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Journal : JURNAL FARMASIMED (JFM)

Antibacterial Activity Test of 96% Ethanol Extract of Red Ginger (Zingiber officinale var. rubrum) Against the Growth of StreptococcusPneumoniae Bacteria Harry Nugraha Bachtiar; Irna Diyana Kartika Kamaluddin; Iin Widya Ningsi; Adriani; Dwi Anggita
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/6z84gr80

Abstract

Abstract Background: Pneumonia is an infectious disease with a high global prevalence that contributes significantly to mortality in children and adults. Red ginger (Zingiber officinale var. rubrum), a traditional Indonesian medicinal plant, has been identified as having antibacterial, antioxidant, and anti-inflammatory properties. Some of its natural constituents, such as flavonoids, have shown antimicrobial activity with a low toxicity profile. Therefore, the phytochemical content in red ginger is assumed to be able to combat Streptococcus pneumoniae bacteria, which is one of the main etiologies of Pneumonia. Objective: Evaluating the potential of 96% ethanol extract of red ginger (Zingiber officinale var. rubrum) as an antimicrobial agent in inhibiting the growth of Streptococcus pneumoniae bacteria. Method: This study applied a true experimental approach with a post-test design to evaluate the effectiveness of 96% ethanol extract of red ginger (Zingiber officinale var. rubrum) as an agent that inhibits the growth of Streptococcus pneumoniae bacteria. The method used was the disc diffusion method (Kirby-Bauer). Results: The study showed that the ethanol extract of red ginger (Zingiber officinale var. rubrum) exhibited antibacterial activity; however, its effectiveness in inhibiting the growth of Streptococcus pneumoniae was not significant.Conclusion: The 96% ethanol extract of red ginger (Zingiber officinale var. rubrum) demonstrated resistance, showing only minimal inhibitory activity against Streptococcus pneumoniae. This condition contrasts with the positive control, chloramphenicol, which produced a significant inhibition zone and was categorized as sensitive. Therefore, the effectiveness of red ginger extract in inhibiting the growth of this bacterium is considerably lower than that of chloramphenicol.
Co-Authors Abdul Hafid Agustina Ahmad, Asman Alfansyah Fathur Amin, Muh Al Amir , Indah Ramadhani Amiruddin K Andi Awal Janwar Antarissubhi Ardiansya, Taufik Ardiansyah, Iksan Ardiyaningsih Puji Lestari Arif, Nurfadhilah Arsyad , Muh. Arsyam, A. Imtitsal Bilqis Awaluddin Bella Oktavianita Darmawati, Junay Dwi Anggita Erni Febriana Harahap Fadjriyah, Sitti Febby Amanda Putri Firdayanti Fuadi, Halil Hafid , Abdul Hamid, Muh. Irfan Harry Nugraha Bachtiar Haswandi.S, Hasrul Hayata Iin Widya Ningsi Irna Diyana Kartika Kamaluddin Islamiah, Nurul Jamaluddin Madjid Jaya, Faisal Nur Juharni Junay Darmawati Jusrifal Maulana Putra Laspida Lateko, Andi Halik Lidya Fransisca Lidya Fransisca, Lidya Linda Handayani Mapegau Maritje Rombe Marliana, Rina Martino , Dede Miftahul Jannah Muh Almahdy, Andi Muhammad Jurnalis Murtiadi Awaluddin Musba, Muh Firmansyah Musdikawati, Sri Nabila, A. Putri Nirwana, Hafsah Novrita, Sri Zulfia Nurhafidhah Nurmin D Nurul Inayah Hutasuhut Nuryadi, Abd Jahman Pentury, Afiq Fauzan Popi Marseli Pratiwi, Rezki Aulia R, Nur Hikma Rafikah Husni Rahmadani, Salsabila Reni Fitria Reni Rahmawati Reza Wardiansyah Ridwang Riskayanti. M Riwawan, Agus Rizal Safaruddin Rosita Safaruddin Sahabuddin Latif Sardjan, Baso Satria Ramli Sherlita Sosiawan Nusifera Sri Aisyah Hidayati St Khadijah Syam, Muh Chairul Juniardi Syamsiar, Syamsiar TALIF Tawakkal, Iqbal Tiara Tidore, Muh Faedly H Weni Nelmira Yesi Elsandra Yudhistira, Ahmad Yusril Yulianda Nofika Yulianto, Elsa Yuniliza Yurleni Zulfamanna Zulkarnain