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All Journal Biomedical Journal of Indonesia Universa Medicina The Indonesian Journal of Infectious Diseases Hearty : Jurnal Kesehatan Masyarakat Jurnal Respirologi Indonesia Majalah Patologi Indonesia Sumatera Medical Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan UMI Medical Journal Dinasti International Journal of Education Management and Social Science Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran The Avicenna Medical Journal Hang Tuah Medical Journal Jurnal Pengabdian Masyarakat Bangsa AMMA : Jurnal Pengabdian Masyarakat GEMBIRA (Pengabdian Kepada Masyarakat) Jurnal Kedokteran Meditek Jurnal Pengabdian Masyarakat Mandira Cendikia (JPKM-MC) Cermin Dunia Kedokteran
Reza Aditya Digambiro
Universitas Trisakti Jakarta, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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PENYULUHAN KESEHATAN SEBAGAI UPAYA MENINGKATKAN KUALITAS HIDUP LANSIA DI POSYANDU BERINGIN III, BEKASI Digambiro, Reza Aditya; Ilona, Florinda; Chendrasari, Julian; Lestari, Indah Widya; Setianingrum, Dyah Ayu Woro
Jurnal Gembira: Pengabdian Kepada Masyarakat Vol 3 No 03 (2025): JUNI 2025
Publisher : Media Inovasi Pendidikan dan Publikasi

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Abstract

Lansia merupakan kelompok masyarakat yang memiliki risiko tinggi terhadap berbagai penyakit degeneratif, terutama akibat perubahan fisiologis seiring bertambahnya usia. Kondisi ini diperparah oleh rendahnya tingkat pendidikan, kurangnya akses terhadap informasi kesehatan, dan minimnya aktivitas fisik di kalangan lansia. Penyuluhan kesehatan berbasis komunitas menjadi salah satu upaya strategis untuk meningkatkan kualitas hidup lansia. Kegiatan ini dilaksanakan di Posyandu Beringin III, Jaticempaka, Bekasi, dengan metode seminar edukatif dan simulasi praktik langsung untuk meningkatkan pemahaman lansia tentang pola hidup sehat, deteksi dini penyakit degeneratif, serta pentingnya menjaga kesehatan mental dan sosial. Kegiatan ini melibatkan 30 peserta lansia dan dipandu oleh tim dari Fakultas Kedokteran Universitas Trisakti. Evaluasi kegiatan menunjukkan adanya peningkatan signifikan dalam pengetahuan dan kesadaran peserta terhadap pentingnya perilaku hidup sehat. Melalui program ini, diharapkan lansia dapat lebih mandiri dalam menjaga kesehatannya dan tetap produktif dalam kehidupan sehari-hari.
Umbilical Cord MSC-Secretome Therapy Enhances Erectile Function in Elderly Men Digambiro, Reza Aditya; Fiji, Wijaya Taufik; Ilona, florinda; Chendrasari, Julian
UMI Medical Journal Vol 10 No 1 (2025): UMI Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/umj.v10i1.348

Abstract

Background: Reduced erectile capacity often appears as part of physiological shifts during aging potentially implicating broader physiological or social realms. These declines originate from intricate underlying conditions: endothelial dysfunction, unstable hormonal patterns, compromised vascular structures, oxidative stress escalations, and inflammatory cascades. Recently, attention has drifted towards secretome derived from umbilical cord mesenchymal stem cells (UCMSC)—an eclectic blend of cytokines, extracellular vesicles, and growth factors—suggesting foundational regenerative qualities surpassing conventional symptomatic therapies, like phosphodiesterase-5 inhibitors (PDE-5i). Methods: In this study, ederly male participants (n=64, aged ≥60) diagnosed with erectile dysfunction (ED) received intracavernosal UCMSC-secretome injections every two weeks for three sessions. No control group was included; efficacy was tracked through pre- and post-intervention evaluations using the International Index of Erectile Function (IIEF-5). Results: A statistically notable improvement emerged—average IIEF-5 scores increasing by about 5.49 points (p<0.001; Cohen’s d=1.99). With the satisfaction averaging approximately 8.03/10. Conclusion: Extensive, randomized controlled trials could more conclusively elucidate the genuine potential of secretome interventions.
The Impact of High Dose Ozone Therapy on Hematological and Biochemical Profiles : An Observational Study Digambiro, Reza Aditya; Parwanto, Edy; Lestari, Indah Widya; Chendrasari, Julian; Setyaningrum, Dyah Ayu Woro; Ilona, Florinda
The Avicenna Medical Journal Vol. 5 No. 1 (2024): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v5i1.34859

Abstract

Background: Ozone therapy, namely High Dose Ozone Therapy (HDO), has become a versatile medical treatment in several clinical settings. Although it is becoming more well acknowledged, there is still a lack of extensive evidence about the impact of this on hematological and biochemical indicators. This study seeks to address this void by examining the consequences of this phenomenon in a clinical environment.Method: An observational study was done, which followed a structured approach, comprising a total of 100 patients who were selected from the SMC Clinic. Hematological and biochemical indices were evaluated before and after ozone therapy sessions to analyze blood parameters. Two blood samples were obtained at two specific time points: prior to the commencement of the ozone therapy (T0) and after the therapy was finished (T1).Results: Substantial alterations were noted in both hematological and biochemical parameters after the therapy. The hematological changes observed in this study showed a substantial rise in the red blood cell count (p=0.009), hemoglobin levels (p=0.004), and hematocrit (p=0.039), along with a decrease in erythrocyte sedimentation rate (ESR) (p=0.020). Notable biochemical changes were observed, including significant modifications in total plasma protein (TPP) (p=0.008) and lactate levels (p=0.001). Furthermore, there was a noteworthy decrease (p<0.05) in the levels of malondialdehyde (MDA), which is a marker for oxidative stress.Conclusion: HDO exerts a regulatory influence on crucial hematological, biochemical, and oxidative stress factors. These findings indicate that HDO may have therapeutic benefits for treating chronic disorders and cancer. It can improve blood parameters and reduce oxidative stress. The decrease in markers of oxidative stress, such as MDA, suggests a potential reduction in the likelihood of problems associated with oxidative damage in chronic diseases. Nevertheless, additional research is required to validate these findings, investigate their wider therapeutic implications, and comprehend the long-term consequences and safety of HDO therapy.
THE INFLUENCE OF SECRETOME THERAPY ON ERECTILE DYSFUNCTION AND D-DIMER LEVELS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS DIGAMBIRO, REZA ADITYA
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol. 7 No. 2 (2024): Al-Iqra Medical Journal: Jurnal Berkala Ilmiah Kedokteran
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v7i2.15635

Abstract

Introduction: The study aimed to determine the therapeutic effect of adipose-derived mesenchymal stem cell (MSC)-derived secretome on erectile function and D-dimer level, a biomarker for vascular health in T2DM men.Methods: An RCT performed on men aged 40 to 70 years with both T2DM and ED. The subjects were randomly allocated to receive secretome or placebo. Erectile function was measured by the International Index of Erectile Function (IIEF) questionnaire. They also had D-dimer levels measured before and after the intervention (ie, at 12 weeks). The primary analysis investigated differences in change of IIEF scores and D-dimer levels between groups using statistical tests. Moreover, we calculated a Pearson correlation coefficient to examine the relationship of both outcomes.Results: IIEF scores in the treatment group rose a mean of 3.06 points, compared to only half that amount with an increase of 0.5 points observed for control groups (p This difference was significant according to t-test (t = 6.72, p = 1.92e-07). The treatment group also experienced a more substantial decrease in D-dimer levels (-0.32 µg/mL on average) compared with the control group (an average change of -0.09 ug/ml), with a t-test statistic being-6.41(p = 4.44e−07). A minimal and not statistically significant correlation was also observed between improvements in IIEF scores with changes D-dimer levels (correlation coefficient: -0.11, p = 0.69).Conclusion : secretome therapy has demonstrated a significant increase in erectile function and reduction of D-dimer levels among patients with type 2 diabetes mellitus. 
Meckel's Diverticulum-Induced Intussusception Coinciding with Diabetes Mellitus in a Young Adult Male: A Rare Case Study Digambiro, Reza Aditya; Parwanto, Edy; Setianingrum, Dyah Ayu Woro; Ilona, Florinda; Lestari, Indah Widya; Chendrasari, Julian
Jurnal Kedokteran Meditek Vol 31 No 1 (2025): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i1.3084

Abstract

Introduction: Intussusception in adults, especially when caused by Meckel's Diverticulum, is a rare occurrence, often presenting with nonspecific symptoms such as abdominal pain and nausea, making it challenging to diagnose. When concurrent with conditions like diabetes mellitus, the situation need particular care. Case Illustration: A 27-year-old male with a medical history of diabetes presented with severe right abdominal pain, nausea, and a reduced appetite. Initial symptomatic treatment did not alleviate the condition. Subsequent CT scans revealed an ileo-ileal intussusception triggered by Meckel's Diverticulum and partial high obstruction ileus, leading to surgical intervention. Discussion: Ileo-ileal resection (end to end anastomosis) and adhesiolysis surgery were successfully performed, followed by vigilant postoperative monitoring for complications, effective pain management, maintenance of drain patency, and careful glucose level monitoring. The patient's significant postoperative improvement underscores the importance of early diagnosis and timely surgical intervention in managing Meckel's Diverticulum-induced intussusception in adults. Conclusion: The clinical course also highlighted the importance of tailoring postoperative care considering the patient's comorbidities, in this case, diabetes mellitus. This case served as a reminder for clinicians to consider Meckel's Diverticulum as a potential cause of intussusception in adults presenting with abdominal pain.
Effects of low-dose filtered kretek cigarette smoke on bronchial smooth muscle in male Sprague-Dawley rats Tjahyadi, David; Parwanto, Edy; Sisca, Sisca; Xavierees, Endrico; Jaya Edy, Hosea; Digambiro, Reza Aditya; Oladimeji, Ashaolu Victoria; Tjahyadi, Joey Joshua Vidova; Gabrielle, Laurentia
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.263-275

Abstract

BackgroundKretek cigarettes contain less nicotine and tar than conventional cigarettes. Exposure to cigarette smoke occurs mainly in the respiratory tract, resulting in histometric changes. The aim of this study was to evaluate the effect of filtered kretek cigarette smoke on bronchial histometric measurements in male Sprague-Dawley rats. MethodsAn experimental laboratory study was conducted involving 18 male Sprague-Dawley rats, aged 2-3 months, ranging from 150 to 250 grams in body weight. They were randomized into group 1 (controls) and experimental groups 2 and 3. Group 2 was exposed to filtered cigarette smoke at a dose of 1 stick/day and group 3 to 2 sticks/day. Treatment time for all groups was 30 days. Observation of bronchial histometric measurements of the lumen include, length, width, area, and perimeter. In addition, the bronchial mucosal and smooth muscle layers were also measured. The one way-ANOVA test was used to analyze the data. ResultsThe mean area and mean perimeter of the bronchial lumen of the rats were significantly greater in group 1 than in groups 2 and 3 (p=0.000). The mean bronchial smooth muscle area of the rats in group 1 was smaller than the mean in group 2, which was in turn smaller than the mean in group 3 (p=0.000). Apparently the rats in the treatment groups had undergone bronchoconstriction. ConclusionExposure to filtered kretek cigarette smoke at a dose of 1 stick/day as well as 2 sticks/day for 30 days caused bronchial mucosal hyperplasia and bronchoconstriction in male rats.
Analysis of Pulmonary Function between E-Cigarette Users and Non-Smokers Aged 20–30 Years in Jakarta Digambiro, Reza Aditya; Parwanto, Edy; Tjahjadi, David; Ditriana, Ditriana
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.791

Abstract

Background: This study aimed to compare pulmonary function between e-cigarette users and non-smokers aged 20–30 years in Jakarta. Methods: A cross-sectional study was carried out between May 2023 and May 2024 at SMC Clinic Jakarta, Ibnusina Hospital Jakarta, and Naura Medika Clinic Depok. The sample consisted of 65 individuals who used e-cigarettes and 63 individuals who did not smoke. Spirometry was employed to evaluate pulmonary function by measuring forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. The data were analyzed using independent t-tests using IBM SPSS software version 25.0. Results: The study revealed substantial disparities in pulmonary function between individuals who use e-cigarettes and those who do not smoke. Individuals who use e-cigarettes had significantly reduced FEV1 at 3.02±0.50 L and FVC at 4.00±0.47 L, in comparison to non-smokers (FEV1=3.51±0.57 L; FVC=4.57±0.50 L). E-cigarette users exhibited a considerably lower FEV1/FVC ratio (74.86±5.55) compared to non-smokers (79.29±5.11), suggesting a higher occurrence of obstructive airway diseases. Conclusion: Young adults aged 20-30 years in Jakarta who use e-cigarettes experience a decrease in pulmonary function. The results emphasize the possible respiratory hazards associated with the use of e-cigarettes and emphasize the necessity for greater awareness and regulatory actions to tackle these hazards.
D-dimer sebagai Biomarker Diagnostik Tuberkulosis Paru pada Efusi Pleura: Tinjauan Pustaka Digambiro, Reza Aditya; Ilona, Florinda; Chendrasari, Julian; Lestari, Indah Widya; Parwanto, Edy
Cermin Dunia Kedokteran Vol 52 No 2 (2025): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i2.1242

Abstract

Background: Tuberculosis (TB) remains a major health threat, especially in developing countries. Although the lungs are the most affected organ, systemic manifestations are quite significant. D-dimer, as one of the fibrin degradation products and also an indicator of coagulation activity, has been extensively researched for its predictive and diagnostic value in various diseases. This study aims to assess the effectiveness of D-dimer as a diagnostic biomarker for pulmonary tuberculosis (TB) in patients with pleural effusion compared to those with non-TB pleural effusion. Methods: The study was conducted as an observational case-control on 64 patients with pulmonary TB with pleural effusion were compared to 64 non-TB subjects with pleural effusion. Result: In the TB patient group, 62.5% of patients were smokers, 46.9% of patients had been exposed to TB. Patients were assessed based on the TB symptom scale and with radiological lung examinations, either x-rays or CT scans. D-dimer levels were correlated with the TB severity. D-dimer levels above the threshold value were significantly higher in patients with severe TB symptoms. Conclusion: A direct correlation was observed between the size of radiological lung lesions and D-dimer levels. The average D-dimer level in the control group was 220 ± 60 ng/mL, which increased to 450 ± 90 ng/mL in TB patients with severe lesions.
Edukasi Pencegahan Kanker Serviks Bagi Ibu PKK Jakarta Utara: Menyambut Bulan Kesadaran Kesehatan Reproduksi Digambiro, Reza Aditya; Parwanto, Edy; Setyaningrum, Dyah Ayu Woro; Chendrasari, Julian; Ilona, Florinda; Lestari, Indah Widya; Hastuty , Dewi
Jurnal Pengabdian Masyarakat Mandira Cendikia Vol. 3 No. 9 (2024)
Publisher : YAYASAN PENDIDIKAN MANDIRA CENDIKIA

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Abstract

Kanker serviks merupakan masalah kesehatan yang signifikan di Indonesia dengan prevalensi tinggi. Edukasi pencegahan kanker serviks melalui deteksi dini dan vaksinasi HPV penting untuk menurunkan angka kejadian dan kematian akibat kanker ini. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan dan kesadaran Ibu-Ibu PKK di Jakarta Utara mengenai pencegahan kanker serviks. Mitra pengabdian adalah Pemerintah Kotamadya Jakarta Utara dan Klinik SMC. Metode yang digunakan adalah presentasi interaktif dan simulasi, diikuti dengan diskusi dan evaluasi pre-test serta post-test untuk mengukur perubahan pengetahuan dan sikap. Hasil menunjukkan peningkatan signifikan pada pemahaman peserta, di mana 70% peserta siap melakukan Pap smear dan 55% siap untuk vaksinasi HPV. Hambatan yang ditemukan adalah waktu pelaksanaan yang terbatas dan masih adanya resistensi terhadap vaksinasi. Edukasi berkelanjutan dan peningkatan akses layanan kesehatan disarankan untuk meningkatkan keberhasilan program di masa mendatang
Hubungan antara Tingkat Pengetahuan tentang Kanker Serviks dan Hasil Pap Smear pada Wanita Dewasa DIGAMBIRO, REZA ADITYA; ILONA, FLORINDA; CHENDRASARI, JULIAN; SETYANINGRUM, DYAH AYU WORO; LESTARI, INDAH WIDYA
Hang Tuah Medical Journal Vol 23 No 1 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i1.809

Abstract

Cervical cancer can arise from a persistent infection with Human Papillomavirus (HPV), which can be avoided through early detection by pap smear screening. Having adequate knowledge about cervical cancer is crucial for encouraging participation in pap smear tests, which can detect non-cancerous or precancerous changes before they progress. This cross-sectional descriptive-analytic study aimed to assess knowledge levels about cervical cancer and their correlation with pap smear results among women of reproductive age in Jakarta, Bogor, and Bekasi (23–50 years). A total of 133 participants underwent a structured questionnaire for assessing knowledge and a pap smear test for evaluating cervical health. The pap smear results showed that 80% were normal, 6% had atypical cells without malignancy, and 14% showed inflammatory lesions. A Chi-square test revealed a significant association between knowledge levels and pap smear outcomes. These findings provide valuable insights for healthcare stakeholders to develop effective health promotion strategies that increase pap smear coverage and encourage early detection of cervical cancer.
Co-Authors Alfred Pakpahan, Alfred Chendrasari, Julian David Tjahjadi, David David Tjahyadi Delyuzar, Delyuzar Devita, Yessi Dewi Hastuty Dewi, Intan Keumala Ditriana, Ditriana Dyah Ayu Woro Edy Parwanto Fadillah, Ibnu Haris Fiji, Wijaya Taufik Florinda Ilona Gabrielle, Laurentia Ganeca Widyatama, Haryo Hastuty , Dewi Ibnu Alferally Ilona, Florinda Indrawan, Rully Jaya Edy, Hosea Lestari, Indah Widya Marsiati, Himmi Oladimeji, Ashaolu Victoria Pangisti Dwi Ananingsih, Pangisti Dwi Parwanto, Edy Restu Syamsul Hadi RR. Ella Evrita Hestiandari Rully Indrawan Sembiring, Rinawati Setianingrum, Dyah Ayu Woro Setyaningrum, Dyah Ayu Woro Sisca Sisca, Sisca Siti Maemunah Sukardimand, Tjuk Tjahyadi, Joey Joshua Vidova Tjuk Sukardimand Xavierees, Endrico