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All Journal Biomedical Journal of Indonesia Universa Medicina The Indonesian Journal of Infectious Diseases Hearty : Jurnal Kesehatan Masyarakat Jurnal Respirologi Indonesia Majalah Patologi Indonesia Sumatera Medical Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan UMI Medical Journal Dinasti International Journal of Education Management and Social Science Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran The Avicenna Medical Journal Hang Tuah Medical Journal Jurnal Ilmu Multidisplin The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Pengabdian Masyarakat Bangsa AMMA : Jurnal Pengabdian Masyarakat GEMBIRA (Pengabdian Kepada Masyarakat) Jurnal Kedokteran Meditek Jurnal Pengabdian Masyarakat Mandira Cendikia (JPKM-MC) Cermin Dunia Kedokteran
Reza Aditya Digambiro
Universitas Trisakti Jakarta, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Analysis of D-Dimer Levels Based on Histopathological Grading of Breast Cancer Devita, Yessi; Digambiro, Reza Aditya; Hastuty, Dewi
Jurnal Kedokteran Meditek Vol 31 No 6 (2025): November
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i6.3974

Abstract

Background: Breast cancer is the most common malignancy among women worldwide. Systemic activation of coagulation, reflected by elevated D-dimer levels, has been associated with advanced stage, metastasis, and poor prognosis in breast cancer. However, it remains unclear whether D-dimer also correlates with histopathological grade as an indicator of intrinsic tumor aggressiveness, particularly among patients with invasive breast cancer in Indonesia. Objective: To evaluate the association between plasma D-dimer levels and histopathological grading of invasive breast cancer. Methods: This cross-sectional study included 180 untreated female patients with primary invasive breast cancer, comprising 60 cases each of Grade I, Grade II, and Grade III tumors. Plasma D-dimer levels were measured using a latex-enhanced immunoturbidimetric assay, and histological grading was determined according to the Nottingham system. Data were analyzed using the Kruskal–Wallis test, ANOVA on log-transformed values, post-hoc tests, and ANCOVA with adjustment for age, body mass index (BMI), clinical stage, C-reactive protein (CRP), lymphovascular invasion, and molecular subtype. Receiver operating characteristic (ROC) analysis was performed to distinguish Grade III from lower grades. Results: Median D-dimer levels increased progressively from Grade I (501.7 ng/mL) to Grade II (831.0 ng/mL) and Grade III (1312.9 ng/mL), with a statistically significant overall difference (p < 0.001). ROC analysis for identifying Grade III yielded an AUC of 0.960 with an optimal cut-off of 965.5 ng/mL FEU (sensitivity 91.7%, specificity 90.0%). Conclusion: Plasma D-dimer levels are significantly associated with histopathological grade in invasive breast cancer, independent of potential confounders. These findings suggest that D-dimer testing may help identify patients with high-grade tumors at an early stage, thereby refining risk stratification, informing more intensive treatment planning, and raising vigilance for thromboembolic complications, particularly in resource-limited settings.. ctice.
Early Medical Technology in Reducing The Mortality Rate in Toll Road Accidents Reza Aditya Digambiro; Rully Indrawan; Siti Maemunah; Tjuk Sukardimand
Dinasti International Journal of Education Management And Social Science Vol. 5 No. 4 (2024): Dinasti International Journal of Education Management and Social Science (April
Publisher : Dinasti Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/dijemss.v5i4.2632

Abstract

Purpose: The research aims to know whether the technological system is effective in bringing improvement to early medical response toward traffic accidents on toll roads in Indonesia, particularly in an attempt to bring down the mortality rate caused by traffic accidents on toll roads.  Methods: The current study holds a research design of a mixed-methods approach that mainly adopts the use of qualitative and quantitative measures of structural equation modeling (SEM. Data collected involved survey, interviews, and field observations that focused on perception of accident risk on toll roads and the effect of technology on early medical handling.  Result: The findings have therefore confirmed that the traffic accident risk perception on the toll roads is generally perceived low, with a mean perception score averaging at 2.65. On the other side, a positive picture is painted regarding the role of technology in improving timeliness and effectiveness of medical responses: its contribution to early medical handling (3.06) and the impact it can have on the reduction in rates of deaths (2.96). Conclusion: The findings highlight the urgent need for increased public awareness and the development of technology-based emergency strategies. Targeted technological interventions, particularly those enhancing early medical response, could significantly reduce toll road accident fatalities.
HIDUP SEHAT TANPA DIABETES : PENYULUHAN BERSAMA WARGA NAGRAK Digambiro, Reza Aditya; Chendrasari, Julian; Krismanuel, Hari; Nugroho, Didi; Ilona, Florinda
Jurnal Gembira: Pengabdian Kepada Masyarakat Vol 4 No 01 (2026): FEBRUARI 2026
Publisher : Media Inovasi Pendidikan dan Publikasi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes melitus merupakan masalah kesehatan masyarakat yang terus meningkat, sementara literasi kesehatan dan akses skrining gula darah di wilayah Nagrak masih terbatas sehingga deteksi dini sering terlambat. Kegiatan pengabdian masyarakat ini bertujuan meningkatkan pengetahuan warga tentang faktor risiko, pencegahan, dan deteksi dini diabetes, sekaligus melakukan skrining gula darah sewaktu. Metode yang digunakan adalah penyuluhan luring interaktif dengan media presentasi dan leaflet, dilanjutkan edukasi gaya hidup sehat serta pemeriksaan gula darah sewaktu menggunakan glukometer portabel disertai konseling singkat hasil pemeriksaan. Evaluasi efektivitas dilakukan dengan desain one-group pretest–posttest menggunakan kuesioner pengetahuan. Sebanyak 30 peserta mengikuti kegiatan dan pemeriksaan, didominasi perempuan usia 30–60 tahun. Skor pengetahuan rata-rata meningkat dari 56±12 (pretest) menjadi 78±10 (posttest) atau naik 39% (p<0,001). Distribusi gula darah sewaktu menunjukkan 60,0% normal, 30,0% pradiabetes, dan 10,0% diabetes. Hasil ini menunjukkan penyuluhan berbasis komunitas yang disertai skrining sederhana efektif meningkatkan pengetahuan dan memberikan gambaran awal kebutuhan tindak lanjut di masyarakat. memuat uraian singkat mengenai masalah dan tujuan pengabdian, metode yang digunakan, dan hasil pengabdian.
EFFECT OF INTRAMUSCULAR SECRETOME ON TREATMENT RESPONSE IN TYPE 2 DIABETES MELLITUS PATIENTS DIGAMBIRO, REZA ADITYA; AMARENDRA, GERIE; HASTUTY, DEWI; ILONA, FLORINDA; CHENDRASARI, JULIAN
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol. 9 No. 1 (2026): Al-Iqra Medical Journal: Jurnal Berkala Ilmiah Kedokteran
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/fgmtjc48

Abstract

Introduction: This study meant to evaluate the efficacy of intramuscular mesenchymal stem cell derived secretome therapy to improve the glycemic control among diabetic patients with Type 2 Diabetes Mellitus (T2DM) on stable insulin or oral hypoglycemic agents (OHO). n=30 per group (Insulin + Secretome; OHO + Secretome). Methods: Pre–post controlled design; biweekly 2 mL intramuscular secretome for 12 weeks; primary outcomes HbA1c, FBG, 2hPP; standard tests per normality. Participants were divided into two groups: Insulin + Secretome and OHO + Secretome. All subjects received intramuscular injections of mesenchymal stem cell (MSC)-derived secretome (2 mL) every two weeks over a 12-week period (six injections total). Primary outcomes included changes in HbA1c, fasting blood glucose (FBG), and two-hour postprandial glucose (2hPPBG). Statistical analyses used paired t-tests or Wilcoxon tests for within-group comparisons and independent t-tests or Mann-Whitney U tests for between-group comparisons. Results: At baseline, both groups had comparable HbA1c and glucose profiles. After 12 weeks, significant reductions were observed in both treatment arms. HbA1c decreased by -1.10 ± 0.45 (Insulin) and -1.33 ± 0.36 (OHO); between-group ΔHbA1c (p < 0.05). Both groups also showed clinically relevant reductions in FBG and 2hPPBG levels. No major adverse effects were reported. Conclusion: Intramuscular MSC-secretome improved glycemic control across background therapies; the benefit was modestly greater with OHO. No majoradverse events were observed
Hubungan antara Gambaran Histopatologi Sumsum Tulang dan Gejala Klinis pada Pasien Leukemia Indra, Zahrah Zahira Pasya; Digambiro, Reza Aditya
Jurnal Ilmu Multidisiplin Vol. 5 No. 1 (2026): Jurnal Ilmu Multidisplin (April - Mei 2026)
Publisher : Green Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/jim.v5i1.1803

Abstract

Leukemia ditandai oleh proliferasi sel blast di sumsum tulang yang menimbulkan berbagai gejala klinis. Hubungan antara gambaran histopatologi dan manifestasi klinis belum selalu konsisten. Penelitian ini bertujuan menganalisis hubungan keduanya pada pasien leukemia. Penelitian ini adalah studi observasional potong lintang menggunakan data biopsi sumsum tulang dan catatan klinis pasien leukemia. Hubungan antara persentase sel blast, selularitas, dan derajat fibrosis dengan gejala klinis dianalisis menggunakan Chi-Square atau Fisher’s Exact Test, dengan p < 0,05 dianggap signifikan. Hasil penelitian menunjukkan bahwa peningkatan sel blast berhubungan signifikan dengan gejala gusi berdarah dan lebam, namun tidak berhubungan signifikan dengan demam maupun nyeri tulang. Selularitas tinggi menunjukkan hubungan bermakna dengan demam, namun tidak dengan gejala perdarahan lainnya. Sementara itu, derajat fibrosis tidak menunjukkan hubungan bermakna dengan seluruh gejala klinis yang diteliti. Respons klinis pasien leukemia bersifat heterogen dan dipengaruhi oleh kombinasi faktor seluler, proses inflamasi, serta derajat invasi jaringan. Kesimpulannya adalah gambaran histopatologi sumsum tulang, terutama persentase sel blast dan tingkat selularitas, memiliki hubungan bermakna dengan beberapa gejala klinis pasien leukemia. Fibrosis tidak berpengaruh signifikan pada fase prefibrotik.
Hubungan Gambaran Histopatologi Sumsum Tulang dengan Hasil Pemeriksaan Hb, Leukosit dan Trombosit pada Pasien Leukemia Nainggolan, Matthew Timothy; Digambiro, Reza Aditya
Jurnal Ilmu Multidisiplin Vol. 5 No. 1 (2026): Jurnal Ilmu Multidisplin (April - Mei 2026)
Publisher : Green Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/jim.v5i1.1804

Abstract

Leukemia merupakan keganasan hematologi akibat proliferasi abnormal sel induk hematopoietik di sumsum tulang yang menyebabkan gangguan hematopoiesis dan perubahan kadar Hb, leukosit, serta trombosit. Secara global, leukemia menyumbang 2,5% insiden kanker baru, sementara di Indonesia insidensinya mencapai 3,4% dari seluruh keganasan. Pemeriksaan histopatologi sumsum tulang merupakan standar emas diagnosis, namun pemeriksaan darah lengkap lebih mudah tersedia secara luas. Tujuan penelitian ini adalah untuk menilai hubungan antara gambaran histopatologi sumsum tulang yang meliputi persentase sel blast, selularitas, dan derajat fibrosis, dengan hasil pemeriksaan darah lengkap yaitu kadar Hb, leukosit, dan trombosit pada pasien leukemia. Sampel berjumlah 100 orang menggunakan teknik consecutive sampling. Analisis hubungan menggunakan uji Pearson Chi-Square atau Fisher’s Exact. Berdasarkan hasil penelitian dapat disimpulkan tidak terdapat hubungan bermakna (p > 0.05) antara gambaran histopatologi sumsum tulang dengan parameter darah lengkap.
Colonic Leiomyoma Presenting as Sigmoid Volvulus in a Young Male Digambiro, Reza Aditya; Amarendra, Gerie; Ilona, Florinda; Chendrasari, Julian; Kehinde, Samuel Abiodun
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 1 (2026): VOLUME 27, NUMBER 1, April, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/271202695-100

Abstract

Colonic leiomyomas are rare tumors that originate from the smooth muscle layer of the colon and are infrequently observed in young individuals. This case report represents a 21-year-old male who presented with a 2-month history of progressive abdominal distension, persistent vomiting, early satiety, and bloating. Computed tomography (CT) of the abdomen suggested sigmoid volvulus with associated bowel obstruction. However, exploratory laparotomy revealed a well-defined, firm intramural mass in the sigmoid colon, leading to segmental resection and primary anastomosis. Histopathological analysis showed intersecting fascicles of bland spindle cells with eosinophilic cytoplasm and cigar-shaped nuclei without atypia or mitotic activity. Immunohistochemistry confirmed positivity for smooth muscle actin (SMA) and negativity for CD117, supporting a diagnosis of colonic leiomyoma and excluding gastrointestinal stromal tumor (GIST). The patient’s postoperative course was uneventful, with complete resolution of obstructive symptoms and restoration of normal bowel function. This case highlights the diagnostic challenge of differentiating colonic leiomyoma from other causes of bowel obstruction, particularly when presenting with features mimicking sigmoid volvulus. It also emphasizes the critical role of histopathology and immunohistochemistry in establishing a definitive diagnosis. Clinicians should consider rare benign tumors in the differential diagnosis of young patients with signs of bowel obstruction.
Co-Authors Alfred Pakpahan Chendrasari, Julian David Tjahjadi, David David Tjahyadi Delyuzar, Delyuzar Devita, Yessi Dewi Hastuty Dewi, Intan Keumala Ditriana, Ditriana Dyah Ayu Woro Edy Parwanto Fadillah, Ibnu Haris Fiji, Wijaya Taufik Florinda Ilona Gabrielle, Laurentia Ganeca Widyatama, Haryo Gerie Amarendra Hari Krismanuel Hastuty , Dewi Ibnu Alferally Ilona, Florinda Indra, Zahrah Zahira Pasya Indrawan, Rully Jaya Edy, Hosea Kehinde, Samuel Abiodun Lestari, Indah Widya Marsiati, Himmi Nainggolan, Matthew Timothy Nugroho, Didi Oladimeji, Ashaolu Victoria Pangisti Dwi Ananingsih, Pangisti Dwi Parwanto, Edy Restu Syamsul Hadi RR. Ella Evrita Hestiandari Rully Indrawan Sembiring, Rinawati Setianingrum, Dyah Ayu Woro Setyaningrum, Dyah Ayu Woro Sisca Sisca, Sisca Siti Maemunah Sukardimand, Tjuk Tjahyadi, Joey Joshua Vidova Tjuk Sukardimand Xavierees, Endrico