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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) E-Jurnal Medika Udayana Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Manuju : Malahayati Nursing Journal Jurnal Farmasi Indonesia Jurnal Karinov Jurnal Farmagazine Jurnal Ilmiah Medicamento Poltekita: Jurnal Pengabdian Masyarakat Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Pengabdian kepada Masyarakat Usadha
Debby Juliadi
UNIVERSITAS MAHASARASWATI DENPASAR
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Formulasi Dan Uji Mutu Fisik Dari Granul Effervescent Ekstrak Daun Salam (Syzyginum polyanthum) Dewi, Ni Luh Samila; Suradnyana, I Gede Made; Juliadi, Debby
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7180

Abstract

  Bay leaf is one plant that has benefits as traditional medicine, acting as an antioxidant with flavonoid content. The processing is still very simple, which has an impact on the short shelf life of the herb. One alternative to prevent this is to formulat e bay leaf extract into effervescent granule preparations, which provide a more comfortable feeling with a large concentration of active substances. This study aims to determine the difference in the physical quality of effervescent granule preparations wit h variations of effervescent salts and to determine the concentration of acids and bases that produce effervescent granules of bay leaf extract with good physical quality. In 3 effervescent granule preparation formulas, the variation in acid and base concentrations (citric acid, tartric acid, and sodium bicarbonate) is F1 by 9.4%; 18.7%; 27%, F2 by 8.6%; 17.2%; 29%, and F3 by 7.9%; 15.8%; 31%. Physical quality evaluation of effervescent granule preparations includes organoleptis, flow velocity, rest angle, disperse time, pH, and moisture content. Quantitative data were analyzed with the One Way Anova test to determine the difference in physical quality of the three effervescent granule preparation formulas. Based on the results of physical quality tests, the three greenish-white granule formulas were obtained, the characteristic smell of bay leaf extract, and the granule form with a flow speed of 10 g / second, a stati onary angle in the range of 31-35 °, a dispersion time of < 5 minutes, a pH in the range of 5-6, and a moisture content of < 5 minutes. The results of One Way Anova testing found that the three formulas with variations of effervescent salts have different physical qualities, and acid-base concentrations that produce good physical qualities, namely F1 and F3
Formulasi dan Uji Mutu Fisik Sediaan Lip Balm Ekstrak Umbi Bit (Beta vulgaris L.) Tiarini, Diah Galuh; Suradnyana, I Gede Made; Juliadi, Debby
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.7181

Abstract

Dry and chapped lips are one of the problems often faced by some people that will cause pain and discomfort. Lip balm is made from the main ingredient oil or fat that will provide moisture to the lips. The addition of color to lip balm preparations will add its own attractiveness, especially for women, because occasionally it can help improve facial aesthetics. Beetroot (Beta vulgaris L.) It is one of the plants that contains betacyanin pigment which has the potential as a natural dye and has very strong antioxidant activity. The purpose of this study was to determine whether there was a difference in the physical quality of lip balm preparations with variations in beetroot extract (Beta vulgaris L). This research is a laboratory study by formulating beetroot ethanol extract into lip balm preparations in 3 formulas with variations in extract concentration, namely formula I (6%), formula II (10%), and formula III (14%). Physical quality tests of the preparations observed are organoleptis, homogeneity, adhesion, and dispersion. Analysis of organoleptical data and homogeneity was carried out descriptively while the results of adhesion and dispersion tests were analyzed with inferential statistics using IBM SPSS statistics 26 at a 95% confidence level with the One-Way ANOVA test. The results of this study showed that there were differences in the physical quality of beetroot extract lip balm (Beta vulgaris L.) at a FI (6%) with a FII (10%) and FIII (14%) especially in the dosage color, adhesion, and spreadability.
Formulasi Dan Evaluasi Mutu Fisik Granul Ekstrak Etanol Kunyit Putih (Curcuma zedoaria) Dengan Variasi Konsentrasi Bahan Pengikat Polivinil Pirolidon Apriliani, Wayan; Juliadi, Debby; Suradnyana, I Gede Made
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7578

Abstract

  White turmeric (Curcuma zedoaria) is a medicinal plant that Indonesian people widely use as a treatment for a disease. This plant is processed by blending it and serving it as a traditional medicine. However, the method of processing which is still very traditional allows errors in processing to make the efficacy of white turmeric not optimal, besides that the preparations that are processed cannot be used for a long time. Granule is a solid dosage form intended for oral use, the advantage of this preparation is the flexible dosage weight which allows for the formulation of large amounts of active ingredients such as most extracts. This study aims to obtain white turmeric ethanol extract granules with varying concentrations of polyvinyl pyrrolidone, namely 1%, 3%, and 5% which have good physical quality. The test results from this study showed that the physical quality of the preparation was good, in which the organoleptic preparation obtained was light yellow, smelled of orange aroma, and granular form. The granule compressibility test of the three formulas complied with the requirements because it was <20%. The granule flow rate test showed that the three formulas met the requirements, namely >10 gram/second. Test angle of repose of the three formula granules meet the requirements> 40o. The granule soluble time test showed that the three formulas met the requirements, namely <5 minutes and the granule water content test of the three formulas met the requirements, namely <5%. Polyvinyl pyrrolidone (PVP) binders with concentrations of 1%, 3%, and 5% produced good granules.
Formulasi dan Uji Stabilitas Krim Ekstrak Aseton Biji Alpukat Suradnyana, I Gede Made; Mendra, Ni Nyoman Yudianti; Juliadi, Debby; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 10 No 2 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i2.8728

Abstract

UV radiation can cause skin damage, thus requiring sunscreen and antioxidants for protection. Sunscreen absorbs or reflects UV rays, while antioxidants help increase antioxidant levels in skin tissues. Avocado seeds have potential as sunscreen and antioxidant agents, as the seed extract contains catechin, which can inhibit the enzymes tyrosinase, elastase, hyaluronidase, and collagenase. This study aims to determine the physical and chemical stability and the sunscreen and antioxidant activity of acetone avocado seed extract cream. The research stages included phytochemical screening, determination of total flavonoid content, antioxidant activity of the extract, cream formulation, physical and chemical stability tests, and sunscreen and antioxidant activity stability tests. The results showed that the extract tested positive for flavonoids, tannins, triterpenoids, phenols, and saponins. The extract's total flavonoid content and IC50 were 68.58±0.88 mg QE/100 g and 7.14 µg/ml, respectively. After six months of storage, there were changes in the color and spreadability of the cream. The spreadability significantly decreased from 50.87±3.17 to 35.21±2.09 g.cm/second, the total flavonoid content decreased from 9.16±0.27 to 4.48±0.16 mg QE/100 g, and the antioxidant activity significantly decreased from 7.41 to 18.72 µg/ml. Additionally, there was a significant increase in the SPF value from 1.62±0.01 to 1.87±0.06. Based on these results, the acetone avocado seed extract cream was unstable regarding physical, chemical, sunscreen, and antioxidant activity after six months of storage at room temperature. To improve the stability of the preparation, buffering in an acidic environment, adding antioxidants such as ascorbic acid, and storing at a cool temperature, are recommended.
Formulasi Gel Ekstrak Metanol Bunga Cempaka Putih (Magnolia alba) sebagai Antijerawat terhadap Bakteri Staphylococcus aureus Ni Nyoman Yudianti Mendra; Kadek Desy Aryantini; Debby Juliadi
Jurnal Farmasi Indonesia Vol 21 No 2 (2024): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v21i2.2152

Abstract

The white champaca flower is an evergreen plant that thrives in Bali, local populations take advantages of its fragrance for ritual purposes and aromatherapy. The antibacterial, antifungal, and antioxidant activity of the white champaca flower (Magnolia alba) are well-known, besides its utility as aromatherapy. These activities were attributed to the presence of secondary metabolites such as flavonoid, tannin, steroid, and saponin. This study aimed to determine the antibacterial activity of methanol extract of Magnolia alba formulated as a gel against Staphylococcus aureus. Gel formulations were prepared using various concentration of extract FI (4%), FII (6%), and FIII (8%). The physical tests included organoleptic, homogeneity, pH, dispersibility, and adhesion test. The antibacterial activity was evaluated using agar well diffusion method, with Clindamycin gel as the positive control. Statistical analysis of the inhibition zone was conducted using a Post Hoc test at a 95% confidence level. The addition of extract in each formula affected its physical properties, particularly the dispersibility. The gel exhibited a spreadability range of 2,67 – 4,22 cm, which fell below the standard 5-7 cm. The gel viscosity increased with a higher concentration of extract, resulting in reduced spreadability of the gel. The Inhibition zone of the sample against S.aureus was observed with an inhibition diameter of 6,33 mm and 11,37 mm for FII and FIII, respectively, compared to the positive control of 22,17 mm. These findings indicate that the methanol extract gel of Magnolia alba can inhibit the growth of S.aureus and has the potential as an anti-acne gel with moderate and strong inhibitory effects. The inhibitory activity of the gel against bacteria increased with a higher concentration of the extract.
Karagenan Rumput Laut Merah Bali (Gracilaria sp.) sebagai Antibakteri terhadap Delapan Bakteri Patogen Sasadara, Maria Malida Vernandes; Cahyaningsih, Erna; Dewi, Ni Luh Kade Arman Anita; Yuda, Putu Era Sandhi Kusuma; Wardani, I Gusti Agung Ayu Kusuma; Juliadi, Debby; Putri, Ni Kadek Dila Pratiwi; Putri, Ni Kadek Nisa Leoni; Darmawan, I Wayan Agus; Yanti, Ni Kadek Pradnya
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.10349

Abstract

The increase in infection cases every year, coupled with the rise in resistance cases, increases the urgency of exploring antimicrobial agents. Gracilaria sp. is a red seaweed that is widely known as one of the potential producers of active metabolites, sulfated polysaccharides. Carrageenan is one form of sulfated polysaccharide that has antimicrobial activity. This study was conducted to evaluate the antibacterial activity of carrageenan derived from Gracilaria sp. against several pathogenic bacteria, including Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecalis, Streptococcus pyogenes, and Salmonella typhi. Carrageenan was extracted from Gracilaria sp. samples obtained from the South Denpasar area (Bali) using KOH. An antibacterial activity assay of carrageenan was carried out using an agar well diffusion method with nutrient agar media. Tests were conducted at concentrations of 1 and 5 mg/mL (E. coli and S. epidermidis), 20, 30, 40 mg/mL (S. aureus, S. pyrogenes, E. faecalis, and S. typhi), 50, 75, and 100 mg/mL (P. aeruginosa and K. pneumoniae). Incubation was carried out for 24 hours at ± 37 °C. Data were analyzed statistically by one-way ANOVA and Kruskal-Wallis with a 95% confidence level. The results showed that carrageenan extracted from Gracilaria sp. exhibited significant antibacterial activity against several pathogenic bacteria, especially gram-negative bacteria. The antibacterial activity produced in this study was proportional to the increase in concentration, where the inhibitory activity produced increased as the concentration of carrageenan increased. It can be concluded that carrageenan has the potential to be an antibacterial.
Pemberdayaan masyarakat melalui pemanfaatan tanaman herbal sebagai obat rumahan dalam upaya peningkatan kesehatan keluarga Mendra, Ni Nyoman Yudianti; Suradnyana, I Gede Made; Juliadi, Debby; Wardani, I Gusti Agung Ayu Kusuma; Sari, Gusti Ayu Putu Laksmi Puspa
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 8 No 2 (2025)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v8i2.22713

Abstract

Lansia memiliki keterbatasan dalam konsumsi obat akibat penurunan fungsi organ, sehingga diperlukan alternatif yang lebih aman, seperti bahan alam. Beberapa tanaman herbal yang juga merupakan bumbu dapur, mengandung metabolit sekunder yang efektif sebagai analgetik dan antiinflamasi. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan lansia dalam memanfaatkan bumbu dapur sebagai minyak gosok. Kegiatan ini mengadopsi metode Participatory Action Research (PAR), dengan melibatkan peserta secara aktif dalam identifikasi kebutuhan, pelatihan, dan praktik pembuatan sediaan. Kegiatan ini melibatkan 50 peserta yoga lansia dari komunitas Gumuh Ayu yang aktif berlatih yoga dan memiliki perhatian pada kesehatan. Selama kegiatan, peserta menunjukkan antusiasme tinggi dan berpartisipasi aktif. Evaluasi kegiatan melalui observasi menunjukkan peningkatan pengetahuan dan keterampilan peserta dalam meracik minyak gosok yang dapat diterapkan untuk kebutuhan pribadi maupun peluang usaha. Pendekatan integratif yang menggabungkan edukasi dan praktik pemanfaatan tanaman herbal berbasis komunitas ini terbukti efektif dan relevan diterapkan di kalangan lansia, terlebih lagi kegiatan berupaya sebagai peningkatan kesehatan keluarga. Program ini berpotensi berkelanjutan melalui integrasi dalam kegiatan rutin komunitas dan pengembangan produk berbasis tanaman herbal.
Review: Pemanfaatan Tanaman sebagai Fitoterapi pada Diabetes Mellitus Dewi, Ni Luh Kade Arman Anita; Prameswari, Putu Nimas Diyah; Cahyaningsih, Erna; Megawati, Fitria; Agustini, Ni Putu Dewi; Juliadi, Debby
Usadha Vol 1 No 3 (2022): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v1i3.5562

Abstract

Diabetes is a chronic disease that occurs due to high levels of sugar in the blood, this can occur when the pancreas does not produce enough insulin (a hormone that regulates blood sugar or glucose), or when the body cannot effectively use the insulin it produces. Management of DM patients can be carried out with non-pharmacological and pharmacological therapies. The method used in the journal review was to search for the keyword "diabetes mellitus herbal medicine" for clinical studies on plant-derived products for the treatment of diabetes mellitus. Search terms included “phytotherapy”, “phytochemicals”, “medicinal plant products”, “herbal medicine”, and “diabetes mellitus”. Involving plant-derived compounds and pigmentation as outcome measures were included. In this review article, 30 journals were collected from which the objectives and results of the research in the journal were obtained. The goal is as an alternative management treatment to control blood sugar levels. For some of the compounds we discuss, among others: Flavonoids, Allicin, Lectins, Alkaloids, Andrographolid, Curcumin, Cinnamaldehyde, peptides, Phenolics, Tannins.
Formulasi Dan Uji Mutu Fisik Sediaan Foot Lotion Ekstrak Etanol Daun Sirih (Piper bettle L.) Dengan Variasi Konsentrasi Asam Stearat Juliadi, Debby; Juanita, Rr Asih; Dewi Agustini, Ni Putu
Usadha Vol 2 No 1 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i1.6420

Abstract

Betel leaf extract (Piper bettle L.) is known to contain flavonoid compounds that have antibacterial activity. Betel leaf extract needs to be formulated as a foot preparation lotion to increase the comfort of use as a topical antibacterial. The composition of the emulsifier influences the physical stability of the preparation foot lotion used. This study aims to determine the variation of stearic acid preparations foot lotion, which has good physical quality and is stable in storage. This research is purely experimental laboratory research that aims at development (development), namely developing something in an existing field (development of test methods, drug formulation). The observed responses were the physical quality of the preparations, which included organoleptic tests, homogeneity tests, pH tests, spreadability tests, and adhesion tests. The physical quality of preparations of foot lotion was analyzed descriptively. This research began with a maceration process using 70% ethanol to obtain a thick betel leaf extract (Piper bettle L.). This study made three preparation formulas with foot lotion with stearic acid concentrations of 10%, 12.5%, and 15%. The preparations that have been made are then tested for their physical quality and stability during four weeks of storage. The results of this study indicate that the preparations obtained foot lotion betel leaf ethanol extract (Piper bettle L.) with a variation of stearic acid of 10% to produce preparations of foot lotion with good physical quality seen from organoleptic tests, homogeneity, pH, spreadability, and adhesion and stable in storage for four weeks.
Tingkat Pengetahuan Penggunaan Tanaman Obat Tradisional Sebagai Alternatif Pengobatan Pada Masyarakat Desa Wisata Bindu Dewi Agustini, Ni Putu; Megawati, Fitria; Juliadi, Debby; Widiari, Ni Nyoman Sri
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i2.7145

Abstract

Public knowledge about the use of plants as medicine is mostly limited to hereditary knowledge as a form of interaction between the community and the environment, especially plants. Currently medicinal plants or herbal plants have been widely used in the medical or health fields. Today's society prefers to use products that come from nature for safety reasons. This study aims to determine the level of knowledge of the use of traditional medicine as an alternative treatment in the community of Bindu Tourism Village. The research method used is a descriptive survey method with a cross-sectional design where the research object is only observed once without any pre-test and post-test with data collection techniques using questionnaires distributed via online in Bindu Tourism Village. The data obtained from the research results were then processed by calculating the percentage of respondent answers. The results of the questionnaire data analysis obtained from 104 respondents showed that the people who had a good level of knowledge were 51 people (49%), 46 people (44%), and the level of knowledge in the poor category were 7 people (7%). The average value of knowledge from 104 respondents is 77% which is included in the range (76%-100%), so the level of knowledge of respondents is good.
Co-Authors Agustini, Ni Putu Dewi Apriliani, Wayan Astya Putri, Ni Kadek Dita Darmawan, I Wayan Agus Dewa Ayu Ika Pramitha Dewi Agustini, Ni Putu Dewi, Kade Ayu Yasinta Dewi, Ni Luh Samila Erna Cahyaningsih Gusti Ayu Putu Laksmi Puspa Sari I Gede Made Suradnyana I Gede Made Suradnyana Suradnyana I Gede Yodhi Trismawan I Putu Pasek Jaya Separsa Ida Ayu Gede Syntya Mahayani Kade Ayu Yasinta Dewi Kadek Desy Aryantini Ketut Agus Adrianta Luh Tuti Suryati Megawati, Fitria Mendra, Ni Nyoman Yudianti Ni Luh Kade Arman Anita Dewi Ni Made Dharma Shantini Suena Ni Made Dwi Mara Widyani Nayaka Ni Nyoman Wahyu Udayani Ni Nyoman Yudianti Mendra Ni Putu Dewi Agustini Ni Putu Udayana Antari Ni Wayan Yuliasih Novita Dewi Nyoman Budiartha Siada Prameswari, Putu Nimas Diyah Puguh Santoso puguh santoso, puguh Putra Hilmi Prayitno Putra, I Made Agus Sunadi Putri, Ni Kadek Dila Pratiwi Putri, Ni Kadek Nisa Leoni Putu Era Sandhi Kusuma Yuda Rika, Putu RR. Asih Juanita Sasadara, Maria Malida Vernandes Suradnyana, I Gede Made Tiarini, Diah Galuh Wardani, I Gusti Agung Ayu Kusuma Widiari, Ni Nyoman Sri Yanti, Ni Kadek Pradnya Yuliasih, Ni Wayan