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Gustini, Gustini
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Journal : AUSTENIT

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BIOCOMPATIBLE P(TM co SA-CAA) HYDROGELS WITH pH RESPONSIVE AND ENHANCED MECHANICAL PERFORMANCE Gustini, Gustini; Kaprawi, Kaprawi; Basri, Hasan; Irmawan, Irmawan; Yani, Irsyadi; Paramita Eka Utami, Nurhabibah
AUSTENIT Vol. 15 No. 2 (2023): AUSTENIT: October 2023
Publisher : Politeknik Negeri Sriwijaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53893/austenit.v15i2.7536

Abstract

In recent years, development of hydrogel that combines biocompatibility, pH responsive and mechanical performance has attracted the attention of researchers. A novel biocompatible hydrogel, composed of P(TM co SA) and P(TM co CAA) was synthesized by a simple admixture and heating process. The results show that with increasing levels of SA-CAA monomer concentration, an increase in tensile strength and elongation at breakpoint was observed and optimal at the ratios P(TM co SA CAA). Tensile strenght and young’s modulus registered an impressive increase of 43% and 40% respectively. These improvements are attributed to strong synergistic hydrogen bonding interactions between the TM and SA-CAA chains. During the experiment, maximum increase in weight was also achieved at pH 10 NaOH solution, it is show the pH-responsive hydrogels. The investigation of P(TM co SA-CAA) hydrogel mechanism showed that more homogenous dispersed through crosslinks dominated by β-sheets from Amide I structures. Furthermore, the SA-CAA molecules contributed to the biocompatibility, pH responsive and mechanical performance of P(TM co SA-CAA) hydrogels. Conclusively, its P(TM co SA-CAA) hydrogels clearly demonstrated the relevance of the provide a bioresponsive material for biomedical applications, such as tissue engineering, regenerative medicine and pH-sensitive drug delivery.
Co-Authors Akib, Asridawati Akmal, Samsul Al Hidayat , Rahmat Al Hidayat, Rahmat Anita Lontaan Arini Arini Asmi, A.Syamsinar Asmi Astuti - Azuwandri, Azuwandri Budi Hartono Chantika, Elmi Desy Purnama Sari, Niluh Dewi Puspitasari Diah Kusuma Pratiwi Dinsan, Dinsan Djamaludin, Djunizar Dwisnu, Erlian edwarman, edwarman Eka Putra, M Bima Eka Putri, Seprianti Eka Sri Wahyuni Ellyanie Ellyanie Ermansyah, Ermansyah Faridah Faridah Farozi, Nour Fhikri , Rijalul Fhikri, Rijalul Gunawan Gunawan Harahap, S. A. Hartono, Rudi Hasan Basri Heiwer Matongka, Yulian Hendri Chandra Hendrik Hendrik Herry Novrianda I Kadek Wartana Indrani4, Farihah Irmawan Irmawan Irsyadi Yani Kaprawi Kaprawi Lestari, Dhea Putri Lucky Hartanti, Lucky M. Hamid Anwar Maria Ulfah Marwani Marwani, Marwani Mohammad Ali Muhartini Salim Muhartini Salim Musaidah, Musaidah Mustamir Kamaruddin Muzayyana, Muzayyana Naidi, Pirman Nordianiwati, Nordianiwati Nurhabibah Paramitha Eka Utami Ovita Charolina Paramita Eka Utami, Nurhabibah Permatasari, Iin Prakoso, Akbar Teguh Praningrum, Praningrum Pratama, M. Arifky Putra, M Bima Eka Putra, M. Bima Eka Putra, M.Bima Eka Putri, Sudriyanti Rendiansyah, Rendiansyah Riman Sipahutar Romdana, Romdana Salius Silih Sarfah, Erma Selvin Marsa Hutabarat Setiawati Setiawati Sibua, Siska N. Sri Buwono . Suko Priyono SUMIYATI SUMIYATI Susanto, Yohanes Suthia Hayu, Rina Sutiswa, Shandra Isasi Syaharuddin Tri Wijayanti, Yoga Ummul Khair Utama Putra, Risky Utami, Nurhabibah Paramitha Eka V Pelima, Robert Yoyoh, Imas Yusri Yusri Zusana A Sasarari