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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Althea Medical Journal Journal of Biomedicine and Translational Research WMJ (Warmadewa Medical Journal) Journal of Agromedicine and Medical Sciences Global Medical and Health Communication Majalah Kedokteran Sriwijaya Universa Medicina Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya NurseLine Journal Jurnal Respirologi Indonesia Jurnal Rekonstruksi dan Estetik JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Jember Medical Journal (JMJ)
Desie Dwi Wisudanti
Departemen Farmakologi Fakultas Kedokteran Universitas Jember
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health

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LITERATURE REVIEW: THERAPEUTIC APPLICATION OF GERANIIN FROM RAMBUTAN (Nephelium lappaceum) PEEL EXTRACT AS ANTIHYPERGLYCEMIC THROUGH ITS ANTIOXCIDANT ACTIVITY IN TYPE 2 DIABETES MELLITUS Desie Dwi Wisudanti
NurseLine Journal Vol 1 No 1 (2016): May 2016
Publisher : Faculty of Nursing, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes mellitus is a disorder in the metabolism of carbohydrates, lipids and proteins, which is characterized by hyperglycemia. Its prevalence in the world is increasing, especially type 2 diabetes, causes an increased incidence of morbidity and mortality throughout the world due to complications of hyperglycemia. Hyperglycemia stimulates the release of superoxide (O2-) at the level of mitochondria which is the trigger early onset of oxidative stress in patients with diabetes mellitus type 2. Therefore one of the therapeutic modalities that can be developed in type 2 diabetes mellitus is a substance as potent antioxidant. Geraniin of rambutan peel extract is known to have the ability as a potent antioxidant and radical scavenging, so it is possible to be a prime candidate antidiabetes in the ype 2 diabetes melitus. We searched Cochrane Library data bases, Google Scholar, Medline and PubMed, from 2006 to 2016, to assess the effect of rambutan peel extract for type 2 diabetes melitus. We obtained 17 articles in accordance with the inclusion criteria. In the peel of rambutan (Nephelium lappaceum), geraniin is the main phenolic compounds that have the potential ability as an antioxidant and antihyperglycemic through inhibition of alfa-glucosidase and alfa-amylase, preventing the polyol (aldol reductase inhibition) and prevents the formation of advanced glicosilation products (AGEs). There is a very strong correlation between the ability as an antioxidant with the ability to inhibit alfa-glucosidase and alfa-amylase, so geraniin of rambutan peel extract (Nephelium lappaceum) expressed as the ideal candidate for the management of hyperglycemia in individuals with diabetes.
Characteristics Of Pediatric Tuberculosis Patients Hospitalized At dr. Soebandi Public Hospital Jember Muhammad Ali Shodikin; Desie Dwi Wisudanti; Annisa Nadhifa Witanto
Majalah Kedokteran Sriwijaya Vol 53, No 3 (2021): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v53i3.13051

Abstract

Background: Tuberculosis (TB) remains a major public health problem globally. TB in children is an important component in TB control. The diagnosis of TB in children until now is still challenging, underdiagnosis often occurs in primary health facilities in Indonesia. This study aims to describe the demographic and clinical features of pediatric tuberculosis patients hospitalized in a tertiary care center.Methods: This study reviewed medical records of children with TB who were hospitalized in a referral hospital in Jember, East Java, Indonesia from January 2018 through December 2019.Results: Among 96 patients, 33,3% happened in the age group of 15-18 years, 53.1% were females, 35,4% had severely underweight nutritional status, majority (84,4%) live in rural area, 79,2% without known TB contact history and 81.1% were new cases. Pulmonary TB was the most common diagnosis (80,2%). Only 4.1% had co-infection with Human Immunodeficiency Virus (HIV) and 4.2% were reported to be resistant to anti-TB drugs. The most common symptoms were fever (84.3%), cough (65.6%), and dyspnea (65.6%). The miliary lesion was the most common lesions on chest X-ray examination results. The successful therapy reached a percentage of 61.4% of all cases.Conclusions: The majority of pediatric TB patients were diagnosed clinically and chest X ray. Examination of HIV status and drug-sensitivity testing is low. The rate of successful therapy was still under WHO target.. Keywords: tuberculosis, children, characteristics
Assessments of quality of life in burn patients after hospital treatment in Jember Agnellia Maulidya Utami; Ulfa Elfiah; Desie Dwi Wisudanti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 2, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss2.art8

Abstract

Background: Burn injuries can contribute to physical and psychological problems affecting quality of life (QoL). The QoL is a parameter to assess medical results after treatment. In Indonesia, studies concerning burn patients’ QoL after treatment are still limited.Objective: This study aims to observe correlations between 8 dimensions of QoL after treatment and histories of burn severity, numbers of surgical procedures, and lengths of hospital stayMethods: A cross sectional study was conducted in December 2018. Subject criteria of this study were patients who have experienced burn injuries for the last 2 years and have been treated at dr. Soebandi Hospital Jember. Then all the patients were discharged from the hospital by following medical advice in recovered conditions. They were asked to complete SF-36 questionnaires that consist of 8 dimensions of QoL. Every dimension was correlated with histories of burn severity, numbers of surgical procedure, and lengths of hospital stay. Next, the obtained data were analysed by Pearson and Spearman.Results: 13 subjects or patients were analysed. Most of them (38.5%) were adults in a range of 41 – 50 years old and were male (69.2%). A bivariate analysis found a significant negative correlation between burn severity and QoL in physical functions, bodily pains, and mental health dimensions (p=0.030, p=0.012, p=0.044). A significant negative correlation was also reported between numbers of surgical procedures and QoL in physical role dimensions (p=0.047). Lengths of hospital stay had a significant negative correlation with physical functions and physical role dimensions (p=0.044, p=0.031).Conclusion: This study revealed significant correlations between burn severity, numbers of surgical procedures, length of hospital stay and the various dimensions of QoL. This study also provided data of QoL, so in the future burn centres can identify dimensions of QoL after burn injuries and can improve their burn management and patient care to improve their QoL.
The Correlation between Fatigue and Quality of Life on Knee Osteoarthritis Patient at RSD dr. Soebandi Jember Yuli Hermansyah; Marwah Pradani Ridlo; Desie Dwi Wisudanti
Journal of Agromedicine and Medical Sciences Vol 8 No 3 (2022)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v8i3.24683

Abstract

Osteoarthritis (OA) is a form of chronic arthritis that mainly attacks the knee joint. The prevalence of knee OA in Indonesia, especially in East Java, is around 27% which is relatively high. Therefore, this study aims to determine the correlation between fatigue and quality of life from knee OA patients at RSD dr. Soebandi Jember. The methodology uses in this study is the analytical observational method with a cross-sectional survey as the research design. For the data, this study uses primary and secondary data. The primary data was obtained through online interviews by phone using a questionnaire instrument, namely Fatigue Assessment Scale (FAS) and World Health Organization Quality of Life (WHOQOL) – BREF. Then, the secondary data was obtained from the medical records of knee OA patients who were undergoing treatment at the RSD dr. Soebandi Jember in the period January 2019 to December 2020. The results of this study showed that the p-value of fatigue with quality of life domain 1 (physical health) was 0.042, domain 2 (psychological) was 0.087, domain 3 (social) was 0.221, and domain 4 (environmental) was 0.426. Therefore, this study concludes that there is a weak relationship between fatigue and quality of life on domain 1 (physical health), with a correlation coefficient of 0.373. Also, there is no relationship between fatigue and quality of life on domain 2 (psychological), domain 3 (social), and domain 4 (environmental) in knee OA patients at RSD dr. Soebandi Jember. Keywords: knee OA, fatigue, quality of life
Patterns Of Drug Use In Patients With Knee Osteoarthritis At The Bina Sehat Jember Hospital Firman Pratama Andraputra; Desie Dwi Wisudanti; Muhammad Ali Shodikin
Saintika Medika Vol. 18 No. 2 (2022): December 2022
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol18.SMUMM2.19748

Abstract

Osteoarthritis is a degenerative disease characterized by progressive damage to joint cartilage. The prevalence of osteoarthritis will continue to increase and continue as the population and age increase. Cases of knee osteoarthritis are more common than other types of osteoarthritis. The high prevalence of osteoarthritis will have implications for the high treatment regimen given to patients. Irrational use of drugs can lead to drug-related problems (DRPs). This study used a descriptive design. The sample in this study were knee osteoarthritis patients at the Bina Sehat Jember Hospital. The sampling technique used is purposive sampling. The data in this study used secondary data from patient medical records for the period January 2020 - April 2021. A total of 3 knee osteoarthritis patients have the potential to experience drug-related problems in the drug interaction category.
Subchronic exposure to Chlorpyrifos, Carbofuran, and Cypermethrin increase sciatic nerve damage and degeneration in adolescent rats Muhammad Ihwan Narwanto; Muhammad Haikal Supriyadi; Desie Dwi Wisudanti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 7 No 1 (2023): Qanun Medika Vol 07 No 01 January 2023
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v7i1.13666

Abstract

Several types of pesticides that are often used are chlorpyrifos (organophosphate), carbofuran (carbamate), and cypermethrin (pyrethroid).  Pesticides can kill pests but also can cause toxic effects on humans when exposed.  One of the adverse effects of pesticide exposure is a disturbance in the peripheral nervous system.  Age is an essential factor in peripheral nerve damage.  Nerve injury is one of the most common injuries in children and adolescents and is estimated at 10% to 15% of all exceptional unit cases.  However, the outcome of peripheral nerve injury is known better in subjects who sustain the injury at a younger age.  This study aims to determine the subchronic exposure effect of chlorpyrifos, carbofuran, and cypermethrin to sciatic nerve histopathology in juvenile rats.  This study used 30 male Wistar rats (Rattus norvegicus) which were divided into 5 groups, normal group (N), control group (K), chlorpyrifos group (P1), carbofuran group (P2) and cypermethrin group (P3).  Subcutaneous injection of pesticides was carried out for 21 days.  Rats were sacrificed using the cervical dislocation method, and the right sciatic nerve was taken for histopathological observation.  Assessment of the degree of ischiatic nerve histopathological damage is using the Jensen et al., (2018) method.  Data were analyzed using the Kruskal-Wallis test and continued with the Mann-Whitney test.  This study showed a significantly increased degree of histopathological damage in the chlorpyrifos group, carbofuran group, and cypermethrin group compared to the control group and the normal group (p<0.05).  It can be concluded that exposure to chlorpyrifos, carbofuran, and cypermethrin pesticides increased damage and degeneration of the ischiadicus nerve in juvenile rats.
Pili Protein 65.5 kDa of Klebsiella pneumoniae Induced a Decrease in IL-10 in Mice Dini Agustina; Mei Liana Wati; Desie Dwi Wisudanti; Muhammad Ali Shodikin; Diana Chusna Mufida; Enny Suswati
Majalah Kedokteran Bandung Vol 54, No 3 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n3.2690

Abstract

Klebsiella pneumoniae is one of the leading cause of nosocomial infection worldwide with clinical isolates mostly found in Multi-Drug Resistant (MDR) or Extensively Drug-Resistant (XDR). This makes therapeutic options due to this bacteria limited. Several studies have shown that the pili protein of K. pneumoniae with different molecular weights plays a role in the virulence factor, as they are hemagglutinin and adhesin proteins. Pili protein 65.5 kDa of K. pneumoniae can be considered as the antigen candidate for vaccines. This study aimed to determine the immune response based on the IL-10 level as induced by pili protein 65.5 kDa K. pneumoniae. This study was conducted from October 2020 to March 2021 at the Faculty of Mathematics and Natural Sciences and Faculty of Medicine of Jember University. This was true experimental with post-test only controlled group design on 27 male BALB/c mice which divided into 3 groups: K1, K2, and K3. The groups were induced with sterile PBS, pili protein and Freund’s adjuvant, and Freund’s adjuvant only, respectively. Samples were drawn through cardiac puncture, then serum was taken to measure the IL-10 levels using the ELISA method. Hemagglutination test showed a positive result with 1/8 as the highest titer. Results showed that the mean IL-10 levels were 290.92±45.33; 235.05±44.53; 218.54±64,81 for K1, K2, and K3, respectively. One-way ANOVA test results showed a statistical difference between groups (p=0,019). This research shows that pili protein 65.5 kDa K. pneumoniae decreases the IL-10 level. However, when it is provided with the Freund’s Adjuvant, there is no proof of the immunogenicity when compared to the control group.
Effectiveness of Vitamin C Administration on Outcome in COVID-19 Patients: A Systematic Review and Meta-Analysis Desie Dwi Wisudanti; Nur Lintang Nabilah Sri Kusumasari; Adelia Handoko; Cholis Abrori; Angga Mardro Raharjo
Jurnal Respirologi Indonesia Vol 43, No 2 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i2.341

Abstract

Background: Numerous studies on the effectiveness of vitamin C against the COVID-19 infection have been widely carried out recently. However, the differences in dosage ranges and therapeutic efficacy in previous studies have prompted a systematic literature review on the effectiveness of vitamin C on outcomes in COVID-19 patients. In addition, this study aimed to determine the appropriate therapeutic dose of vitamin C for COVID-19 patients, either alone or in combination with other supplements, and to determine the side effects.Methods: Gleaned from the search on Pubmed, Science Direct, and Google Scholar databases up to April 25, 2022, fourteen studies were relevant, namely five studies using vitamin C orally and nine studies administered intravenously. We assessed multiple outcomes, including mortality, hospitalization, and symptoms. The quality and risk of bias analyses were performed using JBI critical appraisal tools.Results: The oral administration of vitamin C resulted in a significant difference in the mortality of COVID-19 patients (OR=0.66; 95% CI=0.45–0.97; P=0.04; I2=0%) and a non-significant difference in the outcome. Duration of hospitalization (OR = -0.21; 95% CI = -2.70-2.28; P=0.87; I2=94%). Regarding the cost-effectiveness and side effects manifested in digestive disorders such as nausea, diarrhea, stomach cramps, and vomiting, vitamin C with a dose of 500-1000 mg could be given orally.Conclusion: Oral administration of vitamin C showed a reduction in the mortality of asymptomatic COVID-19 patients with moderate symptoms.
Subchronic Oral Exposure to Chlorpyrifos Decreases Butyrylcholinesterase in Wistar Rat Sakinah, Elly Nurus; Supangat, Supangat; Wisudanti, Desie Dwi; Abrori, Cholis; Mustika, Arifa; Wibsono, Sony; Athoillah, Nabil
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3133

Abstract

Background: Indonesia as an agricultural country has more than 33 million workers in the agriculture. Pesticides have an important role in agriculture because they function as powerful plant pest exterminators. However, its use is considered to cause various toxic effects, one of which is on the nervous system. This study aimed to evaluate the impact of pesticide exposure on cognitive impairment by assessing the butyrylcholinesterase biomarker in the blood of rats as experimental animals.Methods: This was a true experimental study conducted during September–November 2022 at the Pharmacology and Biochemistry Laboratory, Faculty of Medicine, University of Jember with a post-test only approach using Wistar rats which were divided into 1 control group and 4 treatment groups treated with chlorpyrifos 5 mg/kg orally. Serum butyrylcholinesterase enzyme levels were measured using the kinetic photometric method and then analyzed with a regression test in IBM SPSS® Statistics software.Results: The average value of butyrylcholinesterase was 920.23±145.27 (Control group); 904.48±91.6 (7 days after chlorpyrifos administration); 889.81±95.2 (14 days after chlorpyrifos administration); 457.84±69.5 (28 days after chlorpyrifos administration); 575.82±194.25 (56 days after chlorpyrifos administration). The results of the One-Way ANOVA test showed significant differences between groups as indicated by a significance test of 0.024 (p <0.05).Conclusions: There is a relationship between the duration of exposure to chlorpyrifos and butyrylcholinesterase levels in Wistar rats. This fact shows that the longer an organism is exposed to low doses of chlorpyrifos pesticides, the higher the level of neurological system toxicity that occurs in that organism.
Hubungan Pengetahuan terhadap Sikap dan Perilaku Penggunaan Antibiotik pada Mahasiswa Medis dan Kesehatan Universitas Jember Wisudanti, Desie Dwi; Setyaningrum, Wiwied Hary; Efensi, Erfan
Jember Medical Journal Vol. 2 No. 2 (2023)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jembermedicaljournal.v2i2.477

Abstract

Antibiotik merupakan obat yang penggunaannya harus berdasarkan resep dokter. Penggunaan antibiotik tanpa resep di masyarakat relatif tinggi. Penggunaan antibiotik yang tepat dipengaruhi oleh pengetahuan dan sikap dalam menggunakan antibiotik. Pengetahuan mengenai penggunaan antibiotik pada mahasiswa kesehatan dinilai mempunyai peran penting dalam sikap dan perilaku profesional dalam penggunaan antibiotik untuk menurunkan angka resistensi antibiotik. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan, sikap, dan perilaku penggunaan antibiotik pada mahasiswa medis dan kesehatan Universitas Jember serta mengetahui perbedaan pengetahuan, sikap, dan perilaku penggunaan antibiotik pada mahasiswa medis dan kesehatan Universitas Jember. Pengambilan sampel dalam penelitian ini menggunakan metode proportional stratified random sampling dengan menggunakan instrumen pengumpulan data kuesioner. Hasil penelitian menunjukkan bahwa tingkat pengetahuan, sikap, dan perilaku mahasiswa medis dan kesehatan Universitas Jember mengenai penggunaan antibiotik sebagian besar berada pada kategori baik. Terdapat hubungan antara pengetahuan, sikap, dan perilaku dalam penggunaan antibiotik (p<0,05), serta terdapat perbedaan pengetahuan dan perilaku penggunaan antibiotik pada mahasiswa medis dan kesehatan (p<0,05).  
Co-Authors Adelia Handoko Afnan, Muhammad Syifaul Agnellia Maulidya Utami Andriani, Made Prasanti Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Anisa, Devisda Shafiy Annisa Nadhifa Witanto Arifa Mustika Athoillah, Nabil Azham Purwandhono Aziz, Ayu Munawaroh Barus, Marsha Zahra Adyanda Cholis Abrori Cholis Abrori, Cholis Cicih Komariah Diana Chusna Mufida Dini Agustina Dwicahyandari, Winie Septhia Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati Efensi, Erfan Elly Nurus Sakinah, Elly Nurus Enny Suswati ENNY SUSWATI Erfan Efendi F P H, Fransiska Nooril Firman Herdiana Firman Pratama Andraputra Hazbina Fauqi Ramadhan Heni Fatmawati Herdiyana, Firman Hibatulloh, Muhammad Farhan Hidayat, Noval Ida Srisurani Wiji Astuti Jauhani, Muhammad Afiful Laksmi Indreswari M. Ali Shodikin M. Ihwan Narwanto Marwah Pradani Ridlo Maulidiyah, Najma Mei Liana Wati Muhamad Hasan Muhammad Ali Shodikin Muhammad Faizal Akbar Muhammad Haikal Supriyadi Nafisa, Tsabita Nur Lintang Nabilah Sri Kusumasari Octavia, Aulia Mega Nur Pipiet Wulandari Rena Normasari Rini Riyanti Risty Pradana Linggan Wangi Rumastika, Nindya Shinta Salma Naqiyyah Tirtadevi Sarah Kinan Andalusia septa surya wahyudi, septa surya Setyaningrum, Wiwied Hary Sheilla Rachmania, Sheilla Sofi Aliyatul Himah Sugiyanta Sugiyanta Supangat Supangat Suryono Suryono Tegar Syaiful Qodar Tegar Syaiful Qodar Trinita Diyah Permatasari Ulfa Elfiah Wibsono, Sony Widanto, Cika Abadi Laily Yuli Hermansyah Yuli Hermansyah