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All Journal JBIO: jurnal biosains (the journal of biosciences) Jurnal Kedokteran Syiah Kuala Majalah Kedokteran Bandung Dentika Dental Journal Jurnal Farmasi Klinik Indonesia The Indonesian Biomedical Journal Universa Medicina Majalah Kedokteran Nusantara The Journal Of Medical School Buletin Farmatera Sumatera Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Narra J Cermin Dunia Kedokteran Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy The Journal of Society Medicine (JSOCMED) Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
dharma Lindarto, dharma
Department Of Internal Medicine, Faculty Medicine, Universitas Sumatera Utara, Medan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Low Serum Nerve Growth Factor Levels Are Associated with Insulin Resistance, Beta Cell Dysfunction, and Neuropathy Screening Scores in Subjects with Type 2 Diabetes Mellitus Sylvana, Dhini; Lindarto, Dharma; Syafril, Santi
The Indonesian Biomedical Journal Vol 17, No 5 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i5.3750

Abstract

BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (T2DM), associated with chronic hyperglycemia, insulin resistance, and neuroinflammation. Despite the widespread use of Michigan Neuropathy Screening Instrument (MNSI) for early identification in neuropathy screening, studies assessing its relationship between NGF, insulin resistance, and neuropathy in T2DM patients, particularly in Indonesia, remain limited. Therefore, this study was conducted to evaluate associations between serum NGF, insulin resistance, β-cell function, and MNSI scores in T2DM.METHODS: Seventy-seven T2DM subjects were classified into DPN and non-DPN groups using MNSI. Subjects were excluded if they have comorbidities and conditions potentially affecting metabolic, immune, or organ function. Enzyme-linked immunosorbent assay (ELISA) was used for the measurement of serum NGF, enzymatic hexokinase method for fasting plasma glucose (FPG) and 2-hour postprandial glucose (2HPP), high-performance liquid chromatography (HPLC) for glycated hemoglobin (HbA1c), and chemiluminescent immunoassay for fasting insulin. Homeostatic model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-β) were then calculated.RESULTS: Most of the study subjects had NGF level of <11 pg/mL. NGF concentrations showed inverse correlations with HOMA-IR (r=–0.263, p=0.021) and HOMA-β (r=–0.316, p=0.005). In the DPN subgroup, NGF demonstrated a stronger negative correlation with HOMA-β (r=–0.425, p=0.009), whereas no significant correlation was found in non-DPN. HbA1c was higher in DPN (p=0.014). No significant associations were observed between NGF and HbA1c, FPG, or 2HPP. NGF was significantly associated with MNSI Part B scores (p=0.032), reflecting objective neuropathic findings, but not with MNSI Part A or total scores.CONCLUSION: Lower NGF levels were significantly associated with insulin resistance and β-cell dysfunction in T2DM. The association with MNSI part B suggests that physical examination findings may reflect NGF-related neuropathic alterations better than symptom-based assessments.KEYWORDS: diabetic peripheral neuropathy, HOMA-IR, HOMA-β, Michigan Neuropathy Screening Instrument, nerve growth factor, T2DM
Co-Authors Abdurrahim Rasyid Lubis Achmad Rudijanto Adi Koesoema Aman Awaluddin Saragih Awaluddin Saragih Aznan Lelo Brama Ihsan Sazli Dairion Gatot, Dairion Darmadi Darmadi Dasopang, Eva S. Daulay, Milahayati Dhini Sylvana Dian Anindita Lubis Efi Ramadhan Eva S. Dasopang Farik Zarmal Ferry Sandra Ginting, Fransiscus Gontar Alamsyah Siregar Hartono Apriliasta Purba Herniza Yusdani Ihsan, Brama Imelda Rey Imelda Rey Indah Maulidawati Irmayani Irmayani Juwita Sahputri Kembaren, Tambar Kumala, Poppy Malayana Rahmita Nasution Mardianto dr Mardianto Mardianto Mardiya Sari Masrul Lubis Melati Silvanni Nasution Muhammad Budiman Muhammad Diah Muhammad Fahmi Hidayat Muzasti, Riri A. Nasution, Melati Silvanni Nindia Sugih Arto Ozar Sanuddin Pertiwi, Vani Gita Priska Krinanta Ginting Purba, Ambrocious Puteri, Happy Helene Sulung Rahmawati Rahmawati Ratna Akbari Ganie Ratna Akbari Ganie, Ratna Akbari Sahputri, Juwita Santi Syafril Santi Syafril Santi Syafril Santi Syafril Santi Syafril Santi Syafril Santi Syafril Santi Syafril, Santi Sari Harahap Siahaan, Billy Stinggo Sinaga, Bintang YM Sitepu, Annisa Nidya Rahmatika SN, Sigit Anugerah Putra SN Sondang Pintauli Stephen Udjung Suherdy Suherdy Sumadio Hadisahputra Sumantri, Imam Bagus Sylvana, Dhini Theresia, Lydia Tjokorda Gde Dalem Pemayun Urip Harahap Widya Deli Satuti Wismandari Wisnu Yetty Machrina Yulindaa, Wina Zulfikri Muhktar