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All Journal Biomedical Journal of Indonesia Universa Medicina The Indonesian Journal of Infectious Diseases Hearty : Jurnal Kesehatan Masyarakat Jurnal Respirologi Indonesia Majalah Patologi Indonesia Sumatera Medical Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan UMI Medical Journal Dinasti International Journal of Education Management and Social Science Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran The Avicenna Medical Journal Hang Tuah Medical Journal Jurnal Pengabdian Masyarakat Bangsa AMMA : Jurnal Pengabdian Masyarakat GEMBIRA (Pengabdian Kepada Masyarakat) Jurnal Kedokteran Meditek Jurnal Pengabdian Masyarakat Mandira Cendikia (JPKM-MC) Cermin Dunia Kedokteran
Reza Aditya Digambiro
Universitas Trisakti Jakarta, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Hubungan Antara Derajat Histopatologi Karsinoma Penis dengan Tampilan Imunohistokimia HER-2 Reza Aditya Digambiro; Ibnu Alferally; Delyuzar Delyuzar
Majalah Patologi Indonesia Vol 25 No 2 (2016): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

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Abstract

Latar belakang Insidensi karsinoma penis di seluruh dunia sekitar 1/100.000 populasi. Sebanyak 95% dari kanker penis adalah karsinoma sel skuamosa, sisanya adalah melanoma, leiomiosarkoma atau tipe lainnya. Pada umumnya penyakit ini lebih banyak dijumpai pada usia tua, insidensi semakin meningkat pada usia 80 tahun keatas. Phimosis, peradangan menahun, radiasi ultraviolet, adanya riwayat menderita papiloma warts (infeksi Human Papilloma Virus/HPV), atau kondiloma serta tidak disirkumsisi merupakan beberapa faktor risiko terjadinya karsinoma penis. Pada riset yang dilakukan oleh Silva dan rekan-rekan (2012), dijumpai pewarnaan HER-2 yang positif kuat pada 28 kasus karsinoma penis (14,9%). Fakta ini bertentangan dengan penelitian sebelumnya yang dilakukan oleh Stankiewicz dan kawan-kawan (2011), yang menyatakan bahwa HER-2 tidak memiliki hubungan dengan karsinogenesis pada penis. Pada penelitian ini kami menganalisis adakah hubungan antara derajat histopatologi karsinoma penis dengan tampilan imunohistokimia HER-2 pada karsinoma penis dengan melakukan pemeriksaan imunohistokimia HER-2 pada sampel sediaan blok parafin dari jaringan penis. Tujuan penelitian ini untuk mengetahui adanya hubungan antara derajat histopatologi karsinoma penis dengan tampilan imunohistokimia HER-2 pada kasus karsinoma penis di Instalasi Patologi Anatomik Rumah Sakit Haji Adam Malik Medan 2008-2012. Metode Rancangan penelitian ini menggunakan rancangan deskriptif analitik dengan pendekatan cross sectional. Pada penelitian ini tidak memberikan perlakuan terhadap variabel tetapi hanya melihat ekspresi imunohistokimia HER-2. Pengukuran pada variabel hanya dilakukan satu kali dan pada satu saat. Hasil Pada uji korelasi Spearman ternyata secara statistik tidak terdapat hubungan yang signifikan antara derajat histopatologi karsinoma penis dengan tampilan imunohistokimia HER-2 pada karsinoma penis (p>0,05). Kesimpulan Setelah dilakukan uji korelasi Spearman tidak didapati hubungan yang bermakna antara grading histopatologi karsinoma penis terhadap tampilan hasil pulasan imunohistokimia HER-2 pada karsinoma penis. Hubungan Antara HER-2 dengan pewarnaan sitoplasma yang berkaitan dengan keratin mungkin diakibatkan oleh reaksi silang antibodi dengan keratin atau antigen retrieval. Kata kunci : derajat histopatologi, HER-2, karsinoma, penis.
Penyuluhan Dan Penerapan Protokol Kesehatan Untuk Menekan Laju Pandemi Coronavirus Disease-19 Di Kampus Institut Transportasi Dan Logistik Trisakti Reza Aditya Digambiro; Edy Parwanto
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 9 : Oktober (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

The implementation of outreach activities at Institut Transportasi dan Logistik (ITL) Trisakti focuses on a holistic approach to facing the Coronavirus Disease-19 (COVID-19) pandemic. The main problem faced by the ITL Trisakti Academic Community is a lack of comprehensive understanding of health protocols and the long-term impacts of the pandemic. Facing globalization and the need to adapt to the pandemic, the academic community needs to be equipped with knowledge and skills to face these challenges. The purpose of this activity is to increase the awareness and knowledge of the ITL Trisakti Academic Community about COVID-19through mentoring and counseling. The methods used include outreach, training, mentoring, and evaluation during the November 2020 period. The results of this activity show that the understanding and awareness of the academic community have increased, and the implementation of health protocols has improved on campus.
Mucinous Tumors of the Ovary: Current Diagnosis in Histopathological Perspective Florinda Ilona; Dyah Ayu Woro; Reza Aditya Digambiro
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.163

Abstract

Epithelial malignant tumors account for around 90% of all ovarian malignancies and are the most deadly gynecological malignancies and mucinous borderline ovarian tumors are the most common cases in Asia. According to World Health Organization (WHO) 2020, mucinous ovarian tumors are divided into mucinous cystadenoma, borderline mucinous tumor and mucinous carcinoma. Histopathological features of benign, borderline and invasive mucinous carcinoma can be found together in one tumor. The coexixtence of these varied morphological features makes it difficult to establish a diagnosis due to the limited section evaluated and the large size of tumor. It can contribute to inaccurate diagnosis due to heterogeneity of the morphological features. Metastatic mucinous tumors which often resemble primary mucinous tumors in the ovaries.
Tingkat Pengetahuan Kecacingan Di Desa Sukasari Pandeglang Tjahyadi, David; Parwanto, Edy; Ganeca Widyatama, Haryo; Sisca, Sisca; Aditya Digambiro, Reza; Pakpahan, Alfred
AMMA : Jurnal Pengabdian Masyarakat Vol. 3 No. 6 : Juli (2024): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Worm disease still a serious problem and is second health problem in Indonesia come after malnutrition. Cumulative worms in human body can cause loss of substances that are useful for growth. The Filariasis and Worm Worms Sub-Directorate of P2PL stated that the prevalence of worm diseases in Pandeglang Regency was 58.3%. Various worm larvae were found when examining soil samples taken at the homes of residents of Sukasari, Pulosari, Pandeglang villages. The aim of this community service (PKM) is to increase knowledge about worm diseases. This Community Service Method (PKM) uses the counseling or lecture method by the presenter. Before and after counseling, residents were given a questionnaire to measure their level of knowledge about worm diseases. Residents' knowledge increased after being given counseling and it is hoped that this can help the community to prevent the emergence of worm diseases in the future.
ANALISIS KOMPARATIF ATROFI SEREBRAL PADA GANGGUAN KOGNITIF NON-ALZHEIMER DAN PENYAKIT ALZHEIMER DI INDONESIA Digambiro, Reza Aditya; Marsiati, Himmi; Hadi, Restu Syamsul; Hastuty, Dewi; Parwanto, Edy
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.245

Abstract

Abstrak Penelitian ini menganalisis pola atrofi serebral pada pasien gangguan kognitif non-Alzheimer dan penyakit Alzheimer (AD) di Indonesia. Atrofi otak terjadi lebih cepat pada pasien AD dibandingkan penuaan normal, dan percepatan atrofi hipokampus ditemukan pada subjek dengan gangguan kognitif ringan (MCI) yang berkembang menjadi AD. Data diperoleh dari 710 subjek yang menjalani MRI di Rumah Sakit Cipto Mangunkusumo dan Rumah Sakit Hasan Sadikin. Analisis laju atrofi otak keseluruhan, hipokampus, dan pembesaran ventrikel menunjukkan perbedaan signifikan antara kelompok kontrol, MCI, dan AD. Rata-rata percepatan atrofi hipokampus pada subjek MCI mencapai 0,44% per tahun kuadrat (p < 0,05). Temuan ini menggarisbawahi pentingnya deteksi dini dan intervensi terapeutik pada tahap MCI. Penelitian ini juga menunjukkan bahwa pola atrofi serebral di Indonesia serupa dengan temuan global, meskipun terdapat perbedaan faktor risiko lokal. Penelitian lanjutan perlu mencakup analisis longitudinal jangka panjang untuk pemahaman yang lebih baik tentang progresi AD di Indonesia. Kata Kunci: Atrofi serebral, Alzheimer, gangguan kognitif ringan, Indonesia, hipokampus, MRI Abstract This study analyzes cerebral atrophy patterns in patients with non-Alzheimer cognitive impairment and Alzheimer's disease (AD) in Indonesia. Brain atrophy progresses faster in AD patients compared to normal aging, with accelerated hippocampal atrophy observed in mild cognitive impairment (MCI) subjects who progress to AD. Data were obtained from 710 subjects who underwent MRI at Cipto Mangunkusumo Hospital and Hasan Sadikin Hospital. Analysis of overall brain atrophy rates, hippocampal atrophy, and ventricular enlargement revealed significant differences between control, MCI, and AD groups. The average acceleration of hippocampal atrophy in MCI subjects was 0.44% per year squared (p < 0.05). These findings emphasize the importance of early detection and therapeutic intervention at the MCI stage. This study also indicates that cerebral atrophy patterns in Indonesia are similar to global findings, despite local risk factor variations. Further research should include long-term longitudinal analysis to gain a better understanding of AD progression in Indonesia. Keywords: Cerebral atrophy, Alzheimer’s disease, mild cognitive impairment, Indonesia, hippocampus, MRI
Pencegahan Kanker Payudara Melalui Penyuluhan di Masyarakat Nagrak Digambiro, Reza Aditya; Chendrasari, Julian; Ilona, Florinda; Lestari, Indah Widya; Setyaningrum, Dyah Ayu Woro; Fadillah, Ibnu Haris
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 11 (2025): Januari
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i11.1922

Abstract

Kanker payudara tetap menjadi masalah kesehatan masyarakat yang signifikan di Indonesia, terutama di daerah berkembang seperti Nagrak. Tantangan dalam deteksi dini akibat kurangnya kesadaran, fasilitas kesehatan yang terbatas, dan stigma budaya memperburuk prevalensi dan mortalitas akibat kanker payudara. Program pengabdian masyarakat yang dilakukan oleh Fakultas Kedokteran Universitas Trisakti bertujuan untuk meningkatkan kesadaran masyarakat dan memberdayakan perempuan di Nagrak untuk melakukan pemeriksaan payudara sendiri (SADARI) sebagai langkah pencegahan. Program ini melibatkan survei awal untuk menilai pengetahuan masyarakat, diikuti dengan seminar edukasi dan sesi simulasi SADARI yang dipandu oleh tenaga medis dan mahasiswa. Evaluasi pasca-kegiatan menunjukkan peningkatan signifikan dalam pengetahuan dan keterampilan peserta, yang menegaskan efektivitas program ini. Rekomendasi utama meliputi pelaksanaan edukasi rutin, penguatan kerjasama dengan fasilitas kesehatan lokal, dan pemanfaatan media digital untuk memperluas dampak edukasi. Inisiatif ini menegaskan pentingnya pendekatan berbasis komunitas dalam menurunkan prevalensi kanker payudara melalui deteksi dini dan perubahan gaya hidup.
The Impact of High Dose Ozone Therapy on Hematological and Biochemical Profiles : An Observational Study Digambiro, Reza Aditya; Parwanto, Edy; Lestari, Indah Widya; Chendrasari, Julian; Setyaningrum, Dyah Ayu Woro; Ilona, Florinda
The Avicenna Medical Journal Vol 5, No 1 (2024): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v5i1.34859

Abstract

Background: Ozone therapy, namely High Dose Ozone Therapy (HDO), has become a versatile medical treatment in several clinical settings. Although it is becoming more well acknowledged, there is still a lack of extensive evidence about the impact of this on hematological and biochemical indicators. This study seeks to address this void by examining the consequences of this phenomenon in a clinical environment.Method: An observational study was done, which followed a structured approach, comprising a total of 100 patients who were selected from the SMC Clinic. Hematological and biochemical indices were evaluated before and after ozone therapy sessions to analyze blood parameters. Two blood samples were obtained at two specific time points: prior to the commencement of the ozone therapy (T0) and after the therapy was finished (T1).Results: Substantial alterations were noted in both hematological and biochemical parameters after the therapy. The hematological changes observed in this study showed a substantial rise in the red blood cell count (p=0.009), hemoglobin levels (p=0.004), and hematocrit (p=0.039), along with a decrease in erythrocyte sedimentation rate (ESR) (p=0.020). Notable biochemical changes were observed, including significant modifications in total plasma protein (TPP) (p=0.008) and lactate levels (p=0.001). Furthermore, there was a noteworthy decrease (p<0.05) in the levels of malondialdehyde (MDA), which is a marker for oxidative stress.Conclusion: HDO exerts a regulatory influence on crucial hematological, biochemical, and oxidative stress factors. These findings indicate that HDO may have therapeutic benefits for treating chronic disorders and cancer. It can improve blood parameters and reduce oxidative stress. The decrease in markers of oxidative stress, such as MDA, suggests a potential reduction in the likelihood of problems associated with oxidative damage in chronic diseases. Nevertheless, additional research is required to validate these findings, investigate their wider therapeutic implications, and comprehend the long-term consequences and safety of HDO therapy.
THE USE OF TELEMEDICINE IN PRIMARY HEALTHCARE SERVICES IN JAKARTA Digambiro, Reza Aditya; Ilona, Florinda; Setyaningrum, Dyah Ayu Woro; Chendrasari, Julian; Lestari, Indah Widya
HEARTY Vol 13 No 3 (2025): JUNI
Publisher : Fakultas Ilmu Kesehatan, Universitas Ibn Khaldun, Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/hearty.v13i3.18339

Abstract

Background: The advancement of digital technology has transformed the healthcare sector, and telemedicine has become an important innovation in providing remote clinical services. Methods: The research method used is a mixed-method approach, combining quantitative and qualitative approaches. Data collection was conducted through questionnaires distributed to 400 telemedicine users. The sample size was determined using the Slovin formula with a 5% margin of error. Results: 75% of respondents used telemedicine more than once in the past year, with 70% of respondents expressing high satisfaction with the services received. The main reasons for using telemedicine include convenience (65%) and time savings. However, several challenges were identified, such as technical issues (30%), lack of physical examinations, and concerns about service quality. Discussion: The main challenges identified include inadequate technological infrastructure, low digital literacy among certain groups, and unclear regulations. Development opportunities include the integration of telemedicine with electronic health records and increased public education. Conclusion: Telemedicine has great potential to improve the accessibility and efficiency of healthcare services in Jakarta. However, improvements in infrastructure, digital literacy, and supportive regulatory frameworks are needed to maximize the benefits of telemedicine within the healthcare system.
The Effect of Zinc Supplementation on Reducing Dengue-Related Morbidity in Pediatric Patients in Jakarta Digambiro, Reza Aditya; Setyaningrum, Dyah Ayu Woro; Dewi, Intan Keumala; Ananingsih, Pangisti Dwi
The Indonesian Journal of Infectious Diseases Vol. 11 No. 1 (2025): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v11i1.268

Abstract

Background: Dengue hemorrhagic fever is an endemic disease that causes significant morbidity, particularly in Jakarta. Based on previous studies, zinc has immunomodulatory properties that can function to improve the immune response to infections, including dengue. This study aims to evaluate the effectiveness of zinc supplementation in reducing morbidity and improving clinical conditions in pediatric patients with dengue hemorrhagic fever. Methods: This study utilized a prospective cohort method with a sample of 200 pediatric patients suffering from dengue hemorrhagic fever. The sample was divided into two groups: the intervention group (given zinc supplementation) and the control group (standard care without zinc supplementation). Laboratory assessments included serum zinc levels, severity of clinical symptoms, and hematological examination results. Results: The analysis showed a significant increase in serum zinc levels in the group given zinc supplementation, with the mean increasing from 100.34 ± 27.69 µg/dL to 104.28 ± 28.65 µg/dL on day 14 (p < 0.05). The number of patients whose clinical symptoms gradually became milder increased from 40% to 55% in the intervention group, whereas in the control group, there was a decrease in the number of patients with gradually milder symptoms, from 40% to 36%. Conclusion: Zinc supplementation is quite effective in reducing morbidity and improving clinical conditions in pediatric patients with dengue hemorrhagic fever.
Borassus flabellifer Effectively Reduces MDA Levels in High Oxidative Stress Population in Jakarta, Indonesia Digambiro, Reza Aditya; Marsiati, Himmi; Hadi, Restu Syamsul; Parwanto, Edy
Sumatera Medical Journal Vol. 8 No. 2 (2025): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v8i2.18966

Abstract

Background: Malondialdehyde (MDA) is commonly used to assess oxidative stress levels. Objective: This study aimed to investigate the effect of Borassus flabellifer  fruit consumption on MDA levels in individuals with high oxidative stress, providing insights into the fruit’s potential as a natural antioxidant therapy. Methods: A prospective interventional study was conducted in Jakarta, recruiting fifty participants aged 30–60 years with baseline MDA levels >10 nmol/L. Participants consumed 150 grams of Borassus flabellifer fruit daily for 30 days. Blood samples were collected at baseline and post-intervention to assess MDA levels. Results: The average MDA level decreased significantly from 14.35 ± 2.43 nmol/L to 12.00 ± 1.74 nmol/L after 30 days of fruit consumption (p < 0.0001). The Cohen’s d value of 2.92 indicated a large effect size, demonstrating the intervention’s substantial impact. A strong positive correlation (r = 0.91, p < 0.0001) between baseline MDA levels and reduction was observed, suggesting that participants with higher baseline oxidative stress benefited more from the intervention. Conclusion: Borassus flabellifer fruit consumption effectively reduces MDA levels in individuals with high oxidative stress. The results support the inclusion of this fruit in recommendations for managing oxidative stress-related conditions.
Co-Authors Alfred Pakpahan, Alfred Chendrasari, Julian David Tjahjadi, David David Tjahyadi Delyuzar, Delyuzar Devita, Yessi Dewi Hastuty Dewi, Intan Keumala Ditriana, Ditriana Dyah Ayu Woro Edy Parwanto Fadillah, Ibnu Haris Fiji, Wijaya Taufik Florinda Ilona Gabrielle, Laurentia Ganeca Widyatama, Haryo Hastuty , Dewi Ibnu Alferally Ilona, Florinda Indrawan, Rully Jaya Edy, Hosea Lestari, Indah Widya Marsiati, Himmi Oladimeji, Ashaolu Victoria Pangisti Dwi Ananingsih, Pangisti Dwi Parwanto, Edy Restu Syamsul Hadi RR. Ella Evrita Hestiandari Rully Indrawan Sembiring, Rinawati Setianingrum, Dyah Ayu Woro Setyaningrum, Dyah Ayu Woro Sisca Sisca, Sisca Siti Maemunah Sukardimand, Tjuk Tjahyadi, Joey Joshua Vidova Tjuk Sukardimand Xavierees, Endrico