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Beyond Phosphate Binding: A Systematic Review and Meta-Analysis on the Efficacy and Safety of the Novel Paracellular Phosphate Inhibitor, Tenapanor, for Hyperphosphatemia in Dialysis Patients Eva Julita; Ian Effendi; Zulkhair Ali; Novadian; Suprapti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 1 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i1.1492

Abstract

Background: Hyperphosphatemia is a critical driver of cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD) undergoing dialysis. Current management, reliant on phosphate binders, is hampered by high pill burden and poor adherence. Tenapanor, a first-in-class, minimally-absorbed sodium/hydrogen exchanger 3 (NHE3) inhibitor, reduces paracellular phosphate absorption. We performed a systematic review and meta-analysis of all available Phase 3 trials to quantify its efficacy and safety. Methods: We searched PubMed, Embase, and Cochrane CENTRAL through October 2025 for Phase 3 clinical trials evaluating tenapanor for hyperphosphatemia in dialysis patients. Data were extracted from 6 eligible studies (N=1573). We conducted separate random-effects meta-analyses for different study designs: 1) parallel-group monotherapy vs. placebo, 2) withdrawal-design monotherapy vs. placebo, 3) parallel-group add-on therapy vs. placebo, and 4) safety (diarrhea incidence) vs. placebo. Efficacy was measured by Mean Difference (MD) in serum phosphate change; safety by Risk Ratio (RR). Results: Tenapanor demonstrated significant efficacy across all study designs. In parallel-group monotherapy (1 study, N=167), tenapanor was superior to placebo (MD: -1.89 mg/dL; 95% CI: -2.36 to -1.42). In withdrawal-design studies (2 RCTs, N=373), tenapanor maintained serum phosphate levels significantly better than placebo (Pooled MD: -0.75 mg/dL; 95% CI: -1.05 to -0.45; I2=0%). As an add-on therapy (1 RCT, N=235), tenapanor provided additional phosphate reduction versus binders alone (MD: -0.65 mg/dL; 95% CI: -0.96 to -0.35). Tenapanor significantly increased the risk of diarrhea versus placebo (3 RCTs, N=521; Pooled RR: 4.10; 95% CI: 2.50 to 6.72; I2=30%), which was the primary adverse event leading to discontinuation. Conclusion: Tenapanor represents a new mechanistic paradigm for hyperphosphatemia management. It is a highly effective phosphate-lowering agent, both as monotherapy and add-on therapy, but is associated with a significant, mechanism-based risk of gastrointestinal side effects.
Analisis Fasilitas Pelayanan Penumpang Disabilitas Di Bandar Udara Domine Eduard Osok Sorong Andi Andini Armayanti; Suprapti
Jurnal Ilmiah Dan Karya Mahasiswa Vol. 1 No. 2 (2023): APRIL: JURNAL ILMIAH DAN KARYA MAHASISWA
Publisher : Institut Teknologi dan Bisnis (ITB) Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (747.636 KB) | DOI: 10.54066/jikma-itb.v1i2.178

Abstract

Abstract: In providing facilities for the convenience of airport service users, the airport should provide facilities not only for public facilities but facilities that are friendly for passengers with disabilities and also in accordance with existing regulations. This study aims to find out: How are the Disabled Passenger Service Facilities provided by Domine Eduard Osok Sorong Airport. In this study, researchers only limited it to the terminal area of Domine Eduard Osok Sorong Airport, where it is a place for passengers to carry out activities before boarding the plane. This study used qualitative research methods. Data collection techniques used are observation, interviews and documentation. Researchers directly make observations in the field as well as do documentation. For interviews, researchers did it to 3 sources. The data analysis technique used is data collection, data reduction, data presentation, discussion and conclusion. The results of this study indicate that there are still several disabled passenger facilities that are not yet available at Domine Eduard Osok Sorong airport. The facilities provided by the airport are also sufficient for easy access for passengers with disabilities. Disability facilities are very important to support the activities of disabled passengers at the airport.
PENGARUH BAGASI BERBAYAR DAN MINAT PENUMPANG MASKAPAI WINGS AIR DI BANDAR INTERNASIONAL AHMAD YANI SEMARANG Rana Fadhila; Suprapti
Jurnal Ilmiah Dan Karya Mahasiswa Vol. 1 No. 2 (2023): APRIL: JURNAL ILMIAH DAN KARYA MAHASISWA
Publisher : Institut Teknologi dan Bisnis (ITB) Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (679.301 KB) | DOI: 10.54066/jikma-itb.v1i2.190

Abstract

Transportasi udara di Indonesia memegang peranan yang sangat penting dalam melakukan aktivitas perpindahan baik itu barang maupun manusia. Sebelum diterapkanya bagasi berbayar maskapai di Indonesia banyak yang memberikan pelayanan bagasi secara gratis, namun sejak diterbitkan peraturan Direktur Jenderal Perhubungan Skep 302 pasal v pada tahun 2011 maskapai dengan kategori LCC (Low Cost Carier) seperti Lion Air dan Wings Air di susul anak usaha Garuda Grup, yaitu Citilink Indonesia mulai menerapkan sistem baru dengan menerapkan bagasi berbayar yang awalnya tanpa biaya tambahan dan sekarang harus membayar mulai dari hitungan 20 kg. Penelitian ini menggunakan pengujian kuantitatif dengan gambaran strategi yang dipilihan sebagai informasi penting dengan menggunakan kuesioner.Populasi yang akan digunakan dalam penelitian ini yaitu penumpang maskapai wings air di Bandar Udara Internasional Ahmad Yani Semarang.Pada sampel yang berjumlah sebesar 100 responden.Teknik analisis data menggunakan bantuan SPSS statistics 21 & 26 . Untuk mengetahui Pengaruh Bagasi Berbayar Pada Maskapai WingsAir terhadap minat Penumpang Di Bandar Udara Internasional Ahmad Yani Semarang.Dan untuk mengatahui Seberapa besar pengaruh bagasi berbayar pada Maskapai Wings Air terhadap Minat penumpang di Bandar Udara Internasional Ahmad Yani Semarang. Dan untuk mengatahui Hasil penelitian diperoleh nilai signifikasi sebesar 0,000 < 0,05. Maka dapat disimpulkan bahwa Ha diterima dan HO di tolak yang menyatakan Bagasi Berbayar Terhadap Minat Penumpang Maskapai Wings Air Di Bandar Udara Internasional Ahmad Yani Semarang.Besar pengaruh variabel Bagasi Berbayar Terhadap Minta Penumpang Maskapai Wings Air dapat dilihat dari uji koefisien determinasi bahwa koefisien korelasi (R)sebesar 0,875 yang artinya terdapat hubungan yang kuat antara variabel independenterhadap variabel dependen karena nilai R mendekati angka 1. Hal itu menunjukkan semakin besar naliai X maka semakin besar pula nilai Y .nilai R2 sebesar 0,766 yang berarti 76% kepuasan pelanggan dipengaruhi variabel bagasi berbayar. Hal ini menunjukan bahwa bagasi berbayar yang dirasakan mempunyai pengaruh yang kuat terhadap minat penumpang maskapai wings Air di bandar udara ahmad yani semarang.Dalam 100 responden 76% sangat pengaruh bagasi berbayar.24% sangat tidak pengaruh bagasi berbayar terhadap minat penumpang maskapai wings air.
Pelatihan Untuk Meningkatkan Market Segmentation Kelompok UMKM di Kota Salatiga Edwin Zusrony; Budi Santoso, Agustinus; Rakasiwi, Sindhu; Andriana, Myra; Sumarlin, Tantik; Fitrianto, Yuli; Suprapti
Community : Jurnal Pengabdian Pada Masyarakat Vol. 2 No. 3 (2022): November : Jurnal Pengabdian Pada Masyarakat
Publisher : LPPM Sekolah Tinggi Ilmu Ekonomi - Studi Ekonomi Modern

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51903/community.v2i3.222

Abstract

The implementation of community service activities is aimed at the MSME group regarding how to increase market segmentation with various counseling with material on the importance of packaging and labeling, introduction of product sales strategies through e-commerce, introduction of website, digitalization of modern business for MSMEs and the use of Google My Business (GMB). The counseling was carried out by direct interaction between lecturers from the STEKOM University team and participants from the MSME group in the city of Salatiga. Model training and counseling with presentations and hands-on practice using electronic devices, such as laptops, LCDs and smartphones. This outreach program is expected to be sustainable and enable participants to implement strategies to increase market segmentation, especially the MSME group in Salatiga City.
Gut Microbiota in Chronic Kidney Disease: A Narrative Literature Review Abdillah, Novandra; Zulklhair Ali; Novadian; Ian Effendi; Suprapti; Elfiani; Rery TF Yuniarti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 4 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i4.976

Abstract

Chronic kidney disease (CKD) is a growing public health problem related to loss of kidney function and cardiovascular disease as the main causes of morbidity and mortality in CKD. It is known that CKD is associated with intestinal dysbiosis. There is an influence of the gut microbiota on the gut-kidney axis and it works reciprocally: on the one hand, CKD significantly changes the composition and function of the gut microbiota. On the other hand, gut microbiota is able to manipulate the processes that cause the emergence and progression of CKD through inflammatory, endocrine and neurological pathways. Understanding the complex interactions between gut and kidney microbiota may provide novel nephroprotective interventions to prevent the progression of CKD by therapeutically targeting balance of gut microbiota composition.
Peningkatan Kemampuan Menyusun Kalimat Efektif melalui Teknik Menyusun Unsur Kalimat pada Siswa Kelas XI SMA Suprapti
Sasando Vol 3 No 1 (2020): April 2020
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Pancasakti Tegal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24905/sasando.v3i1.112

Abstract

The purpose of this study is (1) obtaining an objective description of the increase in the ability of students of the XI-SMA class in composing effective sentences after the student has been given a provision to compose the sentence element and (2) obtained an objective description of the change in student behaviour during the study. , one way that can be pursued is by increasing the ability to compose effective sentences. The results showed that there was an increase in the ability to compose effective sentences through the technique of arranging the elements of the sentence appears in the results of pretes on composing elements of sentences obtained by the students with an average score of class 5.85, while the results of pretes on the ability to compose effective sentences with the average score of class reaches 6.35. The test results on the sentence element in cycle I reached an average score of 6.58 which means an increase of 0.73 or 1.83%, while the test results on the effective sentence on the I cycle achieved an average score of 7.59 which means an increase of 0.91 or 2.28%, while the test result on effective sentences in cycle II was obtained an average score of 8.01 which means an increase of 0.42 or 1.05% Keywords: increased ability, compose effective sentences, techniques for composing sentence elements.
KEEFEKTIFAN PEMBELAJARAN MENULIS CERPEN DENGAN MODEL SINEKTIK DAN MODEL PETA KONSEP PADA SISWA SEKOLAH MENENGAH PERTAMA Suprapti; Vivi Kumalasari Subroto
Sasando Vol 6 No 1 (2023): SASANDO VOL 6 NO 1 APRIL 2023
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Pancasakti Tegal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24905/sasando.v6i1.215

Abstract

Penelitian ini berjudul “Keefektifan Pembelajaran Menulis Cerpen dengan Model Sinektik dan Model Peta Konsep pada Siswa Sekolah Menengah Pertama”. Permasalahan yang dikaji dalam penelitian ini adalah apakah terdapat perbedaan keterampilan menulis cerpen antara siswa yang diajar dengan model sinektik dengan siswa yang mendapatkan model peta konsep ? Tujuan dari penelitian ini adalah memaparkan ada tidaknya perbedaan kemampuan menulis cerpen dalam pembelajaran menulis cerpen pada siswa SMP dengan digunakannya model sinektik dan model peta konsep. Pembelajaran menulis cerpen di sekolah belum menarik minat siswa. Siswa beranggapan bahwa kegiatan menulis cerpen merupakan materi pembelajaran sulit, bahkan beberapa siswa mengalami kesulitan untuk memulai menulis cerpen. Penyebab tersebut timbul karena siswa tidak memahami kriteria menulis cerpen yang baik, kurang menguasai alur, konflik, klimaks bahkan penokohan yang ada dalam sebuah cerpen. Untuk itu, peneliti memandang bahwa guru perlu melakukan inovasi dalam pembelajaran agar pembelajaran menulis cerpen dapat terlaksana secara efektif. Peneliti berpendapat bahwa model dari cerpen ke cerpen dan model bersafari mengandung aspek-aspek yang dapat meningkatkan minat siswa terhadap pembelajaran menulis cerpen. Penelitian ini terfokus pada keefektifan pembelajaran menulis cerpen di SMP antara kelas yang diberi model sinektik dengan kelas yang diberi model peta konsep. Sesuai dengan permasalahan tersebut, penelitian ini bertujuan untuk mengetahui ada tidaknya perbedaan keberhasilan pembelajaran menulis cerpen dengan digunakannya kedua model tersebut. Hasil dari penelitian ini adalah ada perbedaan yang signifikan antara kelompok eksperimen 1 dengan kelompok eksperimen 2. Perbedaan itu ditunjukkan dengan tingkat signifikansi sebesar 0,001 dengan tingkat signifikansi di kelompok eksperimen 1, yaitu model sinektik. Didapat nilai rata-rata 80,02 dengan standar deviasi 1,99 apabila dibandingkan dengan kelompok eksperimen 2 dengan nilai rata-rata 71,93 dengan standar deviasi 2,04, yaitu model peta konsep. Model sinektik lebih efektif dibandingkan dengan model peta konsep dalam pembelajaran menulis cerpen di SMP. Simpulan yang diperoleh yaitu model sinektik sangat efektif dalam pembelajaran menulis cerpen di SMP. Dengan demikian, penelitian ini menarik dikembangkan lebih lanjut untuk lingkup sekolah menengah atas yang lebih luas, sehingga keefektifan model sinektik akan membawa dampak positif bagi pembelajaran bahasa Indonesia pada umumnya dan menulis cerpen khususnya. Kata kunci: menulis cerpen, model sinektik, model peta konsep.
PENINGKATAN KEAKTIFAN SISWA KELAS III SEKOLAH DASAR PADA PEMBELAJARAN IPAS MELALUI MEDIA INTERAKTIF WORDWALL Jannah, Miftahul; Ayu Prima Pravitasari; Yuni Dwi Astuti; Ratnasari Dyah Utami; Suprapti
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 01 (2025): Volume 10 Nomor 1, Maret 2025
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i01.23144

Abstract

This research based on low students active learning of third grade SDN Kleco 1 Surakarta. Students often passive on learning and not active during class. Low active learning seen on lack of students interaction and completing assignments. This research is Class Action Research (CAR) that aim to increase students active learning on IPAS subject through Wordwall media. This research subject consisted of third grade students on SDN Kleco 1 Surakarta. This research method was conducted of two cycle with. Data collecting through observation and documentation is describe with increasing active learning percentage calculation, then compare with success indicator which is above 75%. Through data collecting show that there’s improvement of 65,19% students had high active learning from cycle I, then improve with 86,88% in cycle II. Based on this result show that Wordwall media is effective to improve third grade students active learning on IPAS subject.
Gut Microbiota in Chronic Kidney Disease: A Narrative Literature Review Abdillah, Novandra; Zulklhair Ali; Novadian; Ian Effendi; Suprapti; Elfiani; Rery TF Yuniarti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 4 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i4.976

Abstract

Chronic kidney disease (CKD) is a growing public health problem related to loss of kidney function and cardiovascular disease as the main causes of morbidity and mortality in CKD. It is known that CKD is associated with intestinal dysbiosis. There is an influence of the gut microbiota on the gut-kidney axis and it works reciprocally: on the one hand, CKD significantly changes the composition and function of the gut microbiota. On the other hand, gut microbiota is able to manipulate the processes that cause the emergence and progression of CKD through inflammatory, endocrine and neurological pathways. Understanding the complex interactions between gut and kidney microbiota may provide novel nephroprotective interventions to prevent the progression of CKD by therapeutically targeting balance of gut microbiota composition.
Is It a Tumor or Not? A Case of Focal Segmental Glomerulosclerosis Secondary to Type 2 Diabetes with a Concomitant Renal Pseudotumor Rery TF Yuniarti; Ian Effendi; Zulkhair Ali; Novadian; Suprapti; Elfiani; Novandra AP; Dila Siti Hamidah; Fadil Pramudhya Husein; Ika Kartika Edi P
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1154

Abstract

Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of glomerular injury that can be primary or secondary to various conditions, including obesity, diabetes, and hypertension. Renal masses, often detected incidentally, can be benign or malignant, with renal cell carcinoma (RCC) being the most common. This case report presents a patient with FSGS secondary to type 2 diabetes and a concomitant renal pseudotumor, initially suspected to be RCC. Case presentation: A 60-year-old woman presented with weakness, fever, and weight loss. Imaging revealed a renal mass, initially suspected to be RCC. A kidney biopsy revealed FSGS, and further evaluation confirmed type 2 diabetes. After controlling her diabetes and hypertension, the renal mass regressed, suggesting a pseudotumor. Conclusion: This case highlights the importance of considering pseudotumors in the differential diagnosis of renal masses, especially in patients with comorbidities such as diabetes. A kidney biopsy can help avoid unnecessary invasive procedures like nephrectomy.