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All Journal Jurnal Kedokteran Diponegoro Medica Hospitalia Diponegoro International Medical Journal (DIMJ) Ophthalmologica Indonesiana Indonesian Journal of Pharmacology and Therapy
Nugroho, Trilaksana
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Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The effect of red cabbage extract to serum MDA levels in rats after maximum physical activity Haris, Nadia Husna; Nugroho, Trilaksana; Utomo, Astika Widy; Yora Nindita
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1117

Abstract

The maximum physical activity led to generate of free radical levels in the human body called oxidative stress. Red cabbage is well known as the vegetable containing highest anthocyanin among various other head cabbage plants. Anthocyanin is an antioxidant which is proven can prevent oxidative stress through reduction of MDA levels. The study aimed to investigate the effect of red cabbage extract (RCE) on MDA levels in rat after doing maximum physical activity. It was a true experimental study with post-test only control group design. Twenty-four male albino Wistar rats were used in this study. The rats were randomly divided into four groups i.e. the rats receiving maximum physical activity without and with RCE administration at dose of 86 mg/kg BW for eight days and the rats not receiving maximum physical activity without and with RCE administration. A swim test was used for maximum physical activity intervention. Serum MDA levels were measured using TBARS method. Data were analysed using one-way Anova followed by post-hoc LSD. A p value <0.005 was considered to be significant. The results showed that the rats treated with RCE both receiving maximum physical activity or not showed significant MDA reduction compared to rats without treated RCE (p=0.011 and p=0.027, respectively). Meanwhile, there was no significant difference in serum MDA levels between rats treated with RCE receiving maximum physical activity and rats not treated with RCE and not receiving maximum physical activity (p=0.540). Supplementation of RCE can reduce serum MDA levels in rats with and without maximum physical activity. Further study to investigate effective dose of RCE is recommended.
Co-Authors Amelia, Sesa Amira Azkadina Arief Wildan, Arief Astika Widy Utomo, Astika Widy Astuti, Fatimah Dyah Nur Bharadaksa, Mohammad Arya Lingga Cahyono, Maharani Catharina Suharti Charles Limantoro DEWI WULANSARI Dharma, Andhika Guna Donna Hermawati Fathur Nur Kholis Fifin L. Rahmi Fifin Luthfia Rahmi Fitriani, Rizky Hari Peni Julianti Haris, Nadia Husna Hermawan Istiadi Hery Djagat Purnomo HS, Heri-Nugroho Ignatius Riwanto, Ignatius Indah Fitria, Indah Ivana Tanoko Jacob, Ni Made Helen Virginia Kingwijati, Syahriza Naufal Maharani Maharani Maharani, Maharani Mahayu Dewi Ariani, Mahayu Dewi Margareth, Ezra Nafia, Nisa Khoirun Nizar Arif Lazuardi, Nizar Arif Nyoman Suci Widyastiti Pambudi Utomo, Gede Puspita Kusuma Dewi, Puspita Kusuma Rahmi, Fifin L Reki, Winarto Rikiandraswida, Zahira Riski Prihatningtias, Riski RR Mahayu Dewi Ariani Ryamizard, Rizal Sadasih, Wisnu Saubig, Arnila Novitasari Septian, Kevin Setyorini, Desti Putri Teguh Setiawan Widijanto, Utami Widyarini, Andriati Nadhilah Wijaya, Friska Winarto Winarto Yora Nindita