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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmacon Jurnal Teknologi dan Sistem Komputer Media Farmasi Journal of Dedicators Community JPSCR : Journal of Pharmaceutical Science and Clinical Research Forest and Society Jurnal Mandala Pharmacon Indonesia Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Ilmiah Cendekia Eksakta Jurnal Mandala Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Abdimas Madani PROFICIO: Jurnal Pengabdian Masyarakat Media Farmasi Indonesia Jurnal Farmasi Sains dan Praktis Borneo Journal of Pharmacy
Ayu Shabrina
Universitas Wahid Hasyim
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Phytochemical Screening of Secondary Metabolites, Antioxidant and Antibacterial Activities of Kalangkala Plant (Litsea Angulata): A Review Article Daipadli, Daipadli; Shabrina, Ayu; Yuliani, Sapto; Nurkhasanah, Nurkhasanah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 2 (2023)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i2.9529

Abstract

Litsea angulata, more commonly known as Kalangkala, is a type of plant that belongs to the Lauraceae family. Empirically, the plant has been used traditionally by local people for the treatment of boils, diarrhea, stomachache, dyspepsia, gastroenteritis, diabetes, insect bites, and anti-irritation. This review article aims to find out the results of phytochemical screening of metabolites from parts of Kalangkala plant with various solvents as well as the results of the tests of antioxidant and antibacterial activities that several researchers have carried out. The method used was a literature search on Google Scholar and Pubmed with the keywords kalangkala, Litsea angulata, phytochemical screening, antioxidant, and antibacterial. The results of this review showed that various solvents, such as water, ethanol, methanol, N-hexane, and ethyl acetate in seed, fruit flesh, bark, stem, and leave parts of Kalangakala plant produces different amounts of secondary metabolites. Secondary metabolites such as alkaloids, flavonoids, saponins, and tannins extracted well using etanol as a solvent due to their polarity. The results of the antioxidant activity showed that the part of kalangakala plant such as the bark of the tree, has a very good antioxidant activity of 2.41 ppm when tested using ethyl acetate solvent. Furthermore, the results of the antibacterial activity test show an inhibition of 50 mm on S. mutans bacteria when tested using ethanol solvent. In conclusion, kalangkala plant has secondary metabolites which act as antioxidants and antimicrobials that also potential to developed as traditional medicine.
Physical Stability and Effectivity Comparison of Nanoemulsion and Nano-emulgel of Avocado Oil with Carbopol 940 Variation Shabrina, Ayu
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.53215

Abstract

Avocado oil (AV) contains of oleic acid that can prevent skin erythema. Nanoemulsion (NE) in a gel system (NG) is a one of a delivery system that increases the drug's effectivity. This study aimed to compare AV's stability and effectivity as anti-erythema in NE and NG with variations of carbopol 940. NE was made with 5% of AV and incorporated in carbopol 940 (for NG) with variations of 0.5 (F1);1 (F2), and 1.5% (F3). The samples were stored in a climatic chamber for 90 days at a temperature of 30 °C ± 2 °C RH 65% ± 5%. Samples were tested for organoleptic, pH, viscosity, particle size (PS), polydispersity index (PDI), and zeta potential (ZP). The samples were also tested based on in vitro SPF values and minimum erythema dose (MED). The results show that NE has a clear appearance whie NG showed a creamy texture. The physical parameters met the criteria for nanoemulsion delivery. F1 NG showed an increase in physical parameters, while F2 and F3 were stable for 90 days of storage. The SPF value of AV in NE and NG were not significantly different, yet the MED showed differences in each formula. Carbopol at a concentration of 0.5-1.5% can produce stable nano-emulgel. Avocado oil nanoemulsion showed better effectivity to prevent erythema than nano-emulgel.
PENGUATAN UMKM PENGOLAHAN BIJI KOPI MELALUI IMPLEMENTASI MESIN SANGRAI TERMOTORISASI DAN MESIN PEMBUBUK BIJI KOPI DI UPPKS “SEJAHTERA” DUSUN PATUKAN, KELURAHAN NGAREANAK, KECAMATAN SINGOROJO, KABUPATEN KENDAL. Pandu Annanto, Gilar; Shabrina, Ayu; Pratama, Fandy Indra
PROFICIO Vol. 5 No. 1 (2024): PROFICIO: Jurnal Abdimas FKIP UTP
Publisher : FKIP UNIVERSITAS TUNAS PEMBANGUNAN SURAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36728/jpf.v5i1.3008

Abstract

Tingginya produktivitas kopi di Kecamatan Singorojo, Kabupaten Kendal, menjadi potensi komoditas yang dapat dimanfaatkan oleh masyarakat setempat dan salah satu yang telah memanfaatkan potensi tersebut adalah unit Usaha Peningkatan Pendapatan Keluarga Sejahtera (UPPKS) “Sejahtera” yang berada di dusun Patukan, Desa Ngareanak. UPPKS “Sejahtera” memiliki produk kopi bubuk yang dijual dengan merk “Kopi Sedep”. Proses produksi kopi bubuk yang dilakukan UPPKS “Sejahtera” masih sangat konvensional, sehingga hal ini berpengaruh pada rendahnya kapasitas produksi. Selain itu, tidak adanya alat pembubuk kopi membuat margin keuntungan menjadi lebih rendah karena harus menggunakan pihak ketiga. Berdasarkan masalah ini, tim pengabdian kepada Masyarakat Universitas Wahid Hasyim melakukan kegiatan pengabdian untuk menjawab masalah mitra melalui perancangan dan penerapan mesin sangrai kopi termotorisasi dan mesin pembubuk biji kopi. Hasil dari penerapan teknologi diketahui memiliki potensi untuk meningkatkan kapasitas produksi serta omset dari mitra sebesar 13 kali.
Physicochemical Properties and Antioxidant Potential of Gels from Foam Mat Drying and Ethanolic Extract of Red Spinach (Amaranthus cruentus) Ibrahim Arifin; Khoirul Anwar; Muhammad Farih Arsyada; Nevy Pratiwi; Ayu Shabrina
Borneo Journal of Pharmacy Vol. 7 No. 4 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i4.6162

Abstract

Red spinach (Amaranthus cruentus), a rich source of antioxidant anthocyanins, is susceptible to light degradation. Foam mat drying (FMD) is a promising technique to preserve these pigments. This study compared the physicochemical properties and antioxidant activity of gels incorporating FMD and ethanolic extracts of A. cruentus (EEAC). Both were incorporated into gels at varying concentrations (1%, 3%, and 5%). FMD gels exhibited a darker red color and significantly higher total anthocyanin content (8.33 ± 0.25/100 g) and stronger antioxidant activity (IC50 of 35.67 ± 1.87 ppm) compared to EEAC gels (10.45 ± 0.15/100 g and IC50 of 47.88 ± 2.45 ppm, respectively). Both gel types had similar pH values (5.32-5.77). Increasing the concentration of either extract affected the viscosity, spreadability, and adhesion of the gels. Importantly, FMD gels displayed significantly higher antioxidant activity (58.75 ± 2.12 to 64.72 ± 2.01%) than EEAC gels (31.75 ± 2.13 to 50.12 ± 3.01%) across all formulations. These findings suggest that FMD-based gels offer a superior delivery system for A. cruentus antioxidants, potentially leading to innovative food products with enhanced nutritional value and health benefits.
Increasing the Knowledge of Gastrointestinal Disorder Related to Mental Health Issue in Supporting Sustainable Development Goals (SGDs) for Indonesia Immigrants in Zagreb, Croatia Shabrina, Ayu
Journal of Dedicators Community Vol 8, No 3 (2024)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v8i3.6964

Abstract

Sustainable development goals (SDGs) involve civil society and other organizations. All health issues in the SDGs are integrated into one goal, such as ensuring a healthy life and promoting well-being for all people. The purpose of this community service is to increase the knowledge of Indonesian immigrants in Zagreb, Croatia, about gastrointestinal disorders related to mental health issues in order to achieve a healthy life. This community service started by analyzing the status of the immigrants' health in Zagreb under the coordination of Bjelovar University and public pharmacy in Bjelovar. This event was held at the Embassy of the Republic of Indonesia in Zagreb, Croatia. The event was continued by socialization about gastrointestinal disorders and the use of herbs and medicines. This event was attended by 35 participants aged 30 to 50 years old. The participants acknowledge the mental health issues that can cause various disorders, such as gastrointestinal disorders, diabetes mellitus and many more. Based on the event, it is known that more than 65% of participants understood about healthy lifestyle, the use of multivitamins and medicines, and also about the metabolic disorder. Overall, this activity increased participants' understanding of gastrointestinal disorders and mental health and promoted a healthy lifestyle.
Formulasi Dan Penetapan Nilai Spf Secara In Vitro Lotion Ekstrak Etanol Daun Buas-Buas (Premna serratifolia L.) Shabrina, Ayu
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.242

Abstract

Ekstrak etanol daun buas-buas memiliki kadar flavonoid tinggi yang dapat berfungsi menangkal radikal bebas dan mampu menyerap sinar UV baik UV A dan UV B sehingga mengurangi intensitasnya pada kulit. Penelitian ini bertujuan untuk memformulasikan dan mengetahui aktivitas tabir surya dari sediaan lotion ekstrak etanol daun buas-buas. Uji aktivitas tabir surya dilakukan dengan metode spektrofotometer UV-Vis dengan panjang gelombang 290-320 nm. Ekstrak etanol daun buas-buas diformulasikan dalam sediaan lotion dengan variasi konsentrasi ekstrak etanol daun buas-buas (F1: 1%, F2: 2%, F3: 3%). Lotion diuji sifat fisik meliputi organoleptik, viskositas, daya sebar, pH, homogenitas, tipe lotion dan kemampuan proteksi. Hasil penelitian menunjukkan bahwa ekstrak etanol daun buas-buas dapat diformulasikan menjadi sediaan lotion, dimana ketiga formula lotion dengan variasi konsentrasi ekstrak etanol daun buas-buas 1%, 2% dan 3% menghasilkan sediaan berwarna hijau kecoklatan, berbau khas oleum citri, semi solid, homogen, emulsi tipe M/A, memenuhi persyaratan pH, viskositas, daya sebar dan memberikan proteksi. Hasil uji aktivitas tabir surya secara berturut-turut yaitu 10,50±0,10; 26,11±0,25; 34,60±0,73, dengan nilai SPF tertinggi yaitu 34,60±0,73 pada konsentrasi 3% yang termasuk kategori proteksi ultra.
Formulation of Spray Gel Containing Soybean Seed (Glycine max) Ethanolic Extract as A Sunscreen Cosmetics Ayu Shabrina; Faza Putri_Maulina Hanik; M_Rifki Pratama_Kharisma Akbar; Elya Zulfa
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 2 (2020): Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 17 N0. 02 Desember 2020
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.435 KB) | DOI: 10.31942/jiffk.v17i2.4067

Abstract

Skin damage caused by free radicals disturbs the health of human skin that needs protection. Soybean extract showed that its SPF value was 6,93 on concentration of 0,5%. The purpose of this study was to determine the effect of variation concentrations of Soybean Seed Ethanol Extract (SSEE) on spray gel characteristic and sunscreen activity in vitro. Soybean seeds were extracted by maceration method using 96% ethanol solvent. Extracts obtained were made into spray gel preparation with variations of SSEE concentration were 2% (F1), 4% (F2), 6% (F3). SSEE spray gel was tested for organoleptic, homogeneity, pH, viscosity, spraying pattern and sunscreen activity test. Data from organoleptic, homogeneity, viscosity, pH and spray patterns and sunscreen activity were analyzed descriptively while viscosity was analyzed using linear regression. The spray gels were homogenous with thick texture, and brownish yellow color also distinctive aroma of soybean seeds. Based on the test results, variations concentrations of SSEE did not affect the spray gel characteristics except the viscosity that decreased. Sunscreen activity test showed that SPF values were 13.82 (F1), 13.96 (F2) and 14.54 (F3) included maximal protection. Keywords: soybeans, sunscreen, spray gel, in vitro
The Potential of Avocado Oil for Topical Use: A Narrative Review Ratna Hapsari Tri Mustika Dewi; Niswatus Sholihah; Rima Nofitasari; Dhimas Adhityasmara; Ayu Shabrina
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v21i1.11218

Abstract

Skin aging is a multifaceted biological process that is impacted by both internal (genetics, hormones, cellular metabolism, and metabolic processes) and external (long-term exposure to UV light, pollution, ionizing radiation, chemicals, and toxins) aspects. Monounsaturated fatty acids, especially oleic acid, found in avocado oil are beneficial for wound healing, moisturizing, and anti-aging. Finding avocado oil's role as an active ingredient in cosmeceuticals was the aim of this investigation. The study's article review technique entails a thorough search of the Pubmed, Google Scholar, Proquest, Springer Link, and Science Direct databases for articles published between 2018 and 2024. The sample utilized in this study consisted of research publications that satisfied the inclusion criteria, resulting in a total of 12 articles. The result of this study showed that avocado oil is mostly formulated in emulgel and cream preparation.  Avocado oil can be used as sunscreen due to the presence of the unsaturated fatty acid such as oleic acid and linoleic acid. All of the topical application of avocado oil showed the potential of this oil as antioxidant, anti-aging and sunscreen. Avocado oil is potential as cosmeceutical at the concentration of 3% to 20%.
UJI AKTIVITAS SUSPENSI SERBUK SPIRULINA PLATENSIS TERHADAP KADAR HORMON TESTOSTERON DAN HISTOPATOLOGIK TESTIS TIKUS WISTAR DIABETES YANG DIINDUKSI STREPTOZOTOCIN Gunawan, Adhi; Kintoko, Kintoko; Yuliani, Sapto; Shabrina, Ayu
CENDEKIA EKSAKTA Vol. 6 No. 1 (2021)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v6i1.4402

Abstract

Diabetes mellitus merupakan penyakit metabolik yang dapat mengganggu fungsi reproduksi pada pria yaitu penurunan kadar hormon testosteron dan kerusakan jaringan testis. Spirulina platensis mengandung fikosianin sebagai antioksidan yang efektif untuk menurunkan kadar gula darah dan kerusakan organ reproduksi pria. Tujuan dari penelitian ini untuk mengetahui efek Spirulina platensis (SP) terhadap kadar hormon testosteron serta gambaran histopatologik testis tikus jantan diabetes yang diinduksi Streptozotocin (STZ). Tikus dibagi menjadi 6 kelompok yang terdiri dari K1 (tikus diberikan suspensi CMC-Na), K2 (tikus yang diinduksi STZ dosis tunggal 45 mg/kgBB), K3 (tikus diberikan suspensi SP 36 mg/200gBB), kelompok 4; 5 dan 6 (tikus diabetes diberikan suspensi SP 36 mg/200kgBB; 72 mg/200gBB dan 144 mg/200gBB). Penelitian dilakukan selama 28 hari dengan parameter yang diamati adalah kadar gula darah, kadar testosteron dan gambaran histopatologik testis dengan Hematoksilin - Eosin (HE). Hasil peneltian ini menunjukkan bahwa kelompok perlakuan dengan Spirulina platensis mampu meningkatkan kadar hormon testosteron yaitu 0,82 µG/mL, 1,13 µG/mL dan 1,66 µG/mL (p < 0,05) dibandingkan kelompok tikus diabetes. Spirulina platensis juga mampu mencegah kerusakan epitel tubulus seminferus pada testis dibandingkan kelompok diabetes. Pada hewan uji yang diberikan dosis 144 mg/kgBB memberikan aktivitas paling baik dalam menghambat kerusakan jaringan testis disebabkan oleh induksi STZ. Kata kunci: diabetes mellitus, gangguan reproduksi, hormon testosteron, Spirulina platensis
PERBANDINGAN NILAI SPF ENDAPAN AIR CUCIAN BERAS PUTIH DAN BERAS MERAH SECARA IN VITRO Wijayatri, Ratna; Wahyuningtyas, Eka Sakti; Hafiz, Nur; Shabrina, Ayu
CENDEKIA EKSAKTA Vol. 7 No. 1 (2022)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v7i1.6546

Abstract

Penggunaan senyawa kimia sebagai agen pelindung sinar UV dapat membahayakan tubuh. Air cucian beras merupakan limbah yang banyak mengandung komponen fenolik dan flavonoid yang mampu menyerap sinar UV. Tujuan penelitian ini adalah untuk membandingkan nilai SPF ekstrak air cucian beras merah (EACBM) dan beras putih (EACBP). EACBM dan EACBP dibuat dengan melakukan ekstraksi dari beras merah dan beras putih kemudian difermentasi selama 3 hari. Endapan yang diperoleh lalu dipekatkan dengan penangas air pada suhu 60°C. Rendemen EACBM dan EACBP dilarutkan dengan aquadest kemudian ditetapkan nilai SPF pada panjang gelombang 290-320 nm menggunakan spektrofotometer UV-Vis. Hasil absorbansi dihitung dengan rumus Mansur. Data nilai SPF dianalisis secara statistik dengan uji t-independent dan dikategorikan proteksinya secara deskriptif. Hasil menunjukkan bahwa nilai SPF EACBM dan EACBP berbeda secara signifikan (p < 0,05). Konsentrasi ekstrak tertinggi yaitu 30000 ppm pada EACBM dan EACBP menghasilkan nilai SPF masing-masing adalah 25,47±1,30 dan 10,28 ±1,40. EACBM dan EACBP pada konsentrasi 30000 ppm masing-masing termasuk kategori proteksi ultra dan proteksi maksimal.dEACBM menujukkan nilai SPF lebih tinggi dibandingkan EACBP. 0 pt, italic)<satu spasi>Kata kunci: Beras merah, beras putih, nilai SPF, tabir surya
Co-Authors Adhi Gunawan Agnes Theresya Poerba Annisa Rahayuning Pratiwi Arnida Lailatul Latifah Astri Risma Debi Auliasari, Dewi Wulandari Aza Zakiyatun Nida Aza Zakiyatun Nida Daipadli Daipadli Dharmawan Dharmawan Dhimas Adhityasmara Diana Anisa Setyani Eka Sakti Wahyuningtyas Elya Zulfa Erika Indah Safitri Faza Putri_Maulina Hanik Gunawan, Adhi Hafiz, Nur Heny Puspasari Heroweti, Junvidya Hidayati, Ishardina C. I Nyoman Sujana Ibrahim Arifin Ibrahim Arifin Ibrahim Arifin Ibrahim Arifin Icha Sabrina Milenia Khansa Ilma Nur Khafifa Inna Syafarina Intan Nuni Wahyuni Intan Pratiwi Junvidya Heroweti Junvidya Herowety Kabur, Savio Ricardus Khoirul Anwar KHOIRUL ANWAR Kintoko Kintoko Kintoko, Kintoko Latifah, Arnida L. M Fatchur Rochman M Fatchur Rochman MARIA ULFAH Mimiek Muurukmihadi Misbahul Munir Muddiin, Muhammad Imaa Muhammad Farih Arsyada Muhammad Ikhsan M_Rifki Pratama_Kharisma Akbar Nalaratih, Novinda Nevy Pratiwi Niswatus Sholihah Nurkhasanah Nurkhasanah Pratama, Fandy Indra Prihantini, Malinda Puspasari, Heny Puspita, Weni Rabiatul Adawiyah Ratna Hapsari Ratna Hapsari Tri Mustika Dewi Rima Nofitasari Ririn Lispita Wulandari Risha Fillah Fithria risha fillah fithria Riyanti, Winanti Adi Rizky Adityo Saputro Saniya Alfa Salsabila Sapto Yuliani Siti Setianingsih Sri Eka Rahmadany Sri Eka Rahmadany Sri Febri Haryati Sri Suwarni Sumantri Sumantri Surti Khayatul Fata Susiana Irmawati Urva Fresiva Uswatun Hasanah Vironica Rizky Fauziah Wahyu Setyo Wibowo Wahyuni, Intan N. Wijayatri, Ratna Yulias Ninik Windriati Zuhriya Muna Zuhriya Muna Firdausi