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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Majalah Kedokteran Bandung e-Journal Pustaka Kesehatan Althea Medical Journal Journal of Biomedicine and Translational Research WMJ (Warmadewa Medical Journal) Journal of Agromedicine and Medical Sciences Global Medical and Health Communication Biology, Medicine, & Natural Product Chemistry Majalah Kedokteran Sriwijaya Universa Medicina Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya NurseLine Journal Jurnal Respirologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Rekonstruksi dan Estetik JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Jember Medical Journal (JMJ)
Desie Dwi Wisudanti
Departemen Farmakologi Fakultas Kedokteran Universitas Jember
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Public Health

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Comparison of the Effectiveness between Oral NSAIDs and Dextrose Prolotherapy in Knee Osteoarthritis Sugiyanta, Sugiyanta; Dwicahyandari, Winie Septhia; Efendi, Erfan; Wisudanti, Desie Dwi
Global Medical & Health Communication (GMHC) Vol 11, No 1 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v11i1.10239

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are the first treatment choice for pain relief in osteoarthritis (OA). However, known to have an 85% risk of side effects on the gastrointestinal and a 40% chance of cardiovascular complications. In addition, in certain classes of NSAIDs, the risk of chronic kidney disease increases due to long-term consumption. On the other hand, dextrose prolotherapy is a regenerative therapy. This study aimed to compare the effectiveness of oral NSAIDs with dextrose prolotherapy in knee OA based on clinical features. This study used an observational method (cross-sectional) conducted in three locations; Jember Clinic Hospital, Balung Hospital, and Harapan Mulya Kertonegoro Jenggawah Clinic from September 2021 to March 2022. Of the 75 population, 23 patients with mild to moderate knee OA were divided into two groups; 15 samples of dextrose prolotherapy and eight samples of oral NSAIDs. Data in the study showed the mean WOMAC score in the dextrose prolotherapy group was 12.4±11.7, while the oral NSAID group was 34.75±17.6. A total of 14 samples experienced a decrease in scores after switching from oral NSAIDs to dextrose prolotherapy. Bivariate analyses were performed using Mann-Whitney and Wilcoxon tests. Both statistical tests show a p=0.001 (p<0.05). Thus, this study concluded that dextrose prolotherapy was more effective than oral NSAIDs in knee OA.
Long-Term Effects of Low-Dose Chlorpyrifos Exposure on Serum Albumin Levels in Male Wistar Rats Wisudanti, Desie Dwi; Hidayat, Noval; Jauhani, Muhammad Afiful
Journal of Biomedicine and Translational Research Vol 10, No 3 (2024): December 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i3.22240

Abstract

Background: Chlorpyrifos is one of the organophosphate pesticide types frequently utilized as a pest control agent in Indonesia. Despite its effectiveness in combating pests, the residue levels of chlorpyrifos in the environment and plants have raised serious concerns. Long-term accumulation of chlorpyrifos in the body can lead to organ damage, particularly in the liver and kidneys, which may decrease serum albumin levels.Objective: To investigate the impact of low-dose chlorpyrifos exposure over time on serum albumin levels in Wistar rats.Methods: Thirty male Wistar rats were divided into five groups: the normal control group (Kn) received normal saline solution (+5% Tween 20) orally for 56 days, while the treatment groups (K1, K2, K3, and K4) were administered chlorpyrifos at a dose of 5 mg/kg body weight for 7 days (acute), 14 days (subacute), 28 days (subchronic), and 56 days (subchronic) orally. Serum albumin levels were measured using the dye-binding method with a spectrophotometer.Results: The measurement results indicate that the normal control group (Kn) had the highest serum albumin levels (4.326±0.519 g/dL). Serum albumin levels decreased in the groups treated with chlorpyrifos. The longer the chlorpyrifos exposure, the lower the serum albumin levels. The lowest serum albumin levels were found in group K4 with chlorpyrifos exposure for 56 days (2.826±0.358 g/dL). Statistical analysis using One-way ANOVA and Post Hoc LSD tests showed significant differences (p<0.05) between all treatment groups (K1, K2, K3, and K4) and the control group (Kn).Conclusion: This study shows that administering low-dose chlorpyrifos over a period of 7 to 56 days has a significant effect in reducing serum albumin levels in Wistar rats. The clinical implications of this decrease in serum albumin levels need to be considered in the context of exposure to organophosphate pesticide residues in humans.
The Correlation Between Organophosphate Pesticide Exposure and Incidence of Prostate Cancer: A Systematic Review Octavia, Aulia Mega Nur; Wisudanti, Desie Dwi; Wulandari, Pipiet
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1112

Abstract

Background: Organophosphate is a type of pesticide that is widely used. However, organophosphates are a group of highly toxic chemicals. The World Health Organization (WHO) estimates that nearly 3 million individuals experience organophosphate poisoning annually. One of the cancers that can develop due to exposure to organophosphate pesticides is prostate cancer. Prostate cancer is the second most prevalent cancer among men. In Indonesia, new cases of prostate cancer reached 13.563, or 7.4% of all new cancer cases in men. This study aims to determine the correlation between organophosphate exposure and the incidence of prostate cancer.Methods: This study is a research with a systematic review design. The data in this study is secondary data obtained from research articles using SPICE criteria. Pubmed, Science Direct, Springer, and Google Scholar are the databases used. The used articles were articles published between 2012 and 2022. Critical assessment was carried out using the NewcastleOttawa Quality Assessment Scale (NOS) questionnaire.Results: A total of 2.149 articles were obtained, with a range of research years from 2012 to 2022. Then a duplication selection process was carried out, free and fulltext selection. This article used the NewcastleOttawa Quality Assessment Scale questionnaire to select eligibility, so 5 articles were obtained. Among all the articles that underwent critical evaluation, it was reported that a relationship exists between organophosphate exposure and the incidence of prostate cancer among farmers. Conclusions: The evidence of this reviewed study suggests a possible association between the incidence of prostate cancer and exposure to organophosphate pesticides.
ANALYSIS OF RAT PLATELET COUNT AFTER ELECTRICAL EXPOSURE IN ACUTE AND SUBACUTE PHASE OF BURN INJURY F P H, Fransiska Nooril; Elfiah, Ulfa; Indreswari, Laksmi; Wisudanti, Desie Dwi
Jurnal Rekonstruksi dan Estetik Vol. 4 No. 1 (2019): Jurnal Rekonstruksi dan Estetik, June 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.759 KB) | DOI: 10.20473/jre.v4i1.24347

Abstract

Highlights: In the acute phase of electric burn injury, there was a significant change in platelet count. Contrarily, no significant change in platelet count was observed during the subacute phase of electric burn injury. Abstract: Introduction: Electrical burns are one of the causes of important health burdens throughout the world with incidences varying between 4–18% of all burns. In electrical burns, blood vessels are the heavily damaged tissue characterized by endothelial erosion, followed by adhesion and aggregation of platelets to form a hemostatic plug. The screening test for assessing the formation of a hemostatic plug is platelet count. Platelet count monitoring is very important during the resuscitation phase and treatment periods in severe burns, namely in acute and subacute phases of burns. The purpose of this study is to determine and analyze the changes in the platelet count of rats after electrical exposure in the acute and subacute phases of burns. Methods: This is a quasi-experimental study in vivo with post-test-only group design. The control group in this study was not given electrical exposure and the rat's blood was taken directly after the adaptation process. In the other five groups, P1, P2, P3, P4, and P5 were exposed to 140 V for 17 seconds, then their blood was taken for platelet counts on days 0, 3, 7, 10, and 14 post-exposure. Results : The result of this study based on a Post Hoc LSD test showed that there was a change of platelet number after exposure in the acute phase of burn injury and there was no change of platelet number after exposure in the burning subacute phase. Conclusions: Platelet count difference in acute phase of electric burn injury and no difference in platelet count difference in subacute phase of electric burn injury.
Associated Risk Factors for Depression in MDR-TB Patients Receiving Cycloserine Therapy at dr. Soebandi Regional Hospital Maulidiyah, Najma; Wisudanti, Desie Dwi; Rachmawati, Dwita Aryadina; Komariah, Cicih; Raharjo, Angga Mardro
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.883

Abstract

Background: The most common psychological disorder in cycloserine treatment is depression. The purpose of this study was to identify the risk factors associated with depression in MDR-TB patients receiving cycloserine therapy at dr. Soebandi Regional Hospital. Data were obtained from medical records and the Depression Anxiety Stress Scales (DASS-42) questionnaire from 89 MDR-TB patients at dr. Soebandi Regional Hospital in 2022-2024. Methods: Data analysis was performed using the Lambda and Somers’ tests, followed by multivariate analysis using ordinal logistic regression. Results: Out of a sample of 89 patients, 27 (30.3%) experienced depression, with the majority experiencing moderate-level depression (18%). The bivariate test results showed that the variables that significantly influenced the level of depression were gender (P=0.011), education (P=0.000), occupation (P=0.037), BMI (P=0.000), and comorbidities (P=0.029). Multivariate tests showed that three variables had a significant effect (P<0.05) on the level of depression: gender (P=0.047), occupation (P=0.001), and comorbidities (P=0.011). The top two dominant risk factors affecting the level of depression are occupation (OR=17.12) and comorbidities (OR=9.14). Conclusion: Occupation and comorbidities are the risk factors that most influence the level of depression in MDR-TB patients receiving cycloserine.
Computational Insights into Leucaena leucocephala Extract Shampoo as a Malassezia furfur Anti-Dandruff Agent Hibatulloh, Muhammad Farhan; Nafisa, Tsabita; Afnan, Muhammad Syifaul; Andriani, Made Prasanti; Widanto, Cika Abadi Laily; Wisudanti, Desie Dwi
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.24051

Abstract

Dandruff is a scalp condition characterized by excessive flaking resulting from colonization by the fungus Malassezia furfur. Chemical-based anti-dandruff shampoos frequently result in side effects, including irritation, resistance, and hair discoloration. This study investigates the efficacy of Leucaena leucocephala leaf extract as a natural treatment for dandruff using an in-silico methodology. This research employed molecular modeling and docking assays targeting the 14-alpha lanosterol demethylase enzyme (CYP51), the primary antifungal target in Malassezia furfur. The docking results indicated that the active compounds in Leucaena leucocephala leaves, namely squalene and lupeol, exhibit a competitive binding affinity for CYP51, similar to the mechanism of action of ketoconazole. Squalene engages in polar interactions akin to the natural ligands of CYP51, whereas lupeol demonstrates robust hydrophobic interactions, suggesting its potential as an enzyme inhibitor. The findings indicate that herbal compounds derived from Leucaena leucocephala may serve as a natural alternative for dandruff treatment, presenting a reduced risk of side effects relative to synthetic chemicals. Further in vivo studies are necessary to validate the effectiveness and safety of anti-dandruff topical formulations. Keywords: CYP51, Dandruff, Leucaena leucocephala, Malassezia furfur, Natural antifungal
The Relationship Between Hypertension and Mortality in COVID-19 Patients at Soedirman M. S. Wonogiri Hospital Anisa, Devisda Shafiy; Wisudanti, Desie Dwi; Wulandari, Pipiet
WMJ (Warmadewa Medical Journal) 80-87
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.10.2.12434.80-87

Abstract

According to data from the Ministry of Health of the Republic of Indonesia, there were 6,103,533 confirmed positive cases of COVID-19, with 156,776 deaths. One factor contributing to the high mortality rate of COVID-19 is the presence of comorbidities. Hypertension and diabetes mellitus are the most common comorbidities found in COVID-19 patients. In cases of hypertension, the SARS-CoV-2 virus can interfere with blood pressure regulation, resulting in sustained increases in blood pressure in infected patients. If this condition is not managed, organ damage may occur and worsen the patient’s clinical status. This study aims to evaluate the effect of comorbid hypertension on the mortality of COVID-19 patients at dr. Soediran M. S. Wonogiri Hospital. This research employed an analytical observational method with a cross-sectional design. Medical record data from 94 COVID-19 patients, consisting of 47 patients with hypertension and 47 patients without hypertension, were analyzed using the Chi-square test. The highest age distribution among COVID-19 patients was in the 51–60-year age group (21.3%). The results showed a significant association between comorbid hypertension and mortality in COVID-19 patients (p = 0.001), with an RR value of 1.27. COVID-19 patients with comorbid hypertension were 1.27 times more likely to die than those without hypertension. This study provides a better understanding of health risks in COVID-19 patients with comorbid hypertension and may assist in developing more effective health policies.
Pengaruh Penyakit Komorbit dengan Keberhasilan Terapi Tuberkulosis Resisten Obat pada pasien DR-TB di Rumah Sakit Dr Soebandi Tahun 2018-2022 Hafa, Muhammad Rafi’uddin; Mufida, Diana Chusna; Wisudanti, Desie Dwi; Raharjo, Angga Mardro
Majalah Kedokteran Indonesia Vol 75 No 5 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.5-2025-1956

Abstract

Introduction: Drug-resistant tuberculosis (DR-TB) is a major health concern in Indonesia, where treatment success rates remain low. Comorbidities such as diabetes mellitus (DM) and human immunodeficiency virus (HIV) may worsen patient outcomes by complicating disease management and increasing the risk of treatment failure. This study aimed to assess the impact of comorbidities on treatment success among DR-TB patients at dr. Soebandi Hospital Jember.Method: An analytic observational study was conducted on 228 DR-TB patients at RS dr. Soebandi in 2018-2022 who had completed treatment, selected using total sampling. Data were analysed using bivariate analysis to examine associations between comorbidities and treatment outcomes.Results: The overall treatment success rate was 36.8%. Comorbidities were present in 37.3% of patients and were associated with a significantly lower success rate compared to those without comorbidities (21.2% vs. 46.2%; p=0.000; OR=3.19). DM (p=0.018; OR=2.17) and HIV (p=0.026; OR=9.31) each significantly reduced treatment success. A combination of DM and hypertension also showed a significant association (p=0.041; OR=9.44).Conclusion: Hypertension alone, chronic kidney disease, and chronic hepatitis were not statistically related to treatment success. Comorbidities, particularly DM, HIV, and the combination of DM with hypertension, significantly affect DR-TB treatment success. Addressing these conditions could improve patient outcomes and enhance treatment programs.
Alteration of Metformin Pharmacokinetic Profile in Rats Exposed to a Low Dose of Chlorpyrifos Insecticide Desie Dwi Wisudanti; Cholis Abrori; Elly Nuru Sakinah; Cicih Komariah; Supangat Supangat
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.15-21

Abstract

Chlorpyrifos (CPF) is an organophosphate pesticide widely used by farmers to control pests and has a broad spectrum of action. Research has shown that organophosphate pesticides can affect efflux pumps, specifically P-glycoprotein (P-gp), which can alter drug absorption and metabolism, indicating the potential risk of changes in a drug's pharmacokinetic profile, which could affect the effectiveness of drugs such as Metformin. This study investigated the impact of low-dose CPF exposure on the pharmacokinetic profile of Metformin, a first-line treatment for type 2 diabetes mellitus (T2DM). This study used 16 rats to examine Metformin's pharmacokinetic profile and 12 for the creatinine clearance examination. The rats were divided into two groups: a control group given normal saline (+5% Tween 20) and a group given CPF 5 mg/kg BW/day, each administered for 7 days. Metformin was administered on day 8, and pharmacokinetic parameters were assessed using UV-HPLC by measuring metformin plasma levels at 0.5, 1, 2, 4, 6, 8, 12, and 24 hours. Serum creatinine levels were examined in 12 rats using the Jaffe method on day 8 after treatment. The pharmacokinetic analysis showed that there was a change in the metformin profile following CPF administration: an increase in the area under the curve (AUC) and peak concentration (Cmax), along with a decrease in time to peak concentration (Tmax), half-life (T½), clearance (Cl), and volume of distribution (Vd). Serum creatinine levels in the CPF-administered group increased significantly (p<0.05). Further research, including pharmacodynamic assessment and clinical trials, is recommended to guide therapeutic decisions in populations with pesticide exposure.
Co-Authors Adelia Handoko Afnan, Muhammad Syifaul Agnellia Maulidya Utami Andriani, Made Prasanti Angga Mardro Raharjo Angga Mardro Raharjo, Angga Mardro Anisa, Devisda Shafiy Annisa Nadhifa Witanto Arifa Mustika Athoillah, Nabil Azham Purwandhono Aziz, Ayu Munawaroh Barus, Marsha Zahra Adyanda Cholis Abrori Cholis Abrori Cholis Abrori, Cholis Cicih Komariah Cicih Komariah Diana Chusna Mufida Diana Chusna Mufida Dini Agustina Dwicahyandari, Winie Septhia Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati Efensi, Erfan Elly Nuru Sakinah Elly Nurus Sakinah, Elly Nurus Enny Suswati ENNY SUSWATI Erfan Efendi F P H, Fransiska Nooril Firman Herdiana Firman Pratama Andraputra Hafa, Muhammad Rafi’uddin Hazbina Fauqi Ramadhan Heni Fatmawati Herdiyana, Firman Hibatulloh, Muhammad Farhan Hidayat, Noval Ida Srisurani Wiji Astuti Jauhani, Muhammad Afiful Laksmi Indreswari M. Ali Shodikin M. Ihwan Narwanto Marwah Pradani Ridlo Maulidiyah, Najma Mei Liana Wati Muhamad Hasan Muhammad Ali Shodikin Muhammad Faizal Akbar Muhammad Haikal Supriyadi Nafisa, Tsabita Nur Lintang Nabilah Sri Kusumasari Octavia, Aulia Mega Nur Pipiet Wulandari Rena Normasari Rini Riyanti Risty Pradana Linggan Wangi Rumastika, Nindya Shinta Salma Naqiyyah Tirtadevi Sarah Kinan Andalusia septa surya wahyudi, septa surya Setyaningrum, Wiwied Hary Sheilla Rachmania, Sheilla Sofi Aliyatul Himah Sugiyanta Sugiyanta Supangat Supangat Supangat Supangat Suryono Suryono Tegar Syaiful Qodar Tegar Syaiful Qodar Trinita Diyah Permatasari Ulfa Elfiah Wibsono, Sony Widanto, Cika Abadi Laily Yuli Hermansyah Yuli Hermansyah