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All Journal ODONTO Dental Journal Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Jurnal Berkala Kesehatan Manuju : Malahayati Nursing Journal Science Midwifery MAHESA : Malahayati Health Student Journal Bioinformatics and Biomedical Research Journal Homeostasis: Jurnal Mahasiswa Pendidikan Dokter Odonto dental journal Jurnal Geografi, Lingkungan dan Kesehatan
Wydiamala, Erida
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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TOXICITY TEST OF Eusideroxylon zwageri BARK EXTRACT ON LIVER HISTOPATHOLOGY PARENCHYMATOUS DEGENERATION AND FATTY DEGENERATION A'idah, Nurul; Aspriyanto, Didit; Krishnawan Firdaus, I Wayan Arya; Sukmana, Bayu Indra; Wydiamala, Erida
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22203

Abstract

Background: Ironwood bark extract can be developed into an alternative herbal medicine for wound healing because it contains phenolics, flavonoids, and proanthocyanidins which can act as an antioxidant. Before being used as an herbal medicine, it is necessary to ensure its safety through an toxicity test. Purpose: To find out whether there is no toxic effect on the orally administration of ironwood bark extract (Eusideroxylon zwageri) at the doses of 1,250 mg/kgBW, 2,750 mg/kgBW, and 4,750 mg/kgBW to the livers of Wistar rats (Rattus norvegicus) based on histopathological appearance of parenchymatous degeneration and fatty degeneration. Methods: This research is purely experimental with a posttest only with control design. The sample in this study were 16 Wistar rats which were divided into  4 groups, namely the control group which was only  administered distilled water and the treatment groups P1, P2, P3 which were administered ironwood bark extrac at the doses of 1,250 mg/kg BW, 2,750 mg/kg BW, and 4,750 mg/kgBW of 2x1 ml every 24 hours for 14 days. Results: The average percentages of histopathological appearance of parenchymatous degeneration and fatty degeneration in the K, P1, P2, and P3 groups showed a score of 0 which was categorized as normal. Data analysis showed that there were no significant differences between groups P1, P2, and P3 with the control group. Conclusion: Ironwood bark extract doses of 1,250 mg/kg BW, 2,750 mg/kg BW, and 4,750 mg/kg BW had no toxic effect on the liver of Wistar rats based on histopathological appearance of parenchymatous degeneration and fatty degeneration.
Co-Authors A'idah, Nurul Adelina, I Dewa Ayu Yulia Agung Biworo Amy Nindia Carabelly Ananda, Gusti M. S. Apriasari, Maharani Lailyza Aspriyanto, Didit Azminida, Dhiya Salma Bayu Indra Sukmana Edi Hartoyo Eko Suhartono Ermina Istiqomah, Ermina Essary, Erika Dewi Fayujana, Astri Meliani Firdaus, I Wayan Arya Krishnawan Fitriyana, Annisa Hadi, Sukses Herawati Herawati Hidayatullah, Syarif Mahardika Husaini Husaini Iqra, Muhammad Joharman Joharman Krishnawan Firdaus, I Wayan Arya Lenie Marlinae Lia Yulia Budiarti M. Bakhriansyah, M. Meitria Syahadatina Noor Melisa Budipramana, Melisa Muhlisin, Mahmud Nur, Radian Oktiani, Beta Widya Prasidina, Alive Ginang Puspitasati, Dewi Putra Ramadhani, Krisna Erlangga Rahman, Yajma Kamiila Robby, Muhammad Robiyansyah, Hengki Saida, Noorsabila Sanyoto, Didik Dwi Sarifah, Norlaila Siti Raudah Syamsul Arifin Tri Putri, Deby Kania Ulfa, Najiya Utami, Juliyatin Putri Veronicha, Anna Marthea Wardhana, Agung Satria Wibowo, Inka Rya Yolanda, Zuhrufa Wanna Yusrinie Wasiaturrahmah Zairin Noor Zoelkarnain, Izaak