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All Journal International Journal of Public Health Science (IJPHS) Jurnal NERS Journal of Educational Science and Technology JURNAL PENDIDIKAN KEPERAWATAN INDONESIA Jurnal Keperawatan Padjadjaran Belitung Nursing Journal Journal Of Nursing Practice Window of Health : Jurnal Kesehatan MATRIK : Jurnal Manajemen, Teknik Informatika, dan Rekayasa Komputer International Journal of Community Service Learning Jurnal Keperawatan Komprehensif (Comprehensive Nursing Journal) Nursing Sciences Journal KESANS : International Journal of Health and Science Journal of Public Health Sciences Journal of Health Sciences and Medical Development International Journal of Disaster Management DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN Indonesian Journal of Community Development Medical-Surgical Journal of Nursing Research Jurnal Keperawatan PPNI Jawa Barat Jurnal Abdimas Sains
Lindayani, Linlin
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Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Jurnal NERS

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Change in cardiovascular risk profile in people with human immunodeficiency virus infection: a-12 months follow up Lindayani, Linlin; Lai, Yiin; Ko, Wen Chien; Wang, Jung-Der; Ko, Nai Ying
Jurnal Ners Vol. 21 No. 1 (2026): VOLUME 21 ISSUE 1 (FEBRUARY 2026)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jn.v21i1.72933

Abstract

Introduction: This study aimed to evaluate longitudinal changes in CVD risk and identify the contributing factors among HIV-positive individuals. Methods: A 12-month prospective study was conducted at an AIDS treatment center in southern Taiwan. A total of 411 adults living with HIV, aged 18 years or older, with no history of CVD treatment, were enrolled. CVD risk was assessed at baseline and 6 and 12 months using the D:A:D risk prediction model. Mixed-effects models were used to examine associated factors. Results: participants ranged in age from 19 to 77 years, with 95.9% being male. At baseline, 47% of the patients were low-risk, 37.7% were moderate-risk, 10.9% were high-risk, and 4.4% were very high-risk. After 12 months, 19% of participants showed a reduction in CVD risk. Increased risk was significantly associated with hepatitis C co-infection, use of lopinavir- or abacavir-based ART, and a longer duration of lopinavir exposure. Conversely, reductions in CVD risk were linked to higher educational attainment, use of antihypertensive or lipid-lowering therapy, and adherence to a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)-based antiretroviral therapy regimen. Conclusions: CVD risk in PLHIV is dynamic and modifiable. The use of NNRTI-based regimens and lipid-lowering therapies contributed to a significant risk reduction. Comprehensive integrated management strategies addressing both HIV infection and cardiovascular health are essential. Further research is needed on the cardiovascular effects of integrase inhibitors (INSTIs), particularly their long-term effects on lipid profiles and endothelial function.
Co-Authors Achmad Fauzi Adawiyah, Dita Rabiatul Adinda, Kharisma Agus Sudrajat, Diwa Agustin, Arwinda Agustiyowati , Tri Hapsari Retno Al Freadman Koa, Apriyadno Jose Al Freadman Koa, Apryadno Jose Amelia, Cici Antika, Tri Aulia, Anida Bayu Erfianto Bedy Purnama Calisane, Nyanyu Nina Putri Calisanie, Nyayu Nina Putri Chou, Cheng-Chen Darmawati, Irma Darmawati, Irma Dharmansyah, Dhika Dian Anggraini Dian Angraenin Dian Priharja Putri Dina Amalia Dioso, Regidor III Diwa Agus Sudrajat Djatmiko, Wisnu Elfira Elfira, Elfira Eva Supriatin, Eva Fauzi, Deni Hamdan Gilang Dwi Pratiwi Hadiyani, Wini Hadiyani, Wini Hendra, Agus Hendra, Agus Heni Purnama Herdiman, Herdiman Iyus Yosep Juliasry, Dheani Juniarni, Lia Ko, Nai Ying Ko, Wen Chien Koa, Apriyadno Jose Al Freadman Koa, Apryadno Jose Al Freadman Krisna Yetti Kusniasih, Susi Kusuma, Murti Lai, Yiin Lia Idealistiana Lilis Suryani Lilis Suryani Linda, Silvana Evi Lucya, Vita Mutiar, Astri Novita Novita Noviyanti, Winia Nugraha, Ananditha Zahra Nunung Nurhayati Nuramalia, Risna Nurdina, Gina Octaviani, Putri Hilda Permana, Bhakti Purnama, Heni Putri, Anisa Dwi Rahma, Ashila RAHMAN, DIAN Rahmani, Hardiyanti Rahmawati, Mega Nur Retno Lestari Rif'an, Muhammad Rosita, Eda Roswendi, Achmad Setya Salsabila, Alfina Sanria, Ariel Sansuwito, Tukimin bin Srinatania, Dewi Sudrajat, Diwa Agus Sukarya, Doni Susri Utami, Susri Taryudi, Taryudi Triantika, Triantika Tuti Yanuarti Vita Lucya Wang, Chi-Jane Wang, Jung-Der Wijaya, Silman Silman Juwana Zulfikar, Fikri