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All Journal Althea Medical Journal Jurnal Ilmu dan Teknologi Kesehatan JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Jurnal Pengabdian kepada Masyarakat Nusantara CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL International Journal of Health Science and Technology Sewagati
Yuliawati, Tri Hartini
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Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Upaya peningkatan pola pengasuhan guru dan orang tua penyandang disabilitas di Pendidikan Khusus dan Layanan Khusus (PK-LK) Shafa Mojokerto Rimbun, Rimbun; Yuliawati, Tri Hartini; Faizah, Zakiyatul; Hamidah, Berliana; Amanda, Bella; Prasetiowati, Lucky; Sari, Dewi Ratna; Purwantari, Kusuma Eko; Wungu, Citrawati Dyah Kencono; Darsini, Ninik; Fepiosardi, Raihenette Amirasanti; Fathimatuzzahroh; Parmanto, Christian Melka
Sewagati Vol 9 No 5 (2025)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j26139960.v9i5.8095

Abstract

Anak Berkebutuhan Khusus (ABK) adalah anak yang mengalami keterbatasan ataukeluarbiasaan, baik fisik, mental-intelektual, sosial, maupun emosional. Keberadaanpendamping bagi siswa ABK memiliki makna yang berarti bagi proses perlindungandan tumbuh kembangnya. Kegiatan pengabdian kepada masyarakat ini bertujuanuntuk meningkatkan pengetahuan guru dan orang tua mengenai pola asuh bagi siswapenyandang disabilitas di Sekolah Shafa Mojokerto. Sebanyak 23 siswa berkebutuhankhusus diberikan asesmen kognitif, sosioemosional dan psikomotor lengkapdengan saran bagi stimulasi tumbuh kembangnya, yang dilakukan oleh psikologklinis dari Layanan Psikologi Rumah Kumbang. Diantaranya, sebanyak 4 siswapenyandang tuna daksa (cerebral palsy) diberikan asesmen fisik yang dilakukan olehDokter Spesialis Kedokteran Fisik dan Rehabilitasi dari RSUD Dr. Soetomo. Selainitu juga diberikan penyuluhan mengenai cerebral palsy, pemeriksaan genetik danpola pengasuhan yang tepat bagi guru dan orang tua siswa. Luaran dari kegiatanPkM yang telah tercapai antara lain tersedianya laporan asesmen psikologis siswadan peningkatan pengetahuan guru dan orang tua yang dibuktikan dengan peningkatanrerata nilai posttest test (80, 63 ± 14, 36) dibanding pretest (61, 88 ± 20, 07)secara signifikan ( ? = 0, 010). Kesiapan dan kesiagaan guru dan orang tua siswaABK merupakan kunci sukses penanganan, ditambah dukungan dari masyarakat danpemerintah dalam menyediakan lingkungan dan fasilitas yang ramah terhadap ABK.
Protective Effect of Ethanol Extract of Tamarillo (Solanum Betaceum) on Renal Interleukin 1 Expression in Lead Acetate-Exposed Mice Trimitasari, Kurnia; Yuliawati, Tri Hartini; I'tishom, Reny; Fatimah, Nurmawati
Majalah Biomorfologi 2026: MAJALAH BIOMORFOLOGI (IN PRESS)
Publisher : Universitas Airlangga, Surabaya, Indonesia

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Abstract

Background: The rise in environmental pollution due to industrial and transportation activities has led to widespread lead (Pb) contamination , which enters the body through inhalation or ingestion and accumulates in the kidneys, triggering excessive Reactive Oxygen Species (ROS) production, which in turn causes oxidative stress and inflammatory responses marked by increased IL-1 expression. Tamarillo, a fruit rich in flavonoids, anthocyanins, and phenolic compounds, exhibits antioxidant and anti-inflammatory properties that may protect renal tissue against lead-induced oxidative stress and inflammation. Objective: To analyze the impact of ethanol extract from tamarillo (Solanum betaceum) on interleukin-1 (IL-1) expression in the kidneys of lead acetate-exposed mice (Mus musculus). Material and Method: This true laboratory experimental study used preserved biological material (BBT) from 30 male mice (Mus musculus), categorized into five distinct groups. The negative control group, labeled K0, received only distilled water; the positive control group, K1, was administered lead acetate at 0.075 g/kgBW; while group P1, P2, and P3 were treated with lead acetate alongside Solanum betaceum extract for 35 days at 100, 200, and 400 mg/kgBW, respectively. IL-1 expression was analyzed via immunohistochemistry (IHC) using the Immunoreactive Score (IRS) method focusing on glomerular and tubular epithelial cells. Result: Significant difference in IL-1 expression among groups (p<0.05). The treatment group that received 100 mg/kgBW tamarillo extract had the lowest levels of IL-1 expression in glomerular cells (mean 4.0) and tubular epithelial cells (mean 5.0) compared to the positive control, indicating dose-dependent. Conclusion: Tamarillo (Solanum betaceum) ethanol extract effectively reduces IL-1 expression in glomerular and tubular regions of lead-exposed mice, with the optimal dose at 100 mg/kg BW, demonstrating its potential as a natural anti-inflammatory agent for combating lead-induced renal inflammation.
Co-Authors Abiyasa Putri, Izdihar Ramadhanty Amanda, Bella Andri Rezano Apriliawati, Dwi Arna, Nadhifa Aswin, R Haryanto Bambang Purwanto Darsini, Ninik Dewanti, Anggita Annisa Wahyu Dewi Ratna Sari Eko Purwanto Elfaretta, Zerlina Wina Faizah, Zakiyatul Fathimatuzzahroh Fathimatuzzahroh, Fathimatuzzahroh Fatimah, Nurmawati Fepiosardi, Raihenette Amirasanti Hakim, Faiq Amirul Hamda, Endanova Nur Hamidah, Berliana Hermawan Susanto Humairah, Ira I'tishom, Reny Irwadi, Irfiansyah Izzatul Fithriyah Izzatunnisa, Nabilah I’tishom, Reny Joni Susanto, Joni Kusuma Eko Purwantari Lucky Prasetiowati Mochammad Abdul Aziz, Mochammad Abdul Mohammad Khoirul Effendi Parmanto, Christian Melka Qorib, Muhammad Fathul Rejeki, Purwo Sri Rimba, Efendi Rimbun, Rimbun Sakina Sakina, Sakina Susanto , Joni Susiana, Okta Margarita Syulthoni, Zain Budi Trimitasari, Kurnia Vinda, Igha Wungu, Citrawati Dyah Kencono