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KEEFEKTIFAN PEMBELAJARAN MENULIS CERPEN DENGAN MODEL SINEKTIK DAN MODEL PETA KONSEP PADA SISWA SEKOLAH MENENGAH PERTAMA Suprapti; Vivi Kumalasari Subroto
Sasando Vol 6 No 1 (2023): SASANDO VOL 6 NO 1 APRIL 2023
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Pancasakti Tegal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24905/sasando.v6i1.215

Abstract

Penelitian ini berjudul “Keefektifan Pembelajaran Menulis Cerpen dengan Model Sinektik dan Model Peta Konsep pada Siswa Sekolah Menengah Pertama”. Permasalahan yang dikaji dalam penelitian ini adalah apakah terdapat perbedaan keterampilan menulis cerpen antara siswa yang diajar dengan model sinektik dengan siswa yang mendapatkan model peta konsep ? Tujuan dari penelitian ini adalah memaparkan ada tidaknya perbedaan kemampuan menulis cerpen dalam pembelajaran menulis cerpen pada siswa SMP dengan digunakannya model sinektik dan model peta konsep. Pembelajaran menulis cerpen di sekolah belum menarik minat siswa. Siswa beranggapan bahwa kegiatan menulis cerpen merupakan materi pembelajaran sulit, bahkan beberapa siswa mengalami kesulitan untuk memulai menulis cerpen. Penyebab tersebut timbul karena siswa tidak memahami kriteria menulis cerpen yang baik, kurang menguasai alur, konflik, klimaks bahkan penokohan yang ada dalam sebuah cerpen. Untuk itu, peneliti memandang bahwa guru perlu melakukan inovasi dalam pembelajaran agar pembelajaran menulis cerpen dapat terlaksana secara efektif. Peneliti berpendapat bahwa model dari cerpen ke cerpen dan model bersafari mengandung aspek-aspek yang dapat meningkatkan minat siswa terhadap pembelajaran menulis cerpen. Penelitian ini terfokus pada keefektifan pembelajaran menulis cerpen di SMP antara kelas yang diberi model sinektik dengan kelas yang diberi model peta konsep. Sesuai dengan permasalahan tersebut, penelitian ini bertujuan untuk mengetahui ada tidaknya perbedaan keberhasilan pembelajaran menulis cerpen dengan digunakannya kedua model tersebut. Hasil dari penelitian ini adalah ada perbedaan yang signifikan antara kelompok eksperimen 1 dengan kelompok eksperimen 2. Perbedaan itu ditunjukkan dengan tingkat signifikansi sebesar 0,001 dengan tingkat signifikansi di kelompok eksperimen 1, yaitu model sinektik. Didapat nilai rata-rata 80,02 dengan standar deviasi 1,99 apabila dibandingkan dengan kelompok eksperimen 2 dengan nilai rata-rata 71,93 dengan standar deviasi 2,04, yaitu model peta konsep. Model sinektik lebih efektif dibandingkan dengan model peta konsep dalam pembelajaran menulis cerpen di SMP. Simpulan yang diperoleh yaitu model sinektik sangat efektif dalam pembelajaran menulis cerpen di SMP. Dengan demikian, penelitian ini menarik dikembangkan lebih lanjut untuk lingkup sekolah menengah atas yang lebih luas, sehingga keefektifan model sinektik akan membawa dampak positif bagi pembelajaran bahasa Indonesia pada umumnya dan menulis cerpen khususnya. Kata kunci: menulis cerpen, model sinektik, model peta konsep.
PENINGKATAN KEAKTIFAN SISWA KELAS III SEKOLAH DASAR PADA PEMBELAJARAN IPAS MELALUI MEDIA INTERAKTIF WORDWALL Jannah, Miftahul; Ayu Prima Pravitasari; Yuni Dwi Astuti; Ratnasari Dyah Utami; Suprapti
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 01 (2025): Volume 10 Nomor 1, Maret 2025
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i01.23144

Abstract

This research based on low students active learning of third grade SDN Kleco 1 Surakarta. Students often passive on learning and not active during class. Low active learning seen on lack of students interaction and completing assignments. This research is Class Action Research (CAR) that aim to increase students active learning on IPAS subject through Wordwall media. This research subject consisted of third grade students on SDN Kleco 1 Surakarta. This research method was conducted of two cycle with. Data collecting through observation and documentation is describe with increasing active learning percentage calculation, then compare with success indicator which is above 75%. Through data collecting show that there’s improvement of 65,19% students had high active learning from cycle I, then improve with 86,88% in cycle II. Based on this result show that Wordwall media is effective to improve third grade students active learning on IPAS subject.
Gut Microbiota in Chronic Kidney Disease: A Narrative Literature Review Abdillah, Novandra; Zulklhair Ali; Novadian; Ian Effendi; Suprapti; Elfiani; Rery TF Yuniarti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 4 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i4.976

Abstract

Chronic kidney disease (CKD) is a growing public health problem related to loss of kidney function and cardiovascular disease as the main causes of morbidity and mortality in CKD. It is known that CKD is associated with intestinal dysbiosis. There is an influence of the gut microbiota on the gut-kidney axis and it works reciprocally: on the one hand, CKD significantly changes the composition and function of the gut microbiota. On the other hand, gut microbiota is able to manipulate the processes that cause the emergence and progression of CKD through inflammatory, endocrine and neurological pathways. Understanding the complex interactions between gut and kidney microbiota may provide novel nephroprotective interventions to prevent the progression of CKD by therapeutically targeting balance of gut microbiota composition.
Is It a Tumor or Not? A Case of Focal Segmental Glomerulosclerosis Secondary to Type 2 Diabetes with a Concomitant Renal Pseudotumor Rery TF Yuniarti; Ian Effendi; Zulkhair Ali; Novadian; Suprapti; Elfiani; Novandra AP; Dila Siti Hamidah; Fadil Pramudhya Husein; Ika Kartika Edi P
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1154

Abstract

Background: Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of glomerular injury that can be primary or secondary to various conditions, including obesity, diabetes, and hypertension. Renal masses, often detected incidentally, can be benign or malignant, with renal cell carcinoma (RCC) being the most common. This case report presents a patient with FSGS secondary to type 2 diabetes and a concomitant renal pseudotumor, initially suspected to be RCC. Case presentation: A 60-year-old woman presented with weakness, fever, and weight loss. Imaging revealed a renal mass, initially suspected to be RCC. A kidney biopsy revealed FSGS, and further evaluation confirmed type 2 diabetes. After controlling her diabetes and hypertension, the renal mass regressed, suggesting a pseudotumor. Conclusion: This case highlights the importance of considering pseudotumors in the differential diagnosis of renal masses, especially in patients with comorbidities such as diabetes. A kidney biopsy can help avoid unnecessary invasive procedures like nephrectomy.
Bridging the Therapeutic Gap: A Systematic Review and Meta-Analysis on the Efficacy, Safety, and Pathophysiological Impact of Sodium Zirconium Cyclosilicate in Enabling Guideline-Directed Medical Therapy Edy Nur Rachman; Ian Effendi; Zulkhair Ali; Novadian; Suprapti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 1 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i1.1489

Abstract

Background: Hyperkalemia is a life-threatening complication of chronic kidney disease (CKD) and heart failure (HF), primarily impeding the use of life-saving renin-angiotensin-aldosterone system inhibitors (RAASi). This systematic review and meta-analysis evaluate the evidence for sodium zirconium cyclosilicate (SZC) in managing hyperkalemia and enabling RAASi therapy. Methods: This systematic review searched Medline, Embase, and Cochrane CENTRAL to September 2025. Dual reviewers independently screened, extracted data, and assessed bias (Cochrane RoB 2, Newcastle-Ottawa Scale). We included RCTs and observational studies of SZC in adults with hyperkalemia. A random-effects meta-analysis was performed on RCTs reporting maintenance-phase efficacy and safety. Results: The search yielded 1,254 citations, with 6 pivotal studies included. The meta-analysis of 3 RCTs found that SZC (5-10g daily) was significantly more effective than placebo at maintaining normokalemia over 12-28 days. The pooled mean difference in serum K+ was -0.58 mEq/L (95% CI: -0.65 to -0.51; I2 = 0%). SZC did increase the risk of edema (pooled Risk Ratio: 2.95; 95% CI: 1.51 to 5.76; I2 = 0%). The narrative synthesis of observational data confirmed that SZC use was associated with a >2.5-fold increase in the likelihood of continuing RAASi therapy. Conclusion: Sodium zirconium cyclosilicate is a highly effective and rapidly acting agent for both acute correction and chronic management of hyperkalemia. Our meta-analysis provides a precise estimate of its high maintenance-phase efficacy. Its primary clinical benefit lies in providing a renal-independent pathway for potassium excretion, thereby "uncoupling" potassium levels from RAASi use and bridging a critical treatment gap.
Modulation of TGF-β/Smad and Nrf2 Signaling Pathways by Thymoquinone in the Attenuation of Renal Fibrosis: A Systematic Review and Meta-Analysis of Pre-clinical Models Chairil Makky; Ian Effendi; Zulkhair Ali; Novadian; Suprapti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 1 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i1.1491

Abstract

Background: Renal fibrosis is the irreversible, final common pathway for all progressive forms of chronic kidney disease (CKD), leading to end-stage renal disease. Its pathogenesis is characterized by the over-activation of pro-fibrotic signaling, chiefly the Transforming Growth Factor-beta (TGF-β)/Smad pathway, and the failure of endogenous cytoprotective mechanisms like the nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant response. Thymoquinone (TQ), the primary bioactive constituent of Nigella sativa, is a pleiotropic compound with known anti-inflammatory and antioxidant properties. This study was designed to systematically quantify its mechanistic efficacy in modulating the core Nrf2 and TGF-β pathways in established pre-clinical models of renal fibrosis and injury. Methods: We conducted a systematic review and meta-analysis following PRISMA guidelines. We performed a comprehensive search of major databases (including PubMed and Scopus) for pre-clinical in vivo studies published between 2014 and 2025 that investigated TQ monotherapy or TQ-dominant combination therapy in rodent models of renal injury. The eight studies that met the inclusion criteria utilized diverse models: Unilateral Ureteral Obstruction (UUO), cisplatin-induced nephrotoxicity, gentamicin-induced nephrotoxicity, 5-fluorouracil (5-FU)-induced acute kidney injury (AKI), lipopolysaccharide (LPS)-induced inflammation, carfilzomib (CFZ)-induced renal impairment, and ischemia-reperfusion (IRI). Primary outcomes were the expression of renal Nrf2 and TGF-β1. Secondary outcomes included markers of fibrosis (collagen deposition, histology scores), renal function (BUN, creatinine), oxidative stress (MDA, SOD, GSH, CAT), and inflammation (TNF-α, NF-κB, IL-6, IL-1β). Data were pooled using a random-effects model, and primary analyses were stratified by injury model subgroup. Results: Thymoquinone treatment resulted in a profound and significant upregulation of the protective Nrf2 pathway (SMD: 2.38; 95% CI [1.05, 3.71]; p < 0.001; 3 studies) and its downstream target Heme Oxygenase-1 (HO-1). Concurrently, TQ treatment markedly suppressed the primary pro-fibrotic driver, TGF-β1 (SMD: -2.09; 95% CI [-2.99, -1.19]; p < 0.001; 2 studies). This pivotal dual modulation translated into significant functional and structural improvements. TQ robustly attenuated renal fibrosis scores (SMD: -1.89; 95% CI [-2.55, -1.23]; p < 0.001; 2 studies). Stratified subgroup analysis showed TQ significantly improved renal function in both chemotoxic AKI models (BUN SMD: -2.31; 95% CI [-3.22, -1.40]) and chronic obstructive/fibrosis models (BUN SMD: -1.17; 95% CI [-1.75, -0.59]). This functional protection was underpinned by potent, broad-spectrum reversal of oxidative stress and inflammation across all subgroups. Conclusion: Thymoquinone consistently ameliorates renal injury and fibrosis across a wide spectrum of pre-clinical models. Its mechanism of action is multifaceted, critically involving the dual modulation of opposing pro-fibrotic and protective pathways: it suppresses the TGF-β1 cascade while simultaneously activating and restoring the Nrf2 antioxidant response. This body of evidence strongly supports Thymoquinone as a high-potential candidate for translational research and development as a novel, network-targeting therapy for human renal fibrosis.
Beyond Phosphate Binding: A Systematic Review and Meta-Analysis on the Efficacy and Safety of the Novel Paracellular Phosphate Inhibitor, Tenapanor, for Hyperphosphatemia in Dialysis Patients Eva Julita; Ian Effendi; Zulkhair Ali; Novadian; Suprapti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 1 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i1.1492

Abstract

Background: Hyperphosphatemia is a critical driver of cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD) undergoing dialysis. Current management, reliant on phosphate binders, is hampered by high pill burden and poor adherence. Tenapanor, a first-in-class, minimally-absorbed sodium/hydrogen exchanger 3 (NHE3) inhibitor, reduces paracellular phosphate absorption. We performed a systematic review and meta-analysis of all available Phase 3 trials to quantify its efficacy and safety. Methods: We searched PubMed, Embase, and Cochrane CENTRAL through October 2025 for Phase 3 clinical trials evaluating tenapanor for hyperphosphatemia in dialysis patients. Data were extracted from 6 eligible studies (N=1573). We conducted separate random-effects meta-analyses for different study designs: 1) parallel-group monotherapy vs. placebo, 2) withdrawal-design monotherapy vs. placebo, 3) parallel-group add-on therapy vs. placebo, and 4) safety (diarrhea incidence) vs. placebo. Efficacy was measured by Mean Difference (MD) in serum phosphate change; safety by Risk Ratio (RR). Results: Tenapanor demonstrated significant efficacy across all study designs. In parallel-group monotherapy (1 study, N=167), tenapanor was superior to placebo (MD: -1.89 mg/dL; 95% CI: -2.36 to -1.42). In withdrawal-design studies (2 RCTs, N=373), tenapanor maintained serum phosphate levels significantly better than placebo (Pooled MD: -0.75 mg/dL; 95% CI: -1.05 to -0.45; I2=0%). As an add-on therapy (1 RCT, N=235), tenapanor provided additional phosphate reduction versus binders alone (MD: -0.65 mg/dL; 95% CI: -0.96 to -0.35). Tenapanor significantly increased the risk of diarrhea versus placebo (3 RCTs, N=521; Pooled RR: 4.10; 95% CI: 2.50 to 6.72; I2=30%), which was the primary adverse event leading to discontinuation. Conclusion: Tenapanor represents a new mechanistic paradigm for hyperphosphatemia management. It is a highly effective phosphate-lowering agent, both as monotherapy and add-on therapy, but is associated with a significant, mechanism-based risk of gastrointestinal side effects.
Analisis Peran Petugas Apron Movement Control dalam Melakukan Pengawasan dan Pengaturan Lalu Lintas Bandar Udara Internasional Yogyakarta Damayanti, Putri; Suprapti; Mandrawaty, Vidyana; Prasetyowati
Jurnal Manajemen Dirgantara Vol 18 No 2 (2025): Jurnal Manajemen Dirgantara, Desember 2025
Publisher : Sekolah Tinggi Teknologi Kedirgantaraan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56521/manajemen-dirgantara.v18i2.1399

Abstract

In the world of aviation, safety and smooth flight traffic are very important factors. Violations that occur in the apron area are the responsibility of AMC officers in carrying out supervisory and regulatory duties to ensure that all activities run safety and smoothly. So this study aims to observe how the role of AMC in carrying out supervisory and regulatory duties in the apron area. This study uses qualitative research using primary data and secondary data. Data collection techniques are in the form of interviews, observation and documentation. The data analysis technique used in triangulation of techniques and sourches. This study lasted for 1 month from March 1 to March 30, 2025 which was conducted at Yogyakarta Ingternastional Airport. The results of this study indicated that AMC officers have an important role in carrying out supervisory and regulatory duties in flight traffic in order to maintain flight safety and smoothness. There were obstacle found by AMC officers in the work area were able to handle them well because they were equippped with good competence and professional work levels.
PENGGUNAAN MEDIA PEMBELAJARAN DIGITAL DALAM MENINGKATKAN MOTIVASI BELAJAR SISWA Abdul Faris; Suprapti; Nurul Inayati; Adwia; Niswatun Hasanah
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 04 (2025): Volume 10 No. 04 Desember 2025 In Order
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i04.35793

Abstract

This research is motivated by the massive development of inFormation and communication technology (ICT), which demands a shift in the education paradigm towards a student-centered model. Digital learning media has become a vital component to overcome monotonous conventional learning, but the main challenge is sustaining student learning motivation. Motivation is a critical key that influences engagement , persistence, and academic outcomes. Therefore, this study aims to conduct a Systematic Literature Review (SLR) to synthesize empirical findings regarding the effectiveness and implementation of digital learning media on student learning motivation.The methodology used is the Systematic Literature Review (SLR), involving the identification, evaluation, and critical analysis of primary studies published within the period of 2020 to 2025. The literature search was conducted through major academic databases (Google Scholar, Scopus, and ERIC) based on predetermined inclusion criteria and search strings. The research stages included determining research questions, article selection, data extraction, and thematic synthesis. The results and discussion indicate that digital learning media has high effectiveness in enhancing student learning motivation due to its interactive, visual, and personal nature. The most dominant types of media used are gamification (such as Quizizz, Kahoot!) and interactive videos. Nevertheless, the implementation still faces major constraints, namely technological infrastructure limitations, insufficient teacher training in digital literacy, and the issue of digital fatigue  among students. The conclusion of this study provides comprehensive insights for educators and curriculum developers regarding optimal strategies for leveraging technology to support adaptive learning motivation in the digital age.
Metode Pendampingan Membaca Permulaan Siswa Fase A Kelas 1 di MI Muhammadiyah Klaseman Gatak Sukoharjo Tahun Ajaran 2025/2026 Pratiwi, Oktavani Putri; Suprapti
Indo-MathEdu Intellectuals Journal Vol. 7 No. 3 (2026): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v7i3.5447

Abstract

This study aims to describe the methods used by teachers in supporting the early reading skills of Year 1 pupils at MI Muhammadiyah Klaseman, to identify the factors that support and hinder their implementation, and to explain the efforts made by teachers to overcome the obstacles that arise. This study employs a descriptive qualitative approach and was conducted at MI Muhammadiyah Klaseman Gatak, Sukoharjo, during the 2025/2026 academic year. The research subjects were Year 1 teachers, with the headteacher and pupils serving as supporting informants. Data were collected through observation, in-depth interviews, and documentation. Data validity was tested using source and method triangulation, whilst data analysis was carried out using the Miles and Huberman interactive model, which includes data reduction, data presentation, and drawing conclusions. The research findings indicate that teachers apply the phonetic method, the Structural Analytic Synthetic (SAS) method, and educational games in an integrated manner. Supporting factors include teacher consistency, the use of varied learning media, and institutional support. Hindering factors include differences in pupils’ initial abilities, time constraints, and a lack of support at home. Teachers overcame these obstacles through individual guidance, grouping based on ability, gradual repetition of material, and active communication with parents. This adaptive approach had a positive impact on the development of pupils’ early reading skills.