, Pengujian menggunakan spektrofotometri UV-Vis. Hasil pengujian antioksidan dengan IC50 ekstrak, fraksi n-heksana, etil asetat dan air yaitu 41,11 ± 0,09, 130,62 ± 0,07, 32,35 ± 0,03, 100,30 ± 0,2 ppm. Kadar flavonoid total pada ekstrak, fraksi n-heksana, etil asetat dan air  sebesar 39,79 ± 0,33, 10,38 ± 0,26, 42,00 ± 0,56, 12,91 ± 0,14 mg QE/g. Kadar fenolik total pada ekstrak, fraksi n-heksana, etil asetat dan air sebesar 140,74 ± 0,21, 55,41 ± 0,19, 303,86 ± 0,99, 63,88 ± 0,56 mg GAE/g.
Comparing Conventional and Modern Methods for The Phycocyanin Extraction from Spirullina sp Marlina, Dian; Purwaningsih, Desi; Pratiwi, Reny; Saputra, Ryan Werytama; Setyaningsih, Widiastuti; Supriyono, Supriyono
Advance Sustainable Science Engineering and Technology Vol. 6 No. 3 (2024): May - July
Publisher : Science and Technology Research Centre Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v6i3.907

Abstract

Spirulina platensis, a blue-green algae abundant in tropical regions, is rich in minerals, vitamins, fibers, and pigments, with low nucleic acid content. It has unique chromoproteins called phycobiliproteins, notably phycocyanin, used in various applications. This study aims to optimize phycocyanin extraction using different solvents (distilled water and sodium phosphate buffer pH 6.7) and methods (freeze-thaw and sonication). Spirulina platensis biomass was extracted in both solvents, then some of them was freeze for 24 and 48 hours followed by thawing overnight. The other was sonicated for 2.5 minutes, 50 Hz then soaked for 1, 2, and 3 hours. All of the samples were centrifuged at 6000 rpm for 10 minutes and the absorbance was measured using a UV-Vis spectrophotometer at wavelengths of 280, 620, and 650 nm. with freeze-thawing for 48 hours yielded the highest phycocyanin concentration (0.55%), with a yield of 11.07 and purity of 0.21. Sonication improved phycocyanin concentration, yield, and purity significantly, yielding 1.108, 25.85, and 0.26, respectively.
Variations of Tween Surfactant and Propylene Glycol Cosurfactant in Topical Microemulsion Formulation on The Penetration of Ibuprofen Fitrianingsih, Sri; Widodo, Gunawan Pamudji; Marlina, Dian
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.5785

Abstract

ABSTRACTIbuprofen is a derivative of propionic acid, a class of non-steroidal anti-inflammatory drugs (NSAIDs). Ibuprofen has side effects on the gastrointestinal tract. So that topical use can be a solution to reduce the side effects of oral use because of the release of topical drugs through the stratum corneum which makes it selective in certain places. The preparation chosen was a topical microemulsion because it is more thermodynamically stable and has no effect on the gastrointestinal tract. This study aims to determine the effect of the ratio of surfactant concentrations of various ratios of tween 20:tween 80 and cosurfactant propylene glycol to the penetration rate of ibuprofen across the membrane and to determine the physical characteristics of topical microemulsions. Selection of tween surfactant and propylene glycol cosurfactant because it has high physical stability. This research is an experimental study, namely by making four formulations with various ratios of surfactant and cosurfactant with a difference of 2.5% in each formulation of topical ibuprofen microemulsion with a concentration of 5% ibuprofen using variations of surfactant tween 20 and tween 80, cosurfactant propylene glycol with black cumin oil phase. Evaluation of the preparation by organoleptic test, pH test of the preparation, examination of the type of emulsion, particle size measurement, microemulsion release test in vitro using the Franz diffusion method. The results show that the concentration ratio of surfactant tween 20:tween 80 and cosurfactant propylene glycol can affect particle size, pH and penetration velocity (flux) in Franz diffusion. The results of the study showed that in F1 using surfactant tween 20:tween 80 with a concentration of 71.6% (6:4) had the smallest particle size of 11.5 nm and the largest flux value was 128.45 g.cm-2.H- 1. In conclusion, variations in surfactant and cosurfactant concentrations can affect the pH of the preparation, particle size, penetration speed (flux). The results obtained that the cumulative percent and penetration speed of all formulas had significant differences (p0.05).
Hydrogen bonding investigation of poly(3-hydroxybutyrate) / glycol chitosan blends studied by infrared and terahertz spectroscopies Marlina, Dian; Sato, Harumi
Advance Sustainable Science, Engineering and Technology Vol 1, No 1 (2019): May-October
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v1i1.4879

Abstract

Poly(3-hydroxybutyrate) (PHB)/glycol chitosan (GC) polymer blend was developed as one of the new biopolymer materials. Effects of different PHB / GC concentrations were analysed as a function of the blend compositions by using Fourier transform infrared (FTIR) and terahertz (THz) spectroscopies to investigate the changes in the higher-order structure and bonding of hydrogen. The higher-order structure and hydrogen bonding monitored in this study include the crystalline structure and (C=O…H-C) hydrogen bonding of PHB. The FTIR and THz spectra showed that PHB's higher-order structure transforms into the less-order structure by adding GC without altering the crystalline structure and PHB's intramolecular (C = O ... H-C) hydrogen bonding with increasing GC concentration. Because of the addition of GC, the intensity ratio of THz bands figure out the crystalline dynamics of PHB, the helical structure deformation occurs first followed by the weakening of intramolecular (C = O ... H-C) hydrogen bonding within PHB-PHB molecules. Keywords: Chitosan, higher-order structure, hydrogen bonding, low-frequency vibrational spectroscopy
Co-Authors 12.520.20.206 Shinta Ratnawati, 12.520.20.206 Achmad Solechan Anak Agung Istri Sri Wiadnyani Anang Kuncoro Rachmad Setiawan Anggraini, Natasya Dila Putri Aris Tri Jaka Harjanta, Aris Tri Arsyeni Destra Anarchy Arsyandi Asiyah, Siti Dwi Bambang Agus Herlambang, Bambang Desi Purwaningsih Febrian Murti Dewanto Fitrianingsih, Sri Gunawan Pamudji Widodo Haryo Kusumo Haryo Kusumo Iswandi Iswandi Jason Merari Peranginangin Kusumo, Haryo Lumbantungkup, Gebi Evelin mayang, anissa Mega Novita Mega Novita Misnovita, Ghina Salsabila Nilawati, Anita Novitarini Novitarini Nur Anggreini Dwi Sasangka Pramukantoro, Ganet Eko Prasetyanto, Panji Kusuma Priyanto, Widodo Purwaningsih, Avianti Eka Dewi Aditya Rahayuningsih, Dwinata Rahmadita, Ivony Reny Pratiwi Reny Pratiwi Rifki Hermana Ryan Werytama Saputra Santi Kartika Dewi, Lensa Erliana Saputra, Ryan Werytama Sato, Harumi Senowarsito, Senowarsito Sephia Febriyanti Setyaningsih, Widiastuti Siwi, Andini Prabandaru Supriyono Supriyono Supriyono Supriyono Sutomo Sutomo Vivin Nopiyanti Widiastuti Setyaningsih Yunitha, Emmellia