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All Journal Jurnal Hortikultura Indonesia (JHI) AGRIKA Jurnal Produksi Tanaman Journal of Degraded and Mining Lands Management Plantropica: Journal of Agricultural Science AGRIVITA, Journal of Agricultural Science Science and Technology Indonesia Jurnal Entomologi Indonesia BUANA SAINS Agro Bali: Agricultural Journal Planta Simbiosa : Jurnal Tanaman Pangan dan Hortikultura Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat)
Didik Hariyono
Department Of Agronomy, Faculty Of Agriculture, Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics Public Health Social Sciences

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Journal : Science and Technology Indonesia

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Anti-Photoaging Effects of Moisturizer and Serum Containing Andrographis paniculata, Syzygium aromaticum, and Pogostemon cablin: A Network Pharmacology, Molecular Docking, and in vivo Study Adianingsih, Oktavia Rahayu; Johan, Christopher Kuncoro; Widarson; Ravsanjani, Eurica Andriani Najwa; Sutiyono, Bershiella Amandari; Qurrotuain, Iffah; Yurina, Valentina; Puspita, Oktavia Eka; Widasmara, Dhelya; Saitama, Akbar; Hariyono, Didik
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.19-34

Abstract

Ultraviolet-B (UVB)-induced photoaging accelerates collagen degradation, disrupts dermal structure, and compromises epidermal integrity. Natural extracts, such as Andrographis paniculata, Syzygium aromaticum, and Pogostemon cablin demonstrated antioxidant and anti-aging properties to mitigate these damages. This study investigated the protective effects of serum and moisturizer containing A. paniculata extract, S. aromaticum oil, and P. cablin oil on UVB-induced photoaging rats, by integrating network pharmacology and in vivo experiment. Compounds and photoaging-associated targets were retrieved through online databases. Enrichment analyses were performed using Metascape. Protein-protein interaction (PPI) construction and herbs-compounds-targets-pathways disease network were performed using STRING and Cytoscape 3.10.0, respectively, followed by molecular docking. An in vivo study was conducted to evaluate epidermal thickness, collagen density, and dermo-epidermal junction (DEJ) structure. Eleven key phytoconstituents and twelve core targets were identified in anti-photoaging molecular mechanisms using network pharmacology. Molecular docking analysis revealed that 7-O-methylwogonin demonstrated favorable binding against ten photoaging-associated targets. KEGG enrichment analysis showed potential inflammation processes inhibition, including photocarcinogenesis, AGE-RAGE signaling pathway, and TNF-α expression. Furthermore, treatment with serum, moisturizer, or combination of both significantly reduced epidermal thickening and enhanced collagen density compared to the UVB-exposed only group. Although no significant difference was observed in DEJ interdigitation index across groups, treated groups exhibited a trend towards better preservation of DEJ structure relative to the UVB group. In summary, serum and moisturizer containing A. paniculata, S. aromaticum, and P. cablin extracts demonstrated potential anti-photoaging effects by reducing epidermal thickness and preserving collagen density in UVB-exposed rats. These findings support these botanical-based formulations potential as effective anti-aging skincare.
Co-Authors Abdillah, Bayu Stiawan Abdillah, Bayu Stiawan Agung Nugroho Agus Suryanto Agus Suryanto Aini Nurul Aini, Nurul Akbar Hidayatullah Zaini Akbar Hidayutallah Zaini Aldiansyah, Mochammad Kiki Alfannany, Ichsanuddin Noorsy Ambarita, Yohanna Ambarita, Yohanna Amelia, Nia Kharisma Amelia, Nia Kharisma Andayani, Donik Retno Putri Andayani, Donik Retno Putri Anna Satyana Karyawati anugrah cahyaty, rikza alfya Anugrah Cahyaty, Rikza Alfya Arifin Arifin Br Ginting, Jesika Ekarina Budi Waluyo Castrena, Widya Castrena, Widya Chaerunnisa, Chaerunnisa Chaerunnisa, Chaerunnisa Delianata, Syifa Sarwahita Dhelya Widasmara Dianwari, Frieska Mayang Dwi Yamika, Wiwin Sumiya E B Manurung, Desri E B Manurung, Desri Efendi, Yayat Emiliya Putri, Nurul Hilmiah Erdien, Ghifani Erdien Fandyka Yufriza Ali Firdaus, Mohammad Nur Firdaus, Mohammad Nur Garfansa, Marchel Putra Garfansa, Marchel Putra Geovandi, M. Sonydio Hanif Fatur Rohman Heddy, Y.B.Suwasono Heddy, YB. Suwasono Ikhsani, Rahmad Faizal Ikhsani, Rahmad Faizal istiqomah istiqomah Istiqomah, Istiqomah Johan, Christopher Kuncoro Junior, David Christian Karima, Naila Karuniawan Puji Wicaksono Kusumawardani, Dinda Anastasia M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Maghfour, Mochammad Dawam Maghfour, Mochammad Dawam Margawati, Dayu Tri Margawati, Dayu Tri Medina, Syifa Medina, Syifa Misnawati Moch. Dawam Maghfoer Mochammad Dawam Maghfoer Mochammad Nawawi Mudji Santoso Muhammad Riduwan Mushoffan Prasetianto Naila Karima Nawawi, Mochammad Ninuk Herlina Norry Eka Palupi Novatriana, Christina Nunun Barunawati Nur Cholid Susianto Nur Edy Suminarti Nur Edy Suminarti Nur Winda Rachmadhani Nurhasanah, Fadila Nurlaelih, Euis Ellih Nurul Aini Nurul Setyanignsih Oktavia Eka Puspita, Oktavia Eka Oktavia Rahayu Adianingsih Onny C. Pandu Pradana Onny Chrisna Pandu Pradana Palupi, Norry Eka Palupi, Norry Eka Pratama, Ahmad Rizky Yuda Pratama, Ahmad Rizky Yuda Prayogo, Yusmani Putri, Fitri Desmarianita Qurrotuain, Iffah Rahmandhias, Deris Trian Rahmani, Novia Thea Rahmani, Novia Thea Rahmanto, Ady Rahmanto, Ady Ramadhan, Alvin Febrian Ramadhan, Alvin Febrian Ravsanjani, Eurica Andriani Najwa Riduwan, Muhammad Rissya Dewi Kusumawati Rochadi, Abigail Kartika Roedy Soelistyono Rohman, Hanif Fatur Rosa, Angela Griya Adinda Saitama, Akbar Saitama, Akbar Saraswaty, Dwi Saraswaty, Dwi Sari, Alusia Destia Sari, Alusia Destia Septiana Septiana Septiana Septiana Setiawan, Rifqi Setyaningsih, Nurul Setyaningsih, Nurul Shinta Shinta Shinta, Shinta Sholikin, Ahmad Riyadlus Sholikin, Ahmad Riyadlus Sija, Patta Simarmata, Hendra Simarmata, Hendra Sisca Fajriani Sumeru Ashari Suniah, Siti Sutiyono, Bershiella Amandari Suwandono, Adi Syafirina, Nanda Madaniya Titin Sumarni Tri Margawati, Dayu Tyas, Nia Trihayuning Tyas, Nia Trihayuning Udayana, Cicik VALENTINA YURINA Vitiara, Mustarini Dessy Wangsitala, Angger Wangsitala, Angger Widarson Widiawati, Rut Ria Widiawati, Rut Ria Wirantika, Resti Wirantika, Resti Wiwin Sumiya Dwi Yamika, Wiwin Sumiya Wuryani, Dwi Wuryani, Dwi Y.B.Suwasono Heddy Yayat Efendi YB. Suwasono Heddy Yogi Sugito Yunita Triliestyana Yusmani Prayogo YUSMANI PRAYOGO Zamzami, Ahmad Nabiel Zawawi, Arie Fakhrul Zawawi, Arie Fakhrul